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This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants res... See more...
Aliases for STS Gene
Aliases for STS Gene
External Ids for STS Gene
- HGNC: 11425
- NCBI Entrez Gene: 412
- Ensembl: ENSG00000101846
- OMIM®: 300747
- UniProtKB/Swiss-Prot: P08842
Previous HGNC Symbols for STS Gene
- ARSC1
Previous GeneCards Identifiers for STS Gene
- GC0XP002655
- GC0XP005924
- GC0XP006533
- GC0XP006599
- GC0XP006997
- GC0XP007147
- GC0XP004994
Summaries for STS Gene
-
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
GeneCards Summary for STS Gene
STS (Steroid Sulfatase) is a Protein Coding gene. Diseases associated with STS include Ichthyosis, X-Linked and Ichthyosis. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Androstenedione and testosterone biosynthesis and metabolism p.1. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and steryl-sulfatase activity. An important paralog of this gene is ARSL.
UniProtKB/Swiss-Prot Summary for STS Gene
-
Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
Additional gene information for STS Gene
- HGNC (11425)
- NCBI Entrez Gene (412)
- Ensembl (ENSG00000101846)
- OMIM® (300747)
- UniProtKB/Swiss-Prot (P08842)
- Open Targets Platform(ENSG00000101846)
- Monarch Initiative
- Search for STS at DataMed
- Search for STS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STS Gene
Genomics for STS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STS Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ007145 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.1 | 93 | 3.8 | TBP BCL11A SMAD5 NONO THAP11 CEBPB SIN3A MAX VEZF1 TRIM22 | PUDP HSALNG0136525 MIR4767 STS | |
| GH0XJ007218 | Promoter/Enhancer | 0.9 | EPDnew Ensembl ENCODE | 250.2 | +72.2 | 72180 | 2.1 | CEBPA TCF7L2 CEBPG TEAD1 | STS PUDP RF00017-8139 HSALNG0136526 HSALNG0136525 VCX | |
| GH0XJ007269 | Enhancer | 0.6 | Ensembl ENCODE | 11.7 | +124.1 | 124064 | 6.2 | SPI1 PKNOX1 HLF CEBPB | STS PUDP HSALNG0136526 RF00017-8140 VCX | |
| GH0XJ007082 | Enhancer | 0.9 | ENCODE dbSUPER | 4.9 | -63.5 | -63468 | 2 | BCL11A IRF4 TRIM22 EBF1 SMARCA5 CBFB SPI1 BHLHE40 BATF POLR2A | PUDP STS HSALNG0136523 piR-53338-139 VCX3A | |
| GH0XJ007251 | Enhancer | 0.6 | Ensembl ENCODE | 6.3 | +105.6 | 105563 | 4.4 | RAD21 SP1 YY1 CEBPG | PUDP STS HSALNG0136526 RF00017-8139 HSALNG0136525 VCX |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STS
- Top Transcription factor binding sites by QIAGEN in the STS gene promoter:
-
- MyoD
- Nkx2-5
- SRF
- SRF (504 AA)
Genomic Locations for STS Gene
Latest Assembly
- chrX:7,147,237-7,804,358
- (GRCh38/hg38)
- Size:
- 657,122 bases
- Orientation:
- Plus strand
Previous Assembly
- chrX:7,065,331-7,272,682
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 207,352 bases
- Orientation:
- Plus strand
- chrX:7,137,497-7,272,851
- (GRCh37/hg19 by Ensembl)
- Size:
- 135,355 bases
- Orientation:
- Plus strand
Genomic View for STS Gene
Genes around STS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.31 by HGNC
- Xp22.31 by Entrez Gene
- Xp22.31 by Ensembl
STS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STS Gene
Proteins for STS Gene
-
Protein details for STS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08842-STS_HUMAN
- Recommended name:
- Steryl-sulfatase
- Protein Accession:
- P08842
- B2RA47
Protein attributes for STS Gene
- Size:
- 583 amino acids
- Molecular mass:
- 65492 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Homodimer.
Protein Expression for STS Gene
Selected DME Specific Peptides for STS Gene
- P08842:
-
- IDGRDLMPLL
- HDPPLLFD
- HEFLFHYC
- NGIYKGG
- WEGGIRVPG
Post-translational modifications for STS Gene
- The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
-
Glycosylation at Asn47 and Asn259
- NX_P08842 (NX_P08842-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- STS_HUMAN (1770)
Other Protein References for STS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences STS / ASC / Steroid Sulfatase Antibody
- Novus Biologicals Antibodies for STS
-
Abcam antibodies for STS
- Invitrogen Antibodies for STS (AFLGC-Sts)
-
Boster Bio Antibodies for STS
Protein products for research
-
OriGene Purified Proteins for STS
- Search Origene for MassSpec and Protein Over-expression Lysates for STS
- Origene Custom Protein Services for STS
- antibodies-online: Show 10 available STS Proteins ranked by validation data
- Compare Top STS Proteins
-
Abcam proteins for STS
Assay products for research
Domains & Families for STS Gene
Gene Families for STS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted membrane proteins
Protein Domains for STS Gene
- InterPro:
- Blocks:
-
- Sulfatase
- ProtoNet:
Suggested Antigen Peptide Sequences for STS Gene
- GenScript: Design optimal peptide antigens:
-
- Steroid sulfatase (A6PYA4_HUMAN)
- Steroid sulfatase (Microsomal), isozyme S (C7BWB5_HUMAN)
- Steroid sulfatase (Microsomal), isozyme S (Q0W975_HUMAN)
- STS protein (Q16244_HUMAN)
- Steryl-sulfate sulfohydrolase (STS_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08842- Family:
-
- Belongs to the sulfatase family.
Function for STS Gene
Molecular function for STS Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3beta-sulfooxy-androst-5-en-17-one + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate; Xref=Rhea:RHEA:19873, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905; EC=3.1.6.2; Evidence={ECO:0000269|PubMed:10844566, ECO:0000269|PubMed:23466819};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone 3-sulfate + H2O = estrone + H(+) + sulfate; Xref=Rhea:RHEA:31055, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:17263, ChEBI:CHEBI:60050; Evidence={ECO:0000269|PubMed:9252398};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=24.8 uM for 3beta-sulfooxy-androst-5-en-17-one (DHEA-S) {ECO:0000269|PubMed:23466819}; Vmax=354.4 umol/min/mg enzyme with 3beta-sulfooxy-androst-5-en-17-one (DHEA-S) {ECO:0000269|PubMed:23466819};
- GENATLAS Biochemistry:
- steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping inactivation
Enzyme Numbers (IUBMB) for STS Gene
Phenotypes From GWAS Catalog for STS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004065 | arylsulfatase activity | IBA | 21873635 |
| GO:0004773 | steryl-sulfatase activity | TAS,IEA | -- |
| GO:0008484 | sulfuric ester hydrolase activity | IEA,IDA | 15962010 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for STS Gene
- GenomeRNAi human phenotypes for STS:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Decreased viability
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased shRNA abundance (Z-score > 2)
- Increased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased S DNA content, increased G2M DNA content
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STS - Starting at $85 >
- * STS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STS
-
Santa Cruz Biotechnology (SCBT) CRISPR for STS
miRNA for STS Gene
- miRTarBase miRNAs that target STS
-
- hsa-miR-148b-3p (MIRT019334)
- hsa-miR-4662a-5p (MIRT443771)
- hsa-miR-539-5p (MIRT443772)
- hsa-miR-3651 (MIRT443773)
- hsa-miR-3976 (MIRT443774)
- hsa-miR-3925-5p (MIRT443775)
- hsa-miR-3123 (MIRT443776)
- hsa-miR-450a-2-3p (MIRT462555)
- hsa-miR-6083 (MIRT462556)
- hsa-miR-6857-5p (MIRT462557)
- hsa-miR-6763-5p (MIRT462558)
- hsa-miR-6810-5p (MIRT462559)
- hsa-miR-3150a-3p (MIRT462560)
- hsa-miR-2110 (MIRT462561)
- hsa-miR-23c (MIRT462562)
- hsa-miR-23b-3p (MIRT462563)
- hsa-miR-23a-3p (MIRT462564)
- hsa-miR-130a-5p (MIRT462565)
- hsa-miR-3147 (MIRT462566)
- hsa-miR-4425 (MIRT462567)
- hsa-miR-6780b-5p (MIRT462568)
- hsa-miR-4725-3p (MIRT462569)
- hsa-miR-4271 (MIRT462570)
- hsa-miR-6739-5p (MIRT462571)
- hsa-miR-6733-5p (MIRT462572)
- hsa-miR-3153 (MIRT462573)
- hsa-miR-4705 (MIRT462574)
- hsa-miR-3200-5p (MIRT462575)
- hsa-miR-1264 (MIRT462576)
- hsa-miR-7848-3p (MIRT532545)
- hsa-miR-6892-3p (MIRT532546)
- hsa-miR-545-5p (MIRT532547)
- hsa-miR-624-5p (MIRT532548)
- hsa-miR-4311 (MIRT785713)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STS
- Browse OriGene Inhibitory RNA Products For STS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STS
Clone products for research
- Applied Biological Materials (abm): Clones for STS - Starting at $45 >
- * STS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STS
Cell Lines for research
-
Horizon Cell Lines for STS
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for STS Gene
Localization for STS Gene
Subcellular locations from UniProtKB/Swiss-Prot for STS Gene
- Cytoplasmic vesicle, secretory vesicle, microneme membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 5 |
| endoplasmic reticulum | 4 |
| endosome | 4 |
| golgi apparatus | 4 |
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | TAS | 2668275 |
| GO:0005768 | endosome | TAS | 2668275 |
| GO:0005783 | endoplasmic reticulum | TAS | 2668275 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for STS Gene
Pathways & Interactions for STS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
| 2 | Sphingolipid metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | Metabolism of proteins | ||
| 5 | Androstenedione and testosterone biosynthesis and metabolism p.1 |
Androstenedione and testosterone biosynthesis and metabolism p.1
.57
|
Estrone metabolism
.57
|
Pathways by source for STS Gene
1 BioSystems pathway for STS Gene
8 Reactome pathways for STS Gene
1 PharmGKB pathway for STS Gene
1 KEGG pathway for STS Gene
2 GeneGo (Thomson Reuters) pathways for STS Gene
- Androstenedione and testosterone biosynthesis and metabolism p.1
- Estrone metabolism
Interacting Proteins for STS Gene
GPS-Prot Interaction Network for STS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
| GO:0006706 | steroid catabolic process | TAS | 6957717 |
| GO:0007565 | female pregnancy | IEA | -- |
| GO:0008202 | steroid metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for STS Gene
Drugs & Compounds for STS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Norelgestromin | Approved, Investigational | Pharma | Enzyme, inhibitor | 25 | ||
| Tibolone | Approved, Investigational | Pharma | Enzyme, inhibitor | 24 | ||
| Tyrosine | Approved, Investigational | Nutra | 1128 | |||
| cholesterol | Approved, Investigational | Pharma | 0 | |||
| Estrone | Approved | Pharma | Estrogenic hormone | 24 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3beta-Hydroxypregn-5-en-20-one sulfate |
|
|
||||
| Androsterone sulfate |
|
2479-86-9 |
|
Transcripts for STS Gene
mRNA/cDNA for STS Gene
- 6 REFSEQ mRNAs :
- 31 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217961 6521 nts (view in UCSC)
- ENST00000658154 3840 nts (view in UCSC)
- ENST00000660000 2838 nts (view in UCSC)
- ENST00000664306 3181 nts (view in UCSC)
- ENST00000666110 6547 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STS - Starting at $85 >
- * STS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STS
-
Santa Cruz Biotechnology (SCBT) CRISPR for STS
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STS
- Browse OriGene Inhibitory RNA Products For STS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STS
Clone products for research
- Applied Biological Materials (abm): Clones for STS - Starting at $45 >
- * STS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STS
Relevant External Links for STS Gene
- GeneLoc Exon Structure for
- STS
Expression for STS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
-
Placenta (Extraembryonic Tissues)
-
Larynx (Respiratory System)
This gene is overexpressed in Nasal epithelium (37.8) and Placenta (28.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STS
SOURCE GeneReport for Unigene cluster for STS Gene:
Hs.522578Evidence on tissue expression from TISSUES for STS Gene
- Liver(4.5)
- Nervous system(4.3)
- Adrenal gland(2.2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STS Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- reproductive
Regions:
Head and neck:
- brain
- eye
- head
Pelvis:
- testicle
Limb:
- nail
General:
- hair
- skin
- sweat gland
Primer products for research
-
OriGene qPCR primer pairs for STS
-
OriGene qPCR primer pairs and template standards for STS
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STS Gene
Orthologs for STS Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STS 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STS 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sts 30 |
|
||
| Chicken (Gallus gallus) |
Aves | STS 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sts 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.32728 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sts 30 31 |
|
OneToOne | |
| sec61a 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | sul-2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for STS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STS Gene
- ENSEMBL:
- Gene Tree for STS (if available)
- TreeFam:
- Gene Tree for STS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STS: view image
Paralogs for STS Gene
Paralogs for STS Gene
(5) SIMAP similar genes for STS Gene using alignment to 5 proteins:
- STS_HUMAN
- A6PYA4_HUMAN
- C7BWB5_HUMAN
- Q0W975_HUMAN
- Q16244_HUMAN
Pseudogenes.org Pseudogenes for STS Gene
Variants for STS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STS Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 931008 | Uncertain Significance: X-linked ichthyosis with steryl-sulfatase deficiency | 7,325,321(+) |
T/C NM_001320752.2(STS):c.1082-18T>C |
INTRON | |
| rs1064795456 | Likely Pathogenic: not provided | 7,325,371(+) |
C/T NM_000351.6(STS):c.1129C>T (p.Arg377Trp) |
MISSENSE | |
| rs137853165 | Pathogenic: X-linked ichthyosis with steryl-sulfatase deficiency. Ichthyosis, X-linked (IXL) [MIM:308100] | 7,325,356(+) |
T/Ap.Trp372Arg NM_000351.6(STS):c.1114T>A (p.Trp372Arg) |
MISSENSE | |
| rs137853166 | Pathogenic: X-linked ichthyosis with steryl-sulfatase deficiency. Ichthyosis, X-linked (IXL) [MIM:308100] | 7,334,066(+) |
G/Ap.Cys446Tyr NM_000351.6(STS):c.1337G>A (p.Cys446Tyr) |
MISSENSE | |
| rs137853167 | Pathogenic: X-linked ichthyosis with steryl-sulfatase deficiency; not provided. Ichthyosis, X-linked (IXL) [MIM:308100] | 7,305,109(+) |
C/Tp.Ser341Leu NM_000351.6(STS):c.1022C>T (p.Ser341Leu) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657313 | CNV | deletion | 23128226 |
| esv2678334 | CNV | deletion | 23128226 |
| esv2758858 | CNV | loss | 17122850 |
| esv3573512 | CNV | loss | 25503493 |
| esv3573513 | CNV | loss | 25503493 |
| esv3576757 | CNV | gain | 25503493 |
| nsv9931 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.18;
23.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STS Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STS Gene
Disorders for STS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ichthyosis, x-linked |
|
|
| ichthyosis |
|
|
| ichthyosis vulgaris |
|
|
| smith-lemli-opitz syndrome |
|
|
| chondrodysplasia punctata syndrome |
|
|
Search STS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
STS_HUMAN- Ichthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. {ECO:0000269 PubMed:10679952, ECO:0000269 PubMed:10844566, ECO:0000269 PubMed:1539590, ECO:0000269 PubMed:9252398}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for STS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for STS Gene
Publications for STS Gene
- Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder. (PMID: 18937300) Brookes KJ … Kent L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
- Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PMID: 17426092) Goodarzi MO … Azziz R (The Journal of clinical endocrinology and metabolism 2007) 3 23 41
- Structure of human estrone sulfatase suggests functional roles of membrane association. (PMID: 12657638) Hernandez-Guzman FG … Ghosh D (The Journal of biological chemistry 2003) 3 4 23
- PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PMID: 10679952) Sugawara T … Fujimoto S (Human mutation 2000) 3 4 23
- Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. (PMID: 9252398) Alperin ES … Shapiro LJ (The Journal of biological chemistry 1997) 3 4 74
ExternalLinks
Products for STS Gene
- Custom Antibody Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Virus packaging for STS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STS
- antibodies-online: Show 24 available STS Antibodies ranked by validation data
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- antibodies-online: Show 13 available STS Elisa Kits ranked by validation data
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- antibodies-online: Show 10 available STS Proteins ranked by validation data
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- Horizon Cell Lines for STS
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STS
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STS
- Boster Bio Antibodies for STS
- Browse Boster Bio ELISA Kits
Sources for STS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
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- (104) diseasecard
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