This locus represents naturally occurring read-through transcription between the neighboring syntaxin 16 (STX16) and aminopeptidase-like 1 (NPEPL1) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011] See more...

Aliases for STX16-NPEPL1 Gene

Subcategory (RNA class) for STX16-NPEPL1 Gene

lncRNA

Aliases for STX16-NPEPL1 Gene

  • STX16-NPEPL1 Readthrough (NMD Candidate) 2 3 5 13
  • STX16-NPEPL1 Readthrough (Non-Protein Coding) 3
  • STX16-NPEPL1 5

External Ids for STX16-NPEPL1 Gene

Previous GeneCards Identifiers for STX16-NPEPL1 Gene

  • GC20U900674
  • GC20P057228
  • GC20P057229

Summaries for STX16-NPEPL1 Gene

Entrez Gene Summary for STX16-NPEPL1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring syntaxin 16 (STX16) and aminopeptidase-like 1 (NPEPL1) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for STX16-NPEPL1 Gene

STX16-NPEPL1 (STX16-NPEPL1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Gene Ontology (GO) annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX16.

Additional gene information for STX16-NPEPL1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STX16-NPEPL1 Gene

Genomics for STX16-NPEPL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STX16-NPEPL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STX16-NPEPL1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for STX16-NPEPL1 Gene

Genomic Locations for STX16-NPEPL1 Gene
chr20:58,651,253-58,715,844
(GRCh38/hg38)
Size:
64,592 bases
Orientation:
Plus strand
chr20:57,226,309-57,290,900
(GRCh37/hg19)
Size:
64,592 bases
Orientation:
Plus strand

Genomic View for STX16-NPEPL1 Gene

Genes around STX16-NPEPL1 on UCSC Golden Path with GeneCards custom track
STX16-NPEPL1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
STX16-NPEPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX16-NPEPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX16-NPEPL1 Gene

Proteins for STX16-NPEPL1 Gene

  • Protein details for STX16-NPEPL1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BU86-H3BU86_HUMAN
    Recommended name:
    STX16-NPEPL1 readthrough (NMD candidate)
    Protein Accession:
    H3BU86

    Protein attributes for STX16-NPEPL1 Gene

    Size:
    382 amino acids
    Molecular mass:
    43229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STX16-NPEPL1 Gene

Post-translational modifications for STX16-NPEPL1 Gene

No Post-translational modifications

Other Protein References for STX16-NPEPL1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for STX16-NPEPL1 Gene

Domains & Families for STX16-NPEPL1 Gene

Gene Families for STX16-NPEPL1 Gene

Unknown:
  • Belongs to the syntaxin family.

Protein Domains for STX16-NPEPL1 Gene

genes like me logo Genes that share domains with STX16-NPEPL1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STX16-NPEPL1 Gene

Function for STX16-NPEPL1 Gene

Phenotypes From GWAS Catalog for STX16-NPEPL1 Gene

Gene Ontology (GO) - Molecular Function for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STX16-NPEPL1 Gene

Localization for STX16-NPEPL1 Gene

Gene Ontology (GO) - Cellular Components for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for STX16-NPEPL1 Gene

Pathways & Interactions for STX16-NPEPL1 Gene

PathCards logo

SuperPathways for STX16-NPEPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048278 vesicle docking IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for STX16-NPEPL1 Gene

Drugs & Compounds for STX16-NPEPL1 Gene

No Compound Related Data Available

Transcripts for STX16-NPEPL1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for STX16-NPEPL1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075AEF2_9606 lncRNA 4048 1

RefSeq: NR_037945,

STX16-NPEPL1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for STX16-NPEPL1 Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX16-NPEPL1 Gene

No ASD Table

Relevant External Links for STX16-NPEPL1 Gene

GeneLoc Exon Structure for
STX16-NPEPL1

Expression for STX16-NPEPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STX16-NPEPL1 Gene

mRNA differential expression in normal tissues according to GTEx for STX16-NPEPL1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.7) and Brain - Cerebellar Hemisphere (x4.2).
genes like me logo Genes that share expression patterns with STX16-NPEPL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX16-NPEPL1 Gene

Orthologs for STX16-NPEPL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX16-NPEPL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STX16-NPEPL1 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Stx16 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
Chicken
(Gallus gallus)
Aves STX16 31
  • 79 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 77 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii stx16 31
  • 72 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Syx16 31
  • 32 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea syx-16 31
  • 27 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TLG2 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
Species where no ortholog for STX16-NPEPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for STX16-NPEPL1 Gene

ENSEMBL:
Gene Tree for STX16-NPEPL1 (if available)
TreeFam:
Gene Tree for STX16-NPEPL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STX16-NPEPL1: view image

Paralogs for STX16-NPEPL1 Gene

Paralogs for STX16-NPEPL1 Gene

(1) SIMAP similar genes for STX16-NPEPL1 Gene using alignment to 1 proteins:

  • H3BU86_HUMAN
genes like me logo Genes that share paralogs with STX16-NPEPL1: view

Variants for STX16-NPEPL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STX16-NPEPL1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
710614 Likely Benign: not provided 58,669,339(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
723495 Benign/Likely Benign: Pseudohypoparathyroidism type 1B; not provided 58,670,549(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
723869 Likely Benign: not provided 58,669,443(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
734383 Likely Benign: not provided 58,671,171(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
735849 Likely Benign: not provided 58,668,094(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for STX16-NPEPL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for STX16-NPEPL1 Gene

Variant ID Type Subtype PubMed ID
esv1002410 CNV deletion 20482838
esv1198718 CNV insertion 17803354
esv2558295 CNV insertion 19546169
esv2665738 CNV deletion 23128226
esv3646226 CNV loss 21293372
nsv1063462 CNV gain 25217958
nsv1118920 CNV deletion 24896259
nsv1125729 CNV tandem duplication 24896259
nsv1129663 CNV tandem duplication 24896259
nsv513552 CNV insertion 21212237
nsv828761 CNV loss 20364138
nsv828762 CNV loss 20364138
nsv955141 CNV deletion 24416366

Additional Variant Information for STX16-NPEPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX16-NPEPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for STX16-NPEPL1 Gene

Disorders for STX16-NPEPL1 Gene

Additional Disease Information for STX16-NPEPL1

No disorders were found for STX16-NPEPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX16-NPEPL1 Gene

Publications for STX16-NPEPL1 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 13

Products for STX16-NPEPL1 Gene

Sources for STX16-NPEPL1 Gene