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Aliases for STRN Gene
Aliases for STRN Gene
External Ids for STRN Gene
- HGNC: 11424
- Entrez Gene: 6801
- Ensembl: ENSG00000115808
- OMIM: 614765
- UniProtKB: O43815
Previous GeneCards Identifiers for STRN Gene
- GC02M037041
- GC02M037222
- GC02M037050
- GC02M036987
- GC02M036924
Summaries for STRN Gene
GeneCards Summary for STRN Gene
STRN (Striatin) is a Protein Coding gene. Diseases associated with STRN include Cherubism and Cerebral Cavernous Malformations 3. Among its related pathways are Plasma membrane estrogen receptor signaling and Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include estrogen receptor binding. An important paralog of this gene is STRN3.
UniProtKB/Swiss-Prot Summary for STRN Gene
-
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
Additional gene information for STRN Gene
- HGNC(11424)
- Entrez Gene(6801)
- Ensembl(ENSG00000115808)
- OMIM(614765)
- UniProtKB(O43815)
- Open Targets Platform(ENSG00000115808)
- Monarch Initiative
- Search for STRN at DataMed
- Search for STRN at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRN Gene
Genomics for STRN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STRN Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J036961 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 612.5 | +1.4 | 1395 | 7.3 | SP1 HNRNPL GATAD2A PRDM10 ZNF512 RFX1 SIX5 LEF1 SOX13 IKZF1 | STRN GPATCH11 piR-50437-373 HEATR5B VIT | |
| GH02J036902 | Promoter/Enhancer | 0.8 | EPDnew Ensembl | 620.3 | +62.5 | 62506 | 3 | CEBPG ZNF24 CEBPB ZFP91 HLF | STRN RNU6-577P piR-50437-373 RF00026-529 VIT | |
| GH02J037012 | Promoter/Enhancer | 1.1 | Ensembl ENCODE | 16.4 | -46.7 | -46705 | 1.4 | IKZF2 SCRT2 EED ARID3A HMBOX1 DPF2 RELB RUNX3 BCLAF1 CBFB | STRN GPATCH11 L13304-019 L13714-258 HEATR5B | |
| GH02J037004 | Enhancer | 0.7 | ENCODE | 18 | -38.6 | -38634 | 0.7 | CTCF STAT3 REST RAD21 ZNF24 IKZF2 RCOR1 TRIM22 EED ARID3A | STRN L13304-019 L13714-258 HEATR5B | |
| GH02J036930 | Enhancer | 0.6 | Ensembl ENCODE | 21.5 | +35.3 | 35307 | 2.2 | NFE2 ZNF316 ZNF664 ZBTB33 EMSY | STRN piR-50437-373 RF00026-529 RNU6-577P VIT |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STRN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRN
- Top Transcription factor binding sites by QIAGEN in the STRN gene promoter:
-
- AML1a
- Elk-1
- HSF1 (long)
- HSF1short
- p53
- POU2F1
- POU2F1a
- RFX1
- RORalpha1
- SRY
Genomic Locations for STRN Gene
Genomic Locations for STRN Gene
- chr2:36,837,698-36,966,607
- (GRCh38/hg38)
- Size:
- 128,910 bases
- Orientation:
- Minus strand
- chr2:37,064,841-37,193,615
- (GRCh37/hg19)
- Size:
- 128,775 bases
- Orientation:
- Minus strand
Genomic View for STRN Gene
Genes around STRN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p22.2 by HGNC
- 2p22.2 by Entrez Gene
- 2p22.2 by Ensembl
STRN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STRN Gene
Proteins for STRN Gene
-
Protein details for STRN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43815-STRN_HUMAN
- Recommended name:
- Striatin
- Protein Accession:
- O43815
- Q3KP65
- Q53TQ8
- Q9NP38
Protein attributes for STRN Gene
- Size:
- 780 amino acids
- Molecular mass:
- 86132 Da
- Quaternary structure:
-
- Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).
Protein Expression for STRN Gene
Post-translational modifications for STRN Gene
Other Protein References for STRN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ STRN Antibody
-
Custom Antibody ServicesOriGene Antibodies for STRN
- Novus Biologicals Antibodies for STRN
-
Abcam antibodies for STRN
- Invitrogen Antibodies for STRN (AFLGC-STRN)
-
Boster Bio Antibodies for STRN
-
Santa Cruz Biotechnology (SCBT) Antibodies for STRN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STRN
- Origene Custom Protein Services for STRN
Assay Products
-
Signalway ELISA kits for STRN
No data available for DME Specific Peptides for STRN Gene
Domains & Families for STRN Gene
Gene Families for STRN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for STRN Gene
- InterPro:
- Blocks:
-
- G-protein beta WD-40 repeat signature
- ProtoNet:
Suggested Antigen Peptide Sequences for STRN Gene
- GenScript: Design optimal peptide antigens:
-
- STRN protein (Q3B874_HUMAN)
- Striatin (STRN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43815- Family:
-
- Belongs to the WD repeat striatin family.
Function for STRN Gene
Molecular function for STRN Gene
- UniProtKB/Swiss-Prot Function:
- Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
- GENATLAS Biochemistry:
- striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and olfactory system
Phenotypes From GWAS Catalog for STRN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17540176 |
| GO:0005516 | calmodulin binding | IBA,NAS | 9693043 |
| GO:0030331 | estrogen receptor binding | IPI | 15569929 |
| GO:0044877 | protein-containing complex binding | IBA,IDA | 18782753 |
| GO:0051721 | protein phosphatase 2A binding | IDA | 18782753 |
Phenotypes for STRN Gene
- MGI mutant phenotypes for STRN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STRN:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Two nuclei (binuclear), decreased viability (cell death)
- Increased homologous recombination repair frequency
Animal Models for STRN Gene
- MGI Knock Outs for STRN:
-
- Strn Strn<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STRN - Select products 50% OFF >
- * STRN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STRN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STRN
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRN
miRNA for STRN Gene
- miRTarBase miRNAs that target STRN
-
- hsa-miR-30a-5p (MIRT005191)
- mmu-miR-340-5p (MIRT010423)
- mmu-miR-15a-5p (MIRT011623)
- hsa-miR-155-5p (MIRT020667)
- hsa-miR-484 (MIRT041939)
- hsa-miR-342-3p (MIRT043722)
- hsa-miR-197-3p (MIRT048077)
- hsa-miR-580-3p (MIRT497891)
- hsa-miR-6502-5p (MIRT497892)
- hsa-miR-1301-5p (MIRT497893)
- hsa-miR-539-5p (MIRT497894)
- hsa-miR-4539 (MIRT497895)
- hsa-miR-554 (MIRT497896)
- hsa-miR-4724-5p (MIRT497897)
- hsa-miR-3935 (MIRT500888)
- hsa-miR-3140-3p (MIRT500889)
- hsa-miR-4708-5p (MIRT500890)
- hsa-miR-4712-3p (MIRT500891)
- hsa-miR-6831-5p (MIRT500892)
- hsa-miR-3927-3p (MIRT500893)
- hsa-miR-583 (MIRT500894)
- hsa-miR-4458 (MIRT500895)
- hsa-miR-98-5p (MIRT500896)
- hsa-let-7i-5p (MIRT500897)
- hsa-let-7c-5p (MIRT500898)
- hsa-let-7d-5p (MIRT500899)
- hsa-miR-4500 (MIRT500900)
- hsa-let-7a-5p (MIRT500901)
- hsa-let-7e-5p (MIRT500902)
- hsa-let-7f-5p (MIRT500903)
- hsa-let-7b-5p (MIRT500904)
- hsa-let-7g-5p (MIRT500905)
- hsa-miR-1277-5p (MIRT510676)
- hsa-miR-6083 (MIRT510677)
- hsa-miR-190a-3p (MIRT510678)
- hsa-miR-5011-5p (MIRT510679)
- hsa-miR-584-5p (MIRT520888)
- hsa-miR-299-5p (MIRT520889)
- hsa-miR-758-5p (MIRT520890)
- hsa-miR-218-2-3p (MIRT520891)
- hsa-miR-656-3p (MIRT520892)
- hsa-miR-4637 (MIRT540739)
- hsa-miR-603 (MIRT540740)
- hsa-miR-8485 (MIRT540741)
- hsa-miR-618 (MIRT540742)
- hsa-miR-30e-5p (MIRT612399)
- hsa-miR-30d-5p (MIRT612400)
- hsa-miR-30c-5p (MIRT612401)
- hsa-miR-30b-5p (MIRT612402)
- hsa-miR-6873-3p (MIRT612403)
- hsa-miR-7157-3p (MIRT612404)
- hsa-miR-6737-3p (MIRT612405)
- hsa-miR-5008-3p (MIRT612406)
- hsa-miR-6889-3p (MIRT612407)
- hsa-miR-6817-3p (MIRT612408)
- hsa-miR-7110-3p (MIRT612409)
- hsa-miR-8064 (MIRT616832)
- hsa-miR-4642 (MIRT627473)
- hsa-miR-6868-3p (MIRT627474)
- hsa-miR-6783-3p (MIRT627475)
- hsa-miR-1343-3p (MIRT627476)
- hsa-miR-3667-3p (MIRT627477)
- hsa-miR-6734-3p (MIRT627478)
- hsa-miR-4254 (MIRT627479)
- hsa-miR-3690 (MIRT627480)
- hsa-miR-141-5p (MIRT627481)
- hsa-miR-5197-5p (MIRT627482)
- hsa-miR-4313 (MIRT628987)
- hsa-miR-4762-5p (MIRT636205)
- hsa-miR-568 (MIRT715396)
- hsa-miR-621 (MIRT715397)
- hsa-miR-3146 (MIRT715398)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STRN
- Browse OriGene Inhibitory RNA Products For STRN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRN
Clone Products
- Applied Biological Materials (abm): Clones for STRN - Select products 50% OFF >
- * STRN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for STRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STRN
Cell Line Products
-
Horizon Cell Lines for STRN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRN Gene
Localization for STRN Gene
Subcellular locations from UniProtKB/Swiss-Prot for STRN Gene
- Cytoplasm. Membrane. Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| cytoskeleton | 3 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005923 | bicellular tight junction | IDA | 18502210 |
| GO:0014069 | postsynaptic density | ISS | -- |
| GO:0016020 | membrane | ISS | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for STRN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling |
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
.32
|
|
| 2 | Plasma membrane estrogen receptor signaling | ||
Pathways by source for STRN Gene
1 BioSystems pathway for STRN Gene
1 GeneGo (Thomson Reuters) pathway for STRN Gene
- Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
Interacting Proteins for STRN Gene
Selected Interacting proteins:
O43815-STRN_HUMAN
ENSP00000263918
for STRN Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for STRN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007626 | locomotory behavior | ISS | -- |
| GO:0008285 | negative regulation of cell proliferation | IMP | 18502210 |
| GO:0016055 | Wnt signaling pathway | IMP | 18502210 |
| GO:0016358 | dendrite development | ISS | -- |
| GO:0070830 | bicellular tight junction assembly | NAS | 18502210 |
No data available for SIGNOR curated interactions for STRN Gene
Transcripts for STRN Gene
mRNA/cDNA for STRN Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263918 14174 nts (view in UCSC)
- ENST00000379213 2254 nts (view in UCSC)
- ENST00000495595 1026 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STRN - Select products 50% OFF >
- * STRN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STRN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STRN
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STRN
- Browse OriGene Inhibitory RNA Products For STRN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRN
Clone Products
- Applied Biological Materials (abm): Clones for STRN - Select products 50% OFF >
- * STRN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for STRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STRN
Relevant External Links for STRN Gene
- GeneLoc Exon Structure for
- STRN
Expression for STRN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Lymph node (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STRN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRN
SOURCE GeneReport for Unigene cluster for STRN Gene:
Hs.127486mRNA Expression by UniProt/SwissProt for STRN Gene:
O43815-STRN_HUMAN
Tissue specificity:
Preferentially expressed in brain.
Evidence on tissue expression from TISSUES for STRN Gene
- Liver(4.4)
- Nervous system(4.1)
- Heart(2.8)
- Muscle(2.5)
- Kidney(2.4)
- Blood(2.2)
- Intestine(2.1)
- Lung(2)
- Skin(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for STRN
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRN Gene
Orthologs for STRN Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STRN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STRN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STRN 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STRN 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Strn 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Strn 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | STRN 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STRN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STRN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | strn 30 |
|
||
| Str.20192 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:158357 30 |
|
||
| STRN 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cka 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | cash-1 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | COP1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10811 31 |
|
OneToOne |
- Species where no ortholog for STRN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STRN Gene
- ENSEMBL:
- Gene Tree for STRN (if available)
- TreeFam:
- Gene Tree for STRN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STRN: view image
Paralogs for STRN Gene
(2) SIMAP similar genes for STRN Gene using alignment to 2 proteins:
- STRN_HUMAN
- Q3B874_HUMAN
Pseudogenes.org Pseudogenes for STRN Gene
Variants for STRN Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3790n100 | CNV | gain | 25217958 |
| esv2719925 | CNV | deletion | 23290073 |
| nsv1144895 | CNV | deletion | 24896259 |
| nsv428395 | CNV | gain | 18775914 |
| nsv456363 | CNV | gain | 19166990 |
| nsv472064 | CNV | novel sequence insertion | 20440878 |
| nsv581470 | CNV | gain | 21841781 |
| nsv828931 | CNV | gain | 20364138 |
| nsv828942 | CNV | loss | 20364138 |
| nsv961027 | CNV | duplication | 23825009 |
| nsv963787 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STRN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRN Gene
Disorders for STRN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cherubism |
|
|
| cerebral cavernous malformations 3 |
|
|
| renal adenoma |
|
|
Search STRN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STRN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STRN Gene
Publications for STRN Gene
- Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PMID: 9693043) Moqrich A … Castets F (Genomics 1998) 2 3 4 23
- A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 23
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41
- The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PMID: 18502210) Breitman M … Rosin-Arbesfeld R (Biochimica et biophysica acta 2008) 3 23
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 41
ExternalLinks
Products for STRN Gene
- Custom Antibody ServicesOriGene Antibodies for STRN
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STRN
- Origene Custom Protein Services for STRN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STRN
- Browse OriGene Inhibitory RNA Products For STRN
- OriGene qPCR primer pairs for STRN
- OriGene CRISPR knockouts for STRN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STRN
- Sino Biological Human cDNA Clone for STRN
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STRN
- Novus Biologicals proteins and lysates for STRN
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STRN
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for STRN (AFLGC-STRN)
- VectorBuilder Custom and pre-made DNA vectors for STRN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for STRN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for STRN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for STRN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STRN
- antibodies-online: Show 55 available Striatin Antibodies ranked by validation data
- Compare Top Striatin Antibodies
- antibodies-online: Search results for available Striatin related products ranked by validation data
- antibodies-online: Show 3 available Striatin Proteins ranked by validation data
- Compare Top Striatin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for STRN
- Search Santa Cruz Biotechnology (SCBT) for STRN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STRN
- Horizon Cell Lines for STRN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STRN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STRN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRN
- Boster Bio Antibodies for STRN
- Browse Boster Bio ELISA Kits
- Signalway ELISA kits for STRN
Sources for STRN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB