This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targe... See more...

Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3 5
  • Syntaxin 5A 2 3
  • Syntaxin-5 3 4
  • STX5A 3 4
  • SED5 2 3
  • STX5 5

External Ids for STX5 Gene

Previous HGNC Symbols for STX5 Gene

  • STX5A

Previous GeneCards Identifiers for STX5 Gene

  • GC11M062331
  • GC11M062574
  • GC11M058904

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include Endometriosis and Smith-Mccort Dysplasia 1. Among its related pathways are Vesicle-mediated transport and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SNAP receptor activity. An important paralog of this gene is STX3.

UniProtKB/Swiss-Prot Summary for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Wiki entry for STX5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STX5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STX5

Top Transcription factor binding sites by QIAGEN in the STX5 gene promoter:
  • AP-1
  • ATF-2

Genomic Locations for STX5 Gene

Latest Assembly
chr11:62,806,860-62,832,053
(GRCh38/hg38)
Size:
25,194 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,574,332-62,599,523
(GRCh37/hg19 by Entrez Gene)
Size:
25,192 bases
Orientation:
Minus strand

chr11:62,574,369-62,599,560
(GRCh37/hg19 by Ensembl)
Size:
25,192 bases
Orientation:
Minus strand

Genomic View for STX5 Gene

Genes around STX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13190-STX5_HUMAN
    Recommended name:
    Syntaxin-5
    Protein Accession:
    Q13190
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    Size:
    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4 (PubMed:19536132). Interacts with GM130/GOLGA2 (By similarity). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (PubMed:18843296).
    Miscellaneous:
    • [Isoform 2]: Produced by alternative initiation at Met-55 of isoform 1.
    • [Isoform 3]: Produced by alternative splicing and alternative initiation.

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX5 Gene

Post-translational modifications for STX5 Gene

  • Ubiquitination at Lys82, Lys148, and Lys241
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STX5 Gene

Domains & Families for STX5 Gene

Gene Families for STX5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX5 Gene

InterPro:
Blocks:
  • Syntaxin, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for STX5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57518, highly similar to Syntaxin-5 (B4DKR0_HUMAN)
  • Syntaxin-5 (STX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13190

UniProtKB/Swiss-Prot:

STX5_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX5: view

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function:
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Phenotypes From GWAS Catalog for STX5 Gene

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA 21873635
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding IPI 18167358
GO:0045296 cadherin binding HDA 25468996
GO:0047485 protein N-terminus binding IPI 19536132
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

Animal Models for STX5 Gene

MGI Knock Outs for STX5:
  • Stx5a Stx5a<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for STX5

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane. Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250 UniProtKB:Q08851}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
plasma membrane 3
nucleus 3
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 9464276
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with STX5: view

Pathways & Interactions for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Pathways by source for STX5 Gene

1 GeneGo (Thomson Reuters) pathway for STX5 Gene
  • Transport Clathrin-coated vesicle cycle
1 Qiagen pathway for STX5 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA 21873635
GO:0016192 vesicle-mediated transport IEA --
GO:0034498 early endosome to Golgi transport IMP 17389686
genes like me logo Genes that share ontologies with STX5: view

No data available for SIGNOR curated interactions for STX5 Gene

Drugs & Compounds for STX5 Gene

(1) Drugs for STX5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

mRNA/cDNA for STX5 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX5

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
STX5

Expression for STX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STX5 Gene

Protein differential expression in normal tissues from HIPED for STX5 Gene

This gene is overexpressed in Cervix (13.6) and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX5 Gene



Protein tissue co-expression partners for STX5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STX5

SOURCE GeneReport for Unigene cluster for STX5 Gene:

Hs.654602

Evidence on tissue expression from TISSUES for STX5 Gene

  • Kidney(4.5)
  • Liver(4.4)
  • Heart(4.4)
  • Blood(4.3)
  • Nervous system(3.5)
  • Skin(2.4)
  • Adrenal gland(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with STX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX5 Gene

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STX5 30 31
  • 99.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STX5 30 31
  • 94.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STX5 30 31
  • 93.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stx5 30
  • 89.74 (n)
Mouse
(Mus musculus)
Mammalia Stx5a 30 17 31
  • 89.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STX5 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STX5 31
  • 65 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STX5 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stx5 30
  • 72.72 (n)
Str.1892 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 30
Zebrafish
(Danio rerio)
Actinopterygii stx5a 30 31
  • 74.59 (n)
OneToMany
stx5al 31
  • 66 (a)
OneToMany
wufb81g12 30
Fruit Fly
(Drosophila melanogaster)
Insecta Syx5 30 31
  • 59.91 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea syx-5 30 31
  • 48.4 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR210C 30
  • 47.77 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 30
  • 45.49 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 30 31 33
  • 43.72 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SYP32 30
  • 48.53 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0179200 30
  • 48.75 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01907 30
  • 51.03 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 30
  • 49.23 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2930 31
  • 49 (a)
OneToOne
Species where no ortholog for STX5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STX5 Gene

ENSEMBL:
Gene Tree for STX5 (if available)
TreeFam:
Gene Tree for STX5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STX5: view image

Paralogs for STX5 Gene

genes like me logo Genes that share paralogs with STX5: view

Variants for STX5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STX5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs370048912 Likely Benign: not provided 62,831,115(-) G/A
NM_003164.5(STX5):c.129C>T (p.Pro43=)
SYNONYMOUS_VARIANT,INTRON
VAR_035642 A breast cancer sample p.Gln79His
rs11231241 - p.Gln72His
rs3802945 - p.Pro51Leu
rs746774052 - p.Ile138Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STX5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
esv991674 OTHER inversion 20482838
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Variation tolerance for STX5 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX5 Gene

Disorders for STX5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for STX5 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search STX5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STX5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with STX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V … Roche PA (Journal of molecular neuroscience : MN 1997) 2 3 4 23
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O … Lev S (The EMBO journal 2009) 3 4 23
  3. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. (PMID: 18843296) Mancias JD … Goldberg J (The EMBO journal 2008) 3 4
  4. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A … Lowe M (The Journal of biological chemistry 2008) 3 23
  5. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PMID: 17389686) Amessou M … Johannes L (Journal of cell science 2007) 3 23

Products for STX5 Gene

Sources for STX5 Gene