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Aliases for STMN4 Gene

Aliases for STMN4 Gene

  • Stathmin 4 2 3 5
  • Stathmin-Like Protein B3 3 4
  • Stathmin-Like 4 2 3
  • RB3 3 4
  • Stathmin-Like-Protein RB3 3
  • Stathmin-4 3

External Ids for STMN4 Gene

Previous GeneCards Identifiers for STMN4 Gene

  • GC08M026874
  • GC08M027599
  • GC08M027115
  • GC08M025639
  • GC08M027092

Summaries for STMN4 Gene

GeneCards Summary for STMN4 Gene

STMN4 (Stathmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tubulin binding. An important paralog of this gene is STMN3.

UniProtKB/Swiss-Prot for STMN4 Gene

  • Exhibits microtubule-destabilizing activity.

Additional gene information for STMN4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN4 Gene

Genomics for STMN4 Gene

GeneHancer (GH) Regulatory Elements for STMN4 Gene

Promoters and enhancers for STMN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I027256 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 550.8 +0.9 865 2.4 ATF1 ZSCAN4 KLF17 ZNF335 ZNF366 SCRT2 RCOR1 ATF7 EGR2 SP3 STMN4 ADRA1A GC08P027227
GH08I027230 Enhancer 1 FANTOM5 ENCODE dbSUPER 17.7 +26.6 26588 2.9 ZNF335 ZFHX2 POLR2A ZNF692 NFE2 FOS EGR2 STMN4 PTK2B GC08P027227
GH08I027280 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.2 -22.8 -22834 2.1 FOXA2 NFXL1 ZNF366 FOS SMARCA5 RXRA CEBPB ZEB2 MAFF PRDM6 STMN4 TRIM35 PTK2B PIR41134
GH08I027403 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -146.4 -146437 3.5 SMARCA5 NR2F1 EBF1 DPF2 ATF2 ZFHX2 BCL11A ZNF512 IKZF1 NFATC1 PTK2B STMN4 MIR6842
GH08I027299 Enhancer 1.1 Ensembl ENCODE 11.2 -41.1 -41124 1.2 FOXA2 MLX ARID4B DMAP1 RAD21 THRB ZSCAN9 RARA YY1 CREM STMN4 TRIM35 PIR41134
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STMN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STMN4 gene promoter:

Genomic Locations for STMN4 Gene

Genomic Locations for STMN4 Gene
chr8:27,235,323-27,258,865
(GRCh38/hg38)
Size:
23,543 bases
Orientation:
Minus strand
chr8:27,092,840-27,115,937
(GRCh37/hg19)

Genomic View for STMN4 Gene

Genes around STMN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN4 Gene

Proteins for STMN4 Gene

  • Protein details for STMN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H169-STMN4_HUMAN
    Recommended name:
    Stathmin-4
    Protein Accession:
    Q9H169
    Secondary Accessions:
    • B7Z2Z7
    • B7Z4I9
    • D3DSS8
    • D3DSS9
    • G5EA16
    • Q2TAB9

    Protein attributes for STMN4 Gene

    Size:
    189 amino acids
    Molecular mass:
    22071 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STMN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN4 Gene

Post-translational modifications for STMN4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for STMN4 Gene

Domains & Families for STMN4 Gene

Gene Families for STMN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STMN4 Gene

Suggested Antigen Peptide Sequences for STMN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H169

UniProtKB/Swiss-Prot:

STMN4_HUMAN :
  • Belongs to the stathmin family.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN4: view

Function for STMN4 Gene

Molecular function for STMN4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity.

Phenotypes From GWAS Catalog for STMN4 Gene

Gene Ontology (GO) - Molecular Function for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA --
genes like me logo Genes that share ontologies with STMN4: view
genes like me logo Genes that share phenotypes with STMN4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STMN4 Gene

Localization for STMN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN4 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN4 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
extracellular 3
cytoskeleton 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STMN4: view

Pathways & Interactions for STMN4 Gene

SuperPathways for STMN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA --
GO:0031110 regulation of microtubule polymerization or depolymerization IEA --
GO:0031175 neuron projection development IBA --
GO:0051493 regulation of cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with STMN4: view

No data available for Pathways by source and SIGNOR curated interactions for STMN4 Gene

Drugs & Compounds for STMN4 Gene

(2) Drugs for STMN4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomustine Approved, Investigational Pharma Target, antagonist Antineoplastic drug 85
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with STMN4: view

Transcripts for STMN4 Gene

Unigene Clusters for STMN4 Gene

Stathmin-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for STMN4 Gene

GeneLoc Exon Structure for
STMN4
ECgene alternative splicing isoforms for
STMN4

Expression for STMN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STMN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x5.2), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.2), Brain - Cortex (x4.2), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for STMN4 Gene

This gene is overexpressed in NK cells (33.4) and Plasma (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STMN4 Gene



NURSA nuclear receptor signaling pathways regulating expression of STMN4 Gene:

STMN4

SOURCE GeneReport for Unigene cluster for STMN4 Gene:

Hs.201058

Evidence on tissue expression from TISSUES for STMN4 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with STMN4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STMN4 Gene

Orthologs for STMN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN4 34 33
  • 99.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STMN4 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STMN4 33 34
  • 92.77 (n)
dog
(Canis familiaris)
Mammalia STMN4 33 34
  • 92.75 (n)
rat
(Rattus norvegicus)
Mammalia Stmn4 33
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Stmn4 33 16 34
  • 88.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STMN4 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STMN4 33 34
  • 82.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn4 33
  • 77.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia stmn4-prov 33
zebrafish
(Danio rerio)
Actinopterygii stmn4l 34
  • 76 (a)
OneToMany
stmn4 33 34
  • 73.94 (n)
wufj44e06 33
fruit fly
(Drosophila melanogaster)
Insecta stai 34
  • 17 (a)
OneToMany
Species where no ortholog for STMN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN4 Gene

ENSEMBL:
Gene Tree for STMN4 (if available)
TreeFam:
Gene Tree for STMN4 (if available)

Paralogs for STMN4 Gene

Paralogs for STMN4 Gene

(3) SIMAP similar genes for STMN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STMN4: view

Variants for STMN4 Gene

Sequence variations from dbSNP and Humsavar for STMN4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000107120 -- 27,252,363(-) A/G intron_variant
rs1000145256 -- 27,238,044(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000145487 -- 27,259,070(-) C/G upstream_transcript_variant
rs1000160648 -- 27,245,932(-) A/G intron_variant
rs1000382245 -- 27,240,274(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STMN4 Gene

Variant ID Type Subtype PubMed ID
nsv831274 CNV gain 17160897
nsv6131 CNV deletion 18451855
nsv1033251 CNV gain 25217958
esv3616716 CNV gain 21293372

Variation tolerance for STMN4 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STMN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STMN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN4 Gene

Disorders for STMN4 Gene

Additional Disease Information for STMN4

No disorders were found for STMN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STMN4 Gene

Publications for STMN4 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. (PMID: 12676564) Bièche I … Curmi PA (Genomics 2003) 3 22 58
  4. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PMID: 9788875) Gavet O … Sobel A (Journal of cell science 1998) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for STMN4 Gene

Sources for STMN4 Gene

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