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The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] See more...
Aliases for STX3 Gene
External Ids for STX3 Gene
- HGNC: 11438
- Entrez Gene: 6809
- Ensembl: ENSG00000166900
- OMIM: 600876
- UniProtKB: Q13277
Previous HGNC Symbols for STX3 Gene
- STX3A
Previous GeneCards Identifiers for STX3 Gene
- GC11P059280
- GC11P059522
- GC11P055873
- GC11P059480
- GC11P059755
Summaries for STX3 Gene
-
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for STX3 Gene
STX3 (Syntaxin 3) is a Protein Coding gene. Diseases associated with STX3 include Diarrhea 2, With Microvillus Atrophy and Hemophagocytic Lymphohistiocytosis, Familial, 5. Among its related pathways are Cytokine Signaling in Immune system and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include SNARE binding and arachidonic acid binding. An important paralog of this gene is STX1A.
UniProtKB/Swiss-Prot Summary for STX3 Gene
-
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Additional gene information for STX3 Gene
- Monarch Initiative
- Search for STX3 at DataMed
- Search for STX3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STX3 Gene
Genomics for STX3 Gene
GeneHancer (GH) Regulatory Elements for STX3 Gene
Promoters and enhancers for STX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STX3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STX3 gene promoter:
-
- Bach2
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
Genomic Locations for STX3 Gene
Genomic Locations for STX3 Gene
- chr11:59,713,456-59,805,882
- (GRCh38/hg38)
- Size:
- 92,427 bases
- Orientation:
- Plus strand
- chr11:59,480,929-59,573,355
- (GRCh37/hg19)
- Size:
- 92,427 bases
- Orientation:
- Plus strand
Genomic View for STX3 Gene
Genes around STX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.1 by HGNC
- 11q12.1 by Entrez Gene
- 11q12.1 by Ensembl
STX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STX3 Gene
Proteins for STX3 Gene
-
Protein details for STX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13277-STX3_HUMAN
- Recommended name:
- Syntaxin-3
- Protein Accession:
- Q13277
- B4DME0
- O43750
- O43751
- Q15360
Protein attributes for STX3 Gene
- Size:
- 289 amino acids
- Molecular mass:
- 33155 Da
- Quaternary structure:
-
- Interacts with REEP6.
Protein Expression for STX3 Gene
Post-translational modifications for STX3 Gene
Other Protein References for STX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-STX3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for STX3
- Novus Biologicals Antibodies for STX3
-
Abcam antibodies for STX3
- Invitrogen Antibodies for STX3 (AFLGC-STX3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for STX3
- Sino Biological Antibodies for STX3
Protein Products
- Atlas Antibodies PrEST Antigen STX3
-
OriGene Purified Proteins for STX3
- Search Origene for MassSpec and Protein Over-expression Lysates for STX3
- Origene Custom Protein Services for STX3
- Sino Biological Recombinant Proteins for STX3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for STX3
-
Abcam proteins for STX3
No data available for DME Specific Peptides for STX3 Gene
Domains & Families for STX3 Gene
Gene Families for STX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for STX3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for STX3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60699, highly similar to Syntaxin-3 (B4DME0_HUMAN)
- cDNA, FLJ93356, Homo sapiens syntaxin 3A (STX3A), mRNA (Q53YE2_HUMAN)
- Syntaxin-3 (STX3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13277- Family:
-
- Belongs to the syntaxin family.
Function for STX3 Gene
Molecular function for STX3 Gene
- UniProtKB/Swiss-Prot Function:
- Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Phenotypes From GWAS Catalog for STX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000149 | SNARE binding | IBA | 21873635 |
| GO:0005484 | SNAP receptor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 17693260 |
| GO:0050544 | arachidonic acid binding | ISS | -- |
Phenotypes for STX3 Gene
- MGI mutant phenotypes for STX3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STX3:
-
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased cell number in S
- Decreased viability with paclitaxel
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for STX3 Gene
- MGI Knock Outs for STX3:
-
- Stx3 Stx3<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for STX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX3
- genomics-online: gRNA clones - Search for available STX3 gRNA products
- Overview of 152 available STX3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for STX3 - Select products 50% OFF >
- * STX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * STX3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX3
miRNA for STX3 Gene
- miRTarBase miRNAs that target STX3
-
- hsa-mir-375 (MIRT019943)
- hsa-mir-92a-3p (MIRT049197)
- hsa-let-7a-5p (MIRT760975)
- hsa-let-7b-5p (MIRT760988)
- hsa-let-7c-5p (MIRT761001)
- hsa-let-7d-5p (MIRT761012)
- hsa-let-7e-5p (MIRT761021)
- hsa-let-7f-5p (MIRT761034)
- hsa-let-7g-5p (MIRT761048)
- hsa-let-7i-5p (MIRT761058)
- hsa-mir-125b-2-3p (MIRT761680)
- hsa-mir-1273h-5p (MIRT762084)
- hsa-mir-202-3p (MIRT763684)
- hsa-mir-3065-3p (MIRT764544)
- hsa-mir-30b-3p (MIRT764622)
- hsa-mir-30c-1-3p (MIRT764676)
- hsa-mir-30c-2-3p (MIRT764721)
- hsa-mir-3120-3p (MIRT764781)
- hsa-mir-3145-5p (MIRT765001)
- hsa-mir-3189-3p (MIRT765340)
- hsa-mir-335-5p (MIRT765659)
- hsa-mir-342-3p (MIRT765751)
- hsa-mir-3689a-3p (MIRT766850)
- hsa-mir-3689b-3p (MIRT766938)
- hsa-mir-3689c (MIRT767026)
- hsa-mir-3927-3p (MIRT767745)
- hsa-mir-4457 (MIRT769213)
- hsa-mir-4458 (MIRT769227)
- hsa-mir-4500 (MIRT769807)
- hsa-mir-4650-3p (MIRT770723)
- hsa-mir-5007-5p (MIRT772951)
- hsa-mir-508-5p (MIRT773198)
- hsa-mir-513b-5p (MIRT773402)
- hsa-mir-5192 (MIRT773615)
- hsa-mir-519a-3p (MIRT773684)
- hsa-mir-519b-3p (MIRT773698)
- hsa-mir-519c-3p (MIRT773712)
- hsa-mir-6731-5p (MIRT777986)
- hsa-mir-6779-5p (MIRT778928)
- hsa-mir-6780a-5p (MIRT779018)
- hsa-mir-6788-5p (MIRT779253)
- hsa-mir-6813-3p (MIRT779778)
- hsa-mir-6814-5p (MIRT779803)
- hsa-mir-6831-5p (MIRT780012)
- hsa-mir-6878-5p (MIRT780777)
- hsa-mir-8085 (MIRT782429)
- hsa-mir-887-5p (MIRT782571)
- hsa-mir-98-5p (MIRT783013)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STX3
- Browse OriGene Inhibitory RNA Products For STX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX3
- genomics-online: shRNA clones - Search for available STX3 shRNA products
- Overview of 152 available STX3 gene related products
Clone Products
-
- MG203904
- MG217792
- MG217805
- MR203904
- MR203904L3
- MR203904L3V
- MR203904L4
- MR203904L4V
- MR217792
- MR217792L3
- MR217792L3V
- MR217792L4
- MR217792L4V
- MR217805
- MR217805L3
- MR217805L3V
- MR217805L4
- MR217805L4V
- MR228385
- RC200658
- RC200658L1
- RC200658L1V
- RC200658L2
- RC200658L2V
- RC200658L3
- RC200658L3V
- RC200658L4
- RC200658L4V
- RC229811
- RC229811L3
- RC229811L3V
- RC229811L4
- RC229811L4V
- RG200658
- RG229811
- RR214053
- RR214053L1
- RR214053L1V
- RR214053L2
- RR214053L2V
- RR214053L3
- RR214053L3V
- RR214053L4
- RR214053L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STX3
- Addgene plasmids for STX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX3
- genomics-online: cdna clones - Search for available STX3 CDNA products
- Overview of 152 available STX3 gene related products
- orf clones - Search for available STX3 ORF products
- Overview of 152 available STX3 gene related products
- Applied Biological Materials (abm): Clones for STX3 - Select products 50% OFF >
- * STX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * STX3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for STX3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for STX3 Gene
Localization for STX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STX3 Gene
- Membrane; Single-pass type IV membrane protein. Note=Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. {ECO:0000250 UniProtKB:Q64704}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 5 |
| cytosol | 3 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| endosome | 1 |
| mitochondrion | 0 |
| nucleus | 0 |
| endoplasmic reticulum | 0 |
- Cytosol (2)
- Golgi apparatus (2)
- Nuclear bodies (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005773 | vacuole | TAS | 16339081 |
| GO:0005886 | plasma membrane | TAS,IBA | -- |
| GO:0005911 | cell-cell junction | IDA | 15576373 |
| GO:0008021 | synaptic vesicle | IBA | 21873635 |
Pathways & Interactions for STX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | ||
| 2 | Synaptic vesicle cycle | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for STX3 Gene
1 BioSystems pathway for STX3 Gene
3 Reactome pathways for STX3 Gene
1 PharmGKB pathway for STX3 Gene
2 KEGG pathways for STX3 Gene
1 Qiagen pathway for STX3 Gene
- Epithelial Tight Junctions
Interacting Proteins for STX3 Gene
Selected Interacting proteins:
Q13277-STX3_HUMAN
ENSP00000338562
for STX3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for STX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006836 | neurotransmitter transport | IEA | -- |
| GO:0006886 | intracellular protein transport | IBA | 21873635 |
| GO:0006887 | exocytosis | IBA,IEA | 21873635 |
| GO:0006906 | vesicle fusion | IBA | 21873635 |
| GO:0008284 | positive regulation of cell proliferation | IMP | 21720706 |
No data available for SIGNOR curated interactions for STX3 Gene
Transcripts for STX3 Gene
mRNA/cDNA for STX3 Gene
- (2) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (280) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000337979 6154 bps (ENST00000337979.8)
- ENST00000528805 615 bps (ENST00000528805.1)
- ENST00000529177 1571 bps (ENST00000529177.5)
- ENST00000530221 534 bps (ENST00000530221.1)
- ENST00000530498 690 bps (ENST00000530498.1)
CRISPR Products
-
OriGene CRISPR knockouts for STX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX3
- genomics-online: gRNA clones - Search for available STX3 gRNA products
- Overview of 152 available STX3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for STX3 - Select products 50% OFF >
- * STX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * STX3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for STX3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STX3
- Browse OriGene Inhibitory RNA Products For STX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX3
- genomics-online: shRNA clones - Search for available STX3 shRNA products
- Overview of 152 available STX3 gene related products
Clone Products
-
- MG203904
- MG217792
- MG217805
- MR203904
- MR203904L3
- MR203904L3V
- MR203904L4
- MR203904L4V
- MR217792
- MR217792L3
- MR217792L3V
- MR217792L4
- MR217792L4V
- MR217805
- MR217805L3
- MR217805L3V
- MR217805L4
- MR217805L4V
- MR228385
- RC200658
- RC200658L1
- RC200658L1V
- RC200658L2
- RC200658L2V
- RC200658L3
- RC200658L3V
- RC200658L4
- RC200658L4V
- RC229811
- RC229811L3
- RC229811L3V
- RC229811L4
- RC229811L4V
- RG200658
- RG229811
- RR214053
- RR214053L1
- RR214053L1V
- RR214053L2
- RR214053L2V
- RR214053L3
- RR214053L3V
- RR214053L4
- RR214053L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STX3
- Addgene plasmids for STX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STX3
- genomics-online: cdna clones - Search for available STX3 CDNA products
- Overview of 152 available STX3 gene related products
- orf clones - Search for available STX3 ORF products
- Overview of 152 available STX3 gene related products
- Applied Biological Materials (abm): Clones for STX3 - Select products 50% OFF >
- * STX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * STX3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | - | - |
Expression for STX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Heart (Cardiovascular System)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for STX3 Gene
This gene is overexpressed in Whole Blood (x8.9).
This gene is overexpressed in Retina (23.6), Lavage (9.0), Milk (8.3), and Urine (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX3 Gene
NURSA nuclear receptor signaling pathways regulating expression of STX3 Gene:
STX3SOURCE GeneReport for Unigene cluster for STX3 Gene:
Hs.180711Evidence on tissue expression from TISSUES for STX3 Gene
- Nervous system(4.7)
- Intestine(4.5)
- Muscle(4.2)
- Kidney(2.6)
- Eye(2.4)
- Skin(2.2)
- Lung(2.1)
- Pancreas(2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STX3 Gene
Germ Layers:
- endoderm
Systems:
- digestive
- immune
Regions:
Abdomen:
- intestine
- large intestine
- small intestine
General:
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for STX3
-
OriGene qPCR primer pairs and template standards for STX3
- genomics-online: primer clones - Search for available STX3 Primer products
- Overview of 152 available STX3 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STX3 Gene
Orthologs for STX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STX3 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | STX3 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stx3 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stx3 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STX3 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STX3 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | STX3 33 32 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STX3 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | STX3 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stx3 32 |
|
||
| Str.14996 32 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | stx3a 33 32 |
|
OneToMany | |
| STX3 (2 of 2) 33 |
|
OneToMany | |||
| zgc65954 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Syx1A 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-64 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for STX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for STX3 Gene
- ENSEMBL:
- Gene Tree for STX3 (if available)
- TreeFam:
- Gene Tree for STX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STX3: view image
Paralogs for STX3 Gene
Paralogs for STX3 Gene
(11) SIMAP similar genes for STX3 Gene using alignment to 5 proteins:
- STX3_HUMAN
- E7ET77_HUMAN
- E9PN33_HUMAN
- E9PQJ8_HUMAN
- F8W9Y0_HUMAN
Variants for STX3 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs797045154 | uncertain-significance, not provided | 59,787,044(+) | A/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000052273 | -- | 59,774,237(+) | A/T | intron_variant | |
| rs1000128950 | -- | 59,764,391(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000162081 | -- | 59,791,460(+) | C/A/G | intron_variant | |
| rs1000207020 | -- | 59,805,730(+) | C/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3626541 | CNV | loss | 21293372 |
| nsv1046086 | CNV | gain | 25217958 |
| nsv1144571 | CNV | deletion | 24896259 |
| nsv473543 | CNV | novel sequence insertion | 20440878 |
| nsv477412 | CNV | novel sequence insertion | 20440878 |
| nsv972034 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.08;
50.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STX3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX3 Gene
Disorders for STX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diarrhea 2, with microvillus atrophy |
|
|
| hemophagocytic lymphohistiocytosis, familial, 5 |
|
|
| congenital diarrhea |
|
|
| bardet-biedl syndrome 17 |
|
|
| tetanus |
|
Search STX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STX3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for STX3 Gene
Publications for STX3 Gene
- Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low SH … Weimbs T (Molecular biology of the cell 2006) 2 3 23 56
- Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martín-Martín B … Mollinedo F (Journal of leukocyte biology 1999) 3 4 23 56
- Human syntaxin 3 is localized apically in human intestinal cells. (PMID: 9378770) Delgrossi MH … Le Bivic A (Journal of cell science 1997) 3 4 23 56
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
- The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. (PMID: 19815536) Lee BY … Horwitz MA (Molecular & cellular proteomics : MCP 2010) 3 23 56
ExternalLinks
Products for STX3 Gene
- Custom Antibody ServicesOriGene Antibodies for STX3
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- antibodies-online: Show 7 available STX3 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for STX3
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- Santa Cruz Biotechnology (SCBT) CRISPR for STX3
- Horizon Cell Lines for STX3
- genomics-online: cdna clones - Search for available STX3 CDNA products
- Overview of 152 available STX3 gene related products
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- Overview of 152 available STX3 gene related products
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- Overview of 152 available STX3 gene related products
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- Overview of 152 available STX3 gene related products
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- Overview of 152 available STX3 gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STX3
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for STX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX3
Sources for STX3 Gene
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