This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generati... See more...

Aliases for STRADB Gene

Aliases for STRADB Gene

  • STE20 Related Adaptor Beta 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2 2 3
  • STE20-Related Kinase Adapter Protein Beta 3 4
  • STE20-Related Kinase Adaptor Beta 2 3
  • Pseudokinase ALS2CR2 3 4
  • STRAD Beta 3 4
  • ALS2CR2 3 4
  • CALS-21 3 4
  • ILPIP 3 4
  • ILP-Interacting Protein ILPIPA 3
  • ILP-Interacting Protein 4
  • PRO1038 3
  • ILPIPA 3
  • PAPK 3

External Ids for STRADB Gene

Previous HGNC Symbols for STRADB Gene

  • ALS2CR2

Previous GeneCards Identifiers for STRADB Gene

  • GC02P202025
  • GC02P202252
  • GC02P194164

Summaries for STRADB Gene

Entrez Gene Summary for STRADB Gene

  • This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for STRADB Gene

STRADB (STE20 Related Adaptor Beta) is a Protein Coding gene. Diseases associated with STRADB include Amyotrophic Lateral Sclerosis 2, Juvenile and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are mTOR signalling and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STRADA.

UniProtKB/Swiss-Prot Summary for STRADB Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Gene Wiki entry for STRADB Gene

Additional gene information for STRADB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRADB Gene

Genomics for STRADB Gene

GeneHancer (GH) Regulatory Elements for STRADB Gene

Promoters and enhancers for STRADB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRADB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRADB

Top Transcription factor binding sites by QIAGEN in the STRADB gene promoter:
  • Bach2
  • CUTL1
  • FOXO4
  • ITF-2
  • Lhx3a
  • LHX3b
  • LyF-1
  • POU2F1
  • POU2F1a
  • Tal-1beta

Genomic Locations for STRADB Gene

Genomic Locations for STRADB Gene
chr2:201,387,858-201,480,851
(GRCh38/hg38)
Size:
92,994 bases
Orientation:
Plus strand
chr2:202,252,581-202,345,574
(GRCh37/hg19)
Size:
92,994 bases
Orientation:
Plus strand

Genomic View for STRADB Gene

Genes around STRADB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRADB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRADB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADB Gene

Proteins for STRADB Gene

  • Protein details for STRADB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K7-STRAB_HUMAN
    Recommended name:
    STE20-related kinase adapter protein beta
    Protein Accession:
    Q9C0K7
    Secondary Accessions:
    • Q5BKY7
    • Q9P1L0

    Protein attributes for STRADB Gene

    Size:
    418 amino acids
    Molecular mass:
    47026 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.

    Alternative splice isoforms for STRADB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRADB Gene

Post-translational modifications for STRADB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRADB Gene

No data available for DME Specific Peptides for STRADB Gene

Domains & Families for STRADB Gene

Gene Families for STRADB Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STRADB Gene

Suggested Antigen Peptide Sequences for STRADB Gene

GenScript: Design optimal peptide antigens:
  • Pseudokinase ALS2CR2 (STRAB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C0K7

UniProtKB/Swiss-Prot:

STRAB_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STRADB: view

Function for STRADB Gene

Molecular function for STRADB Gene

UniProtKB/Swiss-Prot Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Phenotypes From GWAS Catalog for STRADB Gene

Gene Ontology (GO) - Molecular Function for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IEA,IDA 14517248
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 14676191
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STRADB: view
genes like me logo Genes that share phenotypes with STRADB: view

Animal Models for STRADB Gene

MGI Knock Outs for STRADB:
  • Stradb Stradb<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for STRADB

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRADB Gene

Localization for STRADB Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADB Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRADB gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Aggresome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14517248
GO:0005737 cytoplasm IBA,IDA 14517248
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STRADB: view

Pathways & Interactions for STRADB Gene

genes like me logo Genes that share pathways with STRADB: view

Gene Ontology (GO) - Biological Process for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0006468 NOT protein phosphorylation IEA,IDA 14517248
GO:0006611 protein export from nucleus IDA 14517248
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with STRADB: view

No data available for SIGNOR curated interactions for STRADB Gene

Drugs & Compounds for STRADB Gene

No Compound Related Data Available

Transcripts for STRADB Gene

mRNA/cDNA for STRADB Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRADB Gene

No ASD Table

Relevant External Links for STRADB Gene

GeneLoc Exon Structure for
STRADB

Expression for STRADB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRADB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRADB Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for STRADB Gene

This gene is overexpressed in Urine (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STRADB Gene



Protein tissue co-expression partners for STRADB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRADB

SOURCE GeneReport for Unigene cluster for STRADB Gene:

Hs.652338

mRNA Expression by UniProt/SwissProt for STRADB Gene:

Q9C0K7-STRAB_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon.

Evidence on tissue expression from TISSUES for STRADB Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with STRADB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STRADB Gene

Orthologs for STRADB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADB 30
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia STRADB 31 30
  • 93.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STRADB 31 30
  • 93.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stradb 17 31 30
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Stradb 30
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia STRADB 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRADB 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRADB 31 30
  • 73.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRADB 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stradb 30
  • 67.28 (n)
zebrafish
(Danio rerio)
Actinopterygii STRADB 31
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stlk 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea strd-1 31
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKM1 31
  • 13 (a)
ManyToMany
CLA4 31
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Species where no ortholog for STRADB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADB Gene

ENSEMBL:
Gene Tree for STRADB (if available)
TreeFam:
Gene Tree for STRADB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRADB: view image

Paralogs for STRADB Gene

(3) SIMAP similar genes for STRADB Gene using alignment to 4 proteins:

  • STRAB_HUMAN
  • C9JSU7_HUMAN
  • F8WCQ7_HUMAN
  • H7C3S5_HUMAN

Pseudogenes.org Pseudogenes for STRADB Gene

genes like me logo Genes that share paralogs with STRADB: view

Variants for STRADB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRADB Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
725564 Benign: not provided 201,475,734(+) T/C SYNONYMOUS_VARIANT
VAR_041335 A metastatic melanoma sample p.Gly155Glu
rs35636836 - p.Pro386Leu

Additional dbSNP identifiers (rs#s) for STRADB Gene

Structural Variations from Database of Genomic Variants (DGV) for STRADB Gene

Variant ID Type Subtype PubMed ID
esv3575325 CNV gain 25503493
esv3593979 CNV loss 21293372
nsv3111 CNV insertion 18451855
nsv979164 CNV duplication 23825009

Variation tolerance for STRADB Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRADB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRADB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRADB Gene

Disorders for STRADB Gene

MalaCards: The human disease database

(7) MalaCards diseases for STRADB Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STRADB

genes like me logo Genes that share disorders with STRADB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRADB Gene

Publications for STRADB Gene

  1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S … Hayden MR (Genomics 2001) 2 3 4 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PMID: 14517248) Boudeau J … Alessi DR (The EMBO journal 2003) 3 4 54

Products for STRADB Gene

Sources for STRADB Gene