Aliases for STK38 Gene
External Ids for STK38 Gene
Previous GeneCards Identifiers for STK38 Gene
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for STK38 Gene
STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Diseases associated with STK38 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Sweet Taste Signaling and Interactome of polycomb repressive complex 2 (PRC2). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.
UniProtKB/Swiss-Prot Summary for STK38 Gene
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.