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This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Diseases associated with STK38 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Sweet Taste Signaling and Interactome of polycomb repressive complex 2 (PRC2). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 12493777 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 12493777 |
GO:0005515 | protein binding | IPI | 9774336 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 12493777 |
GO:0005737 | cytoplasm | IEA,IDA | 17906693 |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sweet Taste Signaling |
Sperm Motility
.37
|
|
2 | Interactome of polycomb repressive complex 2 (PRC2) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006464 | cellular protein modification process | IDA | 7761441 |
GO:0006468 | protein phosphorylation | IDA | 12493777 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0018105 | peptidyl-serine phosphorylation | IBA | 21873635 |
GO:0035556 | intracellular signal transduction | IDA | 12493777 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STK38 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | STK38 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STK38 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stk38 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | STK38 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STK38 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STK38 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stk38 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | trc-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stk38b 31 |
|
OneToMany | |
stk38a 30 31 |
|
OneToMany | |||
Dr.18403 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | trc 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005521 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | sax-1 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CBK1 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G09890 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.15237 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.21326 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
689595 | Uncertain Significance: Primary dilated cardiomyopathy | 36,524,424(-) | C/CT | FRAMESHIFT_VARIANT | |
708434 | Benign: not provided | 36,497,788(-) | T/C | SYNONYMOUS_VARIANT | |
720945 | Benign: not provided | 36,524,406(-) | T/G | SYNONYMOUS_VARIANT | |
VAR_041196 | A metastatic melanoma sample | p.Glu18Lys | |||
rs56005153 | - | p.Asp145Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
wilson-turner x-linked mental retardation syndrome |
|
|
myeloproliferative syndrome, transient |
|
|