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This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
STRIP1 (Striatin Interacting Protein 1) is a Protein Coding gene. Diseases associated with STRIP1 include Cerebral Cavernous Malformations 3 and Familial Episodic Pain Syndrome. An important paralog of this gene is STRIP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005515 | protein binding | IPI | 18782753 |
GO:0019901 | protein kinase binding | IEA | -- |
GO:0031267 | small GTPase binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 15302935 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IBA,IDA | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007010 | cytoskeleton organization | IBA | 21873635 |
GO:0022604 | regulation of cell morphogenesis | IMP | 21834987 |
GO:0030866 | cortical actin cytoskeleton organization | IMP | 21834987 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | - | ||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STRIP1 31 |
|
OneToOne | |
FAM40A 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | STRIP1 31 |
|
OneToOne | |
FAM40A 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | STRIP1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STRIP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Strip1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Strip1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STRIP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STRIP1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STRIP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | strip1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | strip1 31 31 |
|
OneToMany | |
fam40a 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007902 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11526 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | farl-11 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAR11 31 33 33 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
930957 | Uncertain Significance: See cases | 110,040,713(+) |
G/A NM_033088.4(STRIP1):c.650+10G>A |
INTRON | |
rs112658570 | Benign: not provided | 110,051,897(+) |
T/C NM_033088.4(STRIP1):c.2266+10T>C |
INTRON | |
rs183730102 | Benign: not provided | 110,038,699(+) |
G/A NM_033088.4(STRIP1):c.267G>A (p.Thr89=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR | |
rs35857097 | Benign: not provided | 110,043,255(+) |
C/A NM_033088.4(STRIP1):c.1053C>A (p.Gly351=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
VAR_076430 | - |
p.Lys628Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
cerebral cavernous malformations 3 |
|
|
familial episodic pain syndrome |
|
|