Aliases for STPG2 Gene

Aliases for STPG2 Gene

  • Sperm Tail PG-Rich Repeat Containing 2 2 3 5
  • Sperm-Tail PG-Rich Repeat-Containing Protein 2 3 4
  • C4orf37 3 4
  • Chromosome 4 Open Reading Frame 37 2

External Ids for STPG2 Gene

Previous HGNC Symbols for STPG2 Gene

  • C4orf37

Previous GeneCards Identifiers for STPG2 Gene

  • GC04M098105

Summaries for STPG2 Gene

GeneCards Summary for STPG2 Gene

STPG2 (Sperm Tail PG-Rich Repeat Containing 2) is a Protein Coding gene. Diseases associated with STPG2 include Complex Chromosomal Rearrangement. An important paralog of this gene is STPG1.

Additional gene information for STPG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STPG2 Gene

Genomics for STPG2 Gene

GeneHancer (GH) Regulatory Elements for STPG2 Gene

Promoters and enhancers for STPG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J098259 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.1 -118.1 -118050 4.6 RBPJ POLR2A TCF7L2 MIXL1 CC2D1A HLF L3MBTL2 MAX MNT NKRF ENSG00000214559 RAP1GDS1 lnc-STPG2-3 STPG2
GH04J098142 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 761.1 +0.2 228 2.3 ZBTB40 CTCF LCORL RBPJ POLR2A HLF L3MBTL2 MNT ELF3 ZFX STPG2 lnc-RAP1GDS1-2 piR-51878-029 ADH5
GH04J098148 Enhancer 0.6 Ensembl 10.8 -5.7 -5725 2 ZBTB40 ZNF362 PKNOX1 FOXA1 ZSCAN5C OSR2 CTCF ZFHX2 WT1 ZNF335 STPG2 lnc-RAP1GDS1-2 piR-38580-224
GH04J098110 Enhancer 0.6 Ensembl ENCODE 10.7 +32.4 32409 1.5 POU5F1 MNT NANOG STPG2 HSALNG0035949 piR-51878-029
GH04J098093 Enhancer 0.4 Ensembl ENCODE 10.7 +49.2 49223 1.5 CTCF STPG2 HSALNG0035949 piR-38580-223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STPG2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STPG2 Gene

Genomic Locations for STPG2 Gene
chr4:97,184,093-98,143,476
(GRCh38/hg38)
Size:
959,384 bases
Orientation:
Minus strand
chr4:98,105,244-99,064,391
(GRCh37/hg19)
Size:
959,148 bases
Orientation:
Minus strand

Genomic View for STPG2 Gene

Genes around STPG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STPG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STPG2 Gene

Proteins for STPG2 Gene

  • Protein details for STPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N412-STPG2_HUMAN
    Recommended name:
    Sperm-tail PG-rich repeat-containing protein 2
    Protein Accession:
    Q8N412

    Protein attributes for STPG2 Gene

    Size:
    459 amino acids
    Molecular mass:
    50660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STPG2 Gene

Post-translational modifications for STPG2 Gene

  • Glycosylation at Asn327
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • STPG2_HUMAN (1767)

Other Protein References for STPG2 Gene

No data available for DME Specific Peptides for STPG2 Gene

Domains & Families for STPG2 Gene

Gene Families for STPG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STPG2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with STPG2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STPG2 Gene

Function for STPG2 Gene

Phenotypes From GWAS Catalog for STPG2 Gene

genes like me logo Genes that share phenotypes with STPG2: view

Animal Model Products

CRISPR Products

miRNA for STPG2 Gene

miRTarBase miRNAs that target STPG2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STPG2 Gene

Localization for STPG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STPG2 gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for STPG2 Gene

Pathways & Interactions for STPG2 Gene

PathCards logo

SuperPathways for STPG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STPG2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STPG2 Gene

Drugs & Compounds for STPG2 Gene

No Compound Related Data Available

Transcripts for STPG2 Gene

mRNA/cDNA for STPG2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STPG2 Gene

No ASD Table

Relevant External Links for STPG2 Gene

GeneLoc Exon Structure for
STPG2
ECgene alternative splicing isoforms for
STPG2

Expression for STPG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STPG2 Gene

mRNA differential expression in normal tissues according to GTEx for STPG2 Gene

This gene is overexpressed in Testis (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of STPG2 Gene:

STPG2

SOURCE GeneReport for Unigene cluster for STPG2 Gene:

Hs.680226
genes like me logo Genes that share expression patterns with STPG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STPG2 Gene

Orthologs for STPG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STPG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STPG2 33 32
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STPG2 33 32
  • 87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stpg2 17 33 32
  • 76.19 (n)
rat
(Rattus norvegicus)
Mammalia Stpg2 32
  • 75.69 (n)
oppossum
(Monodelphis domestica)
Mammalia STPG2 33
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STPG2 33
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STPG2 33
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stpg2 32
  • 56.63 (n)
zebrafish
(Danio rerio)
Actinopterygii stpg2 32
  • 50.84 (n)
STPG2 33
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
OneToOne
Species where no ortholog for STPG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STPG2 Gene

ENSEMBL:
Gene Tree for STPG2 (if available)
TreeFam:
Gene Tree for STPG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STPG2: view image

Paralogs for STPG2 Gene

Paralogs for STPG2 Gene

Pseudogenes.org Pseudogenes for STPG2 Gene

genes like me logo Genes that share paralogs with STPG2: view

Variants for STPG2 Gene

Sequence variations from dbSNP and Humsavar for STPG2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000000990 -- 98,120,762(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000012789 -- 97,898,847(-) A/C intron_variant
rs1000015723 -- 97,339,566(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000016655 -- 97,523,287(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000016860 -- 97,259,674(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STPG2 Gene

Variant ID Type Subtype PubMed ID
dgv2862n106 CNV deletion 24896259
dgv325n21 CNV loss 19592680
dgv662n27 CNV gain 19166990
dgv9179n54 CNV gain 21841781
esv1754729 CNV insertion 17803354
esv1928542 CNV deletion 18987734
esv22630 CNV gain 19812545
esv2483371 CNV deletion 19546169
esv2675641 CNV deletion 23128226
esv2728025 CNV deletion 23290073
esv2763382 CNV loss 21179565
esv2779 CNV loss 18987735
esv3417661 CNV insertion 20981092
esv3424246 CNV duplication 20981092
esv3564308 CNV deletion 23714750
esv3601521 CNV loss 21293372
esv3601522 CNV loss 21293372
esv3601523 CNV gain 21293372
esv3601524 CNV gain 21293372
esv3601525 CNV loss 21293372
esv3601526 CNV loss 21293372
esv3601527 CNV loss 21293372
esv3601528 CNV loss 21293372
esv3601530 CNV gain 21293372
esv3601531 CNV loss 21293372
esv3893995 CNV gain 25118596
esv6016 CNV loss 19470904
nsv1000956 CNV loss 25217958
nsv1005567 CNV loss 25217958
nsv1074739 CNV deletion 25765185
nsv1114558 CNV deletion 24896259
nsv1123819 CNV deletion 24896259
nsv1150504 CNV deletion 26484159
nsv1161119 CNV deletion 26073780
nsv292701 CNV insertion 16902084
nsv4436 CNV deletion 18451855
nsv470060 CNV gain 18288195
nsv477183 CNV novel sequence insertion 20440878
nsv509916 OTHER sequence alteration 20534489
nsv594932 CNV gain 21841781
nsv594933 CNV gain 21841781
nsv594936 CNV gain 21841781
nsv594937 CNV gain 21841781
nsv594938 CNV gain 21841781
nsv822663 CNV gain 20364138
nsv822665 CNV gain 20364138
nsv830016 CNV loss 17160897
nsv830017 CNV loss 17160897
nsv956317 CNV deletion 24416366
nsv966297 CNV duplication 23825009
nsv980231 CNV duplication 23825009
nsv998270 CNV loss 25217958
nsv999087 CNV gain 25217958

Variation tolerance for STPG2 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.87; 97.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STPG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STPG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STPG2 Gene

Disorders for STPG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STPG2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
complex chromosomal rearrangement
- elite association - COSMIC cancer census association via MalaCards
Search STPG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STPG2

genes like me logo Genes that share disorders with STPG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STPG2 Gene

Publications for STPG2 Gene

  1. Exceptional complex chromosomal rearrangement and microdeletions at the 4q22.3q23 and 14q31.1q31.3 regions in a patient with azoospermia. (PMID: 23031811) Yakut S … Luleci G (Gene 2013) 2 3 56
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  4. Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. (PMID: 24009623) Jiang J … Wang L (Frontiers in genetics 2013) 3 56
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 56

Products for STPG2 Gene

Sources for STPG2 Gene