This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] See more...

Aliases for STRIP1 Gene

Aliases for STRIP1 Gene

  • Striatin Interacting Protein 1 2 3 5
  • Family With Sequence Similarity 40, Member A 2 3
  • Striatin-Interacting Protein 1 3 4
  • Protein FAM40A 3 4
  • KIAA1761 2 4
  • FAM40A 3 4
  • FAR11A 2 3
  • FAR11 Factor Arrest 11 Homolog A (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog A 3
  • Homolog Of Yeast FAR11 Protein 1 3
  • FLJ14743 2
  • STRIP1 5

External Ids for STRIP1 Gene

Previous HGNC Symbols for STRIP1 Gene

  • FAM40A

Previous GeneCards Identifiers for STRIP1 Gene

  • GC01P110575
  • GC01P110577
  • GC01P110579

Summaries for STRIP1 Gene

Entrez Gene Summary for STRIP1 Gene

  • This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for STRIP1 Gene

STRIP1 (Striatin Interacting Protein 1) is a Protein Coding gene. Diseases associated with STRIP1 include Cerebral Cavernous Malformations 3 and Familial Episodic Pain Syndrome. An important paralog of this gene is STRIP2.

UniProtKB/Swiss-Prot Summary for STRIP1 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Gene Wiki entry for STRIP1 Gene

Additional gene information for STRIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRIP1 Gene

Genomics for STRIP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J110033 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 256.3 +3.4 3377 2.9 CHD2 TBP SP1 ZBTB10 FEZF1 CEBPA SIX5 NR2C1 MNT BRCA1 STRIP1 HSALNG0005943 LOC105378895 MN308970 ALX3
GH01J110030 Promoter/Enhancer 1.2 Ensembl ENCODE 250.7 -0.8 -780 1.8 DEK SMAD5 CTCF REST ZNF395 VEZF1 TRIM22 GABPA SMC3 RFX5 STRIP1 ENSG00000258634 ENSG00000273373 HSALNG0005943 NONHSAG002362.2 AHCYL1
GH01J110032 Promoter 0.7 Ensembl 250.7 +1.1 1124 1 CEBPB IRF9 HDAC2 FOXK2 CEBPG ZNF639 KLF1 MLLT1 DACH1 ATF3 HSALNG0005943 STRIP1 LOC105378895 ALX3
GH01J110029 Enhancer 0.7 ENCODE 250.7 -1.8 -1833 0.2 DEK CTCF REST TRIM22 SMC3 RAD21 RFX5 TCF7L2 USF2 CEBPG STRIP1 NONHSAG002362.2 AHCYL1
GH01J109482 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 63.9 -547.6 -547553 2.4 ZSCAN16 TBP ZBTB10 SP1 FEZF1 SIX5 NR2C1 MNT SMAD5 IRF2 ATXN7L2 HSALNG0005891 ENSG00000258634 PRPF38B STRIP1 RPL17P7 SYPL2 ENSG00000273373 RBM15 ENSG00000228665
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRIP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRIP1

Genomic Locations for STRIP1 Gene

Latest Assembly
chr1:110,031,577-110,074,641
(GRCh38/hg38)
Size:
43,065 bases
Orientation:
Plus strand

Previous Assembly
chr1:110,574,199-110,597,263
(GRCh37/hg19 by Entrez Gene)
Size:
23,065 bases
Orientation:
Plus strand

chr1:110,574,199-110,617,263
(GRCh37/hg19 by Ensembl)
Size:
43,065 bases
Orientation:
Plus strand

Genomic View for STRIP1 Gene

Genes around STRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP1 Gene

Proteins for STRIP1 Gene

  • Protein details for STRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VSL9-STRP1_HUMAN
    Recommended name:
    Striatin-interacting protein 1
    Protein Accession:
    Q5VSL9
    Secondary Accessions:
    • Q0V925
    • Q5VSL8
    • Q658K2
    • Q6ZV31
    • Q8N598
    • Q96SN2
    • Q9C0A2

    Protein attributes for STRIP1 Gene

    Size:
    837 amino acids
    Molecular mass:
    95576 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CDC42BPB (PubMed:25743393). Interacts with CTTNBP2NL (PubMed:18782753).
    SequenceCaution:
    • Sequence=AAH32644.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP1 Gene

Post-translational modifications for STRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRIP1 Gene

No data available for DME Specific Peptides for STRIP1 Gene

Domains & Families for STRIP1 Gene

Gene Families for STRIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STRIP1 Gene

InterPro:
Blocks:
  • N1221-like
ProtoNet:

Suggested Antigen Peptide Sequences for STRIP1 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM40A (FA40A_HUMAN)
  • FAM40A protein (Q8WUN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VSL9

UniProtKB/Swiss-Prot:

STRP1_HUMAN :
  • Belongs to the STRIP family.
Family:
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP1: view

Function for STRIP1 Gene

Molecular function for STRIP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Phenotypes From GWAS Catalog for STRIP1 Gene

Gene Ontology (GO) - Molecular Function for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18782753
GO:0019901 protein kinase binding IEA --
GO:0031267 small GTPase binding IEA --
genes like me logo Genes that share ontologies with STRIP1: view
genes like me logo Genes that share phenotypes with STRIP1: view

Animal Models for STRIP1 Gene

MGI Knock Outs for STRIP1:
  • Strip1 Strip1<tm1b(KOMP)Wtsi>
  • Strip1 Strip1<tm1a(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRIP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRIP1 Gene

Localization for STRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP1 Gene

Cytoplasm. Note=Enriched on the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRIP1 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with STRIP1: view

Pathways & Interactions for STRIP1 Gene

PathCards logo

SuperPathways for STRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IBA 21873635
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0030866 cortical actin cytoskeleton organization IMP 21834987
genes like me logo Genes that share ontologies with STRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP1 Gene

Drugs & Compounds for STRIP1 Gene

No Compound Related Data Available

Transcripts for STRIP1 Gene

mRNA/cDNA for STRIP1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STRIP1

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for STRIP1 Gene

GeneLoc Exon Structure for
STRIP1

Expression for STRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRIP1 Gene

Protein differential expression in normal tissues from HIPED for STRIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STRIP1 Gene



Protein tissue co-expression partners for STRIP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRIP1

SOURCE GeneReport for Unigene cluster for STRIP1 Gene:

Hs.584996

Evidence on tissue expression from TISSUES for STRIP1 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with STRIP1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRIP1 Gene

Orthologs for STRIP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STRIP1 31
  • 100 (a)
OneToOne
FAM40A 30
  • 99.52 (n)
Dog
(Canis familiaris)
Mammalia STRIP1 31
  • 98 (a)
OneToOne
FAM40A 30
  • 92.38 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia STRIP1 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia STRIP1 30 31
  • 92.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Strip1 30
  • 91.76 (n)
Mouse
(Mus musculus)
Mammalia Strip1 30 17 31
  • 91.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STRIP1 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STRIP1 31
  • 96 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STRIP1 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia strip1 30
  • 75.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii strip1 31 31
  • 85 (a)
OneToMany
fam40a 30
  • 75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007902 30
  • 58.62 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG11526 30 31
  • 58.14 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea farl-11 31
  • 32 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 31 33 33
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for STRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STRIP1 Gene

ENSEMBL:
Gene Tree for STRIP1 (if available)
TreeFam:
Gene Tree for STRIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRIP1: view image

Paralogs for STRIP1 Gene

Paralogs for STRIP1 Gene

(3) SIMAP similar genes for STRIP1 Gene using alignment to 1 proteins:

  • STRP1_HUMAN
genes like me logo Genes that share paralogs with STRIP1: view

Variants for STRIP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRIP1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
930957 Uncertain Significance: See cases 110,040,713(+) G/A
NM_033088.4(STRIP1):c.650+10G>A
INTRON
rs112658570 Benign: not provided 110,051,897(+) T/C
NM_033088.4(STRIP1):c.2266+10T>C
INTRON
rs183730102 Benign: not provided 110,038,699(+) G/A
NM_033088.4(STRIP1):c.267G>A (p.Thr89=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs35857097 Benign: not provided 110,043,255(+) C/A
NM_033088.4(STRIP1):c.1053C>A (p.Gly351=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
VAR_076430 - p.Lys628Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STRIP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for STRIP1 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRIP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRIP1 Gene

Disorders for STRIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STRIP1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STRIP1

genes like me logo Genes that share disorders with STRIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRIP1 Gene

Publications for STRIP1 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  3. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-Santamaría P … Revuelta JL (The Journal of biological chemistry 2012) 2 3
  4. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T … Liu Z (Genetics 2012) 2 3
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4

Products for STRIP1 Gene

Sources for STRIP1 Gene