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STRN (Striatin) is a Protein Coding gene. Diseases associated with STRN include Cherubism and Cerebral Cavernous Malformations 3. Among its related pathways are Plasma membrane estrogen receptor signaling and Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include estrogen receptor binding. An important paralog of this gene is STRN3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J036961 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 612.5 | +1.4 | 1395 | 7.3 | SP1 HNRNPL GATAD2A PRDM10 ZNF512 RFX1 SIX5 LEF1 SOX13 IKZF1 | STRN GPATCH11 piR-50437-373 HEATR5B VIT | |
GH02J036902 | Promoter/Enhancer | 0.8 | EPDnew Ensembl | 620.3 | +62.5 | 62506 | 3 | CEBPG ZNF24 CEBPB ZFP91 HLF | STRN RNU6-577P piR-50437-373 RF00026-529 VIT | |
GH02J037012 | Promoter/Enhancer | 1.1 | Ensembl ENCODE | 16.4 | -46.7 | -46705 | 1.4 | IKZF2 SCRT2 EED ARID3A HMBOX1 DPF2 RELB RUNX3 BCLAF1 CBFB | STRN GPATCH11 L13304-019 L13714-258 HEATR5B | |
GH02J037004 | Enhancer | 0.7 | ENCODE | 18 | -38.6 | -38634 | 0.7 | CTCF STAT3 REST RAD21 ZNF24 IKZF2 RCOR1 TRIM22 EED ARID3A | STRN L13304-019 L13714-258 HEATR5B | |
GH02J036930 | Enhancer | 0.6 | Ensembl ENCODE | 21.5 | +35.3 | 35307 | 2.2 | NFE2 ZNF316 ZNF664 ZBTB33 EMSY | STRN piR-50437-373 RF00026-529 RNU6-577P VIT |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17540176 |
GO:0005516 | calmodulin binding | IBA,NAS | 9693043 |
GO:0030331 | estrogen receptor binding | IPI | 15569929 |
GO:0044877 | protein-containing complex binding | IBA,IDA | 18782753 |
GO:0051721 | protein phosphatase 2A binding | IDA | 18782753 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005923 | bicellular tight junction | IDA | 18502210 |
GO:0014069 | postsynaptic density | ISS | -- |
GO:0016020 | membrane | ISS | -- |
GO:0030054 | cell junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling |
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
.32
|
|
2 | Plasma membrane estrogen receptor signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007626 | locomotory behavior | ISS | -- |
GO:0008285 | negative regulation of cell proliferation | IMP | 18502210 |
GO:0016055 | Wnt signaling pathway | IMP | 18502210 |
GO:0016358 | dendrite development | ISS | -- |
GO:0070830 | bicellular tight junction assembly | NAS | 18502210 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STRN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STRN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STRN 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | STRN 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Strn 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Strn 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | STRN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STRN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STRN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | strn 30 |
|
||
Str.20192 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:158357 30 |
|
||
STRN 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cka 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | cash-1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | COP1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10811 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3790n100 | CNV | gain | 25217958 |
esv2719925 | CNV | deletion | 23290073 |
nsv1144895 | CNV | deletion | 24896259 |
nsv428395 | CNV | gain | 18775914 |
nsv456363 | CNV | gain | 19166990 |
nsv472064 | CNV | novel sequence insertion | 20440878 |
nsv581470 | CNV | gain | 21841781 |
nsv828931 | CNV | gain | 20364138 |
nsv828942 | CNV | loss | 20364138 |
nsv961027 | CNV | duplication | 23825009 |
nsv963787 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cherubism |
|
|
cerebral cavernous malformations 3 |
|
|
renal adenoma |
|
|