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Aliases for STK33 Gene

Aliases for STK33 Gene

  • Serine/Threonine Kinase 33 2 3 5
  • EC 2.7.11.1 4
  • EC 2.7.11 56

External Ids for STK33 Gene

Previous GeneCards Identifiers for STK33 Gene

  • GC11M009197
  • GC11M008873
  • GC11M008372
  • GC11M008377
  • GC11M008369
  • GC11M008081

Summaries for STK33 Gene

GeneCards Summary for STK33 Gene

STK33 (Serine/Threonine Kinase 33) is a Protein Coding gene. Diseases associated with STK33 include Large Cell Carcinoma. Among its related pathways are Sweet Taste Signaling and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK2.

UniProtKB/Swiss-Prot for STK33 Gene

  • Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

Additional gene information for STK33 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK33 Gene

Genomics for STK33 Gene

GeneHancer (GH) Regulatory Elements for STK33 Gene

Promoters and enhancers for STK33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I008593 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 568.2 +0.1 149 1.1 ELF3 ARID4B ZNF76 SIN3A BMI1 DMAP1 KLF5 ZNF48 ZSCAN9 RARA STK33 AKIP1 GC11P008585
GH11I008681 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.8 -91.6 -91566 8.7 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNORA3B RPL27A GC11P008722 GC11P008723 GC11P008725 PIR32700 PIR61800 SNORA3A GC11P008729 GC11P008728
GH11I008384 Enhancer 1 Ensembl ENCODE 18.9 +209.9 209877 0.4 BCOR HDAC1 CTCF LEF1 PKNOX1 ATF1 RAD21 FOSL1 CTBP1 ZNF316 STK33 TRIM66 GC11P008380 PIR32026 GC11M008392 GC11M008383
GH11I008603 Enhancer 1 Ensembl ENCODE 17.6 -10.3 -10313 1.5 SIN3A ZNF2 BRCA1 RAD21 RFX5 NCOA2 ZNF335 ZNF143 RCOR1 FOS STK33 TRIM66 SNORA3A RPL27A ENSG00000254665 TMEM9B-AS1 PIR41868
GH11I008697 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -105.5 -105504 4.1 HDAC1 ELF3 PKNOX1 ATF1 RAD21 THRB ZSCAN9 RARA HSF1 CREM TRIM66 STK33 TMEM9B ENSG00000254665 RPL27A PIR56836 ST5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STK33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK33 gene promoter:

Genomic Locations for STK33 Gene

Genomic Locations for STK33 Gene
chr11:8,391,866-8,594,289
(GRCh38/hg38)
Size:
202,424 bases
Orientation:
Minus strand
chr11:8,413,418-8,615,836
(GRCh37/hg19)

Genomic View for STK33 Gene

Genes around STK33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK33 Gene

Proteins for STK33 Gene

  • Protein details for STK33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYT3-STK33_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 33
    Protein Accession:
    Q9BYT3
    Secondary Accessions:
    • Q658S6
    • Q8NEF5

    Protein attributes for STK33 Gene

    Size:
    514 amino acids
    Molecular mass:
    57831 Da
    Quaternary structure:
    • Interacts with VIME.

    Alternative splice isoforms for STK33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK33 Gene

Selected DME Specific Peptides for STK33 Gene

Q9BYT3:
  • RDLKLEN
  • IVHRDLK

Post-translational modifications for STK33 Gene

Domains & Families for STK33 Gene

Gene Families for STK33 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9BYT3

UniProtKB/Swiss-Prot:

STK33_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with STK33: view

Function for STK33 Gene

Molecular function for STK33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

Enzyme Numbers (IUBMB) for STK33 Gene

Phenotypes From GWAS Catalog for STK33 Gene

Gene Ontology (GO) - Molecular Function for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK33: view
genes like me logo Genes that share phenotypes with STK33: view

Animal Model Products

Clone Products

  • Addgene plasmids for STK33

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK33 Gene

Localization for STK33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK33 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK33 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK33: view

Pathways & Interactions for STK33 Gene

genes like me logo Genes that share pathways with STK33: view

Pathways by source for STK33 Gene

1 Qiagen pathway for STK33 Gene
1 Cell Signaling Technology pathway for STK33 Gene

Gene Ontology (GO) - Biological Process for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with STK33: view

No data available for SIGNOR curated interactions for STK33 Gene

Drugs & Compounds for STK33 Gene

No Compound Related Data Available

Transcripts for STK33 Gene

Unigene Clusters for STK33 Gene

Serine/threonine kinase 33:
Representative Sequences:

Clone Products

  • Addgene plasmids for STK33

Alternative Splicing Database (ASD) splice patterns (SP) for STK33 Gene

No ASD Table

Relevant External Links for STK33 Gene

GeneLoc Exon Structure for
STK33
ECgene alternative splicing isoforms for
STK33

Expression for STK33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK33 Gene

mRNA differential expression in normal tissues according to GTEx for STK33 Gene

This gene is overexpressed in Testis (x6.1) and Pituitary (x5.8).

Protein differential expression in normal tissues from HIPED for STK33 Gene

This gene is overexpressed in Heart (44.6) and Adrenal (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK33 Gene



Protein tissue co-expression partners for STK33 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK33 Gene:

STK33

SOURCE GeneReport for Unigene cluster for STK33 Gene:

Hs.501833

mRNA Expression by UniProt/SwissProt for STK33 Gene:

Q9BYT3-STK33_HUMAN
Tissue specificity: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.

Evidence on tissue expression from TISSUES for STK33 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with STK33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK33 Gene

Orthologs for STK33 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK33 33 34
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia STK33 33 34
  • 88.1 (n)
dog
(Canis familiaris)
Mammalia STK33 33 34
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Stk33 33
  • 79.22 (n)
mouse
(Mus musculus)
Mammalia Stk33 33 16 34
  • 78.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK33 34
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK33 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia STK33 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk33 33
  • 68.87 (n)
zebrafish
(Danio rerio)
Actinopterygii stk33 34
  • 47 (a)
OneToOne
Dr.18768 33
worm
(Caenorhabditis elegans)
Secernentea zyg-1 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToOne
Species where no ortholog for STK33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK33 Gene

ENSEMBL:
Gene Tree for STK33 (if available)
TreeFam:
Gene Tree for STK33 (if available)

Paralogs for STK33 Gene

Paralogs for STK33 Gene

Pseudogenes.org Pseudogenes for STK33 Gene

genes like me logo Genes that share paralogs with STK33: view

Variants for STK33 Gene

Sequence variations from dbSNP and Humsavar for STK33 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1057520013 likely-pathogenic, Pancreatic Neoplasms 8,436,118(-) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_041173 A lung large cell carcinoma sample p.Leu160Val
rs1000009115 -- 8,468,792(-) A/G intron_variant
rs1000027131 -- 8,540,715(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000043561 -- 8,401,492(-) G/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK33 Gene

Variant ID Type Subtype PubMed ID
esv2657808 CNV deletion 23128226
esv2667808 CNV deletion 23128226
esv2751035 CNV loss 17911159
esv32551 CNV loss 17666407
esv3333592 CNV duplication 20981092
esv3547287 CNV deletion 23714750
esv3625312 CNV loss 21293372
esv3625314 CNV loss 21293372
esv3625315 CNV loss 21293372
nsv1159831 CNV deletion 26073780
nsv471747 CNV loss 16327809
nsv499766 OTHER inversion 21111241
nsv519052 CNV loss 19592680
nsv7215 OTHER inversion 18451855

Variation tolerance for STK33 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK33

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK33 Gene

Disorders for STK33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK33 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
large cell carcinoma
  • carcinoma large cell
- elite association - COSMIC cancer census association via MalaCards
Search STK33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STK33

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STK33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK33 Gene

Publications for STK33 Gene

  1. A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. (PMID: 11738831) Mujica AO … Schmidt ER (Gene 2001) 2 3 4 58
  2. STK33 kinase activity is nonessential in KRAS-dependent cancer cells. (PMID: 21742770) Babij C … Dussault I (Cancer research 2011) 3 4 58
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 44 58
  4. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 44 58
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58

Products for STK33 Gene

  • Addgene plasmids for STK33

Sources for STK33 Gene

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