Aliases for STMN4 Gene

Aliases for STMN4 Gene

  • Stathmin 4 2 3 5
  • RB3 2 3 4
  • Stathmin-Like Protein B3 3 4
  • Stathmin-Like 4 2 3
  • Stathmin-4 3 4
  • Stathmin-Like-Protein RB3 3
  • STMN4 5

External Ids for STMN4 Gene

Previous GeneCards Identifiers for STMN4 Gene

  • GC08M026874
  • GC08M027599
  • GC08M027115
  • GC08M027149
  • GC08M025639
  • GC08M027092

Summaries for STMN4 Gene

GeneCards Summary for STMN4 Gene

STMN4 (Stathmin 4) is a Protein Coding gene. Diseases associated with STMN4 include Spastic Paraplegia 36, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include tubulin binding. An important paralog of this gene is STMN3.

UniProtKB/Swiss-Prot Summary for STMN4 Gene

Additional gene information for STMN4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STMN4 Gene

Genomics for STMN4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STMN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 -51.6 -51640 5 SP1 HNRNPL GATAD2A ZNF629 REST IKZF1 NFKBIZ ZNF692 POLR2A ZNF7 TRIM35 PTK2B lnc-EPHX2-5 STMN4 ESCO2 ENSG00000254362 ELP3 CHRNA2 EPHX2 piR-48135
GH08J027255 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.4 1368 3.4 ZNF629 RFX1 JUND PRDM1 ZSCAN4 POLR2A PATZ1 ZNF600 ATF7 SCRT2 STMN4 lnc-TRIM35-1 ADRA1A HSALNG0064159
GH08J027230 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +26.6 26588 2.9 ZNF692 POLR2A CEBPB NFE2 FOS ZFHX2 ZNF335 BHLHE40 MAFK EGR2 STMN4 PTK2B HSALNG0064159 lnc-TRIM35-1 ADRA1A
GH08J027280 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -22.7 -22709 2.3 ZNF629 IKZF1 KDM1A SP1 ZNF600 ZNF639 CEBPB FOXA2 HDAC2 NR3C1 piR-38580-337 STMN4 TRIM35 PTK2B HSALNG0064163
GH08J027397 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -149.2 -149236 19.8 CREB1 ZNF512 FOXA1 REST IKZF2 PKNOX1 EED CEBPB SP1 DPF2 FJ601684-442 PTK2B EPHX2 TRIM35 CHRNA2 CLU STMN4 piR-56037-080 RF00017-6909
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STMN4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STMN4

Top Transcription factor binding sites by QIAGEN in the STMN4 gene promoter:
  • AML1a
  • AREB6
  • CUTL1
  • E4BP4
  • MAZR
  • NF-1
  • NF-1/L
  • POU6F1 (c2)
  • S8
  • SRY

Genomic Locations for STMN4 Gene

Genomic Locations for STMN4 Gene
23,558 bases
Minus strand
23,098 bases
Minus strand

Genomic View for STMN4 Gene

Genes around STMN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN4 Gene

Proteins for STMN4 Gene

  • Protein details for STMN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7Z2Z7
    • B7Z4I9
    • D3DSS8
    • D3DSS9
    • G5EA16
    • Q2TAB9

    Protein attributes for STMN4 Gene

    189 amino acids
    Molecular mass:
    22071 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STMN4 Gene

    Alternative splice isoforms for STMN4 Gene


neXtProt entry for STMN4 Gene

Post-translational modifications for STMN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STMN4 Gene

Domains & Families for STMN4 Gene

Gene Families for STMN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STMN4 Gene

  • Stathmin

Suggested Antigen Peptide Sequences for STMN4 Gene

GenScript: Design optimal peptide antigens:
  • Stathmin (B7Z2Z7_HUMAN)
  • Stathmin-like protein B3 (STMN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stathmin family.
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN4: view

Function for STMN4 Gene

Molecular function for STMN4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity.

Phenotypes From GWAS Catalog for STMN4 Gene

Gene Ontology (GO) - Molecular Function for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA 21873635
genes like me logo Genes that share ontologies with STMN4: view
genes like me logo Genes that share phenotypes with STMN4: view

Animal Models for STMN4 Gene

MGI Knock Outs for STMN4:
  • Stmn4 Stmn4<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STMN4

Clone Products

  • Addgene plasmids for STMN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STMN4 Gene

Localization for STMN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN4 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN4 gene
Compartment Confidence
extracellular 3
cytosol 3
golgi apparatus 3
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STMN4: view

Pathways & Interactions for STMN4 Gene

PathCards logo

SuperPathways for STMN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA 21873635
GO:0031110 regulation of microtubule polymerization or depolymerization IEA,IBA 21873635
GO:0031175 neuron projection development IBA 21873635
GO:0051493 regulation of cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with STMN4: view

No data available for Pathways by source and SIGNOR curated interactions for STMN4 Gene

Drugs & Compounds for STMN4 Gene

(2) Drugs for STMN4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomustine Approved, Investigational Pharma Target, antagonist Antineoplastic drug 98
genes like me logo Genes that share compounds with STMN4: view

Transcripts for STMN4 Gene

mRNA/cDNA for STMN4 Gene

10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STMN4

Clone Products

  • Addgene plasmids for STMN4

Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -

Relevant External Links for STMN4 Gene

GeneLoc Exon Structure for

Expression for STMN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STMN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x5.2), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.2), Brain - Cortex (x4.2), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for STMN4 Gene

This gene is overexpressed in NK cells (33.4) and Plasma (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STMN4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STMN4

SOURCE GeneReport for Unigene cluster for STMN4 Gene:


Evidence on tissue expression from TISSUES for STMN4 Gene

  • Nervous system(5)
  • Blood(2.5)
  • Heart(2.2)
  • Intestine(2.2)
  • Liver(2.1)
  • Skin(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with STMN4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STMN4 Gene

Orthologs for STMN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STMN4 30 31
  • 99.65 (n)
(Monodelphis domestica)
Mammalia STMN4 31
  • 97 (a)
(Bos Taurus)
Mammalia STMN4 30 31
  • 92.77 (n)
(Canis familiaris)
Mammalia STMN4 30 31
  • 92.75 (n)
(Rattus norvegicus)
Mammalia Stmn4 30
  • 88.89 (n)
(Mus musculus)
Mammalia Stmn4 30 17 31
  • 88.36 (n)
(Ornithorhynchus anatinus)
Mammalia STMN4 31
  • 48 (a)
(Gallus gallus)
Aves STMN4 30 31
  • 82.72 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stmn4 30
  • 77.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia stmn4-prov 30
(Danio rerio)
Actinopterygii stmn4l 31
  • 76 (a)
stmn4 30 31
  • 73.94 (n)
wufj44e06 30
Fruit Fly
(Drosophila melanogaster)
Insecta stai 31
  • 17 (a)
Species where no ortholog for STMN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STMN4 Gene

Gene Tree for STMN4 (if available)
Gene Tree for STMN4 (if available)
Evolutionary constrained regions (ECRs) for STMN4: view image

Paralogs for STMN4 Gene

Paralogs for STMN4 Gene

(3) SIMAP similar genes for STMN4 Gene using alignment to 5 proteins:

  • B7Z2Z7_HUMAN
  • G5EA16_HUMAN
genes like me logo Genes that share paralogs with STMN4: view

Variants for STMN4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STMN4 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
726534 Likely Benign: not provided 27,239,964(-) C/T INTRON_VARIANT
779430 Benign: not provided 27,236,882(-) C/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
787542 Benign: not provided 27,241,159(-) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for STMN4 Gene

Structural Variations from Database of Genomic Variants (DGV) for STMN4 Gene

Variant ID Type Subtype PubMed ID
esv3616716 CNV gain 21293372
nsv1033251 CNV gain 25217958
nsv6131 CNV deletion 18451855
nsv831274 CNV gain 17160897

Variation tolerance for STMN4 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STMN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN4 Gene

Disorders for STMN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STMN4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic paraplegia 36, autosomal dominant
  • spg36
- elite association - COSMIC cancer census association via MalaCards
Search STMN4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with STMN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STMN4 Gene

Publications for STMN4 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. (PMID: 12676564) Bièche I … Curmi PA (Genomics 2003) 3 23
  4. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PMID: 9788875) Gavet O … Sobel A (Journal of cell science 1998) 3 23
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for STMN4 Gene

  • Signalway Proteins for STMN4

Sources for STMN4 Gene