Aliases for STK38 Gene
Aliases for STK38 Gene
External Ids for STK38 Gene
- HGNC: 17847
- Entrez Gene: 11329
- Ensembl: ENSG00000112079
- OMIM: 606964
- UniProtKB: Q15208
Previous GeneCards Identifiers for STK38 Gene
- GC06M036463
- GC06M036508
- GC06M036569
- GC06M036461
- GC06M036180
Summaries for STK38 Gene
-
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for STK38 Gene
STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Interactome of polycomb repressive complex 2 (PRC2). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.
UniProtKB/Swiss-Prot for STK38 Gene
-
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38 Gene
Genomics for STK38 Gene
GeneHancer (GH) Regulatory Elements for STK38 Gene
Promoters and enhancers for STK38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STK38 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for STK38 Gene
Genomic Locations for STK38 Gene
- chr6:36,493,889-36,547,479
- (GRCh38/hg38)
- Size:
- 53,591 bases
- Orientation:
- Minus strand
- chr6:36,461,669-36,515,247
- (GRCh37/hg19)
Genomic View for STK38 Gene
Genes around STK38 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
STK38 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STK38 Gene
Proteins for STK38 Gene
-
Protein details for STK38 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15208-STK38_HUMAN
- Recommended name:
- Serine/threonine-protein kinase 38
- Protein Accession:
- Q15208
- Q503A1
Protein attributes for STK38 Gene
- Size:
- 465 amino acids
- Molecular mass:
- 54190 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and STK3/MST2.
Protein Expression for STK38 Gene
Selected DME Specific Peptides for STK38 Gene
- Q15208:
-
- KLSDFGLCTGLKK
- SEKAKDLILRFC
- RGAFGEVRLVQKKDTGH
- CDWWSLG
- KVIGRGAF
- YIAETVL
- FQNMNSKRKAETWK
- HRDIKPDN
- ETVLAID
- NLYLIMEFLPGGDMMTLLMKKDTL
- PPFCSETPQETY
- HARKETEFLRLKRTRLGL
- KDWVFINYTYKRFE
- HIRERPAAI
- SIDDTSNFD
- YAMKILRK
- STVGTPDYIAPE
- KVMNWKETL
- GTPDYIAPE
- HIRAERDILVEAD
- VLAIDSIHQL
- TLENFYSNLI
- WVVKMFYSFQDK
- DMLEKEQV
Post-translational modifications for STK38 Gene
- ISGylated.
- Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
Other Protein References for STK38 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for STK38
- Novus Biologicals Antibodies for STK38
-
Abcam antibodies for STK38
- Invitrogen Antibodies for STK38
- GeneTex STK38 antibody for STK38
-
Santa Cruz Biotechnology (SCBT) Antibodies for STK38
Protein Products
-
OriGene Purified Proteins for STK38
- Search Origene for MassSpec and Protein Over-expression Lysates for STK38
- Origene Custom Protein Services for STK38
- Search GeneTex for Proteins for STK38
-
Abcam proteins for STK38
Assay Products
Domains & Families for STK38 Gene
Gene Families for STK38 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for STK38 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STK38 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15208UniProtKB/Swiss-Prot:
STK38_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Function for STK38 Gene
Molecular function for STK38 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
- UniProtKB/Swiss-Prot Function:
- Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
Enzyme Numbers (IUBMB) for STK38 Gene
Phenotypes From GWAS Catalog for STK38 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 12493777 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 12493777 |
| GO:0005515 | protein binding | IPI | 9774336 |
| GO:0005524 | ATP binding | IDA | 12493777 |
Phenotypes for STK38 Gene
- MGI mutant phenotypes for STK38:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STK38:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased NF-kappaB reporter expression
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Misorientated spindle
- Decreased cell proliferation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased viability after TNF/CHX stimulation
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for STK38 Gene
- MGI Knock Outs for STK38:
-
- Stk38 tm1Xen
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STK38
-
-
ViGene Biosciences lentiviral particle packaged cDNA for STK38 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STK38 gene
- Search ViGene Biosciences for STK38
CRISPR Products
-
OriGene CRISPR knockouts for STK38
- genomics-online: gRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- Applied Biological Materials CRISPR for STK38
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK38
- GenScript: Design CRISPR guide RNA sequences for STK38
miRNA for STK38 Gene
- miRTarBase miRNAs that target STK38
-
- hsa-mir-124-3p (MIRT023042)
- hsa-mir-103a-3p (MIRT027196)
- hsa-mir-19b-3p (MIRT031271)
- hsa-mir-16-5p (MIRT031919)
- hsa-mir-454-3p (MIRT039243)
- hsa-let-7b-5p (MIRT052031)
- hsa-mir-4298 (MIRT466902)
- hsa-mir-8061 (MIRT466903)
- hsa-mir-4760-5p (MIRT466904)
- hsa-mir-4665-5p (MIRT466905)
- hsa-mir-1275 (MIRT466906)
- hsa-mir-503-3p (MIRT466907)
- hsa-mir-5010-5p (MIRT466908)
- hsa-mir-4525 (MIRT466909)
- hsa-mir-7111-5p (MIRT466910)
- hsa-mir-6870-5p (MIRT466911)
- hsa-mir-5698 (MIRT466912)
- hsa-mir-4723-5p (MIRT466913)
- hsa-mir-625-5p (MIRT466914)
- hsa-mir-107 (MIRT466915)
- hsa-mir-548e-5p (MIRT466916)
- hsa-mir-15a-5p (MIRT466917)
- hsa-mir-15b-5p (MIRT466918)
- hsa-mir-195-5p (MIRT466919)
- hsa-mir-424-5p (MIRT466920)
- hsa-mir-6838-5p (MIRT466921)
- hsa-mir-497-5p (MIRT466922)
- hsa-mir-3658 (MIRT698784)
- hsa-mir-3156-3p (MIRT698785)
- hsa-mir-1260b (MIRT698786)
- hsa-mir-1260a (MIRT698787)
- hsa-mir-188-3p (MIRT698788)
- hsa-mir-4742-5p (MIRT698789)
- hsa-mir-548o-3p (MIRT698790)
- hsa-mir-1323 (MIRT698791)
- hsa-mir-1322 (MIRT698792)
- hsa-mir-101-5p (MIRT698793)
- hsa-mir-5692a (MIRT698794)
- hsa-mir-5582-3p (MIRT698795)
- hsa-mir-19a-3p (MIRT698796)
- hsa-mir-887-5p (MIRT698797)
- hsa-mir-6780a-5p (MIRT698798)
- hsa-mir-6779-5p (MIRT698799)
- hsa-mir-3689c (MIRT698800)
- hsa-mir-3689b-3p (MIRT698801)
- hsa-mir-3689a-3p (MIRT698802)
- hsa-mir-30b-3p (MIRT698803)
- hsa-mir-1273h-5p (MIRT698804)
- hsa-mir-6788-5p (MIRT698805)
- hsa-mir-30c-2-3p (MIRT698806)
- hsa-mir-30c-1-3p (MIRT698807)
- hsa-mir-4425 (MIRT698808)
- hsa-mir-8085 (MIRT698809)
- hsa-mir-6731-5p (MIRT698810)
- hsa-mir-6878-5p (MIRT698811)
- hsa-mir-4644 (MIRT698812)
- hsa-mir-4306 (MIRT698813)
- hsa-mir-185-5p (MIRT698814)
- hsa-mir-1468-3p (MIRT698815)
- hsa-mir-145-3p (MIRT698816)
- hsa-mir-1253 (MIRT698817)
- hsa-mir-4698 (MIRT698818)
- hsa-mir-4259 (MIRT698819)
- hsa-mir-561-3p (MIRT698820)
- hsa-mir-548at-5p (MIRT698821)
- hsa-mir-433-3p (MIRT698822)
miRNA Products
- Search ViGene Biosciences for STK38
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- genomics-online: shRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STK38 gene
Clone Products
- Sino Biological Human cDNA Clone for STK38
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STK38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK38
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK38
- Applied Biological Materials Clones for STK38
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for STK38
-
ViGene Biosciences adenoviral particle packaged cDNA for STK38 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STK38 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STK38 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38 Gene
Localization for STK38 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12493777 |
| GO:0005737 | cytoplasm | IEA,IDA | 17906693 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for STK38 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Interactome of polycomb repressive complex 2 (PRC2) | ||
Pathways by source for STK38 Gene
1 BioSystems pathway for STK38 Gene
1 Qiagen pathway for STK38 Gene
Interacting Proteins for STK38 Gene
Selected Interacting proteins:
ENSP00000229812
Q15208-STK38_HUMAN
for STK38 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | IDA | 7761441 |
| GO:0006468 | protein phosphorylation | IDA | 12493777 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IBA | -- |
| GO:0035556 | intracellular signal transduction | IDA | 12493777 |
Drugs & Compounds for STK38 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for STK38 Gene
mRNA/cDNA for STK38 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (259) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STK38 Gene
CRISPR Products
-
OriGene CRISPR knockouts for STK38
- genomics-online: gRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- Applied Biological Materials CRISPR for STK38
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK38
- GenScript: Design CRISPR guide RNA sequences for STK38
miRNA Products
- Search ViGene Biosciences for STK38
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- genomics-online: shRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STK38 gene
Clone Products
- Sino Biological Human cDNA Clone for STK38
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STK38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK38
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK38
- Applied Biological Materials Clones for STK38
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for STK38 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for STK38 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK38 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STK38 Gene:
STK38SOURCE GeneReport for Unigene cluster for STK38 Gene:
Hs.409578mRNA Expression by UniProt/SwissProt for STK38 Gene:
Q15208-STK38_HUMAN
Tissue specificity:
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for STK38 Gene
- Nervous system(2.4)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for STK38
-
OriGene qPCR primer pairs and template standards for STK38
- genomics-online: primer clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK38 Gene
Orthologs for STK38 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STK38 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | STK38 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | STK38 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Stk38 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STK38 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STK38 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | STK38 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stk38 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | trc-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stk38b 34 |
|
OneToMany | |
| stk38a 33 34 |
|
||||
| Dr.18403 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | trc 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005521 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sax-1 35 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CBK1 34 36 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G09890 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.15237 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.21326 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for STK38 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for STK38 Gene
Paralogs for STK38 Gene
(31) SIMAP similar genes for STK38 Gene using alignment to 1 proteins:
Variants for STK38 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041196 | A metastatic melanoma sample | p.Glu18Lys | |||
| rs1000047316 | -- | 36,495,032(-) | A/G | 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant | |
| rs1000076522 | -- | 36,549,372(-) | T/C | upstream_transcript_variant | |
| rs1000090681 | -- | 36,500,620(-) | C/T | intron_variant | |
| rs1000122125 | -- | 36,541,190(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.20;
96.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STK38 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STK38
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38 Gene
Disorders for STK38 Gene
Additional Disease Information for STK38
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for STK38 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK38 Gene
Publications for STK38 Gene
- Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S … Hata Y (Oncogene 2008) 3 4 22 58
- Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A … Miyagawa K (Oncogene 2008) 3 4 22 58
- Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel SJ … Hemmings BA (The Journal of biological chemistry 2004) 3 4 22 58
- Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. (PMID: 7761441) Millward T … Hemmings BA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 58
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
Products for STK38 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for STK38
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for STK38
- Search Origene for MassSpec and Protein Over-expression Lysates for STK38
- Origene Custom Protein Services for STK38
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- OriGene qPCR primer pairs and template standards for STK38
- OriGene qPCR primer pairs for STK38
- OriGene CRISPR knockouts for STK38
- OriGene ORF clones in human for STK38
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STK38
- GenScript: Next-day shipping of latest version cDNA ORF clones for STK38 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STK38
- GenScript Custom Assay Services for STK38
- GenScript Custom overexpressing Cell Line Services for STK38
- GenScript: Design CRISPR guide RNA sequences for STK38
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STK38
- Sino Biological Human cDNA Clone for STK38
- Browse Sino Biological Cell Lysates
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for STK38
- Novus Biologicals lysates and proteins for STK38
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for STK38
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for STK38
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for STK38
- VectorBuilder custom plasmid, inducible vectors for STK38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STK38
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STK38
- antibodies-online: Search results for 122 available STK38 Antibodies ranked by validation data
- Compare Top STK38 Antibodies
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- antibodies-online: Search results for available STK38 related products ranked by validation data
- antibodies-online: Search results for 11 available STK38 Proteins ranked by validation data
- Compare Top STK38 Proteins
- GeneTex STK38 antibody for STK38
- Search GeneTex for Proteins for STK38
- ViGene Biosciences adenoviral particle packaged cDNA for STK38 gene
- ViGene Biosciences lentiviral particle packaged cDNA for STK38 gene
- ViGene Biosciences ready-to-package AAV shRNAs for STK38 gene
- Search ViGene Biosciences for STK38
- Santa Cruz Biotechnology (SCBT) Antibodies for STK38
- Search Santa Cruz Biotechnology (SCBT) for STK38 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STK38
- Horizon Cell Lines for STK38
- genomics-online: cdna clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- orf clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- genomics-online: gRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- genomics-online: primer clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
- genomics-online: shRNA clones - Search results for 122 available STK38 gene related products
- Overview of 122 available STK38 gene related products
Sources for STK38 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102)