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The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
STT3A (STT3 Oligosaccharyltransferase Complex Catalytic Subunit A) is a Protein Coding gene. Diseases associated with STT3A include Congenital Disorder Of Glycosylation, Type Iw and Osteogenesis Imperfecta, Type X. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity. An important paralog of this gene is STT3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004576 | oligosaccharyl transferase activity | IEA | -- |
GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity | IBA,ISS | -- |
GO:0005515 | protein binding | IPI | 21903422 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0008250 | oligosaccharyltransferase complex | IDA,TAS | 19167329 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | N-Glycan biosynthesis | ||
2 | Metabolism of proteins | ||
3 | Metabolism | ||
4 | Protein processing in endoplasmic reticulum | ||
5 | Transport to the Golgi and subsequent modification |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | IEA | -- |
GO:0006487 | protein N-linked glycosylation | IMP | 22467853 |
GO:0018279 | protein N-linked glycosylation via asparagine | IBA,TAS | -- |
GO:0043686 | co-translational protein modification | IMP | 19167329 |
GO:0043687 | post-translational protein modification | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Asparagine | Approved, Investigational | Nutra | 36 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Dolichyl diphosphate |
|
37247-98-6 |
|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||
SP7: | |||||||||||||||||||||||
SP8: | |||||||||||||||||||||||
SP9: | |||||||||||||||||||||||
SP10: | |||||||||||||||||||||||
SP11: | |||||||||||||||||||||||
SP12: | - | - | |||||||||||||||||||||
SP13: | |||||||||||||||||||||||
SP14: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STT3A 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STT3A 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STT3A 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | STT3A 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STT3A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stt3a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Stt3a 30 |
|
||
Chicken (Gallus gallus) |
Aves | STT3A 31 |
|
OneToOne | |
LOC100857165 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | STT3A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stt3a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | itm1 30 31 |
|
OneToOne | |
Dr.7858 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1518 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000434 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STT3 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | STT3B 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0675500 30 |
|
||
Os.6190 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.22774 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.3652 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6149 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
660400 | Uncertain Significance: not provided | 125,620,014(+) | G/A | MISSENSE_VARIANT | |
668214 | Likely Benign: not provided | 125,614,434(+) | A/G | INTRON_VARIANT | |
669172 | Likely Benign: not provided | 125,606,336(+) | C/T | SYNONYMOUS_VARIANT | |
702009 | Likely Benign: not provided | 125,611,456(+) | G/A | SYNONYMOUS_VARIANT | |
702848 | Likely Benign: not provided | 125,606,470(+) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv32964 | CNV | gain+loss | 17666407 |
esv3579952 | CNV | loss | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
congenital disorder of glycosylation, type iw |
|
|
osteogenesis imperfecta, type x |
|
|
macular degeneration, age-related, 1 |
|
|
macular degeneration, age-related, 6 |
|
|
macular degeneration, age-related, 4 |
|
|