Aliases for STK33 Gene

Aliases for STK33 Gene

  • Serine/Threonine Kinase 33 2 3 5
  • Serine/Threonine-Protein Kinase 33 3 4
  • EC 4
  • EC 2.7.11 51
  • STK33 5

External Ids for STK33 Gene

Previous GeneCards Identifiers for STK33 Gene

  • GC11M009197
  • GC11M008873
  • GC11M008372
  • GC11M008377
  • GC11M008369
  • GC11M008081

Summaries for STK33 Gene

GeneCards Summary for STK33 Gene

STK33 (Serine/Threonine Kinase 33) is a Protein Coding gene. Diseases associated with STK33 include Lung Large Cell Carcinoma and Tyrosinemia, Type Iii. Among its related pathways are Sweet Taste Signaling and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK1.

UniProtKB/Swiss-Prot Summary for STK33 Gene

  • Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK33 Gene

Genomics for STK33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STK33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J008593 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 619.7 +0.1 89 2 GATAD2A TFE3 RFX1 RFX5 POLR2A BACH1 LARP7 ZNF143 RBFOX2 PATZ1 STK33 lnc-TRIM66-5 lnc-TRIM66-6 AKIP1 TMEM9B-AS1 LMO1
GH11J008551 Promoter 0.3 EPDnew 600.3 +42.4 42351 0.1 STK33 ENSG00000252778 RF00017-853 lnc-TRIM66-5 lnc-TRIM66-6 LMO1
GH11J008681 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 -91.5 -91512 8.8 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 SIX5 SNORA3B RPL27A MN309327 NONHSAG007593.2-002 SNORA3A piR-38755-001 piR-31701 TRIM66 EIF3F ZNF143
GH11J008532 Enhancer 0.8 Ensembl ENCODE 21.8 +60.9 60888 1.2 PRDM1 RELA RAD21 IKZF2 TRIM22 EED ARID3A RELB RUNX3 NFE2 STK33 ENSG00000252778 RF00017-853 piR-54764-072 lnc-TRIM66-5 lnc-TRIM66-6 LMO1
GH11J008384 Enhancer 0.9 Ensembl ENCODE 18.9 +209.7 209698 0.8 CTCF LEF1 JUND PHB2 PKNOX1 REST NR2C1 DPF2 HDAC1 SOX6 STK33 TRIM66 piR-61289-012 HSALNG0082550 LMO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK33

Top Transcription factor binding sites by QIAGEN in the STK33 gene promoter:
  • ATF-2
  • c-Jun
  • c-Myb
  • FAC1
  • FOXO4
  • GR
  • GR-alpha
  • GR-beta
  • POU2F1
  • POU2F1a

Genomic Locations for STK33 Gene

Genomic Locations for STK33 Gene
259,261 bases
Minus strand
202,419 bases
Minus strand

Genomic View for STK33 Gene

Genes around STK33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK33 Gene

Proteins for STK33 Gene

  • Protein details for STK33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 33
    Protein Accession:
    Secondary Accessions:
    • Q658S6
    • Q8NEF5

    Protein attributes for STK33 Gene

    514 amino acids
    Molecular mass:
    57831 Da
    Quaternary structure:
    • Interacts with VIME.

    Alternative splice isoforms for STK33 Gene


neXtProt entry for STK33 Gene

Selected DME Specific Peptides for STK33 Gene


Post-translational modifications for STK33 Gene

Domains & Families for STK33 Gene

Gene Families for STK33 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK33 Gene

Suggested Antigen Peptide Sequences for STK33 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58445, highly similar to Serine/threonine-protein kinase 33 (EC (B4DDH2_HUMAN)
  • Serine/threonine kinase 33, isoform CRA_a (D3DQU7_HUMAN)
  • Serine/threonine-protein kinase 33 (STK33_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with STK33: view

Function for STK33 Gene

Molecular function for STK33 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;.

Enzyme Numbers (IUBMB) for STK33 Gene

Phenotypes From GWAS Catalog for STK33 Gene

Gene Ontology (GO) - Molecular Function for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with STK33: view
genes like me logo Genes that share phenotypes with STK33: view

Animal Models for STK33 Gene

MGI Knock Outs for STK33:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK33

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK33 Gene

Localization for STK33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK33 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK33 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK33: view

Pathways & Interactions for STK33 Gene

PathCards logo

SuperPathways for STK33 Gene

SuperPathway Contained pathways
1 MAP Kinase Signaling
2 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK33: view

Pathways by source for STK33 Gene

1 Qiagen pathway for STK33 Gene
  • Sperm Motility
1 Cell Signaling Technology pathway for STK33 Gene

Gene Ontology (GO) - Biological Process for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0042770 signal transduction in response to DNA damage IBA 21873635
GO:0044773 mitotic DNA damage checkpoint IBA 21873635
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with STK33: view

No data available for SIGNOR curated interactions for STK33 Gene

Drugs & Compounds for STK33 Gene

(1) Drugs for STK33 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with STK33: view

Transcripts for STK33 Gene

mRNA/cDNA for STK33 Gene

12 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK33

Alternative Splicing Database (ASD) splice patterns (SP) for STK33 Gene

No ASD Table

Relevant External Links for STK33 Gene

GeneLoc Exon Structure for

Expression for STK33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for STK33 Gene

This gene is overexpressed in Testis (x6.1) and Pituitary (x5.8).

Protein differential expression in normal tissues from HIPED for STK33 Gene

This gene is overexpressed in Heart (44.6) and Adrenal (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK33 Gene

Protein tissue co-expression partners for STK33 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK33

SOURCE GeneReport for Unigene cluster for STK33 Gene:


mRNA Expression by UniProt/SwissProt for STK33 Gene:

Tissue specificity: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.

Evidence on tissue expression from TISSUES for STK33 Gene

  • Stomach(4.3)
  • Intestine(2.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with STK33: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK33 Gene

Orthologs for STK33 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK33 30 31
  • 98.96 (n)
(Bos Taurus)
Mammalia STK33 30 31
  • 88.1 (n)
(Canis familiaris)
Mammalia STK33 30 31
  • 85.27 (n)
(Rattus norvegicus)
Mammalia Stk33 30
  • 79.22 (n)
(Mus musculus)
Mammalia Stk33 30 17 31
  • 78.5 (n)
(Ornithorhynchus anatinus)
Mammalia STK33 31
  • 52 (a)
(Monodelphis domestica)
Mammalia STK33 31
  • 49 (a)
(Gallus gallus)
Aves -- 31
  • 25 (a)
(Anolis carolinensis)
Reptilia STK33 31
  • 64 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stk33 30
  • 68.87 (n)
(Danio rerio)
Actinopterygii stk33 31
  • 47 (a)
Dr.18768 30
(Caenorhabditis elegans)
Secernentea zyg-1 31
  • 14 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 63 (a)
Species where no ortholog for STK33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STK33 Gene

Gene Tree for STK33 (if available)
Gene Tree for STK33 (if available)
Evolutionary constrained regions (ECRs) for STK33: view image

Paralogs for STK33 Gene

(65) SIMAP similar genes for STK33 Gene using alignment to 12 proteins:

  • C9J319_HUMAN
  • C9J5G1_HUMAN
  • C9J6X7_HUMAN
  • C9J8B1_HUMAN
  • L8E989_HUMAN Pseudogenes for STK33 Gene

genes like me logo Genes that share paralogs with STK33: view

Variants for STK33 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK33 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1057520013 Likely Pathogenic: Pancreatic Neoplasms 8,436,118(-) A/C MISSENSE_VARIANT
VAR_041173 A lung large cell carcinoma sample p.Leu160Val
rs34525052 - p.Glu98Asp
rs35296353 - p.Ala458Glu
rs3751095 - p.Ala437Thr

Additional dbSNP identifiers (rs#s) for STK33 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK33 Gene

Variant ID Type Subtype PubMed ID
esv2657808 CNV deletion 23128226
esv2667808 CNV deletion 23128226
esv2751035 CNV loss 17911159
esv32551 CNV loss 17666407
esv3333592 CNV duplication 20981092
esv3547287 CNV deletion 23714750
esv3625312 CNV loss 21293372
esv3625314 CNV loss 21293372
esv3625315 CNV loss 21293372
nsv1159831 CNV deletion 26073780
nsv471747 CNV loss 16327809
nsv499766 OTHER inversion 21111241
nsv519052 CNV loss 19592680
nsv7215 OTHER inversion 18451855

Variation tolerance for STK33 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK33 Gene

Disorders for STK33 Gene

MalaCards: The human disease database

(4) MalaCards diseases for STK33 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung large cell carcinoma
  • large cell carcinoma of lung
tyrosinemia, type iii
  • tyrsn3
large cell carcinoma
  • carcinoma large cell
mitochondrial complex i deficiency, nuclear type 1
  • mc1dn1
- elite association - COSMIC cancer census association via MalaCards
Search STK33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STK33

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STK33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK33 Gene

Publications for STK33 Gene

  1. A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. (PMID: 11738831) Mujica AO … Schmidt ER (Gene 2001) 2 3 4
  2. STK33 kinase activity is nonessential in KRAS-dependent cancer cells. (PMID: 21742770) Babij C … Dussault I (Cancer research 2011) 3 4
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 41
  4. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 41
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 41

Products for STK33 Gene

  • Signalway Proteins for STK33

Sources for STK33 Gene