Aliases for STRN4 Gene

Aliases for STRN4 Gene

  • Striatin 4 2 3 5
  • Zinedin 2 3 4
  • Protein Phosphatase 2 Regulatory Subunit B'''Gamma 2 3
  • Striatin, Calmodulin Binding Protein 4 2 3
  • Striatin-4 3 4
  • ZIN 3 4
  • PPP2R6C 3

External Ids for STRN4 Gene

Previous GeneCards Identifiers for STRN4 Gene

  • GC19M047614
  • GC19M051898
  • GC19M051914
  • GC19M047222
  • GC19M043647

Summaries for STRN4 Gene

GeneCards Summary for STRN4 Gene

STRN4 (Striatin 4) is a Protein Coding gene. Diseases associated with STRN4 include Cerebral Cavernous Malformations 3 and Muscular Dystrophy-Dystroglycanopathy. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and calmodulin binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot Summary for STRN4 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Wiki entry for STRN4 Gene

Additional gene information for STRN4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRN4 Gene

Genomics for STRN4 Gene

GeneHancer (GH) Regulatory Elements for STRN4 Gene

Promoters and enhancers for STRN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046745 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 527.3 +1.2 1212 3.6 EP300 SIN3A NRF1 POLR2G PHF8 POLR2A ZBTB10 ZBTB11 ZBTB26 SAP30 STRN4 FKRP lnc-CALM3-1 CCDC61 ENSG00000269148 CCDC9 NOP53 ZC3H4 SLC1A5 PRKD2
GH19J046748 Enhancer 0.7 ENCODE 500.7 -1.7 -1695 0.2 CTCF ZBTB7A TRIM22 SMC3 RBM25 KDM1A FOXA2 YY1 KLF13 KLF8 STRN4 FKRP lnc-CALM3-1 piR-56917
GH19J046747 Enhancer 0.4 ENCODE 500.7 -0.7 -692 0.2 RFX1 BMI1 SIN3A ZNF362 STRN4 lnc-CALM3-1 FKRP piR-56917
GH19J046713 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 37.2 +29.8 29759 8.5 ZBTB40 SIN3A POLR2G SP1 PHF8 ZBTB5 REST POLR2A ZBTB10 ZNF423 PRKD2 FKRP STRN4 ZC3H4 lnc-PRKD2-1 lnc-STRN4-2
GH19J046782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.5 -38.8 -38807 6.8 HNRNPK ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 SP1 SLC1A5 CCDC61 ZC3H4 NOP53-AS1 BICRA STRN4 PRKD2 ENSG00000268810 CCDC9 ENSG00000269148
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRN4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRN4

Top Transcription factor binding sites by QIAGEN in the STRN4 gene promoter:
  • AP-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1
  • En-1
  • HTF

Genomic Locations for STRN4 Gene

Genomic Locations for STRN4 Gene
chr19:46,719,509-46,746,994
(GRCh38/hg38)
Size:
27,486 bases
Orientation:
Minus strand
chr19:47,222,764-47,250,251
(GRCh37/hg19)
Size:
27,488 bases
Orientation:
Minus strand

Genomic View for STRN4 Gene

Genes around STRN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN4 Gene

Proteins for STRN4 Gene

  • Protein details for STRN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRL3-STRN4_HUMAN
    Recommended name:
    Striatin-4
    Protein Accession:
    Q9NRL3
    Secondary Accessions:
    • A0A024R0V2
    • B4DQH7
    • F8VYA6
    • Q8NE53

    Protein attributes for STRN4 Gene

    Size:
    753 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.
    Miscellaneous:
    • The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).

    Alternative splice isoforms for STRN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN4 Gene

Post-translational modifications for STRN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STRN4 Gene

Domains & Families for STRN4 Gene

Gene Families for STRN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for STRN4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59384, highly similar to Striatin-4 (B4DQH7_HUMAN)
  • Zinedin (STRN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRL3

UniProtKB/Swiss-Prot:

STRN4_HUMAN :
  • Belongs to the WD repeat striatin family.
Family:
  • Belongs to the WD repeat striatin family.
genes like me logo Genes that share domains with STRN4: view

Function for STRN4 Gene

Molecular function for STRN4 Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Phenotypes From GWAS Catalog for STRN4 Gene

Gene Ontology (GO) - Molecular Function for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0005516 calmodulin binding NAS,IBA 10748158
GO:0019904 protein domain specific binding IEA --
GO:0044877 protein-containing complex binding IDA,IBA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN4: view
genes like me logo Genes that share phenotypes with STRN4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRN4 Gene

Localization for STRN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRN4 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0030425 dendrite IBA 21873635
GO:0032991 protein-containing complex IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STRN4: view

Pathways & Interactions for STRN4 Gene

PathCards logo

SuperPathways for STRN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with STRN4: view

No data available for Pathways by source and SIGNOR curated interactions for STRN4 Gene

Drugs & Compounds for STRN4 Gene

(1) Drugs for STRN4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with STRN4: view

Transcripts for STRN4 Gene

mRNA/cDNA for STRN4 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP12:
SP13: - -
SP14: -

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for STRN4 Gene

GeneLoc Exon Structure for
STRN4

Expression for STRN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRN4 Gene

Protein differential expression in normal tissues from HIPED for STRN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STRN4 Gene



Protein tissue co-expression partners for STRN4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRN4

SOURCE GeneReport for Unigene cluster for STRN4 Gene:

Hs.631590

Evidence on tissue expression from TISSUES for STRN4 Gene

  • Muscle(4.3)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with STRN4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRN4 Gene

Orthologs for STRN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN4 31 30
  • 97.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STRN4 31 30
  • 89.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STRN4 31 30
  • 88.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Strn4 17 31 30
  • 87.78 (n)
rat
(Rattus norvegicus)
Mammalia Strn4 30
  • 87.68 (n)
oppossum
(Monodelphis domestica)
Mammalia STRN4 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN4 31
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN4 31
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii strn4 31 31 30
  • 65.25 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 31
  • 8 (a)
OneToMany
Species where no ortholog for STRN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRN4 Gene

ENSEMBL:
Gene Tree for STRN4 (if available)
TreeFam:
Gene Tree for STRN4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRN4: view image

Paralogs for STRN4 Gene

Paralogs for STRN4 Gene

(6) SIMAP similar genes for STRN4 Gene using alignment to 12 proteins:

  • STRN4_HUMAN
  • B4DQH7_HUMAN
  • F5GYK2_HUMAN
  • F8VYA6_HUMAN
  • M0QXN2_HUMAN
  • M0QYS2_HUMAN
  • M0QZM0_HUMAN
  • M0R0P4_HUMAN
  • M0R0W8_HUMAN
  • M0R2A7_HUMAN
  • M0R317_HUMAN
  • R4GN16_HUMAN
genes like me logo Genes that share paralogs with STRN4: view

Variants for STRN4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRN4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769977 Benign: not provided 46,722,858(-) T/C MISSENSE_VARIANT
781468 Likely Benign: not provided 46,746,401(-) G/T SYNONYMOUS_VARIANT,INTRON_VARIANT
782346 Benign: not provided 46,722,832(-) C/T SYNONYMOUS_VARIANT
785629 Benign: not provided 46,736,888(-) G/A SYNONYMOUS_VARIANT
rs1555735545 Pathogenic: Limb-girdle muscular dystrophy-dystroglycanopathy, type C5 46,746,071(-) G/A FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for STRN4 Gene

Structural Variations from Database of Genomic Variants (DGV) for STRN4 Gene

Variant ID Type Subtype PubMed ID
nsv833850 CNV loss 17160897
nsv953590 CNV deletion 24416366

Variation tolerance for STRN4 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRN4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN4 Gene

Disorders for STRN4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STRN4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral cavernous malformations 3
  • cavernous angiomatous malformations
muscular dystrophy-dystroglycanopathy
  • cmd due to dystroglycanopathy
- elite association - COSMIC cancer census association via MalaCards
Search STRN4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STRN4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STRN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRN4 Gene

Publications for STRN4 Gene

  1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PMID: 10748158) Castets F … Monneron A (The Journal of biological chemistry 2000) 2 3 4 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Genetic susceptibility variants for chronic lymphocytic leukemia. (PMID: 20332261) Slager SL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54
  4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 54
  5. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PMID: 18758461) Di Bernardo MC … Houlston RS (Nature genetics 2008) 3 41 54

Products for STRN4 Gene

Sources for STRN4 Gene