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Aliases for STT3B Gene

Aliases for STT3B Gene

  • STT3B, Catalytic Subunit Of The Oligosaccharyltransferase Complex 2 3 5
  • Dolichyl-Diphosphooligosaccharide Protein Glycotransferase 2 3
  • Source Of Immunodominant MHC-Associated Peptides Homolog 3 4
  • Oligosaccharyl Transferase Subunit STT3B 3 4
  • STT3-B 3 4
  • SIMP 3 4
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S. Cerevisiae) 2
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3B 3
  • STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic) 3
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B 3
  • Source Of Immunodominant MHC Associated Peptides 2
  • Homolog Of Yeast STT3 3
  • EC 2.4.1.119 56
  • EC 2.4.99.18 4
  • CDG1X 3

External Ids for STT3B Gene

Summaries for STT3B Gene

Entrez Gene Summary for STT3B Gene

  • The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

GeneCards Summary for STT3B Gene

STT3B (STT3B, Catalytic Subunit Of The Oligosaccharyltransferase Complex) is a Protein Coding gene. Diseases associated with STT3B include Congenital Disorder Of Glycosylation, Type Ix. Among its related pathways are Protein processing in endoplasmic reticulum and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity. An important paralog of this gene is STT3A.

UniProtKB/Swiss-Prot for STT3B Gene

  • Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Gene Wiki entry for STT3B Gene

Additional gene information for STT3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STT3B Gene

Genomics for STT3B Gene

GeneHancer (GH) Regulatory Elements for STT3B Gene

Promoters and enhancers for STT3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I031530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 367 5.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 GC03M031530 STT3B ZNF860 CMTM6 GC03P031521 GC03M031604
GH03I031461 Enhancer 1 Ensembl ENCODE 17.8 -70.0 -70011 1.9 HDGF CTCF SOX13 FOXA2 SMAD1 TAL1 EBF1 BMI1 ATF7 IKZF2 LOC105377019 STT3B THRAP3P1
GH03I031224 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13 -305.4 -305431 5.1 HDGF ZNF146 MAX EBF1 GATA3 POLR2A IKZF2 RUNX3 SMARCA5 NR2F1 RNA5SP127 STT3B LOC105377018
GH03I031486 Enhancer 0.9 ENCODE 17.7 -45.4 -45379 0.6 HDAC1 HDGF PKNOX1 FOXA2 ARNT NFRKB RARA TCF12 ZNF766 ATF7 STT3B LOC105377019 GC03P031518
GH03I030619 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.6 -897.3 -897253 31.8 PKNOX1 FOXA2 ZFP64 ARID4B IRF4 YY1 FOS PAF1 SP5 JUNB STT3B ENSG00000224618 LOC105377016 TGFBR2 GC03M030649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STT3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STT3B gene promoter:

Genomic Locations for STT3B Gene

Genomic Locations for STT3B Gene
chr3:31,532,501-31,637,622
(GRCh38/hg38)
Size:
105,122 bases
Orientation:
Plus strand
chr3:31,574,130-31,679,112
(GRCh37/hg19)

Genomic View for STT3B Gene

Genes around STT3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STT3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STT3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STT3B Gene

Proteins for STT3B Gene

  • Protein details for STT3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCJ2-STT3B_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
    Protein Accession:
    Q8TCJ2
    Secondary Accessions:
    • Q96JZ4
    • Q96KY7

    Protein attributes for STT3B Gene

    Size:
    826 amino acids
    Molecular mass:
    93674 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).
    SequenceCaution:
    • Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11581.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for STT3B Gene

Selected DME Specific Peptides for STT3B Gene

Q8TCJ2:
  • IPIIASVSEHQP
  • LVDNNTWNN
  • ESIIHEFDPWFN
  • RNAEIGNKD
  • YPGLMIT
  • VPGYISRSVAGS
  • AWGGYVFI
  • DDFREAY
  • YVLVIFGG
  • EHWLVRIYKVK
  • LLNCLMYKM
  • DNEGIAIF
  • VMVRLML
  • RAWYPLGRI

Post-translational modifications for STT3B Gene

  • Ubiquitination at isoforms=719, posLast=749749, posLast=752752, and isoforms=754
  • Glycosylation at posLast=161161, isoforms=616, posLast=623623, posLast=627627, and isoforms=641

Other Protein References for STT3B Gene

Domains & Families for STT3B Gene

Gene Families for STT3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for STT3B Gene

Suggested Antigen Peptide Sequences for STT3B Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCJ2

UniProtKB/Swiss-Prot:

STT3B_HUMAN :
  • Belongs to the STT3 family.
Family:
  • Belongs to the STT3 family.
genes like me logo Genes that share domains with STT3B: view

Function for STT3B Gene

Molecular function for STT3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Enzyme Numbers (IUBMB) for STT3B Gene

Phenotypes From GWAS Catalog for STT3B Gene

Gene Ontology (GO) - Molecular Function for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STT3B: view
genes like me logo Genes that share phenotypes with STT3B: view

Human Phenotype Ontology for STT3B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for STT3B Gene

miRTarBase miRNAs that target STT3B

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for STT3B Gene

Localization for STT3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STT3B Gene

Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STT3B gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0008250 oligosaccharyltransferase complex TAS 19167329
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STT3B: view

Pathways & Interactions for STT3B Gene

genes like me logo Genes that share pathways with STT3B: view

Pathways by source for STT3B Gene

1 GeneGo (Thomson Reuters) pathway for STT3B Gene

UniProtKB/Swiss-Prot Q8TCJ2-STT3B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006516 glycoprotein catabolic process IMP 22607976
GO:0006986 response to unfolded protein IMP 19167329
GO:0018279 protein N-linked glycosylation via asparagine ISS --
GO:0030433 ubiquitin-dependent ERAD pathway IMP 22607976
genes like me logo Genes that share ontologies with STT3B: view

No data available for SIGNOR curated interactions for STT3B Gene

Drugs & Compounds for STT3B Gene

(1) Drugs for STT3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved, Investigational Nutra 0

(1) Additional Compounds for STT3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with STT3B: view

Transcripts for STT3B Gene

Unigene Clusters for STT3B Gene

STT3B, subunit of the oligosaccharyltransferase complex (catalytic):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STT3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - -
SP2:
SP3:
SP4:

Relevant External Links for STT3B Gene

GeneLoc Exon Structure for
STT3B
ECgene alternative splicing isoforms for
STT3B

Expression for STT3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STT3B Gene

Protein differential expression in normal tissues from HIPED for STT3B Gene

This gene is overexpressed in Nasal epithelium (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STT3B Gene



Protein tissue co-expression partners for STT3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STT3B Gene:

STT3B

SOURCE GeneReport for Unigene cluster for STT3B Gene:

Hs.475812

mRNA Expression by UniProt/SwissProt for STT3B Gene:

Q8TCJ2-STT3B_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in skin fibroblasts (at protein level).

Evidence on tissue expression from TISSUES for STT3B Gene

  • Liver(4.4)
  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STT3B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • head
  • skull
Thorax:
  • lung
Abdomen:
  • liver
Pelvis:
  • penis
  • testicle
General:
  • blood
  • coagulation system
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with STT3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STT3B Gene

Orthologs for STT3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STT3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STT3B 33 34
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia STT3B 33 34
  • 96.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STT3B 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STT3B 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STT3B 33 34
  • 93.75 (n)
mouse
(Mus musculus)
Mammalia Stt3b 33 16 34
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Stt3b 33
  • 90.09 (n)
chicken
(Gallus gallus)
Aves STT3B 33 34
  • 84.32 (n)
lizard
(Anolis carolinensis)
Reptilia STT3B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stt3b 33
  • 81.07 (n)
Str.16715 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17193 33
zebrafish
(Danio rerio)
Actinopterygii stt3b 34
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta OstStt3 33 34
  • 65.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002396 33
  • 63.34 (n)
worm
(Caenorhabditis elegans)
Secernentea stt-3 33 34
  • 62.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STT3 33 34 36
  • 59.13 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11627g 33
  • 58.42 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR491W 33
  • 54.66 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7700 33
barley
(Hordeum vulgare)
Liliopsida Hv.4761 33
wheat
(Triticum aestivum)
Liliopsida Ta.9644 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5942 34
  • 73 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes stt3 33
  • 56.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10497 33
  • 55.65 (n)
Species where no ortholog for STT3B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STT3B Gene

ENSEMBL:
Gene Tree for STT3B (if available)
TreeFam:
Gene Tree for STT3B (if available)

Paralogs for STT3B Gene

Paralogs for STT3B Gene

(1) SIMAP similar genes for STT3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STT3B: view

Variants for STT3B Gene

Sequence variations from dbSNP and Humsavar for STT3B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs587777217 pathogenic, Congenital disorder of glycosylation type 1x 31,622,328(+) G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs76400963 benign, not specified, Congenital disorder of glycosylation type 1x 31,596,870(+) T/G intron_variant
rs140420950 likely-benign, not specified 31,633,069(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs143950703 likely-benign, not specified 31,622,167(+) A/G/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, synonymous_variant
rs34176522 likely-benign, not specified 31,624,950(+) C/G/T coding_sequence_variant, genic_downstream_transcript_variant, stop_gained, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for STT3B Gene

Variant ID Type Subtype PubMed ID
esv1008680 CNV deletion 20482838
nsv1003285 CNV gain 25217958
nsv590032 CNV loss 21841781
nsv954458 CNV duplication 24416366

Variation tolerance for STT3B Gene

Residual Variation Intolerance Score: 4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STT3B Gene

Human Gene Mutation Database (HGMD)
STT3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STT3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STT3B Gene

Disorders for STT3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for STT3B Gene - From: OMIM, ClinVar, GTR, and Orphanet

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ix
  • cdg1x
- elite association - COSMIC cancer census association via MalaCards
Search STT3B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STT3B_HUMAN
  • Congenital disorder of glycosylation 1X (CDG1X) [MIM:615597]: A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:23842455}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for STT3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STT3B: view

No data available for Genatlas for STT3B Gene

Publications for STT3B Gene

  1. The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PMID: 12439619) McBride K … Perreault C (Immunogenetics 2002) 2 3 4 22 58
  2. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PMID: 19167329) Ruiz-Canada C … Gilmore R (Cell 2009) 3 4 22 58
  3. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PMID: 12887896) Kelleher DJ … Gilmore R (Molecular cell 2003) 2 3 4 58
  4. Mutations in STT3A and STT3B cause two congenital disorders of glycosylation. (PMID: 23842455) Shrimal S … Freeze HH (Human molecular genetics 2013) 3 4 58
  5. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PMID: 23606741) Dumax-Vorzet A … High S (Journal of cell science 2013) 3 4 58

Products for STT3B Gene

Sources for STT3B Gene

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