This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in sperm... See more...

Aliases for STRA8 Gene

Aliases for STRA8 Gene

  • Stimulated By Retinoic Acid 8 2 3 5
  • Stimulated By Retinoic Acid Gene 8 Protein Homolog 3 4
  • Stimulated By Retinoic Acid Gene 8 Homolog (Mouse) 2
  • Stimulated By Retinoic Acid 8 Homolog (Mouse) 2

External Ids for STRA8 Gene

Previous GeneCards Identifiers for STRA8 Gene

  • GC07P134568
  • GC07P134916
  • GC07P129219

Summaries for STRA8 Gene

Entrez Gene Summary for STRA8 Gene

  • This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

GeneCards Summary for STRA8 Gene

STRA8 (Stimulated By Retinoic Acid 8) is a Protein Coding gene. Diseases associated with STRA8 include Male Infertility and Spermatocytoma. Gene Ontology (GO) annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot Summary for STRA8 Gene

  • Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).

Additional gene information for STRA8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STRA8 Gene

Genomics for STRA8 Gene

GeneHancer (GH) Regulatory Elements for STRA8 Gene

Promoters and enhancers for STRA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J135259 Enhancer 1 Ensembl ENCODE 11.8 +28.9 28922 2.6 ZSCAN5C ZNF10 ZIC2 ZNF423 ZNF341 OSR2 WT1 TCF7L2 ZKSCAN1 ZFHX2 STRA8 WDR91 ENSG00000231794 MTPN piR-43106-189 lnc-WDR91-4 ENSG00000276067
GH07J135206 Enhancer 0.9 ENCODE dbSUPER 11.1 -24.9 -24901 1.6 EP300 JUND BCL11A ARNT MEF2B SMARCA5 BATF IRF1 IRF4 IKZF1 MIR6509 lnc-C7orf49-4 ENSG00000231794 WDR91 STRA8 CYREN TMEM140 AGBL3
GH07J135253 Enhancer 0.8 FANTOM5 ENCODE 12.1 +22.3 22321 1.8 TCF12 JUND ZIC2 MCM3 FOSL2 SPI1 NFE2 FOS ZNF335 ZFP64 WDR91 NUP205 STRA8 CALD1 ENSG00000231794 TMEM140 CNOT4 piR-43106-189 lnc-WDR91-4 ENSG00000276067
GH07J135203 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.1 -27.3 -27295 3.1 NR2F2 ZBTB17 FOS BHLHE40 USF2 MLLT1 ENSG00000231794 STRA8 WDR91 AGBL3 CYREN MIR6509 lnc-C7orf49-4
GH07J135252 Enhancer 0.4 Ensembl 12.1 +20.3 20322 0.2 ZSCAN5C SPI1 NFIC EBF1 STRA8 WDR91 ENSG00000231794 piR-43106-189 ENSG00000276067 lnc-WDR91-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRA8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STRA8

Top Transcription factor binding sites by QIAGEN in the STRA8 gene promoter:
  • CBF-C
  • CP1A
  • CP1C
  • GATA-1
  • GATA-2
  • GATA-3
  • Lmo2
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for STRA8 Gene

Genomic Locations for STRA8 Gene
chr7:135,231,979-135,258,661
(GRCh38/hg38)
Size:
26,683 bases
Orientation:
Plus strand
chr7:134,916,731-134,943,244
(GRCh37/hg19)
Size:
26,514 bases
Orientation:
Plus strand

Genomic View for STRA8 Gene

Genes around STRA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRA8 Gene

Proteins for STRA8 Gene

  • Protein details for STRA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7C7-STRA8_HUMAN
    Recommended name:
    Stimulated by retinoic acid gene 8 protein homolog
    Protein Accession:
    Q7Z7C7

    Protein attributes for STRA8 Gene

    Size:
    330 amino acids
    Molecular mass:
    36908 Da
    Quaternary structure:
    • Interacts with XPO1.

neXtProt entry for STRA8 Gene

Post-translational modifications for STRA8 Gene

Other Protein References for STRA8 Gene

Antibody Products

  • Abcam antibodies for STRA8

No data available for DME Specific Peptides for STRA8 Gene

Domains & Families for STRA8 Gene

Gene Families for STRA8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STRA8 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STRA8 Gene

GenScript: Design optimal peptide antigens:
  • Stimulated by retinoic acid gene 8 protein homolog (STRA8_HUMAN)
genes like me logo Genes that share domains with STRA8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STRA8 Gene

Function for STRA8 Gene

Molecular function for STRA8 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).

Phenotypes From GWAS Catalog for STRA8 Gene

Gene Ontology (GO) - Molecular Function for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with STRA8: view
genes like me logo Genes that share phenotypes with STRA8: view

Animal Models for STRA8 Gene

MGI Knock Outs for STRA8:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STRA8 Gene

Localization for STRA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRA8 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250 UniProtKB:P70278}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRA8 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22899867
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with STRA8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STRA8 Gene

Pathways & Interactions for STRA8 Gene

PathCards logo

SuperPathways for STRA8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0048133 male germ-line stem cell asymmetric division IEA --
genes like me logo Genes that share ontologies with STRA8: view

No data available for Pathways by source and SIGNOR curated interactions for STRA8 Gene

Drugs & Compounds for STRA8 Gene

No Compound Related Data Available

Transcripts for STRA8 Gene

mRNA/cDNA for STRA8 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRA8 Gene

No ASD Table

Relevant External Links for STRA8 Gene

GeneLoc Exon Structure for
STRA8

Expression for STRA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRA8 Gene

This gene is overexpressed in Testis (x15.0), Kidney - Cortex (x12.1), and Skin - Not Sun Exposed (Suprapubic) (x4.6).

Protein differential expression in normal tissues from HIPED for STRA8 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STRA8 Gene



Protein tissue co-expression partners for STRA8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STRA8

SOURCE GeneReport for Unigene cluster for STRA8 Gene:

Hs.592279

mRNA Expression by UniProt/SwissProt for STRA8 Gene:

Q7Z7C7-STRA8_HUMAN
Tissue specificity: Expressed specifically in testis and fetal ovaries.
genes like me logo Genes that share expression patterns with STRA8: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRA8 Gene

Orthologs for STRA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STRA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRA8 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STRA8 31 30
  • 81.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stra8 30
  • 79.98 (n)
cow
(Bos Taurus)
Mammalia STRA8 31 30
  • 79.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stra8 17 31 30
  • 79.08 (n)
oppossum
(Monodelphis domestica)
Mammalia STRA8 31
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRA8 31
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRA8 31 30
  • 65.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRA8 31
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stra8 30
  • 52.12 (n)
Species where no ortholog for STRA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STRA8 Gene

ENSEMBL:
Gene Tree for STRA8 (if available)
TreeFam:
Gene Tree for STRA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRA8: view image

Paralogs for STRA8 Gene

No data available for Paralogs for STRA8 Gene

Variants for STRA8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STRA8 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
VAR_081144 - p.Thr25Ile

Additional dbSNP identifiers (rs#s) for STRA8 Gene

Structural Variations from Database of Genomic Variants (DGV) for STRA8 Gene

Variant ID Type Subtype PubMed ID
esv2676296 CNV deletion 23128226
esv3615116 CNV loss 21293372
nsv1075059 CNV deletion 25765185
nsv523974 CNV loss 19592680

Variation tolerance for STRA8 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRA8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRA8 Gene

Disorders for STRA8 Gene

MalaCards: The human disease database

(5) MalaCards diseases for STRA8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
spermatocytoma
  • spermatocytic seminoma
spermatogenic failure, x-linked, 1
  • spgfx1
cryptorchidism, unilateral or bilateral
  • undescended testis
premature ovarian failure 1
  • pof1
- elite association - COSMIC cancer census association via MalaCards
Search STRA8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STRA8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STRA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRA8 Gene

Publications for STRA8 Gene

  1. Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. (PMID: 12489526) Miyamoto T … Ishikawa M (Journal of assisted reproduction and genetics 2002) 2 3 4 54
  2. Structure of the STRA6 receptor for retinol uptake. (PMID: 27563101) Chen Y … Mancia F (Science (New York, N.Y.) 2016) 2 3 54
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 41 54
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  5. Next-generation sequencing for patients with non-obstructive azoospermia: implications for significant roles of monogenic/oligogenic mutations. (PMID: 28718531) Nakamura S … Fukami M (Andrology 2017) 4 54

Products for STRA8 Gene

Sources for STRA8 Gene