This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants res... See more...

Aliases for STS Gene

Aliases for STS Gene

  • Steroid Sulfatase 2 3 4 5
  • Steryl-Sulfatase 2 3 4
  • Arylsulfatase C 2 3 4
  • Steroid Sulfatase (Microsomal), Isozyme S 2 3
  • Steryl-Sulfate Sulfohydrolase 3 4
  • Estrone Sulfatase 3 4
  • EC 3.1.6.2 4 52
  • ARSC1 3 4
  • ASC 3 4
  • Steroid Sulfatase (Microsomal), Arylsulfatase C, Isozyme S 2
  • HSALNG0136532 167
  • EC 3.1.6 52
  • ARSC 3
  • SSDD 3
  • XLI 3
  • ES 3

External Ids for STS Gene

Previous HGNC Symbols for STS Gene

  • ARSC1

Previous GeneCards Identifiers for STS Gene

  • GC0XP002655
  • GC0XP005924
  • GC0XP006533
  • GC0XP006599
  • GC0XP006997
  • GC0XP007147
  • GC0XP004994

Summaries for STS Gene

Entrez Gene Summary for STS Gene

  • This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

GeneCards Summary for STS Gene

STS (Steroid Sulfatase) is a Protein Coding gene. Diseases associated with STS include Ichthyosis, X-Linked and Ichthyosis. Among its related pathways are Metabolism of proteins and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and steryl-sulfatase activity. An important paralog of this gene is ARSL.

UniProtKB/Swiss-Prot Summary for STS Gene

  • Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.

Gene Wiki entry for STS Gene

Additional gene information for STS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STS Gene

Genomics for STS Gene

GeneHancer (GH) Regulatory Elements for STS Gene

Promoters and enhancers for STS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ007145 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.9 903 4 SIN3A NRF1 POLR2G ZFX EP300 POLR2A ZBTB26 RFX1 MYC RCOR1 PUDP MIR4767 STS
GH0XJ007218 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 500.2 +73.1 73121 1.7 TCF7 TEAD1 ESR1 GATA3 TCF7L2 CEBPG EP300 POLR2A CEBPA STS PUDP RF00017-8139 RF00017-8140
GH0XJ007269 Enhancer 0.6 Ensembl ENCODE 11.7 +124.8 124784 6.2 SPI1 HLF PKNOX1 CEBPB STS PUDP RF00017-8140 RF00017-8139
GH0XJ007082 Enhancer 1 ENCODE dbSUPER 4.9 -62.7 -62748 2 JUND FOS EP300 RELA TRIM22 EZH2 BCL11A TCF12 CBFB POLR2A PUDP STS piR-53338-139 HSALNG0136519
GH0XJ007251 Enhancer 0.7 Ensembl ENCODE 6.3 +106.3 106283 4.4 FOS MEF2B STAT3 MYC RAD21 YY1 SP1 CEBPG PUDP STS RF00017-8139 RF00017-8140
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STS

Top Transcription factor binding sites by QIAGEN in the STS gene promoter:
  • MyoD
  • Nkx2-5
  • SRF
  • SRF (504 AA)

Genomic Locations for STS Gene

Genomic Locations for STS Gene
chrX:7,146,517-7,804,358
(GRCh38/hg38)
Size:
657,842 bases
Orientation:
Plus strand
chrX:7,137,472-7,272,851
(GRCh37/hg19)
Size:
135,380 bases
Orientation:
Plus strand

Genomic View for STS Gene

Genes around STS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STS Gene

Proteins for STS Gene

  • Protein details for STS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08842-STS_HUMAN
    Recommended name:
    Steryl-sulfatase
    Protein Accession:
    P08842
    Secondary Accessions:
    • B2RA47

    Protein attributes for STS Gene

    Size:
    583 amino acids
    Molecular mass:
    65492 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for STS Gene

neXtProt entry for STS Gene

Selected DME Specific Peptides for STS Gene

P08842:
  • IDGRDLMPLL
  • HDPPLLFD
  • HEFLFHYC
  • NGIYKGG
  • WEGGIRVPG

Post-translational modifications for STS Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn47 and Asn259
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Domains & Families for STS Gene

Gene Families for STS Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for STS Gene

Blocks:
  • Sulfatase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STS Gene

GenScript: Design optimal peptide antigens:
  • Steroid sulfatase (A6PYA4_HUMAN)
  • Steroid sulfatase (Microsomal), isozyme S (C7BWB5_HUMAN)
  • Steroid sulfatase (Microsomal), isozyme S (Q0W975_HUMAN)
  • STS protein (Q16244_HUMAN)
  • Steryl-sulfate sulfohydrolase (STS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08842

UniProtKB/Swiss-Prot:

STS_HUMAN :
  • Belongs to the sulfatase family.
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with STS: view

Function for STS Gene

Molecular function for STS Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3beta-sulfooxy-androst-5-en-17-one + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate; Xref=Rhea:RHEA:19873, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905; EC=3.1.6.2; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone 3-sulfate + H2O = estrone + H(+) + sulfate; Xref=Rhea:RHEA:31055, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:17263, ChEBI:CHEBI:60050; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=24.8 uM for 3beta-sulfooxy-androst-5-en-17-one (DHEA-S) {ECO:0000269 PubMed:23466819}; Vmax=354.4 umol/min/mg enzyme with 3beta-sulfooxy-androst-5-en- 17-one (DHEA-S) {ECO:0000269 PubMed:23466819};
GENATLAS Biochemistry:
steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping inactivation

Enzyme Numbers (IUBMB) for STS Gene

Phenotypes From GWAS Catalog for STS Gene

Gene Ontology (GO) - Molecular Function for STS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity IBA 21873635
GO:0004773 steryl-sulfatase activity IEA,TAS --
GO:0008484 sulfuric ester hydrolase activity IDA 15962010
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STS: view
genes like me logo Genes that share phenotypes with STS: view

Human Phenotype Ontology for STS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STS

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for STS Gene

Localization for STS Gene

Subcellular locations from UniProtKB/Swiss-Prot for STS Gene

Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STS gene
Compartment Confidence
plasma membrane 5
lysosome 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for STS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome TAS 2668275
GO:0005768 endosome TAS 2668275
GO:0005783 endoplasmic reticulum TAS 2668275
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with STS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STS Gene

Pathways & Interactions for STS Gene

genes like me logo Genes that share pathways with STS: view

Pathways by source for STS Gene

1 KEGG pathway for STS Gene
2 GeneGo (Thomson Reuters) pathways for STS Gene
  • Androstenedione and testosterone biosynthesis and metabolism p.1
  • Estrone metabolism

Gene Ontology (GO) - Biological Process for STS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006706 steroid catabolic process TAS 6957717
GO:0007565 female pregnancy IEA --
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with STS: view

No data available for SIGNOR curated interactions for STS Gene

Drugs & Compounds for STS Gene

(81) Drugs for STS Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Norelgestromin Approved, Investigational Pharma Enzyme, inhibitor 24
Tibolone Approved, Investigational Pharma Enzyme, inhibitor 24
Tyrosine Approved, Investigational Nutra 985
cholesterol Approved, Investigational Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 23

(31) Additional Compounds for STS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3beta-Hydroxypregn-5-en-20-one sulfate
  • (3beta)-3-(Sulfooxy)pregn-5-en-20-one
  • 5-Pregnen-3beta-ol-20-one sulfate
  • (3b)-3-(Sulfooxy)pregn-5-en-20-one
  • (3b)-3-(Sulphooxy)pregn-5-en-20-one
  • (3beta)-3-(Sulphooxy)pregn-5-en-20-one
Androsterone sulfate
  • 3alpha-Hydroxy-5alpha-androstan-17-one 3-sulfate
  • 5alpha-Androstane-3alpha-ol-17-one sulfate
  • 3a-Hydroxy-5a-androstan-17-one 3-sulfate
  • 3a-Hydroxy-5a-androstan-17-one 3-sulfuric acid
  • 3a-Hydroxy-5a-androstan-17-one 3-sulphate
2479-86-9
genes like me logo Genes that share compounds with STS: view

Transcripts for STS Gene

mRNA/cDNA for STS Gene

6 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 RNACentral transcripts :
1 LncBook transcripts :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STS

Alternative Splicing Database (ASD) splice patterns (SP) for STS Gene

No ASD Table

Relevant External Links for STS Gene

GeneLoc Exon Structure for
STS

Expression for STS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STS Gene

This gene is overexpressed in Nasal epithelium (37.8) and Placenta (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STS

SOURCE GeneReport for Unigene cluster for STS Gene:

Hs.522578

Evidence on tissue expression from TISSUES for STS Gene

  • Liver(4.4)
  • Nervous system(4.2)
  • Skin(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STS Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • eye
  • head
Pelvis:
  • testicle
Limb:
  • nail
General:
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with STS: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STS Gene

Orthologs for STS Gene

This gene was present in the common ancestor of animals.

Orthologs for STS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STS 31 30
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STS 31 30
  • 79.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STS 31 30
  • 77.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 73 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia STS 31
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sts 30
  • 63.37 (n)
chicken
(Gallus gallus)
Aves STS 31 30
  • 67.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STS 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sts 30
  • 62.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32728 30
zebrafish
(Danio rerio)
Actinopterygii sts 31 30
  • 62.05 (n)
OneToOne
sec61a 30
worm
(Caenorhabditis elegans)
Secernentea sul-2 31
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
ManyToMany
Species where no ortholog for STS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STS Gene

ENSEMBL:
Gene Tree for STS (if available)
TreeFam:
Gene Tree for STS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STS: view image

Paralogs for STS Gene

(5) SIMAP similar genes for STS Gene using alignment to 5 proteins:

  • STS_HUMAN
  • A6PYA4_HUMAN
  • C7BWB5_HUMAN
  • Q0W975_HUMAN
  • Q16244_HUMAN

Pseudogenes.org Pseudogenes for STS Gene

genes like me logo Genes that share paralogs with STS: view

Variants for STS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STS Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
10557 Pathogenic: X-linked ichthyosis with steryl-sulfatase deficiency 7,325,499(+) G/T SPLICE_DONOR_VARIANT
625856 Pathogenic: X-linked ichthyosis with steryl-sulfatase deficiency 7,257,478(+) G/A NONSENSE
638373 Uncertain Significance: X-linked ichthyosis with steryl-sulfatase deficiency 7,325,368(+) A/G MISSENSE_VARIANT
707559 Benign: not provided 7,325,495(+) A/G MISSENSE_VARIANT
744311 Likely Benign: not provided 7,259,758(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for STS Gene

Structural Variations from Database of Genomic Variants (DGV) for STS Gene

Variant ID Type Subtype PubMed ID
esv2657313 CNV deletion 23128226
esv2678334 CNV deletion 23128226
esv2758858 CNV loss 17122850
esv3573512 CNV loss 25503493
esv3573513 CNV loss 25503493
esv3576757 CNV gain 25503493
nsv9931 CNV gain 18304495

Variation tolerance for STS Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STS Gene

Human Gene Mutation Database (HGMD)
STS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STS Gene

Disorders for STS Gene

MalaCards: The human disease database

(27) MalaCards diseases for STS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search STS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STS_HUMAN
  • Ichthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. {ECO:0000269 PubMed:10679952, ECO:0000269 PubMed:10844566, ECO:0000269 PubMed:1539590, ECO:0000269 PubMed:9252398}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for STS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STS: view

No data available for Genatlas for STS Gene

Publications for STS Gene

  1. Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder. (PMID: 18937300) Brookes KJ … Kent L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41 54
  2. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PMID: 17426092) Goodarzi MO … Azziz R (The Journal of clinical endocrinology and metabolism 2007) 3 23 41 54
  3. Structure of human estrone sulfatase suggests functional roles of membrane association. (PMID: 12657638) Hernandez-Guzman FG … Ghosh D (The Journal of biological chemistry 2003) 3 4 23 54
  4. PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PMID: 10679952) Sugawara T … Fujimoto S (Human mutation 2000) 3 4 23 54
  5. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J … Hall P (Breast cancer research : BCR 2010) 3 41 54

Products for STS Gene

Sources for STS Gene