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Aliases for STX4 Gene

Aliases for STX4 Gene

  • Syntaxin 4 2 3 5
  • Renal Carcinoma Antigen NY-REN-31 3 4
  • Syntaxin 4A (Placental) 2 3
  • STX4A 3 4
  • Syntaxin-4 3
  • P35-2 3

External Ids for STX4 Gene

Previous HGNC Symbols for STX4 Gene

  • STX4A

Previous GeneCards Identifiers for STX4 Gene

  • GC16P030953
  • GC16P031044
  • GC16P028606

Summaries for STX4 Gene

GeneCards Summary for STX4 Gene

STX4 (Syntaxin 4) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include SNARE binding and sphingomyelin phosphodiesterase activator activity. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX4 Gene

  • Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Gene Wiki entry for STX4 Gene

Additional gene information for STX4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX4 Gene

Genomics for STX4 Gene

GeneHancer (GH) Regulatory Elements for STX4 Gene

Promoters and enhancers for STX4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I031031 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 403 2.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX4 ZNF785 FUS ENSG00000260267 SMG1P5 SRCAP SETD1A HSD3B7 NPIPB13 ZNF747
GH16I030367 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.5 -656.9 -656857 17 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MYLPF ZNF48 TBC1D10B SEPT1 SETD1A SRCAP INO80E NPIPB12 SMG1P5 ZNF764
GH16I031116 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.6 +85.5 85523 3.9 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 KAT8 ENSG00000262766 SRCAP SETD1A NPIPB13 ENSG00000260267 SMG1P5 STX4 PRR14 ENSG00000260304
GH16I030089 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.5 -939.4 -939397 8.1 MLX DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D YPEL3 TBX6 STX4 INO80E SMG1P2 SMG1P5 RNF40 PRR14 FBRS SRCAP
GH16I030533 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.7 -497.9 -497946 3.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000235560 ZNF747 ENSG00000261459 FUS SRCAP SMG1P5 SMG1P2 ZNF785 ENSG00000260267 PRR14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX4 gene promoter:

Genomic Locations for STX4 Gene

Genomic Locations for STX4 Gene
chr16:31,032,889-31,042,975
(GRCh38/hg38)
Size:
10,087 bases
Orientation:
Plus strand
chr16:31,044,210-31,054,296
(GRCh37/hg19)

Genomic View for STX4 Gene

Genes around STX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX4 Gene

Proteins for STX4 Gene

  • Protein details for STX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12846-STX4_HUMAN
    Recommended name:
    Syntaxin-4
    Protein Accession:
    Q12846
    Secondary Accessions:
    • A8MXY0
    • Q15525
    • Q6FHE8

    Protein attributes for STX4 Gene

    Size:
    297 amino acids
    Molecular mass:
    34180 Da
    Quaternary structure:
    • Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).

    Alternative splice isoforms for STX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX4 Gene

Post-translational modifications for STX4 Gene

  • Ubiquitination at posLast=4444, posLast=9191, and isoforms=2243

No data available for DME Specific Peptides for STX4 Gene

Domains & Families for STX4 Gene

Gene Families for STX4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for STX4 Gene

Graphical View of Domain Structure for InterPro Entry

Q12846

UniProtKB/Swiss-Prot:

STX4_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX4: view

Function for STX4 Gene

Molecular function for STX4 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Phenotypes From GWAS Catalog for STX4 Gene

Gene Ontology (GO) - Molecular Function for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12130530
GO:0016230 sphingomyelin phosphodiesterase activator activity IMP 20956541
genes like me logo Genes that share ontologies with STX4: view
genes like me logo Genes that share phenotypes with STX4: view

Animal Models for STX4 Gene

MGI Knock Outs for STX4:

Animal Model Products

CRISPR Products

miRNA for STX4 Gene

miRTarBase miRNAs that target STX4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX4 Gene

Localization for STX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX4 Gene

Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
golgi apparatus 3
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000322 storage vacuole IEA --
GO:0005615 extracellular space IDA 22226963
GO:0005622 intracellular IDA 24055037
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA 20956541
genes like me logo Genes that share ontologies with STX4: view

Pathways & Interactions for STX4 Gene

genes like me logo Genes that share pathways with STX4: view

Gene Ontology (GO) - Biological Process for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0008284 positive regulation of cell proliferation IMP 21720706
genes like me logo Genes that share ontologies with STX4: view

No data available for SIGNOR curated interactions for STX4 Gene

Drugs & Compounds for STX4 Gene

(8) Drugs for STX4 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenprocoumon Approved, Investigational Pharma 32
Warfarin Approved Pharma 505

(2) Additional Compounds for STX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX4: view

Transcripts for STX4 Gene

Unigene Clusters for STX4 Gene

Syntaxin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13: -

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STX4 Gene

GeneLoc Exon Structure for
STX4
ECgene alternative splicing isoforms for
STX4

Expression for STX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX4 Gene

Protein differential expression in normal tissues from HIPED for STX4 Gene

This gene is overexpressed in Nasal epithelium (19.8) and Lavage (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX4 Gene



Protein tissue co-expression partners for STX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX4 Gene:

STX4

SOURCE GeneReport for Unigene cluster for STX4 Gene:

Hs.83734

mRNA Expression by UniProt/SwissProt for STX4 Gene:

Q12846-STX4_HUMAN
Tissue specificity: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

Evidence on tissue expression from TISSUES for STX4 Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Lung(4.4)
  • Eye(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Nervous system(2.5)
  • Pancreas(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with STX4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX4 Gene

Orthologs for STX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX4 33
  • 92.3 (n)
cow
(Bos Taurus)
Mammalia STX4 33 34
  • 92.23 (n)
dog
(Canis familiaris)
Mammalia STX4 33 34
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Stx4a 33 16 34
  • 87.91 (n)
rat
(Rattus norvegicus)
Mammalia Stx4 33
  • 86.21 (n)
oppossum
(Monodelphis domestica)
Mammalia STX4 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX4 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX4 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4372 33
zebrafish
(Danio rerio)
Actinopterygii stx4 33 34
  • 58.56 (n)
zgc56272 33
fruit fly
(Drosophila melanogaster)
Insecta Syx4 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-2 34
  • 24 (a)
ManyToMany
syx-3 34
  • 21 (a)
ManyToMany
syx-4 34
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO2 34
  • 23 (a)
ManyToMany
SSO1 34
  • 22 (a)
ManyToMany
Species where no ortholog for STX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX4 Gene

ENSEMBL:
Gene Tree for STX4 (if available)
TreeFam:
Gene Tree for STX4 (if available)

Paralogs for STX4 Gene

Paralogs for STX4 Gene

(10) SIMAP similar genes for STX4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STX4: view

Variants for STX4 Gene

Sequence variations from dbSNP and Humsavar for STX4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000369536 -- 31,037,643(+) A/G intron_variant
rs1000586302 -- 31,033,152(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000623305 -- 31,032,848(+) C/A upstream_transcript_variant
rs1000760768 -- 31,032,718(+) G/A upstream_transcript_variant
rs1000816221 -- 31,032,408(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for STX4 Gene

Variant ID Type Subtype PubMed ID
nsv833193 CNV gain+loss 17160897
nsv571820 CNV loss 21841781
nsv457483 CNV loss 19166990
dgv35n68 CNV loss 17160897

Variation tolerance for STX4 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX4 Gene

Disorders for STX4 Gene

Additional Disease Information for STX4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX4 Gene

Publications for STX4 Gene

  1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low SH … Weimbs T (Molecular biology of the cell 2006) 2 3 22 58
  2. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish MN … Ward CW (The Biochemical journal 1996) 3 4 22 58
  3. Isolation and sequence analysis of the human syntaxin-encoding gene. (PMID: 8206394) Li H … Seth A (Gene 1994) 2 3 4 58
  4. Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. (PMID: 20434989) Kennedy MJ … Ehlers MD (Cell 2010) 3 22 58
  5. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PMID: 18588921) Brochetta C … Blank U (Biochimica et biophysica acta 2008) 3 22 58

Products for STX4 Gene

Sources for STX4 Gene

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