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This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include Endometriosis and Smith-Mccort Dysplasia 1. Among its related pathways are Vesicle-mediated transport and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SNAP receptor activity. An important paralog of this gene is STX3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IBA | 21873635 |
GO:0005484 | SNAP receptor activity | IDA | 15215310 |
GO:0005515 | protein binding | IPI | 18167358 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0047485 | protein N-terminus binding | IPI | 19536132 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA,IDA | 9464276 |
GO:0005829 | cytosol | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | ||
3 | Vesicle-mediated transport | ||
4 | Metabolism of proteins | ||
5 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
GO:0006906 | vesicle fusion | IBA | 21873635 |
GO:0016192 | vesicle-mediated transport | IEA | -- |
GO:0034498 | early endosome to Golgi transport | IMP | 17389686 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STX5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STX5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STX5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Stx5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Stx5a 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STX5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | STX5 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STX5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stx5 30 |
|
||
Str.1892 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14190 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stx5a 30 31 |
|
OneToMany | |
stx5al 31 |
|
OneToMany | |||
wufb81g12 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Syx5 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | syx-5 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR210C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F17798g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SED5 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SYP32 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0179200 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01907 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sed5 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2930 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs370048912 | Likely Benign: not provided | 62,831,115(-) |
G/A NM_003164.5(STX5):c.129C>T (p.Pro43=) |
SYNONYMOUS_VARIANT,INTRON | |
VAR_035642 | A breast cancer sample |
p.Gln79His |
|||
rs11231241 | - |
p.Gln72His |
|||
rs3802945 | - |
p.Pro51Leu |
|||
rs746774052 | - |
p.Ile138Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
endometriosis |
|
|
smith-mccort dysplasia 1 |
|
|
leukodystrophy, hypomyelinating, 6 |
|
|
dyggve-melchior-clausen disease |
|
|
vohwinkel syndrome |
|
|