STK38L Gene (Protein Coding)

Serine/Threonine Kinase 38 Like

GC12P027243
GIFtS:
43
See more...

Aliases for STK38L Gene

Aliases for STK38L Gene

  • Serine/Threonine Kinase 38 Like 2 3 5
  • NDR2 2 3 4
  • Serine/Threonine-Protein Kinase 38-Like 3 4
  • Nuclear Dbf2-Related Kinase 2 3 4
  • Nuclear Dbf2-Related 2 2 3
  • NDR2 Protein Kinase 3 4
  • EC 2.7.11.1 4 51
  • KIAA0965 2 4
  • EC 2.7.11 51
  • STK38L 5

External Ids for STK38L Gene

Previous GeneCards Identifiers for STK38L Gene

  • GC12P027757
  • GC12P027408
  • GC12P027297
  • GC12P027288
  • GC12P027168
  • GC12P027396

Summaries for STK38L Gene

GeneCards Summary for STK38L Gene

STK38L (Serine/Threonine Kinase 38 Like) is a Protein Coding gene. Diseases associated with STK38L include Ossification Of The Posterior Longitudinal Ligament Of Spine and Warburg Micro Syndrome 3. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38.

UniProtKB/Swiss-Prot Summary for STK38L Gene

  • Involved in the regulation of structural processes in differentiating and mature neuronal cells.

Gene Wiki entry for STK38L Gene

Additional gene information for STK38L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK38L Gene

Genomics for STK38L Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for STK38L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK38L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK38L

Top Transcription factor binding sites by QIAGEN in the STK38L gene promoter:
  • AML1a
  • Evi-1
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • GATA-2
  • LyF-1
  • POU6F1 (c2)

Genomic Locations for STK38L Gene

Genomic Locations for STK38L Gene
chr12:27,243,968-27,325,959
(GRCh38/hg38)
Size:
81,992 bases
Orientation:
Plus strand
chr12:27,396,901-27,478,892
(GRCh37/hg19)
Size:
81,992 bases
Orientation:
Plus strand

Genomic View for STK38L Gene

Genes around STK38L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STK38L Gene

Proteins for STK38L Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for STK38L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H1-ST38L_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 38-like
    Protein Accession:
    Q9Y2H1
    Secondary Accessions:
    • A8K4U0
    • B4E3J8
    • Q8TBX7

    Protein attributes for STK38L Gene

    Size:
    464 amino acids
    Molecular mass:
    54003 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

    Three dimensional structures from OCA and Proteopedia for STK38L Gene

    Alternative splice isoforms for STK38L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK38L Gene

Protein Expression for STK38L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for STK38L Gene

Q9Y2H1:
  • KLSDFGLCTGLKK
  • SEKAKDLILRFC
  • RGAFGEVRLVQKKDTGH
  • CDWWSLG
  • KVIGRGAF
  • FQNMNSKRKAETWK
  • HRDIKPDN
  • ETVLAID
  • NLYLIMEFLPGGDMMTLLMKKDTL
  • PPFCSETPQETY
  • HARKETEFLRLKRTRLGL
  • HIRERPAAI
  • SIDDTSNFD
  • YAMKILRK
  • STVGTPDYIAPE
  • KVMNWKETL
  • GTPDYIAPE
  • HIRAERDILVEAD
  • TLENFYSNLI
  • WVVKMFYSFQDK
  • DMLEKEQV

Post-translational modifications for STK38L Gene

  • Ubiquitination at Lys378
  • Modification sites at PhosphoSitePlus

Other Protein References for STK38L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for STK38L Gene

Gene Families for STK38L Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK38L Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
ProtoNet:

Suggested Antigen Peptide Sequences for STK38L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50384, highly similar to Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (B4E3J8_HUMAN)
  • Nuclear Dbf2-related kinase 2 (ST38L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2H1

UniProtKB/Swiss-Prot:

ST38L_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38L: view

Function for STK38L Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for STK38L Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of structural processes in differentiating and mature neuronal cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.

Enzyme Numbers (IUBMB) for STK38L Gene

Phenotypes From GWAS Catalog for STK38L Gene

Gene Ontology (GO) - Molecular Function for STK38L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 15067004
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 15037617
genes like me logo Genes that share ontologies with STK38L: view
genes like me logo Genes that share phenotypes with STK38L: view

Animal Models for STK38L Gene

MGI Knock Outs for STK38L:
  • Stk38l Stk38l<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for STK38L

CRISPR Products

miRNA for STK38L Gene

miRTarBase miRNAs that target STK38L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK38L

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38L Gene

Localization for STK38L Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38L Gene

Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK38L gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK38L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15037617
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IEA,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STK38L: view

Pathways & Interactions for STK38L Gene

PathCards logo

SuperPathways for STK38L Gene

No Data Available

SIGNOR curated interactions for STK38L Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for STK38L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 15037617
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IDA 15067004
GO:0051128 regulation of cellular component organization IEA,ISS --
genes like me logo Genes that share ontologies with STK38L: view

No data available for Pathways by source for STK38L Gene

Drugs & Compounds for STK38L Gene

Products:

  1. Drug

(4) Drugs for STK38L Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Calcium Nutra 6556

(1) Additional Compounds for STK38L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with STK38L: view

Transcripts for STK38L Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for STK38L Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK38L

Alternative Splicing Database (ASD) splice patterns (SP) for STK38L Gene

No ASD Table

Relevant External Links for STK38L Gene

GeneLoc Exon Structure for
STK38L

Expression for STK38L Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK38L Gene

mRNA expression in normal human tissues for STK38L Gene
mRNA expression by BioGPS for STK38L GenemRNA expression by GTEx for STK38L Gene

mRNA differential expression in normal tissues according to GTEx for STK38L Gene

This gene is overexpressed in Artery - Aorta (x5.0) and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for STK38L Gene

This gene is overexpressed in Lymph node (10.3) and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK38L Gene



Protein tissue co-expression partners for STK38L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK38L

SOURCE GeneReport for Unigene cluster for STK38L Gene:

Hs.184523

mRNA Expression by UniProt/SwissProt for STK38L Gene:

Q9Y2H1-ST38L_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels observed in the thymus.

Evidence on tissue expression from TISSUES for STK38L Gene

  • Nervous system(3)
  • Heart(2.5)
  • Intestine(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with STK38L: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK38L Gene

Orthologs for STK38L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia STK38L 30 31
  • 99.64 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia STK38L 31
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia STK38L 30 31
  • 95.26 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia STK38L 30 31
  • 94.83 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia STK38L 31
  • 91 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Stk38l 30 17 31
  • 89.65 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Stk38l 30
  • 88.18 (n)
Chicken
(Gallus gallus)
 Aves STK38L 30 31
  • 83.83 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia STK38L 31
  • 96 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia stk38l 30
  • 77.63 (n)
Str.11890 30
Zebrafish
(Danio rerio)
 Actinopterygii stk38l 30 31
  • 76.4 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta trc 31 32
  • 68 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea sax-1 30 31 32
  • 62.2 (n)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D07810g 30
  • 57.86 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CBK1 30 31
  • 57.56 (n)
 OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFR035W 30
  • 55.3 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT4G33080 30
  • 56.37 (n)
Rice
(Oryza sativa)
 Liliopsida Os01g0186700 30
  • 56.78 (n)
Barley
(Hordeum vulgare)
 Liliopsida Hv.1876 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.6269 30
Corn
(Zea mays)
 Liliopsida Zm.5558 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 68 (a)
 OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes orb6 30
  • 55.91 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU07296 30
  • 51.62 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1672 30
Species where no ortholog for STK38L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STK38L Gene

ENSEMBL:
Gene Tree for STK38L (if available)
TreeFam:
Gene Tree for STK38L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK38L: view image

Paralogs for STK38L Gene

Paralogs for STK38L Gene

(67) SIMAP similar genes for STK38L Gene using alignment to 9 proteins:

  • ST38L_HUMAN
  • B4E3J8_HUMAN
  • F5GY51_HUMAN
  • F5H0V1_HUMAN
  • F5H277_HUMAN
  • F5H5E6_HUMAN
  • F5H7Z3_HUMAN
  • H0YGN4_HUMAN
  • I3L0D0_HUMAN
genes like me logo Genes that share paralogs with STK38L: view

Variants for STK38L Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK38L Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
728963 Likely Benign: not provided 27,322,413(+) A/G SYNONYMOUS_VARIANT
786605 Benign: not provided 27,297,738(+) G/T SYNONYMOUS_VARIANT
VAR_041199 - p.Gly99Ala

Additional dbSNP identifiers (rs#s) for STK38L Gene

Structural Variations from Database of Genomic Variants (DGV) for STK38L Gene

Variant ID Type Subtype PubMed ID
dgv1406n100 CNV gain 25217958
dgv2417n54 CNV gain 21841781
dgv263e214 CNV gain 21293372
dgv271e199 CNV deletion 23128226
dgv786n106 CNV deletion 24896259
esv1525868 CNV deletion 17803354
esv2395169 CNV deletion 18987734
esv2598897 CNV deletion 19546169
esv2667338 CNV deletion 23128226
esv2672021 CNV deletion 23128226
esv2745664 CNV deletion 23290073
esv2745667 CNV deletion 23290073
esv3253385 CNV deletion 24192839
esv3548925 CNV deletion 23714750
esv3628932 CNV loss 21293372
esv3628933 CNV gain 21293372
esv3628934 CNV loss 21293372
esv4652 CNV loss 18987735
esv7285 CNV loss 19470904
esv996338 CNV deletion 20482838
esv997751 CNV deletion 20482838
nsv1070100 CNV deletion 25765185
nsv436825 CNV insertion 17901297
nsv469175 CNV loss 19166990
nsv521872 CNV gain 19592680
nsv557808 CNV loss 21841781
nsv832356 CNV gain 17160897
nsv958659 CNV deletion 24416366
nsv975462 CNV duplication 23825009

Variation tolerance for STK38L Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK38L Gene

Human Gene Mutation Database (HGMD)
STK38L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK38L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38L Gene

Disorders for STK38L Gene

MalaCards: The human disease database

(5) MalaCards diseases for STK38L Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STK38L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STK38L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK38L Gene

Publications for STK38L Gene

  1. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. (PMID: 15037617) Stegert MR … Hemmings BA (The Journal of biological chemistry 2004) 3 4 23
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  3. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PMID: 16488889) Suzuki A … Esumi H (The Journal of biological chemistry 2006) 2 3
  4. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PMID: 16314523) Stegert MR … Hemmings BA (Molecular and cellular biology 2005) 3 4
  5. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. (PMID: 15582665) Devroe E … Engelman A (Virology 2005) 3 23

ExternalLinks

View latest publications for STK38L gene in Mastermind

Products for STK38L Gene

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