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Aliases for STX18 Gene

Aliases for STX18 Gene

  • Syntaxin 18 2 3 5
  • Cell Growth-Inhibiting Gene 9 Protein 3 4
  • Syntaxin-18 3
  • Ufe1 3

External Ids for STX18 Gene

Previous GeneCards Identifiers for STX18 Gene

  • GC04M004307
  • GC04M004466
  • GC04M004485
  • GC04M004538

Summaries for STX18 Gene

Entrez Gene Summary for STX18 Gene

  • This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for STX18 Gene

STX18 (Syntaxin 18) is a Protein Coding gene. Diseases associated with STX18 include Hemorrhagic Cystitis. Among its related pathways are Golgi-to-ER retrograde transport and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX18 Gene

  • Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Additional gene information for STX18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX18 Gene

Genomics for STX18 Gene

GeneHancer (GH) Regulatory Elements for STX18 Gene

Promoters and enhancers for STX18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I004540 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 552.2 +0.5 483 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 STX18-AS1 STX18 TMEM128 FAM86EP NSG1 ZBTB49 RPS7P15
GH04I003765 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.7 +776.4 776411 1.7 RING1 CTCF SAP130 ARID4B ZNF48 ZEB1 HIC1 ZNF335 ZFHX2 CTBP1 ADRA2C NOP14-AS1 STX18-AS1 ZBTB49 STX18 ENSG00000250986
GH04I003953 Promoter/Enhancer 1.5 Ensembl ENCODE 10.8 +587.3 587326 4 HDGF PKNOX1 CLOCK ATF1 MLX ARID4B SIN3A GLIS2 ZNF207 FOS FAM86EP ENSG00000253917 GC04P003954 LOC105374358 ENSG00000271977 ZBTB49 ENPP7P9 STX18 TMEM128
GH04I004852 Enhancer 0.9 Ensembl ENCODE 10.7 -310.8 -310761 1.2 HDAC1 RING1 CTCF L3MBTL2 SUZ12 ETV1 NRF1 ZBTB11 ZBTB40 GABPA STX18-AS1 ZBTB49 STX18 LINC01396 MSX1
GH04I003767 Enhancer 0.5 ENCODE 10.7 +775.1 775127 0.2 CTCF RING1 MBD1 ZBTB33 ZBTB26 EZH2 ADRA2C NOP14-AS1 STX18-AS1 ZBTB49 STX18 GC04P003863
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STX18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX18 gene promoter:

Genomic Locations for STX18 Gene

Genomic Locations for STX18 Gene
126,605 bases
Minus strand

Genomic View for STX18 Gene

Genes around STX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX18 Gene

Proteins for STX18 Gene

  • Protein details for STX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q596L3
    • Q5TZP5

    Protein attributes for STX18 Gene

    335 amino acids
    Molecular mass:
    38674 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.

neXtProt entry for STX18 Gene

Post-translational modifications for STX18 Gene

No data available for DME Specific Peptides for STX18 Gene

Domains & Families for STX18 Gene

Gene Families for STX18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX18 Gene

Suggested Antigen Peptide Sequences for STX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syntaxin family.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX18: view

Function for STX18 Gene

Molecular function for STX18 Gene

UniProtKB/Swiss-Prot Function:
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IEA --
GO:0005515 protein binding IPI 15029241
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with STX18: view
genes like me logo Genes that share phenotypes with STX18: view

Animal Models for STX18 Gene

MGI Knock Outs for STX18:

Animal Model Products

CRISPR Products

miRNA for STX18 Gene

miRTarBase miRNAs that target STX18

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX18 Gene

Localization for STX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX18 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX18 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
peroxisome 2
mitochondrion 1
nucleus 1
cytosol 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 10788491
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with STX18: view

Pathways & Interactions for STX18 Gene

genes like me logo Genes that share pathways with STX18: view

Gene Ontology (GO) - Biological Process for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA,TAS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX18: view

No data available for SIGNOR curated interactions for STX18 Gene

Drugs & Compounds for STX18 Gene

No Compound Related Data Available

Transcripts for STX18 Gene

Unigene Clusters for STX18 Gene

Syntaxin 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX18 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - -
SP2: - -
SP3: -

Relevant External Links for STX18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX18 Gene

Protein differential expression in normal tissues from HIPED for STX18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Pancreas (11.5), and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX18 Gene

Protein tissue co-expression partners for STX18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX18 Gene:


SOURCE GeneReport for Unigene cluster for STX18 Gene:


mRNA Expression by UniProt/SwissProt for STX18 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for STX18 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with STX18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX18 Gene

Orthologs for STX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX18 33
  • 99.6 (n)
(Canis familiaris)
Mammalia STX18 33 34
  • 91.84 (n)
(Bos Taurus)
Mammalia STX18 33 34
  • 89.25 (n)
(Mus musculus)
Mammalia Stx18 33 16 34
  • 88.92 (n)
(Rattus norvegicus)
Mammalia Stx18 33
  • 88.42 (n)
(Ornithorhynchus anatinus)
Mammalia STX18 34
  • 83 (a)
(Monodelphis domestica)
Mammalia STX18 34
  • 70 (a)
(Gallus gallus)
Aves STX18 33 34
  • 78.71 (n)
(Anolis carolinensis)
Reptilia STX18 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx18 33
  • 72.36 (n)
Str.9979 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4342 33
(Danio rerio)
Actinopterygii stx18 33
  • 68.48 (n)
CABZ01086801.1 34
  • 66 (a)
Dr.19719 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1004 33
fruit fly
(Drosophila melanogaster)
Insecta Syx18 33 34
  • 59.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011160 33
  • 47.69 (n)
(Caenorhabditis elegans)
Secernentea syx-18 34
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP81 33
  • 44.63 (n)
(Oryza sativa)
Liliopsida Os04g0530400 33
  • 48.02 (n)
Species where no ortholog for STX18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX18 Gene

Gene Tree for STX18 (if available)
Gene Tree for STX18 (if available)

Paralogs for STX18 Gene Pseudogenes for STX18 Gene

genes like me logo Genes that share paralogs with STX18: view

No data available for Paralogs for STX18 Gene

Variants for STX18 Gene

Sequence variations from dbSNP and Humsavar for STX18 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000012244 -- 4,448,318(-) T/C intron_variant
rs1000021155 -- 4,422,380(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000029740 -- 4,484,951(-) A/G intron_variant
rs1000030408 -- 4,530,371(-) T/A genic_upstream_transcript_variant, intron_variant
rs10000397 -- 4,445,337(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STX18 Gene

Variant ID Type Subtype PubMed ID
nsv966251 CNV duplication 23825009
nsv528931 CNV gain 19592680
nsv521279 CNV loss 19592680
nsv1007737 CNV gain 25217958
esv34196 OTHER inversion 12058347

Variation tolerance for STX18 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX18 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX18 Gene

Disorders for STX18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STX18 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hemorrhagic cystitis
- elite association - COSMIC cancer census association via MalaCards
Search STX18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STX18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STX18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX18 Gene

Publications for STX18 Gene

  1. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K … Tagaya M (The EMBO journal 2004) 3 4 22 58
  2. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H … Tagaya M (The EMBO journal 2004) 3 4 22 58
  3. Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. (PMID: 10788491) Hatsuzawa K … Tagaya M (The Journal of biological chemistry 2000) 2 3 4 58
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  5. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PMID: 20087401) Ingersoll RG … Beaty TH (European journal of human genetics : EJHG 2010) 3 44 58

Products for STX18 Gene

  • Addgene plasmids for STX18

Sources for STX18 Gene

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