External Ids for STX3 Gene
Previous HGNC Symbols for STX3 Gene
Previous GeneCards Identifiers for STX3 Gene
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for STX3 Gene
STX3 (Syntaxin 3) is a Protein Coding gene. Diseases associated with STX3 include Diarrhea 2, With Microvillus Atrophy and Hemophagocytic Lymphohistiocytosis, Familial, 5. Among its related pathways are Cytokine Signaling in Immune system and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include SNARE binding and arachidonic acid binding. An important paralog of this gene is STX1A.
UniProtKB/Swiss-Prot Summary for STX3 Gene
Potentially involved in docking of synaptic vesicles at presynaptic active zones.