Aliases for STRIP2 Gene

Aliases for STRIP2 Gene

  • Striatin Interacting Protein 2 2 3 5
  • Family With Sequence Similarity 40, Member B 2 3
  • Striatin-Interacting Protein 2 3 4
  • Protein FAM40B 3 4
  • KIAA1170 2 4
  • FAM40B 3 4
  • FAR11B 2 3
  • FAR11 Factor Arrest 11 Homolog B (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog B 3
  • Homolog Of Yeast FAR11 Protein 2 3
  • STRIP2 5

External Ids for STRIP2 Gene

Previous HGNC Symbols for STRIP2 Gene

  • FAM40B

Previous GeneCards Identifiers for STRIP2 Gene

  • GC07P129074
  • GC07P129433

Summaries for STRIP2 Gene

GeneCards Summary for STRIP2 Gene

STRIP2 (Striatin Interacting Protein 2) is a Protein Coding gene. Diseases associated with STRIP2 include Monieziasis and Paralytic Lagophthalmos. An important paralog of this gene is STRIP1.

UniProtKB/Swiss-Prot Summary for STRIP2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Additional gene information for STRIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRIP2 Gene

Genomics for STRIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STRIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRIP2

Genomic Locations for STRIP2 Gene

Genomic Locations for STRIP2 Gene
chr7:129,434,432-129,488,399
(GRCh38/hg38)
Size:
53,968 bases
Orientation:
Plus strand
chr7:129,074,274-129,128,240
(GRCh37/hg19)
Size:
53,967 bases
Orientation:
Plus strand

Genomic View for STRIP2 Gene

Genes around STRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP2 Gene

Proteins for STRIP2 Gene

  • Protein details for STRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULQ0-STRP2_HUMAN
    Recommended name:
    Striatin-interacting protein 2
    Protein Accession:
    Q9ULQ0
    Secondary Accessions:
    • Q8WUZ4

    Protein attributes for STRIP2 Gene

    Size:
    834 amino acids
    Molecular mass:
    95360 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.
    SequenceCaution:
    • Sequence=BAA86484.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP2 Gene

Post-translational modifications for STRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STRIP2 Gene

Domains & Families for STRIP2 Gene

Gene Families for STRIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STRIP2 Gene

InterPro:
Blocks:
  • N1221-like
ProtoNet:

Suggested Antigen Peptide Sequences for STRIP2 Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 40, member B (A4D1K4_HUMAN)
  • Protein FAM40B (FA40B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULQ0

UniProtKB/Swiss-Prot:

STRP2_HUMAN :
  • Belongs to the STRIP family.
Family:
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP2: view

Function for STRIP2 Gene

Molecular function for STRIP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Phenotypes From GWAS Catalog for STRIP2 Gene

Gene Ontology (GO) - Molecular Function for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STRIP2: view
genes like me logo Genes that share phenotypes with STRIP2: view

Animal Model Products

CRISPR Products

miRNA for STRIP2 Gene

miRTarBase miRNAs that target STRIP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP2 Gene

Localization for STRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP2 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRIP2 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21834987
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STRIP2: view

Pathways & Interactions for STRIP2 Gene

PathCards logo

SuperPathways for STRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008360 regulation of cell shape IMP 21834987
GO:0016477 cell migration IMP 21834987
genes like me logo Genes that share ontologies with STRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP2 Gene

Drugs & Compounds for STRIP2 Gene

No Compound Related Data Available

Transcripts for STRIP2 Gene

mRNA/cDNA for STRIP2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRIP2

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP2 Gene

No ASD Table

Relevant External Links for STRIP2 Gene

GeneLoc Exon Structure for
STRIP2

Expression for STRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRIP2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x7.4), and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for STRIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1) and Heart (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STRIP2 Gene



Protein tissue co-expression partners for STRIP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRIP2

SOURCE GeneReport for Unigene cluster for STRIP2 Gene:

Hs.489988

Evidence on tissue expression from TISSUES for STRIP2 Gene

  • Nervous system(4.5)
  • Kidney(4.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with STRIP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRIP2 Gene

Orthologs for STRIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STRIP2 30 31
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STRIP2 30 31
  • 93.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STRIP2 30 31
  • 92.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Strip2 30 17 31
  • 90.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STRIP2 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC500066 30
  • 84.72 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia STRIP2 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STRIP2 31
  • 79 (a)
OneToOne
FAM40B 30
  • 76.57 (n)
Lizard
(Anolis carolinensis)
Reptilia STRIP2 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia strip2 30
  • 69.2 (n)
Str.15326 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8705 30
Zebrafish
(Danio rerio)
Actinopterygii strip2 31
  • 72 (a)
OneToOne
LOC556392 30
  • 70.39 (n)
Dr.14188 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10622 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG11526 31
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea farl-11 30 31
  • 50.28 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 31
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1783 30
Species where no ortholog for STRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STRIP2 Gene

ENSEMBL:
Gene Tree for STRIP2 (if available)
TreeFam:
Gene Tree for STRIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRIP2: view image

Paralogs for STRIP2 Gene

Paralogs for STRIP2 Gene

(3) SIMAP similar genes for STRIP2 Gene using alignment to 1 proteins:

  • STRP2_HUMAN
genes like me logo Genes that share paralogs with STRIP2: view

Variants for STRIP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRIP2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2242030 - p.Arg383Gln

Additional dbSNP identifiers (rs#s) for STRIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for STRIP2 Gene

Variant ID Type Subtype PubMed ID
esv2674446 CNV deletion 23128226
esv3614998 CNV loss 21293372
nsv831128 CNV gain 17160897
nsv966886 CNV duplication 23825009

Variation tolerance for STRIP2 Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRIP2 Gene

Human Gene Mutation Database (HGMD)
STRIP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRIP2 Gene

Disorders for STRIP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STRIP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
monieziasis
paralytic lagophthalmos
cerebral cavernous malformations 3
  • cavernous angiomatous malformations
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with STRIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRIP2 Gene

Publications for STRIP2 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 2 3 4
  2. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-Santamaría P … Revuelta JL (The Journal of biological chemistry 2012) 2 3
  3. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T … Liu Z (Genetics 2012) 2 3
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for STRIP2 Gene

  • Signalway ELISA kits for STRIP2

Sources for STRIP2 Gene