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Aliases for STX10 Gene

Aliases for STX10 Gene

  • Syntaxin 10 2 3 5
  • Syntaxin-10 3 4
  • SYN10 3 4
  • Hsyn10 3
  • Syn10 4

External Ids for STX10 Gene

Previous GeneCards Identifiers for STX10 Gene

  • GC19M013587
  • GC19M013100
  • GC19M013116
  • GC19M013115
  • GC19M013254
  • GC19M012827

Summaries for STX10 Gene

Entrez Gene Summary for STX10 Gene

  • This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for STX10 Gene

STX10 (Syntaxin 10) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX6.

UniProtKB/Swiss-Prot for STX10 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for STX10 Gene

Additional gene information for STX10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX10 Gene

Genomics for STX10 Gene

GeneHancer (GH) Regulatory Elements for STX10 Gene

Promoters and enhancers for STX10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013148 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 609.9 -2.1 -2058 10.8 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF STX10 ENSG00000267598 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS RFX1
GH19J013030 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +116.9 116908 8.2 CC2D1A CTCF CEBPG ZSCAN21 AHR TFE3 SP7 PPARG KLF14 PRDM1 TRMT1 ZNF844 ZNF791 ZNF442 ZNF136 ZNF625 RPS6P25 MRI1 STX10 ZNF433
GH19J013068 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.3 +81.0 80950 4.4 CC2D1A ZKSCAN8 CBFA2T2 ZNF148 MLLT1 GTF2F1 CDC5L TRIM24 ZNF639 EGR1 ENSG00000267610 GC19P013072 LYL1 TRMT1 NACC1 STX10 IER2 GC19P013036 NFIX
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.5 +362.0 362036 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J013042 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +106.9 106933 4 ZNF148 SP7 ZNF600 ZIC2 GATAD2A ZEB2 PATZ1 ZNF692 ZNF561 SCRT2 TRMT1 ZNF20 ZNF490 LYL1 NACC1 RNASEH2A NFIX DAND5 GADD45GIP1 DCAF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STX10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX10 gene promoter:
  • ATF-2
  • CRE-BP1
  • CREB
  • deltaCREB
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Nkx6-1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for STX10 Gene

Genomic Locations for STX10 Gene
chr19:13,144,058-13,151,334
(GRCh38/hg38)
Size:
7,277 bases
Orientation:
Minus strand
chr19:13,254,872-13,261,197
(GRCh37/hg19)
Size:
6,326 bases
Orientation:
Minus strand

Genomic View for STX10 Gene

Genes around STX10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX10 Gene

Proteins for STX10 Gene

  • Protein details for STX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60499-STX10_HUMAN
    Recommended name:
    Syntaxin-10
    Protein Accession:
    O60499
    Secondary Accessions:
    • A6NC41
    • Q6IAP4
    • Q96AE8

    Protein attributes for STX10 Gene

    Size:
    249 amino acids
    Molecular mass:
    28114 Da
    Quaternary structure:
    • Interacts with VPS52.

    Three dimensional structures from OCA and Proteopedia for STX10 Gene

    Alternative splice isoforms for STX10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX10 Gene

Post-translational modifications for STX10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STX10 Gene

Domains & Families for STX10 Gene

Gene Families for STX10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX10 Gene

Suggested Antigen Peptide Sequences for STX10 Gene

GenScript: Design optimal peptide antigens:
  • Syntaxin-10 (STX10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60499

UniProtKB/Swiss-Prot:

STX10_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX10: view

Function for STX10 Gene

Molecular function for STX10 Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Phenotypes From GWAS Catalog for STX10 Gene

Gene Ontology (GO) - Molecular Function for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA 21873635
GO:0005484 SNAP receptor activity IBA,IEA 21873635
GO:0005515 protein binding IPI 15878329
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX10: view
genes like me logo Genes that share phenotypes with STX10: view

Animal Model Products

CRISPR Products

miRNA for STX10 Gene

miRTarBase miRNAs that target STX10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX10 Gene

Localization for STX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX10 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX10 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
peroxisome 1
nucleus 1
endosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IDA 9446797
GO:0005829 cytosol IEA --
GO:0008021 synaptic vesicle IBA 21873635
genes like me logo Genes that share ontologies with STX10: view

Pathways & Interactions for STX10 Gene

genes like me logo Genes that share pathways with STX10: view

Gene Ontology (GO) - Biological Process for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA,IEA 21873635
GO:0006906 vesicle fusion IBA 21873635
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0032880 regulation of protein localization IMP 16154903
genes like me logo Genes that share ontologies with STX10: view

No data available for SIGNOR curated interactions for STX10 Gene

Drugs & Compounds for STX10 Gene

No Compound Related Data Available

Transcripts for STX10 Gene

Unigene Clusters for STX10 Gene

Syntaxin 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STX10

Alternative Splicing Database (ASD) splice patterns (SP) for STX10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for STX10 Gene

GeneLoc Exon Structure for
STX10
ECgene alternative splicing isoforms for
STX10

Expression for STX10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX10 Gene

mRNA differential expression in normal tissues according to GTEx for STX10 Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for STX10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.9), Bone (11.6), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STX10 Gene



Protein tissue co-expression partners for STX10 Gene

NURSA nuclear receptor signaling pathways regulating expression of STX10 Gene:

STX10

SOURCE GeneReport for Unigene cluster for STX10 Gene:

Hs.43812

mRNA Expression by UniProt/SwissProt for STX10 Gene:

O60499-STX10_HUMAN
Tissue specificity: Expressed at high levels in heart, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for STX10 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with STX10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STX10 Gene

Orthologs for STX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX10 35 34
  • 94.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STX10 35 34
  • 92.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STX10 35 34
  • 88.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX10 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx10 34
  • 69.86 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100151249 34
  • 64.94 (n)
CR847925.1 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syx6 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-6 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 35
  • 44 (a)
OneToMany
Species where no ortholog for STX10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX10 Gene

ENSEMBL:
Gene Tree for STX10 (if available)
TreeFam:
Gene Tree for STX10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STX10: view image

Paralogs for STX10 Gene

Paralogs for STX10 Gene

(1) SIMAP similar genes for STX10 Gene using alignment to 9 proteins:

  • STX10_HUMAN
  • F6RTM7_HUMAN
  • K7EIY4_HUMAN
  • K7EJ05_HUMAN
  • K7EK75_HUMAN
  • K7ELY2_HUMAN
  • K7EPP9_HUMAN
  • K7EQ84_HUMAN
  • Q5U8S2_HUMAN
genes like me logo Genes that share paralogs with STX10: view

Variants for STX10 Gene

Sequence variations from dbSNP and Humsavar for STX10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000264223 -- 13,151,707(-) G/A upstream_transcript_variant
rs1000633587 -- 13,146,938(-) C/T intron_variant
rs1000698409 -- 13,151,415(-) G/T upstream_transcript_variant
rs1001727092 -- 13,151,822(-) C/T upstream_transcript_variant
rs1001913788 -- 13,146,226(-) G/A intron_variant

Variation tolerance for STX10 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STX10 Gene

Disorders for STX10 Gene

Additional Disease Information for STX10

No disorders were found for STX10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX10 Gene

Publications for STX10 Gene

  1. Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network. (PMID: 9446797) Tang BL … Hong W (Biochemical and biophysical research communications 1998) 2 3 4 23 58
  2. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley IG … Pfeffer SR (The Journal of cell biology 2008) 3 4 23 58
  3. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PMID: 15878329) Liewen H … Stenner-Liewen F (Experimental cell research 2005) 3 4 23 58
  4. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. (PMID: 16154903) Wang Y … Tang BL (Molecular membrane biology 2005) 3 23 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for STX10 Gene

Sources for STX10 Gene

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