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Aliases for STX6 Gene
External Ids for STX6 Gene
- HGNC: 11441
- NCBI Entrez Gene: 10228
- Ensembl: ENSG00000135823
- OMIM®: 603944
- UniProtKB/Swiss-Prot: O43752
Previous GeneCards Identifiers for STX6 Gene
- GC01M178439
- GC01M176341
- GC01M177433
- GC01M178152
- GC01M178177
- GC01M177644
- GC01M179179
- GC01M179208
- GC01M180941
- GC01M152173
- GC01M180950
- GC01M181097
- GC01M181095
- GC01M181079
- GC01M181291
- GC01M181012
Summaries for STX6 Gene
GeneCards Summary for STX6 Gene
STX6 (Syntaxin 6) is a Protein Coding gene. Diseases associated with STX6 include Leukodystrophy, Hypomyelinating, 6 and Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome. Among its related pathways are Vesicle-mediated transport and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.
UniProtKB/Swiss-Prot Summary for STX6 Gene
-
Involved in intracellular vesicle trafficking.
Additional gene information for STX6 Gene
- HGNC (11441)
- NCBI Entrez Gene (10228)
- Ensembl (ENSG00000135823)
- OMIM® (603944)
- UniProtKB/Swiss-Prot (O43752)
- Open Targets Platform(ENSG00000135823)
- Monarch Initiative
- Search for STX6 at DataMed
- Search for STX6 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STX6 Gene
Genomics for STX6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STX6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STX6
- Top Transcription factor binding sites by QIAGEN in the STX6 gene promoter:
-
- AML1a
- Elk-1
- FOXL1
- GATA-1
- ISGF-3
- POU2F1
- POU2F1a
- RFX1
- Roaz
Genomic Locations for STX6 Gene
Latest Assembly
- chr1:180,972,712-181,023,121
- (GRCh38/hg38)
- Size:
- 50,410 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:180,941,861-180,992,006
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 50,146 bases
- Orientation:
- Minus strand
- chr1:180,941,861-180,992,047
- (GRCh37/hg19 by Ensembl)
- Size:
- 50,187 bases
- Orientation:
- Minus strand
Genomic View for STX6 Gene
Genes around STX6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by HGNC
- 1q25.3 by Entrez Gene
- 1q25.3 by Ensembl
STX6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STX6 Gene
Proteins for STX6 Gene
-
Protein details for STX6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43752-STX6_HUMAN
- Recommended name:
- Syntaxin-6
- Protein Accession:
- O43752
- B2R652
- B4DR17
- Q5VY08
- Q6FH83
Protein attributes for STX6 Gene
- Size:
- 255 amino acids
- Molecular mass:
- 29176 Da
- Quaternary structure:
-
- Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity). Interacts with VPS45A (By similarity). Interacts with MARCHF2 and MARCHF3 (By similarity). Interacts with GOPC (PubMed:11384996). Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).
Protein Expression for STX6 Gene
Post-translational modifications for STX6 Gene
Other Protein References for STX6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences STX6 / Syntaxin 6 Antibody
- G Biosciences Immunotag™ STX6 Antibody
-
Custom Antibody ServicesOriGene Antibodies for STX6
- Novus Biologicals Antibodies for STX6
-
Abcam antibodies for STX6
- Invitrogen Antibodies for STX6 (AFLGC-STX6)
-
Biorbyt antibodies for STX6
-
Custom Antibody ServicesProSci Antibodies for STX6
- Sino Biological Antibodies for STX6
Protein products for research
- G Biosciences Human Syntaxin-6/STX6, Lyophilized
-
OriGene Purified Proteins for STX6
- Search Origene for MassSpec and Protein Over-expression Lysates for STX6
- Origene Custom Protein Services for STX6
- ProSpec Recombinant Proteins for STX6
-
ProSci Proteins for STX6
-
Abcam proteins for STX6
Assay products for research
- RayBiotech Custom Human Syntaxin 6 ELISA
- antibodies-online: Show 3 available STX6 Elisa Kits ranked by validation data
- Compare Top STX6 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for STX6 Gene
Domains & Families for STX6 Gene
Gene Families for STX6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for STX6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for STX6 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57566, highly similar to Syntaxin-6 (B4DR17_HUMAN)
- Syntaxin-6 (STX6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43752- Family:
-
- Belongs to the syntaxin family.
Function for STX6 Gene
Molecular function for STX6 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in intracellular vesicle trafficking.
Phenotypes From GWAS Catalog for STX6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000149 | SNARE binding | IBA | 21873635 |
| GO:0005484 | SNAP receptor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 11384996 |
| GO:0019905 | syntaxin binding | IPI | 16154903 |
Phenotypes for STX6 Gene
- MGI mutant phenotypes for STX6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STX6:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STX6 - Starting at $85 >
- * STX6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STX6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX6
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX6
miRNA for STX6 Gene
- miRTarBase miRNAs that target STX6
-
- hsa-miR-375 (MIRT019742)
- hsa-miR-20a-5p (MIRT439512)
- hsa-miR-106b-5p (MIRT439513)
- hsa-miR-7855-5p (MIRT466808)
- hsa-miR-6858-5p (MIRT466809)
- hsa-miR-4689 (MIRT466810)
- hsa-miR-19b-3p (MIRT466811)
- hsa-miR-4710 (MIRT466812)
- hsa-miR-19a-3p (MIRT466813)
- hsa-miR-4792 (MIRT466814)
- hsa-miR-4644 (MIRT466815)
- hsa-miR-4306 (MIRT466816)
- hsa-miR-185-5p (MIRT466817)
- hsa-miR-1468-3p (MIRT466818)
- hsa-miR-548x-5p (MIRT466819)
- hsa-miR-548g-5p (MIRT466820)
- hsa-miR-548f-5p (MIRT466821)
- hsa-miR-548aj-5p (MIRT466822)
- hsa-miR-4784 (MIRT466823)
- hsa-miR-3150b-3p (MIRT466824)
- hsa-miR-4786-5p (MIRT466825)
- hsa-miR-3124-3p (MIRT466826)
- hsa-miR-3691-3p (MIRT466827)
- hsa-miR-454-3p (MIRT466828)
- hsa-miR-4295 (MIRT466829)
- hsa-miR-3666 (MIRT466830)
- hsa-miR-301b-3p (MIRT466831)
- hsa-miR-301a-3p (MIRT466832)
- hsa-miR-130b-3p (MIRT466833)
- hsa-miR-130a-3p (MIRT466834)
- hsa-miR-634 (MIRT466835)
- hsa-miR-519c-3p (MIRT466836)
- hsa-miR-519b-3p (MIRT466837)
- hsa-miR-519a-3p (MIRT466838)
- hsa-miR-3591-5p (MIRT466839)
- hsa-miR-548aw (MIRT466840)
- hsa-miR-4291 (MIRT466841)
- hsa-miR-142-3p (MIRT466842)
- hsa-miR-6787-3p (MIRT466843)
- hsa-miR-5690 (MIRT466844)
- hsa-miR-3619-5p (MIRT466845)
- hsa-miR-761 (MIRT466846)
- hsa-miR-214-3p (MIRT466847)
- hsa-miR-2115-3p (MIRT466848)
- hsa-miR-922 (MIRT466849)
- hsa-miR-561-3p (MIRT466850)
- hsa-miR-548at-5p (MIRT466851)
- hsa-miR-3180-5p (MIRT466852)
- hsa-miR-6869-5p (MIRT466853)
- hsa-miR-3944-5p (MIRT466854)
- hsa-miR-4697-3p (MIRT466855)
- hsa-miR-567 (MIRT466856)
- hsa-miR-5191 (MIRT466857)
- hsa-miR-107 (MIRT466858)
- hsa-miR-103a-3p (MIRT466859)
- hsa-miR-665 (MIRT466860)
- hsa-miR-4307 (MIRT466861)
- hsa-miR-411-5p (MIRT466862)
- hsa-miR-483-5p (MIRT466863)
- hsa-miR-548al (MIRT466864)
- hsa-miR-4445-3p (MIRT466865)
- hsa-miR-8066 (MIRT466866)
- hsa-miR-513b-3p (MIRT466867)
- hsa-miR-148b-3p (MIRT466868)
- hsa-miR-148a-3p (MIRT466869)
- hsa-miR-152-3p (MIRT466870)
- hsa-miR-1-3p (MIRT466871)
- hsa-miR-206 (MIRT466872)
- hsa-miR-613 (MIRT466873)
- hsa-miR-4530 (MIRT553915)
- hsa-miR-6739-3p (MIRT698722)
- hsa-miR-576-5p (MIRT698723)
- hsa-miR-4263 (MIRT698724)
- hsa-miR-4677-5p (MIRT698725)
- hsa-miR-7156-5p (MIRT698726)
- hsa-miR-4273 (MIRT698727)
- hsa-miR-4684-5p (MIRT698728)
- hsa-miR-4799-5p (MIRT698729)
- hsa-miR-5579-3p (MIRT698730)
- hsa-miR-2117 (MIRT698731)
- hsa-miR-138-2-3p (MIRT698732)
- hsa-miR-6809-3p (MIRT719689)
- hsa-miR-6842-3p (MIRT719690)
- hsa-miR-4753-3p (MIRT719691)
- hsa-miR-647 (MIRT719692)
- hsa-miR-670-5p (MIRT719693)
- hsa-miR-642b-5p (MIRT719694)
- hsa-miR-4445-5p (MIRT719695)
- hsa-miR-9-5p (MIRT719696)
- hsa-miR-6839-5p (MIRT719697)
- hsa-miR-378j (MIRT719698)
- hsa-miR-130b-5p (MIRT719699)
- hsa-miR-6791-5p (MIRT719700)
- hsa-miR-4292 (MIRT719701)
- hsa-miR-4308 (MIRT719702)
- hsa-miR-519d-3p (MIRT726411)
- hsa-miR-93-5p (MIRT726412)
- hsa-miR-17-5p (MIRT726413)
- hsa-miR-20b-5p (MIRT726414)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STX6
- Browse OriGene Inhibitory RNA Products For STX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6
Clone products for research
- Applied Biological Materials (abm): Clones for STX6 - Starting at $45 >
- * STX6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STX6
- Addgene plasmids for STX6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX6
Cell Lines for research
-
Horizon Cell Lines for STX6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX6 Gene
Localization for STX6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene
- Golgi apparatus membrane. Single-pass type IV membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Golgi apparatus (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005769 | early endosome | IDA | 10506127 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 19224922 |
| GO:0005802 | trans-Golgi network | IDA | 16154903 |
Pathways & Interactions for STX6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) |
Delta508-CFTR traffic / ER-to-Golgi in CF
.33
Normal wtCFTR traffic / ER-to-Golgi
.33
|
wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.33
Transport Clathrin-coated vesicle cycle
.32
|
| 2 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Cytoskeletal Signaling | ||
| 5 | Golgi-to-ER retrograde transport | ||
Pathways by source for STX6 Gene
5 Reactome pathways for STX6 Gene
1 PharmGKB pathway for STX6 Gene
1 KEGG pathway for STX6 Gene
4 GeneGo (Thomson Reuters) pathways for STX6 Gene
- Delta508-CFTR traffic / ER-to-Golgi in CF
- Normal wtCFTR traffic / ER-to-Golgi
- Transport Clathrin-coated vesicle cycle
- wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
1 Cell Signaling Technology pathway for STX6 Gene
Interacting Proteins for STX6 Gene
Selected Interacting proteins:
O43752-STX6_HUMAN
ENSP00000258301
for STX6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STX6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | 21873635 |
| GO:0006906 | vesicle fusion | IPI | 10506127 |
| GO:0007032 | endosome organization | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016189 | synaptic vesicle to endosome fusion | IEA | -- |
No data available for SIGNOR curated interactions for STX6 Gene
Drugs & Compounds for STX6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for STX6 Gene
mRNA/cDNA for STX6 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258301 4810 nts (view in UCSC)
- ENST00000469135 4842 nts (view in UCSC)
- ENST00000496476 434 nts (view in UCSC)
- ENST00000542060 4809 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STX6 - Starting at $85 >
- * STX6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STX6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX6
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STX6
- Browse OriGene Inhibitory RNA Products For STX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6
Clone products for research
- Applied Biological Materials (abm): Clones for STX6 - Starting at $45 >
- * STX6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STX6
- Addgene plasmids for STX6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX6
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for STX6 Gene
- GeneLoc Exon Structure for
- STX6
Expression for STX6 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (32.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STX6
SOURCE GeneReport for Unigene cluster for STX6 Gene:
Hs.518417Evidence on tissue expression from TISSUES for STX6 Gene
- Nervous system(4.9)
- Muscle(4.3)
- Skin(2.3)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for STX6
-
OriGene qPCR primer pairs and template standards for STX6
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX6 Gene
Orthologs for STX6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STX6 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | STX6 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| STX6 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | STX6 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Stx6 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stx6 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STX6 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STX6 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STX6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stx6 30 |
|
||
| Str.15502 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2793 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | stx6 30 31 |
|
OneToOne | |
| Dr.11734 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Syx6 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006251 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | syx-6 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SYP61 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0963300 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7279 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01199 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tlg1 30 |
|
- Species where no ortholog for STX6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STX6 Gene
- ENSEMBL:
- Gene Tree for STX6 (if available)
- TreeFam:
- Gene Tree for STX6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STX6: view image
Paralogs for STX6 Gene
Variants for STX6 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2719940 | CNV | deletion | 23290073 |
| esv2719951 | CNV | deletion | 23290073 |
| esv2719962 | CNV | deletion | 23290073 |
| esv3359336 | CNV | duplication | 20981092 |
| esv3890804 | CNV | gain | 25118596 |
| nsv1122427 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STX6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STX6
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STX6 Gene
Disorders for STX6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukodystrophy, hypomyelinating, 6 |
|
|
| cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome |
|
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| supranuclear palsy, progressive, 1 |
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Search STX6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STX6
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STX6 Gene
Publications for STX6 Gene
- Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martín-Martín B … Mollinedo F (Journal of leukocyte biology 1999) 2 3 4
- BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4
- Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) Höglinger GU … Schellenberg GD (Nature genetics 2011) 3 41
- A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes. (PMID: 20163565) Otto GP … Tooze SA (Traffic (Copenhagen, Denmark) 2010) 4 23
- Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J … Guggino WB (Molecular biology of the cell 2010) 3 23
ExternalLinks
Products for STX6 Gene
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Sources for STX6 Gene
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