Aliases for STT3A-AS1 Gene

Subcategory (RNA class) for STT3A-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for STT3A-AS1 Gene

  • STT3A Antisense RNA 1 2 3
  • STT3A-AS1 2 165
  • Fasciculation And Elongation Protein Zeta 1 5
  • Fasciculation And Elongation Protein Zeta-1 4
  • NONHSAG009958.2 91
  • HSALNG0087953 164
  • Zygin I 4
  • Zygin-1 4
  • FEZ1 5

External Ids for STT3A-AS1 Gene

Previous GeneCards Identifiers for STT3A-AS1 Gene

  • GC11M125570

Summaries for STT3A-AS1 Gene

GeneCards Summary for STT3A-AS1 Gene

STT3A-AS1 (STT3A Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. An important paralog of this gene is FEZ2.

UniProtKB/Swiss-Prot Summary for STT3A-AS1 Gene

  • May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Additional gene information for STT3A-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STT3A-AS1 Gene

Genomics for STT3A-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STT3A-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J125591 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.3 -323 4.2 SP1 CREB1 GATAD2A ZNF629 TFE3 SOX13 IKZF1 NFKBIZ POLR2A ZNF692 STT3A FEZ1 STT3A-AS1 CHEK1 MSANTD2 ENSG00000255062 TMEM218 ENSG00000254509 ENSG00000254694 EI24
GH11J126057 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -468.1 -468055 6.9 RNF2 SP1 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 SIX5 ZNF692 CDON STT3A TMEM218 STT3A-AS1 TIRAP piR-54178 VSIG10L2
GH11J125624 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.6 -33.7 -33710 3.8 HNRNPL CREB1 CTCF TEAD4 PRDM10 ZNF629 TFE3 LEF1 SOX13 IKZF1 CHEK1 MN309420 lnc-ACRV1-2 TMEM218 ENSG00000255062 MSANTD2 TIRAP STT3A CCDC15 STT3A-AS1
GH11J125467 Enhancer 0.5 dbSUPER 11.3 +123.8 123807 1.6 CEBPA ATF4 HNF4A ATF3 KDM1A HNF4G CEBPG ZNF384 LOC403312 FEZ1 STT3A-AS1 PATE4 lnc-ACRV1-1 EI24 PKNOX2
GH11J125470 Enhancer 0.4 FANTOM5 dbSUPER 11 +122.0 122014 0.1 FEZ1 LOC403312 STT3A-AS1 PKNOX2 DDX25 lnc-ACRV1-1 EI24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STT3A-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for STT3A-AS1 Gene

Genomic Locations for STT3A-AS1 Gene
chr11:125,442,881-125,592,578
(GRCh38/hg38)
Size:
149,698 bases
Orientation:
Minus strand
chr11:125,440,180-125,462,473
(GRCh37/hg19)
Size:
22,294 bases
Orientation:
Minus strand

Genomic View for STT3A-AS1 Gene

Genes around STT3A-AS1 on UCSC Golden Path with GeneCards custom track
STT3A-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
STT3A-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STT3A-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STT3A-AS1 Gene

Proteins for STT3A-AS1 Gene

  • Protein details for STT3A-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99689-FEZ1_HUMAN
    Recommended name:
    Fasciculation and elongation protein zeta-1
    Protein Accession:
    Q99689
    Secondary Accessions:
    • O00679
    • O00728
    • Q6IBI7

    Protein attributes for STT3A-AS1 Gene

    Size:
    392 amino acids
    Molecular mass:
    45119 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation.

    Alternative splice isoforms for STT3A-AS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STT3A-AS1 Gene

Post-translational modifications for STT3A-AS1 Gene

  • Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
  • Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STT3A-AS1 Gene

No data available for DME Specific Peptides for STT3A-AS1 Gene

Domains & Families for STT3A-AS1 Gene

Gene Families for STT3A-AS1 Gene

Protein Domains for STT3A-AS1 Gene

InterPro:
Blocks:
  • FEZ-like
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99689

UniProtKB/Swiss-Prot:

FEZ1_HUMAN :
  • Belongs to the zygin family.
Family:
  • Belongs to the zygin family.
genes like me logo Genes that share domains with STT3A-AS1: view

No data available for Suggested Antigen Peptide Sequences for STT3A-AS1 Gene

Function for STT3A-AS1 Gene

Molecular function for STT3A-AS1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Phenotypes From GWAS Catalog for STT3A-AS1 Gene

Gene Ontology (GO) - Molecular Function for STT3A-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI --
GO:0043015 gamma-tubulin binding IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with STT3A-AS1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STT3A-AS1 Gene

Localization for STT3A-AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STT3A-AS1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for STT3A-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with STT3A-AS1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for STT3A-AS1 Gene

Pathways & Interactions for STT3A-AS1 Gene

PathCards logo

SuperPathways for STT3A-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STT3A-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS --
GO:0007399 nervous system development TAS --
GO:0007411 axon guidance TAS --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0021766 hippocampus development IEA --
genes like me logo Genes that share ontologies with STT3A-AS1: view

No data available for Pathways by source and SIGNOR curated interactions for STT3A-AS1 Gene

Drugs & Compounds for STT3A-AS1 Gene

No Compound Related Data Available

Transcripts for STT3A-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for STT3A-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008E39E6_9606 lncRNA 434 3

HGNC: 44585,

RefSeq: NR_132372,

LNCipedia: STT3A-AS1:9,

URS00008B51C2_9606 lncRNA 469 3

LncBook: HSALNT0182851,

LNCipedia: STT3A-AS1:3,

NONCODE: NONHSAT024964.2,

URS0000D58E83_9606 lncRNA 2540 2

LncBook: HSALNT0182850,

LNCipedia: STT3A-AS1:8,

URS00004B248E_9606 lncRNA 429 2

LNCipedia: STT3A-AS1:2,

NONCODE: NONHSAT024960.2,

URS0000D5B821_9606 lncRNA 347 2

LncBook: HSALNT0182843,

LNCipedia: STT3A-AS1:4,

STT3A-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for STT3A-AS1 Gene

2 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for STT3A-AS1 Gene

No ASD Table

Relevant External Links for STT3A-AS1 Gene

GeneLoc Exon Structure for
STT3A-AS1

Expression for STT3A-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STT3A-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for STT3A-AS1 Gene

This gene is overexpressed in Testis (x15.4).

mRNA Expression by UniProt/SwissProt for STT3A-AS1 Gene:

Q99689-FEZ1_HUMAN
Tissue specificity: Mainly expressed in brain.
genes like me logo Genes that share expression patterns with STT3A-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STT3A-AS1 Gene

Orthologs for STT3A-AS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STT3A-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FEZ1 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FEZ1 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fez1 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FEZ1 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FEZ1 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FEZ1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FEZ1 31
  • 61 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FEZ1 31
  • 81 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fez1 31
  • 69 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Unc-76 31
  • 24 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-76 31
  • 28 (a)
OneToMany
Species where no ortholog for STT3A-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for STT3A-AS1 Gene

ENSEMBL:
Gene Tree for STT3A-AS1 (if available)
TreeFam:
Gene Tree for STT3A-AS1 (if available)

Paralogs for STT3A-AS1 Gene

Paralogs for STT3A-AS1 Gene

genes like me logo Genes that share paralogs with STT3A-AS1: view

Variants for STT3A-AS1 Gene

Additional dbSNP identifiers (rs#s) for STT3A-AS1 Gene

Additional Variant Information for STT3A-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STT3A-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for STT3A-AS1 Gene

Disorders for STT3A-AS1 Gene

Additional Disease Information for STT3A-AS1

No disorders were found for STT3A-AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STT3A-AS1 Gene

Publications for STT3A-AS1 Gene

  1. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. (PMID: 24098481) Behrens C … Kühnel K (PloS one 2013) 4
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 4
  3. Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport. (PMID: 20812761) Alborghetti MR … Kobarg J (Journal of proteome research 2010) 4
  4. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. (PMID: 18439996) Lanza DC … Kobarg J (Experimental cell research 2008) 4
  5. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann EM … Kobarg J (The Journal of biological chemistry 2006) 4

No data available for Mastermind for STT3A-AS1 Gene

Products for STT3A-AS1 Gene

Sources for STT3A-AS1 Gene