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Aliases for STRIP1 Gene

Aliases for STRIP1 Gene

  • Striatin Interacting Protein 1 2 3 5
  • Family With Sequence Similarity 40, Member A 2 3
  • Protein FAM40A 3 4
  • FAM40A 3 4
  • FAR11 Factor Arrest 11 Homolog A (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog A 3
  • Homolog Of Yeast FAR11 Protein 1 3
  • Striatin-Interacting Protein 1 3
  • KIAA1761 4
  • FAR11A 3

External Ids for STRIP1 Gene

Previous HGNC Symbols for STRIP1 Gene

  • FAM40A

Previous GeneCards Identifiers for STRIP1 Gene

  • GC01P110575
  • GC01P110577
  • GC01P110579

Summaries for STRIP1 Gene

Entrez Gene Summary for STRIP1 Gene

  • This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for STRIP1 Gene

STRIP1 (Striatin Interacting Protein 1) is a Protein Coding gene. An important paralog of this gene is STRIP2.

UniProtKB/Swiss-Prot for STRIP1 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Gene Wiki entry for STRIP1 Gene

Additional gene information for STRIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP1 Gene

Genomics for STRIP1 Gene

GeneHancer (GH) Regulatory Elements for STRIP1 Gene

Promoters and enhancers for STRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I110033 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.4 +3.2 3211 2.6 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 STRIP1 LOC105378895
GH01I110029 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -1.0 -1025 2.3 PKNOX1 ATF1 YY1 ZNF766 ZNF143 RUNX3 DEK CAVIN1 REST ZNF592 STRIP1 ENSG00000258634 ENSG00000273373 AHCYL1
GH01I109482 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 61.7 -547.5 -547473 2.3 CLOCK YBX1 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ATXN7L2 ENSG00000258634 RPL17P7 PRPF38B STRIP1 CLCC1 SYPL2 RPS27P6 ENSG00000273373 RBM15
GH01I110334 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +307.1 307072 7.4 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D RBM15 GC01P110337 RBM15-AS1 PIR47446 ENSG00000258634 CEPT1 STRIP1 DRAM2 ENSG00000273373 UBL4B
GH01I110962 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.2 +932.0 932047 3.2 ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D ENSG00000273010 LRIF1 ENSG00000258634 ENSG00000243960 CEPT1 STRIP1 DDX20 ENSG00000273373 DRAM2 RBM15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STRIP1 Gene

Genomic Locations for STRIP1 Gene
43,065 bases
Plus strand

Genomic View for STRIP1 Gene

Genes around STRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP1 Gene

Proteins for STRIP1 Gene

  • Protein details for STRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Striatin-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • Q0V925
    • Q5VSL8
    • Q658K2
    • Q6ZV31
    • Q8N598
    • Q96SN2
    • Q9C0A2

    Protein attributes for STRIP1 Gene

    837 amino acids
    Molecular mass:
    95576 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CDC42BPB (PubMed:25743393). Interacts with CTTNBP2NL (PubMed:18782753).
    • Sequence=AAH32644.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP1 Gene


neXtProt entry for STRIP1 Gene

Post-translational modifications for STRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRIP1 Gene

No data available for DME Specific Peptides for STRIP1 Gene

Domains & Families for STRIP1 Gene

Gene Families for STRIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STRIP1 Gene


Suggested Antigen Peptide Sequences for STRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STRIP family.
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP1: view

Function for STRIP1 Gene

Molecular function for STRIP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Phenotypes From GWAS Catalog for STRIP1 Gene

Gene Ontology (GO) - Molecular Function for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18782753
GO:0017048 Rho GTPase binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with STRIP1: view

Phenotypes for STRIP1 Gene

genes like me logo Genes that share phenotypes with STRIP1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP1 Gene

Localization for STRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP1 Gene

Cytoplasm. Note=Enriched on the plasma membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRIP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with STRIP1: view

Pathways & Interactions for STRIP1 Gene

SuperPathways for STRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0030866 cortical actin cytoskeleton organization IMP 21834987
genes like me logo Genes that share ontologies with STRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP1 Gene

Drugs & Compounds for STRIP1 Gene

No Compound Related Data Available

Transcripts for STRIP1 Gene

Unigene Clusters for STRIP1 Gene

Striatin interacting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP6: -
SP8: -

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: -

Relevant External Links for STRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRIP1 Gene

Protein differential expression in normal tissues from HIPED for STRIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRIP1 Gene

Protein tissue co-expression partners for STRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRIP1 Gene:


SOURCE GeneReport for Unigene cluster for STRIP1 Gene:


Evidence on tissue expression from TISSUES for STRIP1 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with STRIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRIP1 Gene

Orthologs for STRIP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STRIP1 34
  • 100 (a)
FAM40A 33
  • 99.52 (n)
(Canis familiaris)
Mammalia STRIP1 34
  • 98 (a)
FAM40A 33
  • 92.38 (n)
(Ornithorhynchus anatinus)
Mammalia STRIP1 34
  • 94 (a)
(Bos Taurus)
Mammalia STRIP1 34 33
  • 92.35 (n)
(Rattus norvegicus)
Mammalia Strip1 33
  • 91.76 (n)
(Mus musculus)
Mammalia Strip1 33 16 34
  • 91.12 (n)
(Monodelphis domestica)
Mammalia STRIP1 34
  • 90 (a)
(Gallus gallus)
Aves STRIP1 34
  • 96 (a)
(Anolis carolinensis)
Reptilia STRIP1 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia strip1 33
  • 75.88 (n)
(Danio rerio)
Actinopterygii strip1 34 34
  • 85 (a)
fam40a 33
  • 75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007902 33
  • 58.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11526 33 34
  • 58.14 (n)
(Caenorhabditis elegans)
Secernentea farl-11 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 34 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for STRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP1 Gene

Gene Tree for STRIP1 (if available)
Gene Tree for STRIP1 (if available)

Paralogs for STRIP1 Gene

Paralogs for STRIP1 Gene

(3) SIMAP similar genes for STRIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP1: view

Variants for STRIP1 Gene

Sequence variations from dbSNP and Humsavar for STRIP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000115039 -- 110,034,329(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000143465 -- 110,032,287(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000182198 -- 110,049,656(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000364380 -- 110,040,102(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000381441 -- 110,050,047(+) T/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for STRIP1 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRIP1 Gene

Disorders for STRIP1 Gene

Additional Disease Information for STRIP1

No disorders were found for STRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRIP1 Gene

Publications for STRIP1 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T … Liu Z (Genetics 2012) 2 3 58
  4. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-Santamaría P … Revuelta JL (The Journal of biological chemistry 2012) 2 3 58
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58

Products for STRIP1 Gene

Sources for STRIP1 Gene

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