Aliases for STX6 Gene
External Ids for STX6 Gene
- HGNC: 11441
- Entrez Gene: 10228
- Ensembl: ENSG00000135823
- OMIM: 603944
- UniProtKB: O43752
Previous GeneCards Identifiers for STX6 Gene
- GC01M178439
- GC01M176341
- GC01M177433
- GC01M178152
- GC01M178177
- GC01M177644
- GC01M179179
- GC01M179208
- GC01M180941
- GC01M152173
- GC01M180972
Summaries for STX6 Gene
GeneCards Summary for STX6 Gene
STX6 (Syntaxin 6) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.
UniProtKB/Swiss-Prot for STX6 Gene
-
Involved in intracellular vesicle trafficking.
Additional gene information for STX6 Gene
- Monarch Initiative
- Search for STX6 at DataMed
- Search for STX6 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX6 Gene
Genomics for STX6 Gene
GeneHancer (GH) Regulatory Elements for STX6 Gene
Promoters and enhancers for STX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around STX6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STX6 gene promoter:
-
- Roaz
- GATA-1
- POU2F1
- Elk-1
- POU2F1a
- ISGF-3
- FOXL1
- RFX1
- AML1a
Regulatory Element Products
Genomic Locations for STX6 Gene
Genomic Locations for STX6 Gene
- chr1:180,949,690-181,023,121
- (GRCh38/hg38)
- Size:
- 73,432 bases
- Orientation:
- Minus strand
- chr1:180,941,861-180,992,047
- (GRCh37/hg19)
- Size:
- 50,187 bases
- Orientation:
- Minus strand
Genomic View for STX6 Gene
Genes around STX6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by Entrez Gene
- 1q25.3 by HGNC
- 1q25.3 by Ensembl
STX6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STX6 Gene
Proteins for STX6 Gene
-
Protein details for STX6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43752-STX6_HUMAN
- Recommended name:
- Syntaxin-6
- Protein Accession:
- O43752
- B2R652
- B4DR17
- Q5VY08
- Q6FH83
Protein attributes for STX6 Gene
- Size:
- 255 amino acids
- Molecular mass:
- 29176 Da
- Quaternary structure:
-
- Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity). Interacts with VPS45A (By similarity). Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC (PubMed:11384996). Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).
Protein Expression for STX6 Gene
Post-translational modifications for STX6 Gene
Other Protein References for STX6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STX6 (Syntaxin 6)
-
Custom Antibody ServicesOriGene Antibodies for STX6
- Novus Biologicals Antibodies for STX6
-
Abcam antibodies for STX6
- Invitrogen Antibodies for STX6
- GeneTex STX6 Antibody for STX6
-
Boster Bio Antibodies for STX6
- Sino Biological Antibodies for STX6
Protein Products
-
OriGene Purified Proteins for STX6
- Search Origene for MassSpec and Protein Over-expression Lysates for STX6
- Origene Custom Protein Services for STX6
- ProSpec Recombinant Proteins for STX6
- Search GeneTex for Proteins for STX6
-
ProSci Proteins for STX6
-
Abcam proteins for STX6
Assay Products
- antibodies-online: Search results for 1 available STX6 Elisa Kits ranked by validation data
- Compare Top STX6 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for STX6 Gene
Domains & Families for STX6 Gene
Gene Families for STX6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
Protein Domains for STX6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for STX6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43752- Family:
-
- Belongs to the syntaxin family.
Function for STX6 Gene
Molecular function for STX6 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in intracellular vesicle trafficking.
Phenotypes From GWAS Catalog for STX6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000149 | SNARE binding | IBA | -- |
| GO:0005484 | SNAP receptor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 11384996 |
| GO:0019905 | syntaxin binding | IPI | 16154903 |
Phenotypes for STX6 Gene
- GenomeRNAi human phenotypes for STX6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STX6
-
CRISPR Products
-
OriGene CRISPR knockouts for STX6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX6
- genomics-online: gRNA clones - Search results for available STX6 gene related products
- Applied Biological Materials CRISPR for STX6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX6
- GenScript: Design CRISPR guide RNA sequences for STX6
miRNA for STX6 Gene
- miRTarBase miRNAs that target STX6
-
- hsa-mir-375 (MIRT019742)
- hsa-mir-20a-5p (MIRT439512)
- hsa-mir-106b-5p (MIRT439513)
- hsa-mir-7855-5p (MIRT466808)
- hsa-mir-6858-5p (MIRT466809)
- hsa-mir-4689 (MIRT466810)
- hsa-mir-19b-3p (MIRT466811)
- hsa-mir-4710 (MIRT466812)
- hsa-mir-19a-3p (MIRT466813)
- hsa-mir-4792 (MIRT466814)
- hsa-mir-4644 (MIRT466815)
- hsa-mir-4306 (MIRT466816)
- hsa-mir-185-5p (MIRT466817)
- hsa-mir-1468-3p (MIRT466818)
- hsa-mir-548x-5p (MIRT466819)
- hsa-mir-548g-5p (MIRT466820)
- hsa-mir-548f-5p (MIRT466821)
- hsa-mir-548aj-5p (MIRT466822)
- hsa-mir-4784 (MIRT466823)
- hsa-mir-3150b-3p (MIRT466824)
- hsa-mir-4786-5p (MIRT466825)
- hsa-mir-3124-3p (MIRT466826)
- hsa-mir-3691-3p (MIRT466827)
- hsa-mir-454-3p (MIRT466828)
- hsa-mir-4295 (MIRT466829)
- hsa-mir-3666 (MIRT466830)
- hsa-mir-301b-3p (MIRT466831)
- hsa-mir-301a-3p (MIRT466832)
- hsa-mir-130b-3p (MIRT466833)
- hsa-mir-130a-3p (MIRT466834)
- hsa-mir-634 (MIRT466835)
- hsa-mir-519c-3p (MIRT466836)
- hsa-mir-519b-3p (MIRT466837)
- hsa-mir-519a-3p (MIRT466838)
- hsa-mir-3591-5p (MIRT466839)
- hsa-mir-548aw (MIRT466840)
- hsa-mir-4291 (MIRT466841)
- hsa-mir-142-3p (MIRT466842)
- hsa-mir-6787-3p (MIRT466843)
- hsa-mir-5690 (MIRT466844)
- hsa-mir-3619-5p (MIRT466845)
- hsa-mir-761 (MIRT466846)
- hsa-mir-214-3p (MIRT466847)
- hsa-mir-2115-3p (MIRT466848)
- hsa-mir-922 (MIRT466849)
- hsa-mir-561-3p (MIRT466850)
- hsa-mir-548at-5p (MIRT466851)
- hsa-mir-3180-5p (MIRT466852)
- hsa-mir-6869-5p (MIRT466853)
- hsa-mir-3944-5p (MIRT466854)
- hsa-mir-4697-3p (MIRT466855)
- hsa-mir-567 (MIRT466856)
- hsa-mir-5191 (MIRT466857)
- hsa-mir-107 (MIRT466858)
- hsa-mir-103a-3p (MIRT466859)
- hsa-mir-665 (MIRT466860)
- hsa-mir-4307 (MIRT466861)
- hsa-mir-411-5p (MIRT466862)
- hsa-mir-483-5p (MIRT466863)
- hsa-mir-548al (MIRT466864)
- hsa-mir-4445-3p (MIRT466865)
- hsa-mir-8066 (MIRT466866)
- hsa-mir-513b-3p (MIRT466867)
- hsa-mir-148b-3p (MIRT466868)
- hsa-mir-148a-3p (MIRT466869)
- hsa-mir-152-3p (MIRT466870)
- hsa-mir-1-3p (MIRT466871)
- hsa-mir-206 (MIRT466872)
- hsa-mir-613 (MIRT466873)
- hsa-mir-4530 (MIRT553915)
- hsa-mir-6739-3p (MIRT698722)
- hsa-mir-576-5p (MIRT698723)
- hsa-mir-4263 (MIRT698724)
- hsa-mir-4677-5p (MIRT698725)
- hsa-mir-7156-5p (MIRT698726)
- hsa-mir-4273 (MIRT698727)
- hsa-mir-4684-5p (MIRT698728)
- hsa-mir-4799-5p (MIRT698729)
- hsa-mir-5579-3p (MIRT698730)
- hsa-mir-2117 (MIRT698731)
- hsa-mir-138-2-3p (MIRT698732)
- hsa-mir-6809-3p (MIRT719689)
- hsa-mir-6842-3p (MIRT719690)
- hsa-mir-4753-3p (MIRT719691)
- hsa-mir-647 (MIRT719692)
- hsa-mir-670-5p (MIRT719693)
- hsa-mir-642b-5p (MIRT719694)
- hsa-mir-4445-5p (MIRT719695)
- hsa-mir-9-5p (MIRT719696)
- hsa-mir-6839-5p (MIRT719697)
- hsa-mir-378j (MIRT719698)
- hsa-mir-130b-5p (MIRT719699)
- hsa-mir-6791-5p (MIRT719700)
- hsa-mir-4292 (MIRT719701)
- hsa-mir-4308 (MIRT719702)
- hsa-mir-519d-3p (MIRT726411)
- hsa-mir-93-5p (MIRT726412)
- hsa-mir-17-5p (MIRT726413)
- hsa-mir-20b-5p (MIRT726414)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STX6
- Browse OriGene Inhibitory RNA Products For STX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6
- genomics-online: shRNA clones - Search results for available STX6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for STX6
- VectorBuilder custom plasmid, inducible vectors for STX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STX6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STX6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX6
- genomics-online: cdna clones - Search results for available STX6 gene related products
- orf clones - Search results for available STX6 gene related products
- Applied Biological Materials Clones for STX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for STX6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX6 Gene
Localization for STX6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene
- Golgi apparatus membrane; Single-pass type IV membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| cytoskeleton | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005769 | early endosome | IDA | 10506127 |
| GO:0005794 | Golgi apparatus | IDA,IEA | 19224922 |
| GO:0005802 | trans-Golgi network | IDA | 16154903 |
Pathways & Interactions for STX6 Gene
Pathways by source for STX6 Gene
5 Reactome pathways for STX6 Gene
1 PharmGKB pathway for STX6 Gene
1 KEGG pathway for STX6 Gene
4 GeneGo (Thomson Reuters) pathways for STX6 Gene
1 Cell Signaling Technology pathway for STX6 Gene
Interacting Proteins for STX6 Gene
Selected Interacting proteins:
O43752-STX6_HUMAN
ENSP00000258301
for STX6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STX6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | -- |
| GO:0006906 | vesicle fusion | IPI | 10506127 |
| GO:0007032 | endosome organization | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
No data available for SIGNOR curated interactions for STX6 Gene
Transcripts for STX6 Gene
mRNA/cDNA for STX6 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (159) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000258301 4851 bps (uc021pfr.3)
- ENST00000469135 4842 bps (uc057nsh.1)
- ENST00000496476 434 bps (uc057nsi.1)
- ENST00000542060 4809 bps (uc010pnr.4)
CRISPR Products
-
OriGene CRISPR knockouts for STX6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX6
- genomics-online: gRNA clones - Search results for available STX6 gene related products
- Applied Biological Materials CRISPR for STX6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX6
- GenScript: Design CRISPR guide RNA sequences for STX6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STX6
- Browse OriGene Inhibitory RNA Products For STX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6
- genomics-online: shRNA clones - Search results for available STX6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for STX6
- VectorBuilder custom plasmid, inducible vectors for STX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STX6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STX6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX6
- genomics-online: cdna clones - Search results for available STX6 gene related products
- orf clones - Search results for available STX6 gene related products
- Applied Biological Materials Clones for STX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: |
Expression for STX6 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (32.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STX6 Gene:
STX6SOURCE GeneReport for Unigene cluster for STX6 Gene:
Hs.518417Evidence on tissue expression from TISSUES for STX6 Gene
- Nervous system(4.8)
- Muscle(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for STX6
-
OriGene qPCR primer pairs for STX6
- genomics-online: primer clones - Search results for available STX6 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX6 Gene
Orthologs for STX6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STX6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| STX6 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | STX6 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STX6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stx6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stx6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STX6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STX6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | STX6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stx6 33 |
|
||
| Str.15502 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2793 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stx6 34 33 |
|
OneToOne | |
| Dr.11734 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Syx6 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006251 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | syx-6 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SYP61 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0963300 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7279 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01199 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tlg1 33 |
|
- Species where no ortholog for STX6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for STX6 Gene
- ENSEMBL:
- Gene Tree for STX6 (if available)
- TreeFam:
- Gene Tree for STX6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STX6: view image
Paralogs for STX6 Gene
Variants for STX6 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000038024 | -- | 181,009,882(-) | C/G | intron_variant | |
| rs1000083084 | -- | 180,963,614(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000088599 | -- | 181,010,077(-) | G/A/C | intron_variant | |
| rs1000099315 | -- | 180,963,823(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000144255 | -- | 180,967,146(-) | A/G | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2719940 | CNV | deletion | 23290073 |
| esv2719951 | CNV | deletion | 23290073 |
| esv2719962 | CNV | deletion | 23290073 |
| esv3359336 | CNV | duplication | 20981092 |
| esv3890804 | CNV | gain | 25118596 |
| nsv1122427 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STX6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STX6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX6 Gene
Disorders for STX6 Gene
Additional Disease Information for STX6
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for STX6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX6 Gene
Publications for STX6 Gene
- Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martín-Martín B … Mollinedo F (Journal of leukocyte biology 1999) 2 3 4 58
- BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4 58
- Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) Höglinger GU … Schellenberg GD (Nature genetics 2011) 3 44 58
- Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J … Guggino WB (Molecular biology of the cell 2010) 3 22 58
- A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes. (PMID: 20163565) Otto GP … Tooze SA (Traffic (Copenhagen, Denmark) 2010) 4 22 58
Products for STX6 Gene
- R&D Systems Antibodies for STX6 (Syntaxin 6)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for STX6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for STX6
- Search Origene for MassSpec and Protein Over-expression Lysates for STX6
- Origene Custom Protein Services for STX6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STX6
- Browse OriGene Inhibitory RNA Products For STX6
- OriGene qPCR primer pairs and template standards for STX6
- OriGene qPCR primer pairs for STX6
- OriGene CRISPR knockouts for STX6
- OriGene ORF clones in human for STX6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STX6
- GenScript: Next-day shipping of latest version cDNA ORF clones for STX6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STX6
- GenScript Custom Assay Services for STX6
- GenScript Custom overexpressing Cell Line Services for STX6
- GenScript: Design CRISPR guide RNA sequences for STX6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STX6
- Sino Biological Human cDNA Clone for STX6
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for STX6
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STX6
- Novus Biologicals proteins and lysates for STX6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STX6
- Abcam proteins for STX6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for STX6
- Cyagen custom Knockout/knockin (KOKI) mouse models for STX6
- VectorBuilder custom plasmid, inducible vectors for STX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STX6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STX6
- antibodies-online: Search results for 118 available STX6 Antibodies ranked by validation data
- Compare Top STX6 Antibodies
- antibodies-online: Search results for 1 available STX6 Elisa Kits ranked by validation data
- Compare Top STX6 Elisa Kits
- Recommended
- antibodies-online: Search results for 17 available STX6 Proteins ranked by validation data
- Compare Top STX6 Proteins
- GeneTex STX6 Antibody for STX6
- Search GeneTex for Proteins for STX6
- Search for STX6 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for STX6
- Horizon Cell Lines for STX6
- genomics-online: cdna clones - Search results for available STX6 gene related products
- orf clones - Search results for available STX6 gene related products
- genomics-online: gRNA clones - Search results for available STX6 gene related products
- genomics-online: primer clones - Search results for available STX6 gene related products
- genomics-online: shRNA clones - Search results for available STX6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX6
- GeneCopoeia miRNA 3'UTR Target clone products for STX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX6
- Boster Bio Antibodies for STX6
- Browse Boster Bio ELISA Kits
Sources for STX6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt