Aliases for STRA6 Gene
- Signaling Receptor And Transporter Of Retinol STRA6 2 3 5
- Stimulated By Retinoic Acid Gene 6 Protein Homolog 3 4
- Retinol-Binding Protein Receptor STRA6 3 4
- Retinol Binding Protein 4 Receptor 2 3
- Receptor For Retinol Uptake STRA6 3 4
- RBP Receptor 2 3
- Stimulated By Retinoic Acid Gene 6 Homolog (Mouse) 2
External Ids for STRA6 Gene
Previous GeneCards Identifiers for STRA6 Gene
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for STRA6 Gene
STRA6 (Signaling Receptor And Transporter Of Retinol STRA6) is a Protein Coding gene. Diseases associated with STRA6 include Microphthalmia, Syndromic 9 and Colobomatous Microphthalmia. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. An important paralog of this gene is CCDC180.
UniProtKB/Swiss-Prot Summary for STRA6 Gene
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031).