STK4 Gene (Protein Coding)

Serine/Threonine Kinase 4

GC20P044966
GIFtS:
48
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosph... See more...

Aliases for STK4 Gene

Aliases for STK4 Gene

  • Serine/Threonine Kinase 4 2 3 5
  • KRS2 2 3 4
  • MST1 2 3 4
  • Mammalian STE20-Like Protein Kinase 1 3 4
  • Serine/Threonine-Protein Kinase Krs-2 3 4
  • Serine/Threonine-Protein Kinase 4 3 4
  • Kinase Responsive To Stress 2 2 3
  • Mammalian Sterile 20-Like 1 2 3
  • STE20-Like Kinase MST1 3 4
  • EC 2.7.11.1 4 51
  • YSK3 2 3
  • Yeast Ste20-Like 2
  • EC 2.7.11 51
  • MST-1 4
  • STK4 5

External Ids for STK4 Gene

Previous GeneCards Identifiers for STK4 Gene

  • GC20P043323
  • GC20P044233
  • GC20P044280
  • GC20P043028
  • GC20P043595
  • GC20P040336

Summaries for STK4 Gene

Entrez Gene Summary for STK4 Gene

  • The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK4 Gene

STK4 (Serine/Threonine Kinase 4) is a Protein Coding gene. Diseases associated with STK4 include T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations and Lung Cancer. Among its related pathways are Sweet Taste Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK3.

UniProtKB/Swiss-Prot Summary for STK4 Gene

  • Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

Gene Wiki entry for STK4 Gene

Additional gene information for STK4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK4 Gene

Genomics for STK4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for STK4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK4

Top Transcription factor binding sites by QIAGEN in the STK4 gene promoter:
  • AML1a
  • GATA-1
  • Ik-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pbx1a
  • S8

Genomic Locations for STK4 Gene

Genomic Locations for STK4 Gene
chr20:44,966,470-45,080,021
(GRCh38/hg38)
Size:
113,552 bases
Orientation:
Plus strand
chr20:43,595,115-43,708,600
(GRCh37/hg19)
Size:
113,486 bases
Orientation:
Plus strand

Genomic View for STK4 Gene

Genes around STK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STK4 Gene

Proteins for STK4 Gene

Products:

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  • Protein details for STK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13043-STK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 4
    Protein Accession:
    Q13043
    Secondary Accessions:
    • B2RCR8
    • Q15802
    • Q4G156
    • Q5H982
    • Q6PD60
    • Q9BR32
    • Q9NTZ4

    Protein attributes for STK4 Gene

    Size:
    487 amino acids
    Molecular mass:
    55630 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714). Interacts with SCRIB in the presence of DLG5 (PubMed:28169360).
    SequenceCaution:
    • Sequence=AAH29511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58916.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK4 Gene

    Alternative splice isoforms for STK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK4 Gene

Protein Expression for STK4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for STK4 Gene

Q13043:
  • DIKAGNIL
  • SILRDLINEAMD
  • EMAEGKPPY
  • GTPFWMAP
  • QQREVDQ
  • EEIRQKY
  • YYGSYFK
  • LEKLGEG
  • DFVKQCL
  • ATQLLQHPF
  • VAIKQVPVESD
  • PQDGDYEFLK
  • ALDPMME
  • QCLVKSP
  • TGQIVAIK
  • ADFGVAGQLTDT
  • KAGNILL
  • HRDIKAGN
  • MGTVRVASTM
  • KLGEGSYGSV
  • IMQQCDS
  • WMAPEVI
  • PSFLEYFEQK
  • TMIEHDDTLPSQLGTMVIN
  • VYKAIHK
  • IHPMRAIFMIP

Post-translational modifications for STK4 Gene

  • Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3.
  • Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for STK4 Gene

Gene Families for STK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for STK4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STK4 Gene

GenScript: Design optimal peptide antigens:
  • STK4 protein (A0PJ51_HUMAN)
  • Serine/threonine-protein kinase Krs-2 (STK4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13043

UniProtKB/Swiss-Prot:

STK4_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK4: view

Function for STK4 Gene

Products:

  1. Animal Model
  2. CRISPR
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  6. Cell Line

Molecular function for STK4 Gene

UniProtKB/Swiss-Prot Function:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Activity increases during mitosis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation.
GENATLAS Biochemistry:
serine/threonine kinase 4,65kDa,mainly expressed in pancreas,heart and skeletal muscle,highly homolog to the DM protein kinase

Enzyme Numbers (IUBMB) for STK4 Gene

Phenotypes From GWAS Catalog for STK4 Gene

Gene Ontology (GO) - Molecular Function for STK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 8566796
GO:0004672 protein kinase activity IEA,IGI 19962960
GO:0004674 protein serine/threonine kinase activity IEA,IDA 8566796
GO:0005515 protein binding IPI 14729613
genes like me logo Genes that share ontologies with STK4: view
genes like me logo Genes that share phenotypes with STK4: view

Human Phenotype Ontology for STK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STK4 Gene

MGI Knock Outs for STK4:
  • Stk4 Stk4<tm1Dlim>
  • Stk4 Stk4<tm1.1Kina>
  • Stk4 Stk4<tm1.1Yy>
  • Stk4 Stk4<tm1.2Wtao>

Animal Model Products

  • Taconic Biosciences Mouse Models for STK4

CRISPR Products

miRNA for STK4 Gene

miRTarBase miRNAs that target STK4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK4

No data available for Transcription Factor Targets and HOMER Transcription for STK4 Gene

Localization for STK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK4 Gene

Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17932490
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 17932490
GO:0005829 cytosol IDA,TAS --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with STK4: view

Pathways & Interactions for STK4 Gene

genes like me logo Genes that share pathways with STK4: view

Pathways by source for STK4 Gene

2 Reactome pathways for STK4 Gene
1 Qiagen pathway for STK4 Gene
  • Sperm Motility
3 Cell Signaling Technology pathways for STK4 Gene

SIGNOR curated interactions for STK4 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for STK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IDA 11805089
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001841 neural tube formation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 19962960
GO:0003157 endocardium development IEA --
genes like me logo Genes that share ontologies with STK4: view

Drugs & Compounds for STK4 Gene

Products:

  1. Drug

(4) Drugs for STK4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for STK4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with STK4: view

Transcripts for STK4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for STK4 Gene

2 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK4

Alternative Splicing Database (ASD) splice patterns (SP) for STK4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: -
SP3:

Relevant External Links for STK4 Gene

GeneLoc Exon Structure for
STK4

Expression for STK4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK4 Gene

mRNA expression in normal human tissues for STK4 Gene
mRNA expression by BioGPS for STK4 GenemRNA expression by GTEx for STK4 Gene

mRNA differential expression in normal tissues according to GTEx for STK4 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for STK4 Gene

This gene is overexpressed in Lung (21.0), Lymph node (13.6), and Peripheral blood mononuclear cells (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK4 Gene



Protein tissue co-expression partners for STK4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK4

SOURCE GeneReport for Unigene cluster for STK4 Gene:

Hs.472838

mRNA Expression by UniProt/SwissProt for STK4 Gene:

Q13043-STK4_HUMAN
Tissue specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed.

Evidence on tissue expression from TISSUES for STK4 Gene

  • Nervous system(4.5)
  • Liver(4.5)
  • Bone(4.2)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Intestine(2.7)
  • Blood(2.6)
  • Heart(2.4)
  • Lung(2.3)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Skin(2.1)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STK4 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
Regions:
Head and neck:
  • ear
Thorax:
  • heart
  • heart valve
Limb:
  • digit
  • foot
  • lower limb
  • toe
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with STK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for STK4 Gene

Orthologs for STK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia STK4 30 31
  • 99.59 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 96 (a)
 OneToMany
-- 31
  • 71 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia STK4 31
  • 95 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia STK4 30 31
  • 91.92 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia STK4 30 31
  • 91.79 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Stk4 30 17 31
  • 90.9 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Stk4 30
  • 89.39 (n)
Chicken
(Gallus gallus)
 Aves STK4 30 31
  • 82.17 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia STK4 31
  • 87 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia stk4 30
  • 72.58 (n)
MGC75656 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC68762 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11228 32
  • 50 (a)
hpo 31
  • 43 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea C24A8.4a 32
  • 61 (a)
C24A8.4b 32
  • 61 (a)
cst-2 31
  • 55 (a)
 ManyToMany
cst-1 31
  • 53 (a)
 ManyToMany
F14H12.4a 32
  • 52 (a)
F14H12.4b 32
  • 52 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SPS1 31
  • 28 (a)
 OneToMany
CDC15 33
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.8767 31
  • 67 (a)
 OneToMany
Species where no ortholog for STK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for STK4 Gene

ENSEMBL:
Gene Tree for STK4 (if available)
TreeFam:
Gene Tree for STK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK4: view image

Paralogs for STK4 Gene

Paralogs for STK4 Gene

(53) SIMAP similar genes for STK4 Gene using alignment to 3 proteins:

  • STK4_HUMAN
  • A0PJ51_HUMAN
  • F5H5B4_HUMAN

Pseudogenes.org Pseudogenes for STK4 Gene

genes like me logo Genes that share paralogs with STK4: view

Variants for STK4 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK4 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
37324 Pathogenic: T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 45,001,308(+) AT/A FRAMESHIFT_VARIANT
37325 Pathogenic: T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 44,997,224(+) G/A NONSENSE
641185 Uncertain Significance: T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 44,997,197(+) C/T MISSENSE_VARIANT
641778 Uncertain Significance: T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 45,024,997(+) C/T MISSENSE_VARIANT
645801 Uncertain Significance: T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 45,025,048(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for STK4 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK4 Gene

Variant ID Type Subtype PubMed ID
esv3346137 CNV insertion 20981092
nsv1056102 CNV loss 25217958
nsv179332 CNV deletion 16902084

Variation tolerance for STK4 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.89; 83.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK4 Gene

Human Gene Mutation Database (HGMD)
STK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK4 Gene

Disorders for STK4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for STK4 Gene - From: LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search STK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STK4_HUMAN
  • T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations (TIIAC) [MIM:614868]: A primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T-cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, autoimmune manifestations, and cardiac malformations, including atrial septal defect. {ECO:0000269 PubMed:22294732}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for STK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STK4: view

No data available for Genatlas for STK4 Gene

Publications for STK4 Gene

  1. Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. (PMID: 11517310) Ura S … Gotoh Y (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 23
  2. Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. (PMID: 18986304) You B … Sun J (The Biochemical journal 2009) 3 4 23
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M … Avruch J (Current biology : CB 2008) 3 4 23
  4. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (PMID: 16751106) Lehtinen MK … Bonni A (Cell 2006) 3 4 23
  5. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. (PMID: 16510573) Oh HJ … Lim DS (Cancer research 2006) 3 4 23

ExternalLinks

View latest publications for STK4 gene in Mastermind

Products for STK4 Gene

  • Addgene plasmids for STK4

Sources for STK4 Gene