Aliases for STRA8 Gene
External Ids for STRA8 Gene
Previous GeneCards Identifiers for STRA8 Gene
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
GeneCards Summary for STRA8 Gene
STRA8 (Stimulated By Retinoic Acid 8) is a Protein Coding gene. Diseases associated with STRA8 include Male Infertility and Spermatocytoma. Gene Ontology (GO) annotations related to this gene include protein dimerization activity.
UniProtKB/Swiss-Prot Summary for STRA8 Gene
Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).