Aliases for STRADB Gene
- STE20 Related Adaptor Beta 2 3 5
- Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein 3 4
- Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2 2 3
- STE20-Related Kinase Adapter Protein Beta 3 4
- STE20-Related Kinase Adaptor Beta 2 3
- Pseudokinase ALS2CR2 3 4
- STRAD Beta 3 4
External Ids for STRADB Gene
Previous HGNC Symbols for STRADB Gene
Previous GeneCards Identifiers for STRADB Gene
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for STRADB Gene
STRADB (STE20 Related Adaptor Beta) is a Protein Coding gene. Diseases associated with STRADB include Amyotrophic Lateral Sclerosis 2, Juvenile and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are mTOR signalling and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STRADA.
UniProtKB/Swiss-Prot Summary for STRADB Gene
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).