This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC... See more...

Aliases for STK38 Gene

Aliases for STK38 Gene

  • Serine/Threonine Kinase 38 2 3 5
  • Serine/Threonine-Protein Kinase 38 3 4
  • Nuclear Dbf2-Related Kinase 1 3 4
  • NDR1 Protein Kinase 3 4
  • EC 2.7.11.1 4 52
  • NDR1 3 4
  • Ndr Ser/Thr Kinase-Like Protein 3
  • Nuclear Dbf2-Related 1 2
  • EC 2.7.11 52
  • NDR 3

External Ids for STK38 Gene

Previous GeneCards Identifiers for STK38 Gene

  • GC06M036463
  • GC06M036508
  • GC06M036569
  • GC06M036461
  • GC06M036180

Summaries for STK38 Gene

Entrez Gene Summary for STK38 Gene

  • This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for STK38 Gene

STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Diseases associated with STK38 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Sweet Taste Signaling and Interactome of polycomb repressive complex 2 (PRC2). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot Summary for STK38 Gene

  • Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Gene Wiki entry for STK38 Gene

Additional gene information for STK38 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK38 Gene

Genomics for STK38 Gene

GeneHancer (GH) Regulatory Elements for STK38 Gene

Promoters and enhancers for STK38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK38 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK38

Top Transcription factor binding sites by QIAGEN in the STK38 gene promoter:
  • AML1a
  • Cart-1
  • CUTL1
  • GATA-6
  • Pax-3
  • Pax-4a
  • RORalpha1

Genomic Locations for STK38 Gene

Genomic Locations for STK38 Gene
chr6:36,493,889-36,547,479
(GRCh38/hg38)
Size:
53,591 bases
Orientation:
Minus strand
chr6:36,461,669-36,515,247
(GRCh37/hg19)
Size:
53,579 bases
Orientation:
Minus strand

Genomic View for STK38 Gene

Genes around STK38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38 Gene

Proteins for STK38 Gene

  • Protein details for STK38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15208-STK38_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 38
    Protein Accession:
    Q15208
    Secondary Accessions:
    • Q503A1

    Protein attributes for STK38 Gene

    Size:
    465 amino acids
    Molecular mass:
    54190 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimeric S100B binds two molecules of STK38 (PubMed:14661952). Interacts with MOB1 and MOB2 (PubMed:15067004, PubMed:15197186). Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain) (PubMed:17906693). Forms a tripartite complex with MOBKL1B and STK3/MST2 (PubMed:18362890). Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for STK38 Gene

neXtProt entry for STK38 Gene

Selected DME Specific Peptides for STK38 Gene

Q15208:
  • KLSDFGLCTGLKK
  • SEKAKDLILRFC
  • RGAFGEVRLVQKKDTGH
  • CDWWSLG
  • KVIGRGAF
  • YIAETVL
  • FQNMNSKRKAETWK
  • HRDIKPDN
  • ETVLAID
  • NLYLIMEFLPGGDMMTLLMKKDTL
  • PPFCSETPQETY
  • HARKETEFLRLKRTRLGL
  • KDWVFINYTYKRFE
  • HIRERPAAI
  • SIDDTSNFD
  • YAMKILRK
  • STVGTPDYIAPE
  • KVMNWKETL
  • GTPDYIAPE
  • HIRAERDILVEAD
  • VLAIDSIHQL
  • TLENFYSNLI
  • WVVKMFYSFQDK
  • DMLEKEQV

Post-translational modifications for STK38 Gene

Other Protein References for STK38 Gene

Domains & Families for STK38 Gene

Gene Families for STK38 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK38 Gene

Blocks:
  • Protein kinase C-terminal domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STK38 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear Dbf2-related kinase 1 (STK38_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15208

UniProtKB/Swiss-Prot:

STK38_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38: view

Function for STK38 Gene

Molecular function for STK38 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.

Enzyme Numbers (IUBMB) for STK38 Gene

Phenotypes From GWAS Catalog for STK38 Gene

Gene Ontology (GO) - Molecular Function for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12493777
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IBA 12493777
GO:0005515 protein binding IPI 9774336
GO:0005524 ATP binding IDA 12493777
genes like me logo Genes that share ontologies with STK38: view
genes like me logo Genes that share phenotypes with STK38: view

Animal Models for STK38 Gene

MGI Knock Outs for STK38:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK38

CRISPR Products

miRNA for STK38 Gene

miRTarBase miRNAs that target STK38

Clone Products

  • Addgene plasmids for STK38

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38 Gene

Localization for STK38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK38 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12493777
GO:0005737 cytoplasm IDA,IEA 17906693
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STK38: view

Pathways & Interactions for STK38 Gene

PathCards logo

SuperPathways for STK38 Gene

genes like me logo Genes that share pathways with STK38: view

Pathways by source for STK38 Gene

1 BioSystems pathway for STK38 Gene
1 Qiagen pathway for STK38 Gene
  • Sperm Motility

SIGNOR curated interactions for STK38 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 7761441
GO:0006468 protein phosphorylation IDA 12493777
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IDA 12493777
genes like me logo Genes that share ontologies with STK38: view

Drugs & Compounds for STK38 Gene

(4) Drugs for STK38 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Calcium Approved Nutra 7884
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK38: view

Transcripts for STK38 Gene

mRNA/cDNA for STK38 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for STK38

Alternative Splicing Database (ASD) splice patterns (SP) for STK38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7:

Relevant External Links for STK38 Gene

GeneLoc Exon Structure for
STK38

Expression for STK38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK38 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for STK38 Gene

This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK38 Gene



Protein tissue co-expression partners for STK38 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK38

SOURCE GeneReport for Unigene cluster for STK38 Gene:

Hs.409578

mRNA Expression by UniProt/SwissProt for STK38 Gene:

Q15208-STK38_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for STK38 Gene

  • Nervous system(2.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with STK38: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK38 Gene

Orthologs for STK38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK38 31 30
  • 99.93 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia STK38 31 30
  • 96.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STK38 31 30
  • 96.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stk38 17 31 30
  • 92.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK38 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK38 31 30
  • 84.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK38 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38 30
  • 78.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia trc-prov 30
zebrafish
(Danio rerio)
Actinopterygii stk38b 31
  • 89 (a)
OneToMany
stk38a 31 30
  • 76.85 (n)
OneToMany
Dr.18403 30
fruit fly
(Drosophila melanogaster)
Insecta trc 31 32 30
  • 64.59 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005521 30
  • 62.8 (n)
worm
(Caenorhabditis elegans)
Secernentea sax-1 31 32
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 33 31
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09890 30
  • 53.15 (n)
soybean
(Glycine max)
eudicotyledons Gma.15237 30
rice
(Oryza sativa)
Liliopsida Os.21326 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 67 (a)
OneToMany
Species where no ortholog for STK38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK38 Gene

ENSEMBL:
Gene Tree for STK38 (if available)
TreeFam:
Gene Tree for STK38 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK38: view image

Paralogs for STK38 Gene

Paralogs for STK38 Gene

genes like me logo Genes that share paralogs with STK38: view

Variants for STK38 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK38 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
689595 Uncertain Significance: Primary dilated cardiomyopathy 36,524,424(-) C/CT FRAMESHIFT_VARIANT
VAR_041196 A metastatic melanoma sample p.Glu18Lys
rs56005153 - p.Asp145Asn
rs56105564 - p.Lys267Arg

Additional dbSNP identifiers (rs#s) for STK38 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK38 Gene

Variant ID Type Subtype PubMed ID
nsv473402 CNV novel sequence insertion 20440878
nsv5260 CNV deletion 18451855

Variation tolerance for STK38 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.20; 96.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK38

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38 Gene

Disorders for STK38 Gene