Aliases for STK4 Gene
Aliases for STK4 Gene
External Ids for STK4 Gene
- HGNC: 11408
- Entrez Gene: 6789
- Ensembl: ENSG00000101109
- OMIM: 604965
- UniProtKB: Q13043
Previous GeneCards Identifiers for STK4 Gene
- GC20P043323
- GC20P044233
- GC20P044280
- GC20P043028
- GC20P043595
- GC20P040336
Summaries for STK4 Gene
-
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
GeneCards Summary for STK4 Gene
STK4 (Serine/Threonine Kinase 4) is a Protein Coding gene. Diseases associated with STK4 include T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations and Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant. Among its related pathways are MAPK signaling pathway and Signaling by Hippo. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK3.
UniProtKB/Swiss-Prot for STK4 Gene
-
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates Ser-14 of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on Ser-212 and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on Ser-650 and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Additional gene information for STK4 Gene
- Monarch Initiative
- Search for STK4 at DataMed
- Search for STK4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK4 Gene
Genomics for STK4 Gene
GeneHancer (GH) Regulatory Elements for STK4 Gene
Promoters and enhancers for STK4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STK4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for STK4 Gene
Genomic Locations for STK4 Gene
- chr20:44,966,474-45,079,975
- (GRCh38/hg38)
- Size:
- 113,502 bases
- Orientation:
- Plus strand
- chr20:43,595,115-43,708,600
- (GRCh37/hg19)
Genomic View for STK4 Gene
Genes around STK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
STK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STK4 Gene
Proteins for STK4 Gene
-
Protein details for STK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13043-STK4_HUMAN
- Recommended name:
- Serine/threonine-protein kinase 4
- Protein Accession:
- Q13043
- B2RCR8
- Q15802
- Q4G156
- Q5H982
- Q6PD60
- Q9BR32
- Q9NTZ4
Protein attributes for STK4 Gene
- Size:
- 487 amino acids
- Molecular mass:
- 55630 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714). Interacts with SCRIB in the presence of DLG5 (PubMed:28169360).
- SequenceCaution:
-
- Sequence=AAH29511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58916.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for STK4 Gene
Protein Expression for STK4 Gene
Selected DME Specific Peptides for STK4 Gene
- Q13043:
-
- DIKAGNIL
- SILRDLINEAMD
- EMAEGKPPY
- GTPFWMAP
- QQREVDQ
- EEIRQKY
- YYGSYFK
- LEKLGEG
- DFVKQCL
- ATQLLQHPF
- VAIKQVPVESD
- PQDGDYEFLK
- ALDPMME
- QCLVKSP
- TGQIVAIK
- ADFGVAGQLTDT
- KAGNILL
- HRDIKAGN
- MGTVRVASTM
- KLGEGSYGSV
- IMQQCDS
- WMAPEVI
- PSFLEYFEQK
- TMIEHDDTLPSQLGTMVIN
- VYKAIHK
- IHPMRAIFMIP
Post-translational modifications for STK4 Gene
- Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3.
- Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for STK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STK4 (MST1/STK4)
-
Custom Antibody ServicesOriGene Antibodies for STK4
- Novus Biologicals Antibodies for STK4
-
Abcam antibodies for STK4
- Invitrogen Antibodies for STK4
- GeneTex STK4 antibody for STK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for STK4
- Sino Biological Antibodies for STK4
Protein Products
-
OriGene Purified Proteins for STK4
- Search Origene for MassSpec and Protein Over-expression Lysates for STK4
- Origene Custom Protein Services for STK4
- Sino Biological Cell Lysates for STK4
- Sino Biological Recombinant Proteins for STK4
- Search GeneTex for Proteins for STK4
-
Abcam proteins for STK4
Assay Products
- antibodies-online: Search results for 1 available STK4 Elisa Kits ranked by validation data
- Compare Top STK4 Elisa Kits
-
Recommended
- Sino Biological Assays for STK4
Domains & Families for STK4 Gene
Gene Families for STK4 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for STK4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for STK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13043UniProtKB/Swiss-Prot:
STK4_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for STK4 Gene
Molecular function for STK4 Gene
- GENATLAS Biochemistry:
- serine/threonine kinase 4,65kDa,mainly expressed in pancreas,heart and skeletal muscle,highly homolog to the DM protein kinase
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation.
- UniProtKB/Swiss-Prot Function:
- Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates Ser-14 of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on Ser-212 and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on Ser-650 and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
- UniProtKB/Swiss-Prot Induction:
- Activity increases during mitosis.
Enzyme Numbers (IUBMB) for STK4 Gene
Phenotypes From GWAS Catalog for STK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 8566796 |
| GO:0004672 | protein kinase activity | IGI,IEA | 19962960 |
| GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 8566796 |
| GO:0005515 | protein binding | IPI | 14729613 |
| GO:0005524 | ATP binding | IDA,IEA | 8566796 |
Phenotypes for STK4 Gene
- MGI mutant phenotypes for STK4:
-
inferred from 10 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for STK4:
-
- Increased viability
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Decreased POU5F1-GFP protein expression
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased viability
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased Sindbis virus (SINV) infection
- Condensed cis-Golgi
- Decreased OCT4 protein expression
- Paclitaxel antagonistic effect
Animal Models for STK4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for STK4
- Cyagen custom Knockout/knockin (KOKI) mouse models for STK4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for STK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STK4 gene
- Search ViGene Biosciences for STK4
CRISPR Products
-
OriGene CRISPR knockouts for STK4
- genomics-online: gRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- Applied Biological Materials CRISPR for STK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK4
- GenScript: Design CRISPR guide RNA sequences for STK4
miRNA for STK4 Gene
- miRTarBase miRNAs that target STK4
-
- hsa-mir-373-3p (MIRT002541)
- hsa-mir-92a-3p (MIRT048938)
- hsa-let-7a-5p (MIRT118582)
- hsa-let-7b-5p (MIRT118583)
- hsa-let-7c-5p (MIRT118584)
- hsa-let-7d-5p (MIRT118585)
- hsa-let-7e-5p (MIRT118586)
- hsa-let-7f-5p (MIRT118587)
- hsa-mir-98-5p (MIRT118588)
- hsa-let-7g-5p (MIRT118589)
- hsa-let-7i-5p (MIRT118590)
- hsa-mir-202-3p (MIRT118591)
- hsa-mir-3185 (MIRT118592)
- hsa-mir-4428 (MIRT118593)
- hsa-mir-4458 (MIRT118594)
- hsa-mir-4500 (MIRT118595)
- hsa-mir-518f-3p (MIRT202015)
- hsa-mir-518b (MIRT202016)
- hsa-mir-518c-3p (MIRT202017)
- hsa-mir-518a-3p (MIRT202018)
- hsa-mir-518d-3p (MIRT202019)
- hsa-mir-4424 (MIRT202021)
- hsa-mir-4682 (MIRT202022)
- hsa-mir-887-5p (MIRT202025)
- hsa-mir-1273f (MIRT235751)
- hsa-mir-18a-5p (MIRT438460)
- hsa-mir-4709-3p (MIRT496782)
- hsa-mir-4724-5p (MIRT496783)
- hsa-mir-4476 (MIRT509134)
- hsa-mir-6876-5p (MIRT509135)
- hsa-mir-3921 (MIRT534038)
- hsa-mir-4653-5p (MIRT534039)
- hsa-mir-3121-5p (MIRT534040)
- hsa-mir-4714-5p (MIRT534041)
- hsa-mir-501-5p (MIRT534042)
- hsa-mir-500a-5p (MIRT534043)
- hsa-mir-605-5p (MIRT534044)
- hsa-mir-548e-5p (MIRT534045)
- hsa-mir-6780a-5p (MIRT621987)
- hsa-mir-6779-5p (MIRT621988)
- hsa-mir-3689c (MIRT621989)
- hsa-mir-3689b-3p (MIRT621990)
- hsa-mir-3689a-3p (MIRT621991)
- hsa-mir-30b-3p (MIRT621992)
- hsa-mir-1273h-5p (MIRT621993)
- hsa-mir-6514-3p (MIRT621994)
- hsa-mir-7977 (MIRT621995)
- hsa-mir-4769-5p (MIRT621996)
- hsa-mir-4654 (MIRT621997)
- hsa-mir-6778-5p (MIRT621998)
- hsa-mir-1233-5p (MIRT621999)
- hsa-mir-4648 (MIRT622000)
- hsa-mir-6799-5p (MIRT622001)
- hsa-mir-6883-5p (MIRT622002)
- hsa-mir-6785-5p (MIRT622003)
- hsa-mir-4728-5p (MIRT622004)
- hsa-mir-149-3p (MIRT622005)
- hsa-mir-7106-5p (MIRT622006)
- hsa-mir-6811-3p (MIRT622007)
- hsa-mir-214-5p (MIRT622008)
- hsa-mir-6499-3p (MIRT622009)
- hsa-mir-4530 (MIRT622010)
- hsa-mir-4302 (MIRT622011)
- hsa-mir-4519 (MIRT622012)
- hsa-mir-6847-3p (MIRT630214)
- hsa-mir-6513-5p (MIRT698747)
- hsa-mir-3913-5p (MIRT698748)
- hsa-mir-3122 (MIRT698749)
- hsa-mir-450a-1-3p (MIRT698750)
- hsa-mir-4435 (MIRT698751)
- hsa-mir-24-3p (MIRT698752)
- hsa-mir-4284 (MIRT698753)
- hsa-mir-6809-5p (MIRT698754)
- hsa-mir-4755-3p (MIRT698755)
- hsa-mir-4645-5p (MIRT698756)
- hsa-mir-4673 (MIRT698757)
- hsa-mir-4742-5p (MIRT698758)
- hsa-mir-4761-5p (MIRT698759)
- hsa-mir-6865-5p (MIRT698760)
- hsa-mir-6815-5p (MIRT698761)
- hsa-mir-6516-5p (MIRT698762)
- hsa-mir-455-3p (MIRT698763)
- hsa-mir-7703 (MIRT698764)
- hsa-mir-6720-5p (MIRT698765)
- hsa-mir-6512-3p (MIRT698766)
- hsa-mir-566 (MIRT698767)
- hsa-mir-6789-3p (MIRT698768)
- hsa-mir-196a-3p (MIRT698769)
- hsa-mir-661 (MIRT698770)
- hsa-mir-4252 (MIRT698771)
- hsa-mir-4537 (MIRT698772)
- hsa-mir-6860 (MIRT698773)
- hsa-mir-612 (MIRT698774)
- hsa-mir-5189-5p (MIRT698775)
- hsa-mir-3187-5p (MIRT698776)
- hsa-mir-1285-3p (MIRT698777)
- hsa-mir-4793-3p (MIRT698778)
- hsa-mir-766-3p (MIRT698779)
- hsa-mir-6849-3p (MIRT698780)
- hsa-mir-1273g-3p (MIRT698781)
- hsa-mir-652-3p (MIRT698782)
- hsa-mir-508-5p (MIRT698783)
- hsa-mir-6749-3p (MIRT712170)
- hsa-mir-3156-3p (MIRT712171)
- hsa-mir-3157-5p (MIRT712172)
- hsa-mir-3934-3p (MIRT712173)
- hsa-mir-532-3p (MIRT712174)
- hsa-mir-4301 (MIRT712175)
- hsa-mir-3934-5p (MIRT712176)
- hsa-mir-764 (MIRT712177)
- hsa-mir-125a-3p (MIRT712178)
- hsa-mir-19b-3p (MIRT726423)
- hsa-mir-19a-3p (MIRT726424)
- hsa-mir-101-5p (MIRT735802)
- hsa-mir-1180-5p (MIRT735877)
- hsa-mir-1256 (MIRT736608)
- hsa-mir-1275 (MIRT736937)
- hsa-mir-1276 (MIRT736961)
- hsa-mir-3115 (MIRT739927)
- hsa-mir-3675-5p (MIRT742140)
- hsa-mir-3910 (MIRT742839)
- hsa-mir-4525 (MIRT745929)
- hsa-mir-4665-5p (MIRT746775)
- hsa-mir-4668-5p (MIRT746831)
- hsa-mir-4723-5p (MIRT747673)
- hsa-mir-4753-5p (MIRT748352)
- hsa-mir-488-3p (MIRT749153)
- hsa-mir-5010-5p (MIRT749511)
- hsa-mir-548a-3p (MIRT750467)
- hsa-mir-548an (MIRT750551)
- hsa-mir-548ar-3p (MIRT750585)
- hsa-mir-548az-3p (MIRT750647)
- hsa-mir-548e-3p (MIRT750700)
- hsa-mir-548f-3p (MIRT750710)
- hsa-mir-5681a (MIRT751154)
- hsa-mir-5698 (MIRT751306)
- hsa-mir-625-5p (MIRT752608)
- hsa-mir-6507-5p (MIRT752966)
- hsa-mir-6730-5p (MIRT753978)
- hsa-mir-6768-3p (MIRT755151)
- hsa-mir-6870-5p (MIRT758006)
- hsa-mir-6890-5p (MIRT758661)
- hsa-mir-7111-5p (MIRT759064)
- hsa-mir-7114-3p (MIRT759135)
- hsa-mir-1224-3p (MIRT783138)
- hsa-mir-125b-2-3p (MIRT783237)
- hsa-mir-3165 (MIRT784719)
- hsa-mir-363-5p (MIRT784989)
- hsa-mir-3656 (MIRT785035)
- hsa-mir-3667-5p (MIRT785104)
- hsa-mir-3974 (MIRT785489)
- hsa-mir-4433a-3p (MIRT785853)
- hsa-mir-4457 (MIRT785929)
- hsa-mir-4459 (MIRT785934)
- hsa-mir-4768-3p (MIRT786672)
- hsa-mir-4794 (MIRT786811)
- hsa-mir-513b-5p (MIRT787149)
- hsa-mir-6087 (MIRT788015)
- hsa-mir-624-3p (MIRT788138)
- hsa-mir-664a-5p (MIRT788430)
- hsa-mir-6745 (MIRT788541)
- hsa-mir-6765-3p (MIRT788615)
miRNA Products
- Search ViGene Biosciences for STK4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STK4
- Browse OriGene Inhibitory RNA Products For STK4
- genomics-online: shRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STK4 gene
Clone Products
- Sino Biological Human cDNA Clone for STK4
- VectorBuilder custom plasmid, inducible vectors for STK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK4
- Applied Biological Materials Clones for STK4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for STK4
-
ViGene Biosciences adenoviral particle packaged cDNA for STK4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STK4 gene
No data available for Transcription Factor Targets and HOMER Transcription for STK4 Gene
Localization for STK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STK4 Gene
- Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (4)
- Nucleoplasm (4)
- Nuclear bodies (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 17932490 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17932490 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for STK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
| 2 | MAPK signaling pathway | ||
| 3 | Endometrial cancer | ||
| 4 | Pathways in cancer | ||
| 5 | Ras signaling pathway | ||
Pathways by source for STK4 Gene
2 Reactome pathways for STK4 Gene
5 KEGG pathways for STK4 Gene
1 Qiagen pathway for STK4 Gene
3 Cell Signaling Technology pathways for STK4 Gene
Interacting Proteins for STK4 Gene
Selected Interacting proteins:
Q13043-STK4_HUMAN
ENSP00000361892
for STK4 Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for STK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IDA | 11805089 |
| GO:0001569 | branching involved in blood vessel morphogenesis | IEA | -- |
| GO:0001841 | neural tube formation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 19962960 |
| GO:0003157 | endocardium development | IEA | -- |
Drugs & Compounds for STK4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for STK4 Gene
mRNA/cDNA for STK4 Gene
- (13) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (205) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STK4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for STK4
- genomics-online: gRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- Applied Biological Materials CRISPR for STK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK4
- GenScript: Design CRISPR guide RNA sequences for STK4
miRNA Products
- Search ViGene Biosciences for STK4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STK4
- Browse OriGene Inhibitory RNA Products For STK4
- genomics-online: shRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STK4 gene
Clone Products
- Sino Biological Human cDNA Clone for STK4
- VectorBuilder custom plasmid, inducible vectors for STK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK4
- Applied Biological Materials Clones for STK4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: |
Expression for STK4 Gene
mRNA differential expression in normal tissues according to GTEx for STK4 Gene
This gene is overexpressed in Whole Blood (x8.3).
This gene is overexpressed in Lung (21.0), Lymph node (13.6), and Peripheral blood mononuclear cells (13.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STK4 Gene:
STK4SOURCE GeneReport for Unigene cluster for STK4 Gene:
Hs.472838mRNA Expression by UniProt/SwissProt for STK4 Gene:
Q13043-STK4_HUMAN
Tissue specificity:
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed.
Evidence on tissue expression from TISSUES for STK4 Gene
- Nervous system(4.3)
- Liver(4.2)
- Bone(4)
- Lymph node(2.3)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STK4 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
Regions:
Head and neck:
- ear
Thorax:
- heart
- heart valve
Limb:
- digit
- foot
- lower limb
- toe
General:
- blood
- bone marrow
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for STK4
-
OriGene qPCR primer pairs and template standards for STK4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for STK4 Gene
Orthologs for STK4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STK4 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | STK4 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | STK4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | STK4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Stk4 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stk4 33 |
|
||
| chicken (Gallus gallus) |
Aves | STK4 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | STK4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stk4 33 |
|
||
| MGC75656 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68762 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11228 35 |
|
|
|
| hpo 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | C24A8.4a 35 |
|
|
|
| C24A8.4b 35 |
|
|
|||
| cst-2 34 |
|
ManyToMany | |||
| cst-1 34 |
|
ManyToMany | |||
| F14H12.4a 35 |
|
|
|||
| F14H12.4b 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPS1 34 |
|
OneToMany | |
| CDC15 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8767 34 |
|
OneToMany |
- Species where no ortholog for STK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for STK4 Gene
Paralogs for STK4 Gene
(53) SIMAP similar genes for STK4 Gene using alignment to 3 proteins:
- STK4/SLC36AL fusion
- DKFZp686A2068
- STK3
- CDK2
- CDKL2
- MAP4K5
- STK25
- MYO3A
- PAK3
- MAP4K1
- PAK1
- MST4
- PAK4
- MAP4K3
- MYO3B
- STK24
- PAK7
- MST094
- CDK7
- MAP4K4
- MAP4K2
- MAP3K2
- CDKL4
- PAK2
- NRK
- MARK4
- STRADA
- SLK
- MAP2K5
- TNIK
- MINK1
- DKFZp686J1430
- NEK6
- CHEK1
- CDK4
- OXSR1
- TAOK3
- STK10
- MAP3K19
- TAOK2
- PRKAA1
- NEK7
- MAP2K6
- MAP2K4
- MAP2K3
- STK17A
- MAP2K1
- DKFZp686L02273
- TAOK1
- MAP2K2
- KIN27
- PRKACB
- STK36
Pseudogenes.org Pseudogenes for STK4 Gene
Variants for STK4 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs35447878 | uncertain-significance, T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations | 45,000,489(+) | G/A/C | coding_sequence_variant, missense_variant | |
| rs387907316 | pathogenic, T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations | 44,981,932(+) | C/T | coding_sequence_variant, stop_gained | |
| rs528301360 | likely-benign, T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations | 44,995,083(+) | A/C/G | intron_variant | |
| rs776978911 | uncertain-significance, T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations | 45,001,237(+) | C/G/T | coding_sequence_variant, missense_variant | |
| rs771955007 | uncertain-significance, not specified | 45,001,210(+) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3346137 | CNV | insertion | 20981092 |
| nsv1056102 | CNV | loss | 25217958 |
| nsv179332 | CNV | deletion | 16902084 |
Residual Variation Intolerance Score:
34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.89;
83.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STK4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK4 Gene
Disorders for STK4 Gene
(3) MalaCards diseases for STK4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| t-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations |
|
|
| hyper-ige recurrent infection syndrome, autosomal dominant |
|
|
| seborrheic dermatitis |
|
|
Search STK4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
STK4_HUMAN- T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations (TIIAC) [MIM:614868]: A primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T-cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, autoimmune manifestations, and cardiac malformations, including atrial septal defect. {ECO:0000269 PubMed:22294732}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for STK4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for STK4 Gene
Publications for STK4 Gene
- Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. (PMID: 11517310) Ura S … Gotoh Y (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
- Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. (PMID: 18986304) You B … Sun J (The Biochemical journal 2009) 3 4 22 58
- MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M … Avruch J (Current biology : CB 2008) 3 4 22 58
- Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. (PMID: 16510573) Oh HJ … Lim DS (Cancer research 2006) 3 4 22 58
- A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (PMID: 16751106) Lehtinen MK … Bonni A (Cell 2006) 3 4 22 58
Products for STK4 Gene
- R&D Systems Antibodies for STK4 (MST1/STK4)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for STK4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for STK4
- Search Origene for MassSpec and Protein Over-expression Lysates for STK4
- Origene Custom Protein Services for STK4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK4
- Browse OriGene Inhibitory RNA Products For STK4
- OriGene qPCR primer pairs and template standards for STK4
- OriGene qPCR primer pairs for STK4
- OriGene CRISPR knockouts for STK4
- OriGene ORF clones in human for STK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STK4
- GenScript: Next-day shipping of latest version cDNA ORF clones for STK4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STK4
- GenScript Custom Assay Services for STK4
- GenScript Custom overexpressing Cell Line Services for STK4
- GenScript: Design CRISPR guide RNA sequences for STK4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STK4
- Sino Biological Human cDNA Clone for STK4
- Sino Biological Cell Lysates for STK4
- Sino Biological Recombinant Proteins for STK4
- Sino Biological Antibodies for STK4
- Sino Biological Assays for STK4
- Browse Sino Biological ELISA Kits
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- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for STK4
- Novus Biologicals lysates and proteins for STK4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STK4
- Abcam proteins for STK4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for STK4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for STK4
- Cyagen custom Knockout/knockin (KOKI) mouse models for STK4
- VectorBuilder custom plasmid, inducible vectors for STK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK4
- antibodies-online: Search results for 79 available STK4 Antibodies ranked by validation data
- Compare Top STK4 Antibodies
- antibodies-online: Search results for 1 available STK4 Elisa Kits ranked by validation data
- Compare Top STK4 Elisa Kits
- Recommended
- antibodies-online: Search results for 18 available STK4 Proteins ranked by validation data
- Compare Top STK4 Proteins
- GeneTex STK4 antibody for STK4
- Search GeneTex for Proteins for STK4
- ViGene Biosciences adenoviral particle packaged cDNA for STK4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for STK4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for STK4 gene
- Search ViGene Biosciences for STK4
- Santa Cruz Biotechnology (SCBT) Antibodies for STK4
- Search Santa Cruz Biotechnology (SCBT) for STK4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STK4
- Horizon Cell Lines for STK4
- genomics-online: cdna clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- orf clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- genomics-online: gRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- genomics-online: primer clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
- genomics-online: shRNA clones - Search results for 103 available STK4 gene related products
- Overview of 103 available STK4 gene related products
Sources for STK4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems