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Aliases for STPG1 Gene

Aliases for STPG1 Gene

  • Sperm Tail PG-Rich Repeat Containing 1 2 3 5
  • Sperm-Tail PG-Rich Repeat-Containing Protein 1 3 4
  • O6-Methylguanine-Induced Apoptosis 2 2 3
  • C1orf201 3 4
  • MAPO2 3 4
  • O(6)-Methylguanine-Induced Apoptosis 2 3
  • Chromosome 1 Open Reading Frame 201 2
  • UPF0490 Protein C1orf201 3

External Ids for STPG1 Gene

Previous HGNC Symbols for STPG1 Gene

  • C1orf201

Previous GeneCards Identifiers for STPG1 Gene

  • GC01M024684
  • GC01M024685

Summaries for STPG1 Gene

GeneCards Summary for STPG1 Gene

STPG1 (Sperm Tail PG-Rich Repeat Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for STPG1 Gene

  • May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.

Additional gene information for STPG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STPG1 Gene

Genomics for STPG1 Gene

GeneHancer (GH) Regulatory Elements for STPG1 Gene

Promoters and enhancers for STPG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I024414 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 569.2 -0.3 -337 5.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 CBX5 STPG1 NIPAL3 SRRM1 SRSF10 ELOA RCAN3 SYF2 NCMAP ENSG00000261349 GC01P024477
GH01I024411 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 569.2 +3.9 3884 2.9 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 FOS STPG1 NIPAL3 NCMAP PIR44101
GH01I025246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14 -830.1 -830120 3.4 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RSRP1 ENSG00000272432 SRRM1 ENSG00000261349 SYF2 ZNF593 STPG1 MAN1C1 PAQR7 ENSG00000284657
GH01I024438 Enhancer 1 ENCODE dbSUPER 29.3 -21.7 -21696 0.6 HDAC1 PKNOX1 ATF1 RB1 KLF17 TCF12 ATF7 PHF21A REST ZNF148 STPG1 NIPAL3 NCMAP GRHL3 LOC105376871 GC01P024477
GH01I024390 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.9 +24.4 24358 3.4 HDGF RB1 ARID4B BATF ZNF2 IRF4 RAD21 YY1 ZNF366 ARID2 STPG1 NIPAL3 IFNLR1 GRHL3 LOC105376871 NCMAP PIR44101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STPG1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STPG1 Gene

Genomic Locations for STPG1 Gene
chr1:24,356,999-24,416,934
(GRCh38/hg38)
Size:
59,936 bases
Orientation:
Minus strand
chr1:24,683,489-24,743,424
(GRCh37/hg19)

Genomic View for STPG1 Gene

Genes around STPG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STPG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STPG1 Gene

Proteins for STPG1 Gene

  • Protein details for STPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TH74-STPG1_HUMAN
    Recommended name:
    O(6)-methylguanine-induced apoptosis 2
    Protein Accession:
    Q5TH74
    Secondary Accessions:
    • Q49AP0
    • Q6P3R4
    • Q86VU9
    • Q8WVQ3

    Protein attributes for STPG1 Gene

    Size:
    334 amino acids
    Molecular mass:
    36786 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STPG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STPG1 Gene

Post-translational modifications for STPG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for STPG1 Gene

Domains & Families for STPG1 Gene

Gene Families for STPG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STPG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STPG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TH74

UniProtKB/Swiss-Prot:

STPG1_HUMAN :
  • Belongs to the STPG1 family.
Family:
  • Belongs to the STPG1 family.
genes like me logo Genes that share domains with STPG1: view

Function for STPG1 Gene

Molecular function for STPG1 Gene

UniProtKB/Swiss-Prot Function:
May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.

Gene Ontology (GO) - Molecular Function for STPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STPG1: view
genes like me logo Genes that share phenotypes with STPG1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STPG1 Gene

Localization for STPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STPG1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STPG1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IMP 23028632
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with STPG1: view

Pathways & Interactions for STPG1 Gene

SuperPathways for STPG1 Gene

No Data Available

Interacting Proteins for STPG1 Gene

Gene Ontology (GO) - Biological Process for STPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043065 positive regulation of apoptotic process IMP 23028632
GO:0090073 positive regulation of protein homodimerization activity IMP 23028632
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process IMP 23028632
genes like me logo Genes that share ontologies with STPG1: view

No data available for Pathways by source and SIGNOR curated interactions for STPG1 Gene

Drugs & Compounds for STPG1 Gene

No Compound Related Data Available

Transcripts for STPG1 Gene

Unigene Clusters for STPG1 Gene

Sperm-tail PG-rich repeat containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STPG1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for STPG1 Gene

GeneLoc Exon Structure for
STPG1
ECgene alternative splicing isoforms for
STPG1

Expression for STPG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STPG1 Gene

mRNA differential expression in normal tissues according to GTEx for STPG1 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for STPG1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STPG1 Gene



Protein tissue co-expression partners for STPG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STPG1 Gene:

STPG1

SOURCE GeneReport for Unigene cluster for STPG1 Gene:

Hs.403187

Evidence on tissue expression from TISSUES for STPG1 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with STPG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STPG1 Gene

Orthologs for STPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STPG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STPG1 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia STPG1 33 34
  • 84.33 (n)
cow
(Bos Taurus)
Mammalia STPG1 33 34
  • 83.83 (n)
rat
(Rattus norvegicus)
Mammalia Stpg1 33
  • 76.22 (n)
mouse
(Mus musculus)
Mammalia Stpg1 33 16 34
  • 75.48 (n)
oppossum
(Monodelphis domestica)
Mammalia STPG1 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STPG1 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STPG1 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stpg1 33
  • 56.88 (n)
zebrafish
(Danio rerio)
Actinopterygii stpg1 33 34
  • 50.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for STPG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STPG1 Gene

ENSEMBL:
Gene Tree for STPG1 (if available)
TreeFam:
Gene Tree for STPG1 (if available)

Paralogs for STPG1 Gene

No data available for Paralogs for STPG1 Gene

Variants for STPG1 Gene

Sequence variations from dbSNP and Humsavar for STPG1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035614 A breast cancer sample p.Ser254Phe
rs6694170 benign, not specified 24,364,186(-) G/A/T intron_variant
rs1000024751 -- 24,357,255(-) G/A 3_prime_UTR_variant
rs1000111264 -- 24,398,670(-) T/C intron_variant
rs1000140329 -- 24,383,053(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STPG1 Gene

Variant ID Type Subtype PubMed ID
nsv834447 CNV loss 17160897
nsv469575 CNV loss 16826518

Variation tolerance for STPG1 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STPG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STPG1 Gene

Disorders for STPG1 Gene

Additional Disease Information for STPG1

No disorders were found for STPG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STPG1 Gene

Publications for STPG1 Gene

  1. The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. (PMID: 23028632) Fujikane R … Hidaka M (PloS one 2012) 2 3 4 58
  2. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V … Han DK (Science signaling 2009) 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for STPG1 Gene

Sources for STPG1 Gene

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