Aliases for STK32A Gene

Aliases for STK32A Gene

  • Serine/Threonine Kinase 32A 2 3 5
  • Serine/Threonine-Protein Kinase 32A 3 4
  • Yet Another Novel Kinase 1 3 4
  • EC 2.7.11.1 4 52
  • YANK1 3 4
  • A930015B13Rik 3
  • CTB-108O6.2 3
  • EC 2.7.11 52

External Ids for STK32A Gene

Previous GeneCards Identifiers for STK32A Gene

  • GC05P146645
  • GC05P146594
  • GC05P141761

Summaries for STK32A Gene

GeneCards Summary for STK32A Gene

STK32A (Serine/Threonine Kinase 32A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

Additional gene information for STK32A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK32A Gene

Genomics for STK32A Gene

GeneHancer (GH) Regulatory Elements for STK32A Gene

Promoters and enhancers for STK32A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J147234 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 505.4 -0.3 -262 2.6 ZIC2 ZNF423 ZBTB26 ZNF341 POLR2A SMC3 SP2 ZBTB17 MXI1 ZNF524 STK32A STK32A-AS1 ENSG00000286468
GH05J147451 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +218.7 218710 6.1 HNRNPK EP300 CTCF MYC USF1 ZBTB10 ZBTB26 SAP30 KLF7 RAD21 DPYSL3 STK32A STK32A-AS1 JAKMIP2 PPP2R2B RF00017-4990 piR-59804-022
GH05J147216 Enhancer 0.6 Ensembl ENCODE 27 -18.3 -18262 1.4 TEAD1 FOXA2 YY1 FOXA1 FOXA3 STK32A STK32A-AS1 ENSG00000286468
GH05J147560 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 11 +326.0 326038 2.4 TEAD4 HDAC2 POLR2A CTCF NANOG RAD21 CHD1 TAF1 CHD7 TBP JAKMIP2-AS1 DPYSL3 STK32A STK32A-AS1 piR-44878-014
GH05J147174 Enhancer 1 Ensembl ENCODE 10.8 -58.6 -58640 3.3 NCOR1 JUND TCF7 ZBTB25 SMARCC2 SKI TEAD1 TBX3 FOXA2 KMT2B STK32A STK32A-AS1 ENSG00000286468
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK32A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK32A

Top Transcription factor binding sites by QIAGEN in the STK32A gene promoter:
  • aMEF-2
  • c-Myb
  • CREB
  • deltaCREB
  • IRF-7A
  • MEF-2A
  • MyoD
  • Nkx2-5
  • S8
  • Sox9

Genomic Locations for STK32A Gene

Genomic Locations for STK32A Gene
chr5:147,234,963-147,401,533
(GRCh38/hg38)
Size:
166,571 bases
Orientation:
Plus strand
chr5:146,614,526-146,767,415
(GRCh37/hg19)
Size:
152,890 bases
Orientation:
Plus strand

Genomic View for STK32A Gene

Genes around STK32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32A Gene

Proteins for STK32A Gene

  • Protein details for STK32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU08-ST32A_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32A
    Protein Accession:
    Q8WU08
    Secondary Accessions:
    • B3KSY0

    Protein attributes for STK32A Gene

    Size:
    396 amino acids
    Molecular mass:
    46369 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STK32A Gene

    Alternative splice isoforms for STK32A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32A Gene

Selected DME Specific Peptides for STK32A Gene

Q8WU08:
  • KMYAMKYMNKQ
  • GKGSFGKV
  • CDPTFELEEMILES
  • KPPVFDE
  • ILRAIGKGSFGKVCIV
  • LGGDLRYH

Post-translational modifications for STK32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for STK32A
  • Santa Cruz Biotechnology (SCBT) Antibodies for STK32A

Domains & Families for STK32A Gene

Gene Families for STK32A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK32A Gene

Suggested Antigen Peptide Sequences for STK32A Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78841, highly similar to Serine/threonine-protein kinase 32A (EC 2.7.11.1) (B7Z9H7_HUMAN)
  • YANK1 (ST32A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WU08

UniProtKB/Swiss-Prot:

ST32A_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32A: view

Function for STK32A Gene

Molecular function for STK32A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.

Enzyme Numbers (IUBMB) for STK32A Gene

Phenotypes From GWAS Catalog for STK32A Gene

Gene Ontology (GO) - Molecular Function for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IEA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32A: view
genes like me logo Genes that share phenotypes with STK32A: view

Animal Models for STK32A Gene

MGI Knock Outs for STK32A:
  • Stk32a Stk32a<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK32A Gene

Localization for STK32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK32A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32A gene
Compartment Confidence
plasma membrane 3
cytosol 3
extracellular 1
nucleus 1
cytoskeleton 0
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STK32A: view

Pathways & Interactions for STK32A Gene

PathCards logo

SuperPathways for STK32A Gene

No Data Available

Gene Ontology (GO) - Biological Process for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with STK32A: view

No data available for Pathways by source and SIGNOR curated interactions for STK32A Gene

Drugs & Compounds for STK32A Gene

(3) Drugs for STK32A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK32A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK32A: view

Transcripts for STK32A Gene

mRNA/cDNA for STK32A Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32A Gene

No ASD Table

Relevant External Links for STK32A Gene

GeneLoc Exon Structure for
STK32A

Expression for STK32A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK32A Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for STK32A Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK32A Gene



Protein tissue co-expression partners for STK32A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK32A

SOURCE GeneReport for Unigene cluster for STK32A Gene:

Hs.585069
genes like me logo Genes that share expression patterns with STK32A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK32A Gene

Orthologs for STK32A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK32A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32A 31 30
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STK32A 31 30
  • 90.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32a 30
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Stk32a 17 31 30
  • 88.22 (n)
dog
(Canis familiaris)
Mammalia STK32A 31 30
  • 87.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK32A 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32A 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32A 31 30
  • 76.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK32A 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32a 30
  • 72.32 (n)
zebrafish
(Danio rerio)
Actinopterygii stk32a 31
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32944 31
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 31
  • 42 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07062 30
  • 50.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk33 30
  • 48.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for STK32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32A Gene

ENSEMBL:
Gene Tree for STK32A (if available)
TreeFam:
Gene Tree for STK32A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK32A: view image

Paralogs for STK32A Gene

Variants for STK32A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK32A Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
711933 Likely Benign: not provided 147,395,716(+) T/G SYNONYMOUS_VARIANT
776074 Benign: not provided 147,399,154(+) C/G SYNONYMOUS_VARIANT
777398 Benign: not provided 147,400,843(+) G/A INTRON_VARIANT
VAR_041164 A metastatic melanoma sample p.Ser89Phe
VAR_041165 A lung neuroendocrine carcinoma sample p.Met316Ile

Additional dbSNP identifiers (rs#s) for STK32A Gene

Structural Variations from Database of Genomic Variants (DGV) for STK32A Gene

Variant ID Type Subtype PubMed ID
dgv975n67 CNV gain 20364138
esv1301490 CNV deletion 17803354
esv2669201 CNV deletion 23128226
esv2670464 CNV deletion 23128226
esv2670979 CNV deletion 23128226
esv2730887 CNV deletion 23290073
esv2730888 CNV deletion 23290073
esv2730889 CNV deletion 23290073
esv2763507 CNV loss 21179565
esv3566783 CNV deletion 23714750
esv3607090 CNV loss 21293372
esv3607092 CNV loss 21293372
nsv1114741 CNV deletion 24896259
nsv476569 CNV novel sequence insertion 20440878
nsv519847 CNV gain+loss 19592680
nsv599938 CNV gain 21841781
nsv819857 CNV gain 19587683
nsv820475 CNV deletion 20802225

Variation tolerance for STK32A Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32A Gene

Disorders for STK32A Gene

Additional Disease Information for STK32A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STK32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32A Gene

Publications for STK32A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen LL … Saavalainen P (Tissue antigens 2009) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 54

Products for STK32A Gene

Sources for STK32A Gene