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Aliases for STX6 Gene

Aliases for STX6 Gene

  • Syntaxin 6 2 3 5
  • Syntaxin-6 3

External Ids for STX6 Gene

Previous GeneCards Identifiers for STX6 Gene

  • GC01M178439
  • GC01M176341
  • GC01M177433
  • GC01M178152
  • GC01M178177
  • GC01M177644
  • GC01M179179
  • GC01M179208
  • GC01M180941
  • GC01M152173
  • GC01M180972

Summaries for STX6 Gene

GeneCards Summary for STX6 Gene

STX6 (Syntaxin 6) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.

UniProtKB/Swiss-Prot for STX6 Gene

  • Involved in intracellular vesicle trafficking.

Gene Wiki entry for STX6 Gene

Additional gene information for STX6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX6 Gene

Genomics for STX6 Gene

GeneHancer (GH) Regulatory Elements for STX6 Gene

Promoters and enhancers for STX6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J181020 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 625 3.1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 YY1 STX6 LHX4 ACBD6 KIAA1614 ENSG00000243155
GH01J181086 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -69.4 -69442 11.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF263 GC01M181092 PIR40361 GC01P181092 LHX4 ACBD6 IER5 ENSG00000225359 MR1 STX6 GC01M181116
GH01J181139 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.1 -118.1 -118078 4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A ZNF2 ZNF143 FOS KLF13 IER5 STX6 MR1 GC01M181116 LINC01732
GH01J181132 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -111.8 -111795 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A YBX1 DMAP1 LHX4 ACBD6 IER5 ENSG00000225359 ENSG00000232309 KIAA1614 MR1 STX6 GC01M181116 LINC01732
GH01J181159 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.6 -137.5 -137472 3.2 HDAC1 TCF12 EGR1 IKZF2 RUNX3 SMARCA5 CBFB ELF1 IKZF1 KDM1A IER5 MR1 STX6 LINC01732 GC01M181116
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX6 gene promoter:
  • Roaz
  • GATA-1
  • POU2F1
  • Elk-1
  • POU2F1a
  • ISGF-3
  • FOXL1
  • RFX1
  • AML1a

Genomic Locations for STX6 Gene

Genomic Locations for STX6 Gene
73,432 bases
Minus strand
50,187 bases
Minus strand

Genomic View for STX6 Gene

Genes around STX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX6 Gene

Proteins for STX6 Gene

  • Protein details for STX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R652
    • B4DR17
    • Q5VY08
    • Q6FH83

    Protein attributes for STX6 Gene

    255 amino acids
    Molecular mass:
    29176 Da
    Quaternary structure:
    • Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity). Interacts with VPS45A (By similarity). Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC (PubMed:11384996). Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).

    Three dimensional structures from OCA and Proteopedia for STX6 Gene

    Alternative splice isoforms for STX6 Gene


neXtProt entry for STX6 Gene

Post-translational modifications for STX6 Gene

  • Ubiquitination at posLast=139139 and posLast=7777
  • Modification sites at PhosphoSitePlus

Other Protein References for STX6 Gene

No data available for DME Specific Peptides for STX6 Gene

Domains & Families for STX6 Gene

Gene Families for STX6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for STX6 Gene

Suggested Antigen Peptide Sequences for STX6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syntaxin family.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX6: view

Function for STX6 Gene

Molecular function for STX6 Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular vesicle trafficking.

Phenotypes From GWAS Catalog for STX6 Gene

Gene Ontology (GO) - Molecular Function for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11384996
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX6: view
genes like me logo Genes that share phenotypes with STX6: view

Animal Model Products

CRISPR Products

miRNA for STX6 Gene

miRTarBase miRNAs that target STX6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6

Clone Products

  • Addgene plasmids for STX6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX6 Gene

Localization for STX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 5
endosome 5
cytoskeleton 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IDA 10506127
GO:0005794 Golgi apparatus IDA,IEA 19224922
GO:0005802 trans-Golgi network IDA 16154903
genes like me logo Genes that share ontologies with STX6: view

Pathways & Interactions for STX6 Gene

genes like me logo Genes that share pathways with STX6: view

Gene Ontology (GO) - Biological Process for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IPI 10506127
GO:0007032 endosome organization IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX6: view

No data available for SIGNOR curated interactions for STX6 Gene

Drugs & Compounds for STX6 Gene

(4) Drugs for STX6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for STX6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX6: view

Transcripts for STX6 Gene

mRNA/cDNA for STX6 Gene

Unigene Clusters for STX6 Gene

Syntaxin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6

Clone Products

  • Addgene plasmids for STX6

Alternative Splicing Database (ASD) splice patterns (SP) for STX6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP4: - - - -

Relevant External Links for STX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX6 Gene

Protein differential expression in normal tissues from HIPED for STX6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX6 Gene

Protein tissue co-expression partners for STX6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX6 Gene:


SOURCE GeneReport for Unigene cluster for STX6 Gene:


Evidence on tissue expression from TISSUES for STX6 Gene

  • Nervous system(4.8)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with STX6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX6 Gene

Orthologs for STX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX6 34 33
  • 99.87 (n)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
STX6 33
  • 92.61 (n)
-- 34
  • 74 (a)
(Monodelphis domestica)
Mammalia STX6 34
  • 93 (a)
(Bos Taurus)
Mammalia STX6 34 33
  • 92.61 (n)
(Mus musculus)
Mammalia Stx6 16 34 33
  • 91.07 (n)
(Rattus norvegicus)
Mammalia Stx6 33
  • 90.52 (n)
(Ornithorhynchus anatinus)
Mammalia STX6 34
  • 88 (a)
(Gallus gallus)
Aves STX6 34 33
  • 82.14 (n)
(Anolis carolinensis)
Reptilia STX6 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx6 33
  • 73 (n)
Str.15502 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2793 33
(Danio rerio)
Actinopterygii stx6 34 33
  • 70.31 (n)
Dr.11734 33
fruit fly
(Drosophila melanogaster)
Insecta Syx6 34 33
  • 57.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006251 33
  • 54.61 (n)
(Caenorhabditis elegans)
Secernentea syx-6 34
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP61 33
  • 45.48 (n)
(Oryza sativa)
Liliopsida Os01g0963300 33
  • 48.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 34
  • 48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01199 33
  • 45.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tlg1 33
  • 42.18 (n)
Species where no ortholog for STX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX6 Gene

Gene Tree for STX6 (if available)
Gene Tree for STX6 (if available)
Evolutionary constrained regions (ECRs) for STX6: view image

Paralogs for STX6 Gene

Paralogs for STX6 Gene

(1) SIMAP similar genes for STX6 Gene using alignment to 2 proteins:

  • B4DR17_HUMAN
genes like me logo Genes that share paralogs with STX6: view

Variants for STX6 Gene

Sequence variations from dbSNP and Humsavar for STX6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000038024 -- 181,009,882(-) C/G intron_variant
rs1000083084 -- 180,963,614(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000088599 -- 181,010,077(-) G/A/C intron_variant
rs1000099315 -- 180,963,823(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000144255 -- 180,967,146(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STX6 Gene

Variant ID Type Subtype PubMed ID
esv2719940 CNV deletion 23290073
esv2719951 CNV deletion 23290073
esv2719962 CNV deletion 23290073
esv3359336 CNV duplication 20981092
esv3890804 CNV gain 25118596
nsv1122427 CNV deletion 24896259

Variation tolerance for STX6 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX6 Gene

Disorders for STX6 Gene

Additional Disease Information for STX6

No disorders were found for STX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX6 Gene

Publications for STX6 Gene

  1. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martín-Martín B … Mollinedo F (Journal of leukocyte biology 1999) 2 3 4 58
  2. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4 58
  3. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) Höglinger GU … Schellenberg GD (Nature genetics 2011) 3 44 58
  4. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J … Guggino WB (Molecular biology of the cell 2010) 3 22 58
  5. A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes. (PMID: 20163565) Otto GP … Tooze SA (Traffic (Copenhagen, Denmark) 2010) 4 22 58

Products for STX6 Gene

  • Addgene plasmids for STX6

Sources for STX6 Gene

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