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Aliases for STOX2 Gene

Aliases for STOX2 Gene

  • Storkhead Box 2 2 3 5
  • KIAA1392 4

External Ids for STOX2 Gene

Previous GeneCards Identifiers for STOX2 Gene

  • GC04P185202
  • GC04P185063
  • GC04P184827
  • GC04P180581
  • GC04P183853

Summaries for STOX2 Gene

Entrez Gene Summary for STOX2 Gene

  • This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for STOX2 Gene

STOX2 (Storkhead Box 2) is a Protein Coding gene. An important paralog of this gene is STOX1.

Additional gene information for STOX2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOX2 Gene

Genomics for STOX2 Gene

GeneHancer (GH) Regulatory Elements for STOX2 Gene

Promoters and enhancers for STOX2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I183904 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 556.4 +109.9 109858 3 ZFP64 ZNF133 SIN3A RAD21 YY1 ZNF335 GLIS2 RCOR1 EGR2 RXRA STOX2 ENSG00000248206 GC04P183820
GH04I183797 Promoter/Enhancer 1.4 FANTOM5 Ensembl 550.8 +1.5 1470 1.6 SIN3A ZNF335 GLIS2 ZNF213 SCRT2 EGR2 ZNF202 SP3 ZNF398 ZEB2 STOX2 CDKN2AIP PRIMPOL TRAPPC11 RNU6-1053P GC04P183820
GH04I184103 Enhancer 1.1 Ensembl ENCODE 11.5 +308.3 308312 1.7 FOXA2 MLX ARID4B ETS1 YY1 RXRA REST PPARG KAT8 PPARGC1A STOX2 GC04P184127 LOC100421006 ENPP6
GH04I183875 Enhancer 1.1 Ensembl ENCODE 11.2 +80.0 80012 2.1 ZSCAN4 INSM2 KLF17 FEZF1 ZNF2 BRCA1 ZNF335 GLIS2 ZNF366 ZSCAN5C PRIMPOL TRAPPC11 STOX2 RNU6-1053P GC04P183820 ENSG00000248206
GH04I183830 Enhancer 1 FANTOM5 Ensembl ENCODE 11.4 +34.9 34870 2 IKZF1 ZNF512 NR2F1 ZNF24 NR2F2 SPI1 STOX2 GC04P183820 ENSG00000248206
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STOX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STOX2 gene promoter:

Genomic Locations for STOX2 Gene

Genomic Locations for STOX2 Gene
227,196 bases
Plus strand

Genomic View for STOX2 Gene

Genes around STOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOX2 Gene

Proteins for STOX2 Gene

  • Protein details for STOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Storkhead-box protein 2
    Protein Accession:
    Secondary Accessions:
    • A6H8U4
    • Q9NPS8

    Protein attributes for STOX2 Gene

    926 amino acids
    Molecular mass:
    102671 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STOX2 Gene


neXtProt entry for STOX2 Gene

Post-translational modifications for STOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STOX2 Gene

Domains & Families for STOX2 Gene

Gene Families for STOX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for STOX2 Gene


Suggested Antigen Peptide Sequences for STOX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STOX2: view

No data available for UniProtKB/Swiss-Prot for STOX2 Gene

Function for STOX2 Gene

Phenotypes From GWAS Catalog for STOX2 Gene

Gene Ontology (GO) - Molecular Function for STOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STOX2: view

Phenotypes for STOX2 Gene

genes like me logo Genes that share phenotypes with STOX2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STOX2 Gene

Localization for STOX2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STOX2 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with STOX2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STOX2 Gene

Pathways & Interactions for STOX2 Gene

SuperPathways for STOX2 Gene

No Data Available

Interacting Proteins for STOX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9P2F5-STOX2_HUMAN ENSP00000311257 for STOX2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001893 maternal placenta development IEP 20643876
GO:0009790 embryo development IEP 20643876
genes like me logo Genes that share ontologies with STOX2: view

No data available for Pathways by source and SIGNOR curated interactions for STOX2 Gene

Drugs & Compounds for STOX2 Gene

No Compound Related Data Available

Transcripts for STOX2 Gene

Unigene Clusters for STOX2 Gene

Storkhead box 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STOX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP3: - -

Relevant External Links for STOX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STOX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STOX2 Gene

This gene is overexpressed in Amniocyte (57.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STOX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STOX2 Gene:


SOURCE GeneReport for Unigene cluster for STOX2 Gene:


Evidence on tissue expression from TISSUES for STOX2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with STOX2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STOX2 Gene

Orthologs for STOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STOX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STOX2 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia STOX2 33 34
  • 91.32 (n)
(Bos Taurus)
Mammalia STOX2 33 34
  • 89.27 (n)
(Rattus norvegicus)
Mammalia Stox2 33
  • 89.09 (n)
(Ornithorhynchus anatinus)
Mammalia STOX2 34
  • 89 (a)
(Mus musculus)
Mammalia Stox2 33 16 34
  • 88.41 (n)
(Monodelphis domestica)
Mammalia STOX2 34
  • 78 (a)
(Gallus gallus)
Aves STOX2 33 34
  • 78.74 (n)
(Anolis carolinensis)
Reptilia STOX2 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stox2 33
  • 74.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34676 33
(Danio rerio)
Actinopterygii stox2a 33 34
  • 64.8 (n)
STOX2 (2 of 2) 34
  • 61 (a)
Dr.16351 33
fruit fly
(Drosophila melanogaster)
Insecta ko 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea ham-1 34
  • 18 (a)
Species where no ortholog for STOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOX2 Gene

Gene Tree for STOX2 (if available)
Gene Tree for STOX2 (if available)

Paralogs for STOX2 Gene

Paralogs for STOX2 Gene

genes like me logo Genes that share paralogs with STOX2: view

Variants for STOX2 Gene

Sequence variations from dbSNP and Humsavar for STOX2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000013315 -- 183,989,630(+) A/G intron_variant
rs1000024934 -- 183,892,121(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000029618 -- 183,813,461(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000039148 -- 183,916,712(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000047739 -- 183,859,880(+) T/ genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STOX2 Gene

Variant ID Type Subtype PubMed ID
esv1964372 CNV deletion 18987734
esv2608282 CNV deletion 19546169
esv2728882 CNV deletion 23290073
esv2728883 CNV deletion 23290073
esv2728885 CNV deletion 23290073
esv2728886 CNV deletion 23290073
esv3346003 CNV duplication 20981092
esv3569851 CNV loss 25503493
esv3603449 CNV loss 21293372
esv3603450 CNV loss 21293372
esv4197 CNV loss 18987735
esv7581 CNV gain 19470904
nsv1025333 CNV gain 25217958
nsv1030766 CNV gain 25217958
nsv1074246 CNV deletion 25765185
nsv1074247 CNV deletion 25765185
nsv1130822 CNV deletion 24896259
nsv4637 CNV insertion 18451855
nsv822878 CNV gain 20364138
nsv830166 CNV gain 17160897
nsv956407 CNV deletion 24416366

Variation tolerance for STOX2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STOX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STOX2 Gene

Disorders for STOX2 Gene

Additional Disease Information for STOX2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STOX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STOX2 Gene

Publications for STOX2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression. (PMID: 27050375) Sasahira T … Kuniyasu H (Oncotarget 2016) 3 58

Products for STOX2 Gene

Sources for STOX2 Gene

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