This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellu... See more...

Aliases for STK39 Gene

Aliases for STK39 Gene

  • Serine/Threonine Kinase 39 2 3 5
  • DCHT 2 3 4
  • SPAK 2 3 4
  • STE20/SPS1-Related Proline-Alanine-Rich Protein Kinase 3 4
  • Serine/Threonine-Protein Kinase 39 3 4
  • Ste-20-Related Kinase 3 4
  • EC 2.7.11.1 4 50
  • Serine Threonine Kinase 39 (STE20/SPS1 Homolog, Yeast) 3
  • Proline-Alanine-Rich STE20-Related Kinase 3
  • Small Intestine SPAK-Like Kinase 3
  • STE20/SPS1 Homolog (Yeast) 2
  • Serine Threonine Kinase 39 2
  • Ste20-Like Protein Kinase 3
  • STE20/SPS1 Homolog 3
  • EC 2.7.11 50
  • STK39 5
  • PASK 3

External Ids for STK39 Gene

Previous GeneCards Identifiers for STK39 Gene

  • GC02M166862
  • GC02M167352
  • GC02M168774
  • GC02M169013
  • GC02M168636
  • GC02M168518
  • GC02M160690

Summaries for STK39 Gene

Entrez Gene Summary for STK39 Gene

  • This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK39 Gene

STK39 (Serine/Threonine Kinase 39) is a Protein Coding gene. Diseases associated with STK39 include Neuropathy, Hereditary Sensory And Autonomic, Type Iia and Epilepsy, Idiopathic Generalized 14. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot Summary for STK39 Gene

  • May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.

Gene Wiki entry for STK39 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK39 Gene

Genomics for STK39 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STK39 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J168243 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 257.4 +1.2 1238 5.3 ZNF600 CEBPA ZNF10 ZSCAN16 ZIC2 POLR2A ZBTB10 MXD4 HES1 FEZF1 STK39 5EW4_A-031 LOC107985959 lnc-CERS6-1 PHF5GP B3GALT1
GH02J168181 Enhancer 1.2 Ensembl ENCODE dbSUPER 25.5 +63.2 63178 8 SSRP1 CEBPA CHD4 KLF11 HOMEZ KMT2B THAP11 FOXA2 PRDM1 MAFF STK39 RF00017-3017 lnc-SPC25-3 B3GALT1
GH02J168209 Enhancer 1 ENCODE dbSUPER 26.3 +36.0 36015 3.2 JUND CEBPA CEBPB HOMEZ ZNF217 EP300 THAP11 MBD2 ELF1 FOXA2 STK39 lnc-SPC25-3 RF00017-3017 B3GALT1
GH02J168156 Enhancer 0.9 Ensembl ENCODE 24.8 +91.0 90994 2 JUND ATF2 ZNF10 CTCF ZNF24 REST ZBTB21 BHLHE40 SP7 JUN STK39 RF00017-3017 lnc-SPC25-4 B3GALT1
GH02J168136 Enhancer 1 FANTOM5 Ensembl ENCODE 21.4 +109.7 109693 3 MXD4 HOMEZ CTCF RAD21 SMC3 ZSCAN9 SOX5 YBX1 ZNF143 ZNF652 lnc-SPC25-4 STK39 RF00017-3017 B3GALT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK39 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK39

Top Transcription factor binding sites by QIAGEN in the STK39 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • HSF2
  • Sp1

Genomic Locations for STK39 Gene

Latest Assembly
chr2:167,954,020-168,247,595
(GRCh38/hg38)
Size:
293,576 bases
Orientation:
Minus strand

Previous Assembly
chr2:168,810,532-169,104,105
(GRCh37/hg19 by Entrez Gene)
Size:
293,574 bases
Orientation:
Minus strand

chr2:168,810,530-169,104,651
(GRCh37/hg19 by Ensembl)
Size:
294,122 bases
Orientation:
Minus strand

Genomic View for STK39 Gene

Genes around STK39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK39 Gene

Proteins for STK39 Gene

  • Protein details for STK39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEW8-STK39_HUMAN
    Recommended name:
    STE20/SPS1-related proline-alanine-rich protein kinase
    Protein Accession:
    Q9UEW8
    Secondary Accessions:
    • O14774
    • Q53S90
    • Q53SL7
    • Q53SS1
    • Q9UER4
    • X5D9C8

    Protein attributes for STK39 Gene

    Size:
    545 amino acids
    Molecular mass:
    59474 Da
    Quaternary structure:
    • The phosphorylated form forms a complex with WNK2 (By similarity). Interacts with RELT (By similarity). Interacts with SORL1 (via cytosolic C-terminus) (PubMed:20385770).

    Alternative splice isoforms for STK39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK39 Gene

Selected DME Specific Peptides for STK39 Gene

Q9UEW8:
  • RGYDFKA
  • YELQEVIGSGATAVVQAA
  • SLCLQKDP
  • YYTSFVVKDELWLVMKLLSGGS
  • RPTAAELL
  • KAGNILL
  • KELNDIRFEFTPGRDTA
  • KFFQKAKN
  • GITAIEL
  • HPNVVTYY
  • KLIGFAQLS
  • VAIKRINLEKCQTSMDELLKEIQAMSQC
  • ILLGEDG
  • KKYGKSFRK
  • VIVAANLQKIV

Post-translational modifications for STK39 Gene

  • Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727). Autophosphorylation at Thr-231 positively regulates its activity (By similarity).
  • Ubiquitination at Lys83 and Lys349
  • Modification sites at PhosphoSitePlus

Other Protein References for STK39 Gene

Antibodies for research

  • Abcam antibodies for STK39

Domains & Families for STK39 Gene

Gene Families for STK39 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for STK39 Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase 39 (STK39_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UEW8

UniProtKB/Swiss-Prot:

STK39_HUMAN :
  • PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK39: view

Function for STK39 Gene

Molecular function for STK39 Gene

UniProtKB/Swiss-Prot Function:
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for STK39 Gene

Phenotypes From GWAS Catalog for STK39 Gene

Gene Ontology (GO) - Molecular Function for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,ISS --
GO:0005515 protein binding IPI 16669787
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK39: view
genes like me logo Genes that share phenotypes with STK39: view

Animal Models for STK39 Gene

MGI Knock Outs for STK39:

Animal Models for research

  • Taconic Biosciences Mouse Models for STK39

miRNA for STK39 Gene

miRTarBase miRNAs that target STK39

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK39

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK39 Gene

Localization for STK39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK39 Gene

Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK39 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
cytoskeleton 3
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,ISS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with STK39: view

Pathways & Interactions for STK39 Gene

genes like me logo Genes that share pathways with STK39: view

Pathways by source for STK39 Gene

1 BioSystems pathway for STK39 Gene
1 PharmGKB pathway for STK39 Gene
1 Qiagen pathway for STK39 Gene
  • Sperm Motility
1 Cell Signaling Technology pathway for STK39 Gene

SIGNOR curated interactions for STK39 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA,IMP 10980603
GO:0006468 protein phosphorylation ISS --
GO:0007165 signal transduction IMP 16669787
GO:0008217 regulation of blood pressure IEA --
GO:0010820 positive regulation of T cell chemotaxis IMP 27400149
genes like me logo Genes that share ontologies with STK39: view

Drugs & Compounds for STK39 Gene

(7) Drugs for STK39 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Losartan Approved Pharma 366
ATP Investigational Nutra 0

(3) Additional Compounds for STK39 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with STK39: view

Transcripts for STK39 Gene

mRNA/cDNA for STK39 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK39

Alternative Splicing Database (ASD) splice patterns (SP) for STK39 Gene

No ASD Table

Relevant External Links for STK39 Gene

GeneLoc Exon Structure for
STK39

Expression for STK39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK39 Gene

This gene is overexpressed in Salivary gland (8.9) and Frontal cortex (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK39 Gene



Protein tissue co-expression partners for STK39 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK39

SOURCE GeneReport for Unigene cluster for STK39 Gene:

Hs.276271

mRNA Expression by UniProt/SwissProt for STK39 Gene:

Q9UEW8-STK39_HUMAN
Tissue specificity: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

Evidence on tissue expression from TISSUES for STK39 Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Kidney(2.7)
  • Heart(2.2)
  • Muscle(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with STK39: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK39 Gene

Orthologs for STK39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK39 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STK39 29 30
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STK39 29 30
  • 94.68 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STK39 30
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STK39 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Stk39 29 16 30
  • 90.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stk39 29
  • 90.62 (n)
Cow
(Bos Taurus)
Mammalia STK39 30
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STK39 29 30
  • 85.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STK39 30
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488948 29
  • 78.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii oxsr1a 29
  • 69.46 (n)
CABZ01117519.1 30
  • 53 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta fray 30 31
  • 54 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y59A8B.23 31
  • 55 (a)
gck-3 30
  • 49 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKM1 30
  • 17 (a)
ManyToMany
CLA4 30
  • 13 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9457 30
  • 59 (a)
OneToMany
Species where no ortholog for STK39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STK39 Gene

ENSEMBL:
Gene Tree for STK39 (if available)
TreeFam:
Gene Tree for STK39 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK39: view image
Alliance of Genome Resources:
Additional Orthologs for STK39

Paralogs for STK39 Gene

(5) SIMAP similar genes for STK39 Gene using alignment to 1 proteins:

  • STK39_HUMAN

Pseudogenes.org Pseudogenes for STK39 Gene

genes like me logo Genes that share paralogs with STK39: view

Variants for STK39 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK39 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs537577117 Benign: not provided 168,247,286(-) C/CGCCGGG
NM_013233.3(STK39):c.126_131CCCGGC[5] (p.43_44PA[5])
INFRAME_INSERTION
rs576855530 Likely Benign: not provided 168,247,349(-) C/G
NM_013233.3(STK39):c.87G>C (p.Ala29=)
SYNONYMOUS
rs886043154 Uncertain Significance: not provided 168,247,366(-) CCGCCGCTGTCACCGG
NM_013233.3(STK39):c.54_69del (p.Pro19fs)
FRAMESHIFT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STK39 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STK39 Gene

Variant ID Type Subtype PubMed ID
dgv2087n106 CNV deletion 24896259
esv1331913 CNV deletion 17803354
esv2214356 CNV deletion 18987734
esv2665325 CNV deletion 23128226
esv2668311 CNV deletion 23128226
esv2670762 CNV deletion 23128226
esv2721096 CNV deletion 23290073
esv2721097 CNV deletion 23290073
esv2721098 CNV deletion 23290073
esv275050 CNV gain+loss 21479260
esv3560497 CNV deletion 23714750
esv3560498 CNV deletion 23714750
esv3593301 CNV loss 21293372
esv3593302 CNV loss 21293372
esv3593303 CNV loss 21293372
esv3593304 CNV loss 21293372
esv3593306 CNV loss 21293372
esv5404 CNV loss 18987735
esv999027 CNV deletion 20482838
nsv1011828 CNV loss 25217958
nsv1072464 CNV deletion 25765185
nsv1138864 CNV deletion 24896259
nsv1148814 CNV deletion 26484159
nsv1149975 CNV deletion 26484159
nsv3022 CNV insertion 18451855
nsv459941 CNV gain 19166990
nsv476192 CNV novel sequence insertion 20440878
nsv478431 CNV novel sequence insertion 20440878
nsv478733 CNV novel sequence insertion 20440878
nsv522749 CNV loss 19592680
nsv523543 CNV loss 19592680
nsv583596 CNV gain 21841781
nsv583597 CNV gain 21841781
nsv956656 CNV deletion 24416366
nsv963745 CNV duplication 23825009

Variation tolerance for STK39 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.62; 94.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK39 Gene

Human Gene Mutation Database (HGMD)
STK39
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK39
Leiden Open Variation Database (LOVD)
STK39

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK39 Gene

Disorders for STK39 Gene

MalaCards: The human disease database

(18) MalaCards diseases for STK39 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search STK39 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STK39

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with STK39: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK39 Gene

Publications for STK39 Gene

  1. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (PMID: 19114657) Wang Y … Chang YP (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 40
  2. An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. (PMID: 18348195) Ramoz N … Buxbaum JD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 40
  3. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. (PMID: 10980603) Johnston AM … DeAizpurua HJ (Oncogene 2000) 2 3 4
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4
  5. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) International Parkinson Disease Genomics Consortium … Wood NW (Lancet (London, England) 2011) 3 40

Products for STK39 Gene

Sources for STK39 Gene