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STX6 (Syntaxin 6) is a Protein Coding gene. Diseases associated with STX6 include Leukodystrophy, Hypomyelinating, 6 and Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome. Among its related pathways are Intra-Golgi traffic and Retrograde transport at the Trans-Golgi-Network. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IBA | 21873635 |
GO:0005484 | SNAP receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 11384996 |
GO:0019905 | syntaxin binding | IPI | 16154903 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005769 | early endosome | IDA | 10506127 |
GO:0005794 | Golgi apparatus | IEA,IDA | 19224922 |
GO:0005802 | trans-Golgi network | IDA | 16154903 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Delta508-CFTR traffic / ER-to-Golgi in CF |
Delta508-CFTR traffic / ER-to-Golgi in CF
.33
Normal wtCFTR traffic / ER-to-Golgi
.33
|
wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.33
Transport Clathrin-coated vesicle cycle
.32
|
2 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | ||
3 | Vesicle-mediated transport | ||
4 | Cytoskeletal Signaling | ||
5 | Golgi-to-ER retrograde transport |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0006906 | vesicle fusion | IPI | 10506127 |
GO:0007032 | endosome organization | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0016189 | synaptic vesicle to endosome fusion | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STX6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STX6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
STX6 30 |
|
||||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | STX6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stx6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Stx6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | STX6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STX6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STX6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stx6 30 |
|
||
Str.15502 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.2793 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stx6 30 31 |
|
OneToOne | |
Dr.11734 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Syx6 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006251 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | syx-6 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SYP61 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0963300 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7279 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01199 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tlg1 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2719940 | CNV | deletion | 23290073 |
esv2719951 | CNV | deletion | 23290073 |
esv2719962 | CNV | deletion | 23290073 |
esv3359336 | CNV | duplication | 20981092 |
esv3890804 | CNV | gain | 25118596 |
nsv1122427 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukodystrophy, hypomyelinating, 6 |
|
|
cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome |
|
|
supranuclear palsy, progressive, 1 |
|
|