External Ids for STX5 Gene
Previous HGNC Symbols for STX5 Gene
Previous GeneCards Identifiers for STX5 Gene
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for STX5 Gene
STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include Endometriosis and Smith-Mccort Dysplasia 1. Among its related pathways are Vesicle-mediated transport and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SNAP receptor activity. An important paralog of this gene is STX3.
UniProtKB/Swiss-Prot Summary for STX5 Gene
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.