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This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC... See more...
Aliases for STK38 Gene
Aliases for STK38 Gene
External Ids for STK38 Gene
- HGNC: 17847
- Entrez Gene: 11329
- Ensembl: ENSG00000112079
- OMIM: 606964
- UniProtKB: Q15208
Previous GeneCards Identifiers for STK38 Gene
- GC06M036463
- GC06M036508
- GC06M036569
- GC06M036461
- GC06M036180
Summaries for STK38 Gene
-
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for STK38 Gene
STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Diseases associated with STK38 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Sweet Taste Signaling and Interactome of polycomb repressive complex 2 (PRC2). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.
UniProtKB/Swiss-Prot Summary for STK38 Gene
-
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
Additional gene information for STK38 Gene
- HGNC(17847)
- Entrez Gene(11329)
- Ensembl(ENSG00000112079)
- OMIM(606964)
- UniProtKB(Q15208)
- Open Targets Platform(ENSG00000112079)
- Search for STK38 at DataMed
- Search for STK38 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK38 Gene
Genomics for STK38 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STK38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STK38 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK38
- Top Transcription factor binding sites by QIAGEN in the STK38 gene promoter:
-
- AML1a
- Cart-1
- CUTL1
- GATA-6
- Pax-3
- Pax-4a
- RORalpha1
Genomic Locations for STK38 Gene
Genomic Locations for STK38 Gene
- chr6:36,493,889-36,547,479
- (GRCh38/hg38)
- Size:
- 53,591 bases
- Orientation:
- Minus strand
- chr6:36,461,669-36,515,247
- (GRCh37/hg19)
- Size:
- 53,579 bases
- Orientation:
- Minus strand
Genomic View for STK38 Gene
Genes around STK38 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by HGNC
- 6p21.31 by Entrez Gene
- 6p21.31 by Ensembl
STK38 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STK38 Gene
Proteins for STK38 Gene
-
Protein details for STK38 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15208-STK38_HUMAN
- Recommended name:
- Serine/threonine-protein kinase 38
- Protein Accession:
- Q15208
- Q503A1
Protein attributes for STK38 Gene
- Size:
- 465 amino acids
- Molecular mass:
- 54190 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimeric S100B binds two molecules of STK38 (PubMed:14661952). Interacts with MOB1 and MOB2 (PubMed:15067004, PubMed:15197186). Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain) (PubMed:17906693). Forms a tripartite complex with MOBKL1B and STK3/MST2 (PubMed:18362890). Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity).
Protein Expression for STK38 Gene
Selected DME Specific Peptides for STK38 Gene
- Q15208:
-
- KLSDFGLCTGLKK
- SEKAKDLILRFC
- RGAFGEVRLVQKKDTGH
- CDWWSLG
- KVIGRGAF
- YIAETVL
- FQNMNSKRKAETWK
- HRDIKPDN
- ETVLAID
- NLYLIMEFLPGGDMMTLLMKKDTL
- PPFCSETPQETY
- HARKETEFLRLKRTRLGL
- KDWVFINYTYKRFE
- HIRERPAAI
- SIDDTSNFD
- YAMKILRK
- STVGTPDYIAPE
- KVMNWKETL
- GTPDYIAPE
- HIRAERDILVEAD
- VLAIDSIHQL
- TLENFYSNLI
- WVVKMFYSFQDK
- DMLEKEQV
Post-translational modifications for STK38 Gene
- ISGylated.
- Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for STK38 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences STK38 Monoclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for STK38
- Novus Biologicals Antibodies for STK38
-
Abcam antibodies for STK38
- Invitrogen Antibodies for STK38 (AFLGC-STK38)
-
Boster Bio Antibodies for STK38
-
Santa Cruz Biotechnology (SCBT) Antibodies for STK38
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STK38
- Origene Custom Protein Services for STK38
-
Abcam proteins for STK38
Domains & Families for STK38 Gene
Gene Families for STK38 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for STK38 Gene
- InterPro:
- Blocks:
-
- Protein kinase C-terminal domain
- ProtoNet:
Suggested Antigen Peptide Sequences for STK38 Gene
- GenScript: Design optimal peptide antigens:
-
- Nuclear Dbf2-related kinase 1 (STK38_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15208UniProtKB/Swiss-Prot:
STK38_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Function for STK38 Gene
Molecular function for STK38 Gene
- UniProtKB/Swiss-Prot Function:
- Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
Enzyme Numbers (IUBMB) for STK38 Gene
Phenotypes From GWAS Catalog for STK38 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 12493777 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 12493777 |
| GO:0005515 | protein binding | IPI | 9774336 |
Phenotypes for STK38 Gene
- MGI mutant phenotypes for STK38:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for STK38:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Decreased cell migration
- Decreased NF-kappaB reporter expression
- Increased Salmonella enterica Typhimurium invasion
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased ionizing radiation sensitivity
- Decreased viability in colon lineage
- Misorientated spindle
- Increased viability after TNF/CHX stimulation
- Decreased replication of vaccinia virus (VACV)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased cell–culture–derived Hepatitis C virus (HCVcc; Luc–Jc1) infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation, increased cell spreading
- Decreased cell proliferation
Animal Models for STK38 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for STK38
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STK38 - Select products 50% OFF >
- * STK38 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STK38
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK38
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK38
miRNA for STK38 Gene
- miRTarBase miRNAs that target STK38
-
- mmu-miR-425-5p (MIRT008640)
- mmu-miR-15a-5p (MIRT011751)
- mmu-miR-24-3p (MIRT013867)
- mmu-miR-149-5p (MIRT014707)
- hsa-miR-124-3p (MIRT023042)
- hsa-miR-103a-3p (MIRT027196)
- hsa-miR-19b-3p (MIRT031271)
- hsa-miR-16-5p (MIRT031919)
- hsa-miR-454-3p (MIRT039243)
- hsa-let-7b-5p (MIRT052031)
- hsa-miR-4298 (MIRT466902)
- hsa-miR-8061 (MIRT466903)
- hsa-miR-4760-5p (MIRT466904)
- hsa-miR-4665-5p (MIRT466905)
- hsa-miR-1275 (MIRT466906)
- hsa-miR-503-3p (MIRT466907)
- hsa-miR-5010-5p (MIRT466908)
- hsa-miR-4525 (MIRT466909)
- hsa-miR-7111-5p (MIRT466910)
- hsa-miR-6870-5p (MIRT466911)
- hsa-miR-5698 (MIRT466912)
- hsa-miR-4723-5p (MIRT466913)
- hsa-miR-625-5p (MIRT466914)
- hsa-miR-107 (MIRT466915)
- hsa-miR-548e-5p (MIRT466916)
- hsa-miR-15a-5p (MIRT466917)
- hsa-miR-15b-5p (MIRT466918)
- hsa-miR-195-5p (MIRT466919)
- hsa-miR-424-5p (MIRT466920)
- hsa-miR-6838-5p (MIRT466921)
- hsa-miR-497-5p (MIRT466922)
- hsa-miR-3658 (MIRT698784)
- hsa-miR-3156-3p (MIRT698785)
- hsa-miR-1260b (MIRT698786)
- hsa-miR-1260a (MIRT698787)
- hsa-miR-188-3p (MIRT698788)
- hsa-miR-4742-5p (MIRT698789)
- hsa-miR-548o-3p (MIRT698790)
- hsa-miR-1323 (MIRT698791)
- hsa-miR-1322 (MIRT698792)
- hsa-miR-101-5p (MIRT698793)
- hsa-miR-5692a (MIRT698794)
- hsa-miR-5582-3p (MIRT698795)
- hsa-miR-19a-3p (MIRT698796)
- hsa-miR-887-5p (MIRT698797)
- hsa-miR-6780a-5p (MIRT698798)
- hsa-miR-6779-5p (MIRT698799)
- hsa-miR-3689c (MIRT698800)
- hsa-miR-3689b-3p (MIRT698801)
- hsa-miR-3689a-3p (MIRT698802)
- hsa-miR-30b-3p (MIRT698803)
- hsa-miR-1273h-5p (MIRT698804)
- hsa-miR-6788-5p (MIRT698805)
- hsa-miR-30c-2-3p (MIRT698806)
- hsa-miR-30c-1-3p (MIRT698807)
- hsa-miR-4425 (MIRT698808)
- hsa-miR-8085 (MIRT698809)
- hsa-miR-6731-5p (MIRT698810)
- hsa-miR-6878-5p (MIRT698811)
- hsa-miR-4644 (MIRT698812)
- hsa-miR-4306 (MIRT698813)
- hsa-miR-185-5p (MIRT698814)
- hsa-miR-1468-3p (MIRT698815)
- hsa-miR-145-3p (MIRT698816)
- hsa-miR-1253 (MIRT698817)
- hsa-miR-4698 (MIRT698818)
- hsa-miR-4259 (MIRT698819)
- hsa-miR-561-3p (MIRT698820)
- hsa-miR-548at-5p (MIRT698821)
- hsa-miR-433-3p (MIRT698822)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK38
Clone Products
- Applied Biological Materials (abm): Clones for STK38 - Select products 50% OFF >
- * STK38 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for STK38
- Addgene plasmids for STK38
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK38
Cell Line Products
-
Horizon Cell Lines for STK38
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38 Gene
Localization for STK38 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12493777 |
| GO:0005737 | cytoplasm | IEA,IDA | 17906693 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for STK38 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
Sperm Motility
.37
|
|
| 2 | Interactome of polycomb repressive complex 2 (PRC2) | ||
Pathways by source for STK38 Gene
1 BioSystems pathway for STK38 Gene
1 Qiagen pathway for STK38 Gene
- Sperm Motility
Interacting Proteins for STK38 Gene
Selected Interacting proteins:
Q15208-STK38_HUMAN
ENSP00000229812
for STK38 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STK38
SIGNOR curated interactions for STK38 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | IDA | 7761441 |
| GO:0006468 | protein phosphorylation | IDA | 12493777 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IBA | 21873635 |
| GO:0035556 | intracellular signal transduction | IDA | 12493777 |
Drugs & Compounds for STK38 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| Calcium | Nutra | 6556 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for STK38 Gene
mRNA/cDNA for STK38 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000229812 3585 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STK38 - Select products 50% OFF >
- * STK38 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STK38
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK38
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK38
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK38
Clone Products
- Applied Biological Materials (abm): Clones for STK38 - Select products 50% OFF >
- * STK38 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for STK38
- Addgene plasmids for STK38
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK38
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for STK38 Gene
- GeneLoc Exon Structure for
- STK38
Expression for STK38 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for STK38 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK38 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK38
SOURCE GeneReport for Unigene cluster for STK38 Gene:
Hs.409578mRNA Expression by UniProt/SwissProt for STK38 Gene:
Q15208-STK38_HUMAN
Tissue specificity:
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for STK38 Gene
- Nervous system(3.2)
- Blood(2.8)
- Intestine(2.5)
- Kidney(2.4)
- Skin(2.3)
- Spleen(2.2)
- Heart(2.2)
- Liver(2.1)
- Lung(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for STK38
-
OriGene qPCR primer pairs and template standards for STK38
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK38 Gene
Orthologs for STK38 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STK38 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | STK38 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STK38 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Stk38 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STK38 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STK38 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STK38 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stk38 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | trc-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | stk38b 31 |
|
OneToMany | |
| stk38a 30 31 |
|
OneToMany | |||
| Dr.18403 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | trc 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005521 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | sax-1 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CBK1 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G09890 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.15237 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os.21326 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for STK38 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STK38 Gene
- ENSEMBL:
- Gene Tree for STK38 (if available)
- TreeFam:
- Gene Tree for STK38 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STK38: view image
Paralogs for STK38 Gene
(31) SIMAP similar genes for STK38 Gene using alignment to 1 proteins:
- STK38_HUMAN
Variants for STK38 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK38 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 689595 | Uncertain Significance: Primary dilated cardiomyopathy | 36,524,424(-) | C/CT | FRAMESHIFT_VARIANT | |
| 708434 | Benign: not provided | 36,497,788(-) | T/C | SYNONYMOUS_VARIANT | |
| 720945 | Benign: not provided | 36,524,406(-) | T/G | SYNONYMOUS_VARIANT | |
| VAR_041196 | A metastatic melanoma sample | p.Glu18Lys | |||
| rs56005153 | - | p.Asp145Asn |
Residual Variation Intolerance Score:
16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.20;
96.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STK38 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STK38
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38 Gene
Disorders for STK38 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilson-turner x-linked mental retardation syndrome |
|
|
| myeloproliferative syndrome, transient |
|
|
Search STK38 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STK38
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STK38 Gene
Publications for STK38 Gene
- Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A … Miyagawa K (Oncogene 2008) 3 4 23
- Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S … Hata Y (Oncogene 2008) 3 4 23
- Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel SJ … Hemmings BA (The Journal of biological chemistry 2004) 3 4 23
- Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. (PMID: 7761441) Millward T … Hemmings BA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 41
ExternalLinks
Products for STK38 Gene
- Custom Antibody ServicesOriGene Antibodies for STK38
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STK38
- Origene Custom Protein Services for STK38
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK38
- Browse OriGene Inhibitory RNA Products For STK38
- OriGene qPCR primer pairs for STK38
- OriGene qPCR primer pairs and template standards for STK38
- OriGene CRISPR knockouts for STK38
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STK38
- Sino Biological Human cDNA Clone for STK38
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STK38
- Novus Biologicals proteins and lysates for STK38
- Browse Antibodies
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- Abcam proteins for STK38
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- Taconic Biosciences Mouse Models for STK38
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for STK38 (AFLGC-STK38)
- VectorBuilder Custom and pre-made DNA vectors for STK38 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for STK38 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for STK38 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for STK38 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STK38
- Addgene plasmids for STK38
- antibodies-online: Show 31 available STK38 Antibodies ranked by validation data
- Compare Top STK38 Antibodies
- Quality Products:
- antibodies-online: Search results for available STK38 related products ranked by validation data
- antibodies-online: Show 11 available STK38 Proteins ranked by validation data
- Compare Top STK38 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for STK38
- Search Santa Cruz Biotechnology (SCBT) for STK38 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STK38
- Horizon Cell Lines for STK38
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK38
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK38
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STK38
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK38
- Boster Bio Antibodies for STK38
- Browse Boster Bio ELISA Kits
Sources for STK38 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108)