Aliases for STMN4 Gene

Aliases for STMN4 Gene

  • Stathmin 4 2 3 5
  • Stathmin-Like Protein B3 3 4
  • Stathmin-Like 4 2 3
  • Stathmin-4 3 4
  • RB3 3 4
  • Stathmin-Like-Protein RB3 3

External Ids for STMN4 Gene

Previous GeneCards Identifiers for STMN4 Gene

  • GC08M026874
  • GC08M027599
  • GC08M027115
  • GC08M027149
  • GC08M025639
  • GC08M027092

Summaries for STMN4 Gene

GeneCards Summary for STMN4 Gene

STMN4 (Stathmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tubulin binding. An important paralog of this gene is STMN3.

UniProtKB/Swiss-Prot Summary for STMN4 Gene

Additional gene information for STMN4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STMN4 Gene

Genomics for STMN4 Gene

GeneHancer (GH) Regulatory Elements for STMN4 Gene

Promoters and enhancers for STMN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 764.6 -51.6 -51640 5 E2F8 SP1 ZBTB40 RBPJ SMARCE1 POLR2A ATF1 FOS HCFC1 MIXL1 STMN4 TRIM35 PTK2B lnc-EPHX2-5 PNMA2 ENSG00000254362 NUGGC ENSG00000253208 CHRNA2 EPHX2
GH08J027255 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.6 +1.4 1368 3.4 NFYC SP7 PRDM1 RFX1 ZSCAN4 ZEB2 PATZ1 POLR2A ZNF629 SP2 STMN4 lnc-TRIM35-1 ADRA1A HSALNG0064159
GH08J027771 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.4 -514.7 -514736 4.8 SIN3A ZBTB40 SP1 SIX5 RBPJ SMARCE1 POLR2A USF2 HDAC2 ATF1 CCDC25 ESCO2 RNU6-1276P NONHSAG049838.2 RF00026-1061 STMN4 CLU SCARA3 RF00017-6909
GH08J027230 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +26.6 26588 2.9 POLR2A ZNF692 NFE2 FOS ZFHX2 ZNF335 STMN4 PTK2B HSALNG0064159 lnc-TRIM35-1
GH08J027280 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -22.7 -22709 2.3 HLF SP1 MAFK IKZF1 CREB1 RXRA ZNF639 ZEB2 FOXA2 CEBPB piR-38580-337 STMN4 TRIM35 PTK2B HSALNG0064163
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STMN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STMN4 gene promoter:
  • AML1a
  • AREB6
  • CUTL1
  • E4BP4
  • MAZR
  • NF-1
  • NF-1/L
  • POU6F1 (c2)
  • S8
  • SRY

Genomic Locations for STMN4 Gene

Genomic Locations for STMN4 Gene
23,543 bases
Minus strand
23,098 bases
Minus strand

Genomic View for STMN4 Gene

Genes around STMN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN4 Gene

Proteins for STMN4 Gene

  • Protein details for STMN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7Z2Z7
    • B7Z4I9
    • D3DSS8
    • D3DSS9
    • G5EA16
    • Q2TAB9

    Protein attributes for STMN4 Gene

    189 amino acids
    Molecular mass:
    22071 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STMN4 Gene

    Alternative splice isoforms for STMN4 Gene


neXtProt entry for STMN4 Gene

Post-translational modifications for STMN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STMN4 Gene

Domains & Families for STMN4 Gene

Gene Families for STMN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STMN4 Gene

Suggested Antigen Peptide Sequences for STMN4 Gene

GenScript: Design optimal peptide antigens:
  • Stathmin (B7Z2Z7_HUMAN)
  • Stathmin-like protein B3 (STMN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stathmin family.
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN4: view

Function for STMN4 Gene

Molecular function for STMN4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity.

Phenotypes From GWAS Catalog for STMN4 Gene

Gene Ontology (GO) - Molecular Function for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA 21873635
genes like me logo Genes that share ontologies with STMN4: view
genes like me logo Genes that share phenotypes with STMN4: view

Animal Models for STMN4 Gene

MGI Knock Outs for STMN4:
  • Stmn4 Stmn4<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STMN4 Gene

Localization for STMN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN4 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN4 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
extracellular 2
cytoskeleton 2
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STMN4: view

Pathways & Interactions for STMN4 Gene

PathCards logo

SuperPathways for STMN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA 21873635
GO:0031110 regulation of microtubule polymerization or depolymerization IBA,IEA 21873635
GO:0031175 neuron projection development IBA 21873635
GO:0051493 regulation of cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with STMN4: view

No data available for Pathways by source and SIGNOR curated interactions for STMN4 Gene

Drugs & Compounds for STMN4 Gene

(2) Drugs for STMN4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomustine Approved, Investigational Pharma Target, antagonist Antineoplastic drug 95
genes like me logo Genes that share compounds with STMN4: view

Transcripts for STMN4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -

Relevant External Links for STMN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STMN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STMN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x5.2), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.2), Brain - Cortex (x4.2), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for STMN4 Gene

This gene is overexpressed in NK cells (33.4) and Plasma (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STMN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of STMN4 Gene:


SOURCE GeneReport for Unigene cluster for STMN4 Gene:


Evidence on tissue expression from TISSUES for STMN4 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with STMN4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STMN4 Gene

Orthologs for STMN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STMN4 33 32
  • 99.65 (n)
(Monodelphis domestica)
Mammalia STMN4 33
  • 97 (a)
(Bos Taurus)
Mammalia STMN4 33 32
  • 92.77 (n)
(Canis familiaris)
Mammalia STMN4 33 32
  • 92.75 (n)
(Rattus norvegicus)
Mammalia Stmn4 32
  • 88.89 (n)
(Mus musculus)
Mammalia Stmn4 17 33 32
  • 88.36 (n)
(Ornithorhynchus anatinus)
Mammalia STMN4 33
  • 48 (a)
(Gallus gallus)
Aves STMN4 33 32
  • 82.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn4 32
  • 77.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia stmn4-prov 32
(Danio rerio)
Actinopterygii stmn4l 33
  • 76 (a)
stmn4 33 32
  • 73.94 (n)
wufj44e06 32
fruit fly
(Drosophila melanogaster)
Insecta stai 33
  • 17 (a)
Species where no ortholog for STMN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN4 Gene

Gene Tree for STMN4 (if available)
Gene Tree for STMN4 (if available)
Evolutionary constrained regions (ECRs) for STMN4: view image

Paralogs for STMN4 Gene

Paralogs for STMN4 Gene

(3) SIMAP similar genes for STMN4 Gene using alignment to 5 proteins:

  • B7Z2Z7_HUMAN
  • G5EA16_HUMAN
genes like me logo Genes that share paralogs with STMN4: view

Variants for STMN4 Gene

Sequence variations from dbSNP and Humsavar for STMN4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000107120 -- 27,252,363(-) A/G intron_variant
rs1000145256 -- 27,238,044(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000145487 -- 27,259,070(-) C/G upstream_transcript_variant
rs1000160648 -- 27,245,932(-) A/G intron_variant
rs1000382245 -- 27,240,274(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STMN4 Gene

Variant ID Type Subtype PubMed ID
esv3616716 CNV gain 21293372
nsv1033251 CNV gain 25217958
nsv6131 CNV deletion 18451855
nsv831274 CNV gain 17160897

Variation tolerance for STMN4 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STMN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN4 Gene

Disorders for STMN4 Gene

Additional Disease Information for STMN4

No disorders were found for STMN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STMN4 Gene

Publications for STMN4 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. (PMID: 12676564) Bièche I … Curmi PA (Genomics 2003) 3 23 56
  4. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PMID: 9788875) Gavet O … Sobel A (Journal of cell science 1998) 3 23 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for STMN4 Gene

Sources for STMN4 Gene