The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants.... See more...

Aliases for STK32C Gene

Aliases for STK32C Gene

  • Serine/Threonine Kinase 32C 2 3 5
  • Serine/Threonine-Protein Kinase 32C 3 4
  • Yet Another Novel Kinase 3 3 4
  • EC 2.7.11.1 4 52
  • YANK3 3 4
  • PKE 3 4
  • Testicular Tissue Protein Li 187 3
  • PKE Protein Kinase 3
  • EC 2.7.11 52

External Ids for STK32C Gene

Previous GeneCards Identifiers for STK32C Gene

  • GC10M133456
  • GC10M133870
  • GC10M134020
  • GC10M127572

Summaries for STK32C Gene

Entrez Gene Summary for STK32C Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STK32C Gene

STK32C (Serine/Threonine Kinase 32C) is a Protein Coding gene. Diseases associated with STK32C include Chlamydia Pneumonia. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

Additional gene information for STK32C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK32C Gene

Genomics for STK32C Gene

GeneHancer (GH) Regulatory Elements for STK32C Gene

Promoters and enhancers for STK32C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J132328 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 523.7 +1.1 1132 5 FOXK2 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 JUND PHF8 TEAD4 STK32C LRRC27
GH10J132307 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 510.4 +24.6 24555 3.4 MYC POLR2G PHF8 ZFX ZBTB10 POLR2A ZBTB26 RFX1 TGIF2 EZH2 STK32C lnc-LRRC27-2 lnc-BNIP3-3
GH10J132277 Promoter 0.3 EPDnew 514 +55.0 54966 0.1 STK32C DPYSL4 ENSG00000235010 lnc-LRRC27-1 lnc-BNIP3-3
GH10J132392 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.5 -76.1 -76146 32.2 FOXK2 ZNF217 POLR2G USF1 PHF8 TEAD4 ZFX CTCF ZIC2 POLR2A PWWP2B TUBGCP2 ENSG00000180066 STK32C ENSG00000234311 ENSG00000235245 PAOX PPP2R2D ZNF511 LRRC27
GH10J132334 Promoter/Enhancer 1.3 Ensembl ENCODE 22 -4.1 -4128 3.2 POLR2G SP1 ZNF639 ZIC2 ZBTB10 ZNF423 ZNF740 MYC POLR2A NFYB LRRC27 STK32C ENSG00000180066 ENSG00000234311 PWWP2B NONHSAG007216.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK32C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK32C

Top Transcription factor binding sites by QIAGEN in the STK32C gene promoter:
  • C/EBPbeta
  • Cdc5
  • E47
  • Nkx2-5
  • Pax-5
  • Pbx1a
  • SEF-1 (1)
  • SRY
  • STAT3
  • Tal-1beta

Genomic Locations for STK32C Gene

Genomic Locations for STK32C Gene
chr10:132,207,489-132,332,256
(GRCh38/hg38)
Size:
124,768 bases
Orientation:
Minus strand
chr10:134,020,996-134,145,351
(GRCh37/hg19)
Size:
124,356 bases
Orientation:
Minus strand

Genomic View for STK32C Gene

Genes around STK32C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32C Gene

Proteins for STK32C Gene

  • Protein details for STK32C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UX6-ST32C_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32C
    Protein Accession:
    Q86UX6
    Secondary Accessions:
    • Q5T0Q5
    • Q86UE1

    Protein attributes for STK32C Gene

    Size:
    486 amino acids
    Molecular mass:
    54994 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK32C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32C Gene

Selected DME Specific Peptides for STK32C Gene

Q86UX6:
  • KMYAMKYMNKQ
  • GKGSFGKV
  • FQILRAI
  • CDPTFELEEMILES
  • IHRDVKPDN
  • ILRAIGKGSFGKVCIV
  • LGGDLRYH

Post-translational modifications for STK32C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK32C Gene

Gene Families for STK32C Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK32C Gene

Suggested Antigen Peptide Sequences for STK32C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56265, highly similar to Serine/threonine-protein kinase 32C (EC 2.7.11.1) (B7Z7J1_HUMAN)
  • YANK3 (ST32C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UX6

UniProtKB/Swiss-Prot:

ST32C_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32C: view

Function for STK32C Gene

Molecular function for STK32C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.

Enzyme Numbers (IUBMB) for STK32C Gene

Phenotypes From GWAS Catalog for STK32C Gene

Gene Ontology (GO) - Molecular Function for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32C: view
genes like me logo Genes that share phenotypes with STK32C: view

Animal Models for STK32C Gene

MGI Knock Outs for STK32C:
  • Stk32c Stk32c<tm2b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK32C

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STK32C Gene

Localization for STK32C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32C gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for STK32C Gene

Pathways & Interactions for STK32C Gene

PathCards logo

SuperPathways for STK32C Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.37
genes like me logo Genes that share pathways with STK32C: view

Pathways by source for STK32C Gene

1 Qiagen pathway for STK32C Gene
  • Sperm Motility

Gene Ontology (GO) - Biological Process for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with STK32C: view

No data available for SIGNOR curated interactions for STK32C Gene

Drugs & Compounds for STK32C Gene

(2) Drugs for STK32C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK32C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK32C: view

Transcripts for STK32C Gene

mRNA/cDNA for STK32C Gene

7 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK32C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for STK32C Gene

GeneLoc Exon Structure for
STK32C

Expression for STK32C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK32C Gene

mRNA differential expression in normal tissues according to GTEx for STK32C Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for STK32C Gene

This gene is overexpressed in Liver (41.2), Frontal cortex (9.5), Peripheral blood mononuclear cells (6.7), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK32C Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK32C

SOURCE GeneReport for Unigene cluster for STK32C Gene:

Hs.469002

Evidence on tissue expression from TISSUES for STK32C Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with STK32C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK32C Gene

Orthologs for STK32C Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32C 31 30
  • 99.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STK32C 31 30
  • 90.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STK32C 31 30
  • 89.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32c 30
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Stk32c 17 31 30
  • 87.52 (n)
oppossum
(Monodelphis domestica)
Mammalia STK32C 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32C 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32C 31 30
  • 80.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK32C 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32c 30
  • 71.45 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072625.1 31
  • 88 (a)
OneToMany
CABZ01092745.1 31
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32944 31
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 31
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
Cin.12751 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12751 30
Species where no ortholog for STK32C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32C Gene

ENSEMBL:
Gene Tree for STK32C (if available)
TreeFam:
Gene Tree for STK32C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK32C: view image

Paralogs for STK32C Gene

(42) SIMAP similar genes for STK32C Gene using alignment to 7 proteins:

  • ST32C_HUMAN
  • B7Z7J1_HUMAN
  • F2Z300_HUMAN
  • H0Y349_HUMAN
  • H0Y431_HUMAN
  • I6L972_HUMAN
  • Q5SZH1_HUMAN
genes like me logo Genes that share paralogs with STK32C: view

Variants for STK32C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK32C Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs764558009 A colorectal cancer sample p.Arg376His
rs17854384 - p.Thr334Ala
rs55812591 - p.Glu467Lys
rs56109103 - p.Ala454Thr

Additional dbSNP identifiers (rs#s) for STK32C Gene

Structural Variations from Database of Genomic Variants (DGV) for STK32C Gene

Variant ID Type Subtype PubMed ID
dgv116e201 CNV deletion 23290073
dgv553n106 CNV duplication 24896259
esv1144814 CNV insertion 17803354
esv1302998 CNV insertion 17803354
esv1920267 CNV deletion 18987734
esv2109501 CNV deletion 18987734
esv2490403 CNV deletion 19546169
esv2661595 CNV deletion 23128226
esv2676196 CNV deletion 23128226
esv2676420 CNV deletion 23128226
esv2743637 CNV deletion 23290073
esv2743638 CNV deletion 23290073
esv2743639 CNV deletion 23290073
esv2743640 CNV deletion 23290073
esv2743642 CNV deletion 23290073
esv2743643 CNV deletion 23290073
esv2743644 CNV deletion 23290073
esv2743645 CNV deletion 23290073
esv2743646 CNV deletion 23290073
esv2743649 CNV deletion 23290073
esv2743650 CNV deletion 23290073
esv2743651 CNV deletion 23290073
esv2743653 CNV deletion 23290073
esv2761642 CNV gain 21179565
esv3345984 CNV duplication 20981092
esv3402854 CNV insertion 20981092
esv3547102 CNV deletion 23714750
esv3547103 CNV deletion 23714750
esv3547105 CNV deletion 23714750
esv3624956 CNV gain 21293372
nsv1051555 CNV gain 25217958
nsv1054569 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv1069525 CNV deletion 25765185
nsv1069526 CNV deletion 25765185
nsv1075822 CNV duplication 25765185
nsv1122574 CNV deletion 24896259
nsv1131011 CNV deletion 24896259
nsv1148296 CNV deletion 26484159
nsv1152012 CNV duplication 26484159
nsv1154007 CNV deletion 26484159
nsv24619 CNV insertion 16902084
nsv467490 CNV loss 19166990
nsv470975 CNV gain 18288195
nsv552502 CNV loss 21841781
nsv552504 CNV loss 21841781
nsv552505 CNV loss 21841781
nsv832030 CNV loss 17160897
nsv951885 CNV deletion 24416366
nsv951886 CNV deletion 24416366
nsv951887 CNV deletion 24416366
nsv951888 CNV deletion 24416366

Variation tolerance for STK32C Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK32C Gene

Human Gene Mutation Database (HGMD)
STK32C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK32C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32C Gene

Disorders for STK32C Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK32C Gene - From: DISEASES

Disorder Aliases PubMed IDs
chlamydia pneumonia
  • chlamydia pneumoniae
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STK32C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STK32C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK32C Gene

Publications for STK32C Gene

  1. Replication of recently described type 2 diabetes gene variants in a South Indian population. (PMID: 20580033) Chidambaram M … Mohan V (Metabolism: clinical and experimental 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for STK32C Gene

Sources for STK32C Gene