This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] See more...

Aliases for STK32B Gene

Aliases for STK32B Gene

  • Serine/Threonine Kinase 32B 2 3 5
  • Serine/Threonine-Protein Kinase 32B 3 4
  • Yet Another Novel Kinase 2 3 4
  • EC 4 52
  • YANK2 3 4
  • Gene For Serine/Threonine Protein Kinase 3
  • HSA250839 3
  • EC 2.7.11 52
  • STK32 3
  • STKG6 3

External Ids for STK32B Gene

Previous GeneCards Identifiers for STK32B Gene

  • GC04P005120
  • GC04P005171
  • GC04P004990

Summaries for STK32B Gene

Entrez Gene Summary for STK32B Gene

  • This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for STK32B Gene

STK32B (Serine/Threonine Kinase 32B) is a Protein Coding gene. Diseases associated with STK32B include Ellis-Van Creveld Syndrome and Essential Tremor. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32C.

Additional gene information for STK32B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK32B Gene

Genomics for STK32B Gene

GeneHancer (GH) Regulatory Elements for STK32B Gene

Promoters and enhancers for STK32B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J005050 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 426 2.7 HNRNPK CTCF ZNF10 ZBTB10 ZBTB26 REST RAD21 SMC3 ZNF341 EZH2 STK32B lnc-CYTL1-2 CYTL1 piR-31508-040
GH04J005018 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.4 -32.1 -32137 1.6 CTCF MAX POLR2A EZH2 KDM1A CYTL1 HSALNG0032581 STK32B piR-38537-036
GH04J005002 Enhancer 1.1 Ensembl ENCODE 11.5 -47.9 -47910 3 PHB2 ZBTB11 AFF1 TARDBP HES1 ZNF740 MYC TOE1 CTBP1 JUN STK32B piR-40110-500 piR-38537-036
GH04J004995 Enhancer 0.9 Ensembl ENCODE 11.7 -55.6 -55610 1.6 CTCF REST MYC CTBP1 RAD21 HINFP SMC3 HDAC2 BCOR SKIL HSALNG0032571 STK32B piR-40110-500
GH04J005206 Enhancer 0.8 Ensembl ENCODE 10.5 +154.8 154790 2.4 JUND FOS FOSL2 NFE2 FOSL1 ZFHX2 BHLHE40 MYC EGR2 ATF3 STK32B LOC105374362 piR-59769-429
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK32B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK32B

Top Transcription factor binding sites by QIAGEN in the STK32B gene promoter:
  • E47
  • Evi-1
  • FOXL1
  • HNF-4alpha1
  • ISGF-3
  • ITF-2
  • Lmo2
  • STAT5B
  • Tal-1beta

Genomic Locations for STK32B Gene

Genomic Locations for STK32B Gene
449,788 bases
Plus strand
449,557 bases
Plus strand

Genomic View for STK32B Gene

Genes around STK32B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32B Gene

Proteins for STK32B Gene

  • Protein details for STK32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 32B
    Protein Accession:
    Secondary Accessions:
    • Q6UXH3
    • Q8IY14

    Protein attributes for STK32B Gene

    414 amino acids
    Molecular mass:
    47883 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • [Isoform 2]: It is unsure whether Met-1 or Met-3 is the initiator.
    • Sequence=AAQ88719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK32B Gene


neXtProt entry for STK32B Gene

Selected DME Specific Peptides for STK32B Gene


Post-translational modifications for STK32B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK32B Gene

Gene Families for STK32B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK32B Gene

Suggested Antigen Peptide Sequences for STK32B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32B: view

Function for STK32B Gene

Molecular function for STK32B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=; Evidence=. ;.

Enzyme Numbers (IUBMB) for STK32B Gene

Phenotypes From GWAS Catalog for STK32B Gene

Gene Ontology (GO) - Molecular Function for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32B: view
genes like me logo Genes that share phenotypes with STK32B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32B

CRISPR Products

miRNA for STK32B Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK32B Gene

Localization for STK32B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STK32B Gene

Pathways & Interactions for STK32B Gene

PathCards logo

SuperPathways for STK32B Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32B: view

Pathways by source for STK32B Gene

1 Qiagen pathway for STK32B Gene
  • Sperm Motility

Gene Ontology (GO) - Biological Process for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with STK32B: view

No data available for SIGNOR curated interactions for STK32B Gene

Drugs & Compounds for STK32B Gene

(2) Drugs for STK32B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK32B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK32B: view

Transcripts for STK32B Gene

mRNA/cDNA for STK32B Gene

13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -

Relevant External Links for STK32B Gene

GeneLoc Exon Structure for

Expression for STK32B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK32B

SOURCE GeneReport for Unigene cluster for STK32B Gene:

genes like me logo Genes that share expression patterns with STK32B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK32B Gene

Orthologs for STK32B Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK32B 31 30
  • 94.39 (n)
(Bos Taurus)
Mammalia STK32B 31 30
  • 90.7 (n)
(Ornithorhynchus anatinus)
Mammalia STK32B 31
  • 90 (a)
(Canis familiaris)
Mammalia STK32B 31 30
  • 89.69 (n)
(Monodelphis domestica)
Mammalia STK32B 31
  • 88 (a)
(Mus musculus)
Mammalia Stk32b 17 31 30
  • 86.88 (n)
(Rattus norvegicus)
Mammalia Stk32b 30
  • 86.47 (n)
(Gallus gallus)
Aves STK32B 31 30
  • 79.23 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32b 30
  • 75.33 (n)
(Danio rerio)
Actinopterygii LOC100330817 30
  • 67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000477 30
  • 59.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32944 31 30
  • 58.93 (n)
(Caenorhabditis elegans)
Secernentea M03C11.1 31 30
  • 53.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
Species where no ortholog for STK32B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32B Gene

Gene Tree for STK32B (if available)
Gene Tree for STK32B (if available)
Evolutionary constrained regions (ECRs) for STK32B: view image

Paralogs for STK32B Gene

(37) SIMAP similar genes for STK32B Gene using alignment to 3 proteins:

  • D6R9Y2_HUMAN
genes like me logo Genes that share paralogs with STK32B: view

Variants for STK32B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK32B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs796052163 Likely Benign: Long QT syndrome 5,416,859(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
VAR_041166 A metastatic melanoma sample p.Gly35Glu
rs35207488 - p.Arg244His
rs3733182 - p.Arg198Gly
rs55961955 - p.Lys342Thr

Additional dbSNP identifiers (rs#s) for STK32B Gene

Structural Variations from Database of Genomic Variants (DGV) for STK32B Gene

Variant ID Type Subtype PubMed ID
dgv134n6 CNV deletion 16902084
dgv1453e212 CNV loss 25503493
dgv1454e212 CNV loss 25503493
dgv1455e212 CNV loss 25503493
dgv5094n100 CNV gain 25217958
dgv639n27 CNV loss 19166990
dgv8931n54 CNV loss 21841781
esv1007800 CNV deletion 20482838
esv1526304 CNV deletion 17803354
esv1790419 CNV deletion 17803354
esv23244 CNV loss 19812545
esv2657644 CNV deletion 23128226
esv2663309 CNV deletion 23128226
esv2668377 CNV deletion 23128226
esv2678136 CNV deletion 23128226
esv2726971 CNV deletion 23290073
esv2726972 CNV deletion 23290073
esv2726974 CNV deletion 23290073
esv2726975 CNV deletion 23290073
esv2752049 CNV loss 17911159
esv2760874 CNV loss 21179565
esv2762403 CNV loss 21179565
esv3269 OTHER inversion 18987735
esv34196 OTHER inversion 12058347
esv3563305 CNV deletion 23714750
esv3569264 CNV loss 25503493
esv3569267 CNV loss 25503493
esv3599472 CNV loss 21293372
esv3599476 CNV loss 21293372
esv3599477 CNV loss 21293372
esv3599478 CNV loss 21293372
esv3599480 CNV loss 21293372
esv3599481 CNV loss 21293372
esv3599482 CNV loss 21293372
esv3599483 CNV loss 21293372
esv3599484 CNV loss 21293372
esv3599485 CNV loss 21293372
esv3893863 CNV loss 25118596
esv3893864 CNV gain 25118596
esv9538 OTHER inversion 19470904
nsv1001085 CNV loss 25217958
nsv1010013 CNV gain 25217958
nsv1011885 CNV loss 25217958
nsv1074140 CNV deletion 25765185
nsv1074141 CNV deletion 25765185
nsv1074142 CNV deletion 25765185
nsv1109577 CNV deletion 24896259
nsv1117056 CNV deletion 24896259
nsv1117057 CNV deletion 24896259
nsv1124883 CNV duplication 24896259
nsv1128028 CNV deletion 24896259
nsv1136811 CNV deletion 24896259
nsv1144070 CNV deletion 24896259
nsv1144071 CNV deletion 24896259
nsv1149536 CNV deletion 26484159
nsv461181 CNV loss 19166990
nsv471805 CNV loss 16327809
nsv520417 CNV loss 19592680
nsv521349 CNV loss 19592680
nsv527143 CNV loss 19592680
nsv527989 CNV gain 19592680
nsv593479 CNV gain 21841781
nsv593480 CNV loss 21841781
nsv593481 CNV gain 21841781
nsv593482 CNV loss 21841781
nsv593483 CNV loss 21841781
nsv593484 CNV loss 21841781
nsv593485 CNV loss 21841781
nsv593488 CNV loss 21841781
nsv593489 CNV loss 21841781
nsv949774 CNV duplication 24416366
nsv954406 CNV deletion 24416366
nsv997889 CNV gain 25217958
nsv997905 CNV gain 25217958
nsv999245 CNV loss 25217958

Variation tolerance for STK32B Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK32B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32B Gene

Disorders for STK32B Gene

MalaCards: The human disease database

(4) MalaCards diseases for STK32B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ellis-van creveld syndrome
  • evc
essential tremor
  • tremor, hereditary essential, 1
generalized anxiety disorder
  • anxiety generalized
  • dysostoses
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STK32B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STK32B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK32B Gene

Publications for STK32B Gene

  1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PMID: 10700184) Ruiz-Perez VL … Goodship J (Nature genetics 2000) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PMID: 20087401) Ingersoll RG … Beaty TH (European journal of human genetics : EJHG 2010) 3 41 54
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  5. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PMID: 19389651) Smith JG … Newton-Cheh C (Heart rhythm 2009) 3 41 54

Products for STK32B Gene

Sources for STK32B Gene