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Aliases for STK32A Gene

Aliases for STK32A Gene

  • Serine/Threonine Kinase 32A 2 3 5
  • Yet Another Novel Kinase 1 3 4
  • EC 4 56
  • YANK1 3 4
  • Serine/Threonine-Protein Kinase 32A 3
  • A930015B13Rik 3
  • CTB-108O6.2 3
  • EC 2.7.11 56

External Ids for STK32A Gene

Previous GeneCards Identifiers for STK32A Gene

  • GC05P146645
  • GC05P146594
  • GC05P141761

Summaries for STK32A Gene

GeneCards Summary for STK32A Gene

STK32A (Serine/Threonine Kinase 32A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

Additional gene information for STK32A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32A Gene

Genomics for STK32A Gene

GeneHancer (GH) Regulatory Elements for STK32A Gene

Promoters and enhancers for STK32A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I147234 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.2 -233 1.1 CTCF MXI1 KLF1 ZNF449 ZIC2 ZNF335 GLIS2 POLR2A ZNF366 ZBTB48 STK32A STK32A-AS1 GC05P147165
GH05I147451 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +219.0 218993 5.6 SIN3A ZNF2 ETS1 GLIS2 ZNF143 KLF7 KLF13 SP3 REST ZNF518A DPYSL3 STK32A STK32A-AS1 JAKMIP2 PPP2R2B GC05P147435
GH05I147552 Enhancer 1 FANTOM5 Ensembl ENCODE 10.6 +319.4 319379 3.6 JUND GATA3 RFX1 POLR2A CREB1 RCOR1 DPYSL3 STK32A STK32A-AS1 JAKMIP2-AS1 PIR44601 GC05M147550
GH05I147174 Enhancer 0.9 ENCODE 10.8 -58.6 -58640 3.3 FOXA2 DMAP1 DNMT3B RAD21 RARA ETS1 YY1 SMARCC2 FOS CREM STK32A STK32A-AS1 GC05P147165
GH05I147558 Enhancer 0.8 ENCODE dbSUPER 11 +324.1 324070 0.2 CTCF ZNF654 ZNF10 TRIM22 SIN3A RAD21 ZNF335 ZNF143 JAKMIP2-AS1 DPYSL3 STK32A STK32A-AS1 PIR44601 GC05M147550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STK32A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK32A gene promoter:

Genomic Locations for STK32A Gene

Genomic Locations for STK32A Gene
166,571 bases
Plus strand

Genomic View for STK32A Gene

Genes around STK32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32A Gene

Proteins for STK32A Gene

  • Protein details for STK32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 32A
    Protein Accession:
    Secondary Accessions:
    • B3KSY0

    Protein attributes for STK32A Gene

    396 amino acids
    Molecular mass:
    46369 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STK32A Gene

    Alternative splice isoforms for STK32A Gene


neXtProt entry for STK32A Gene

Selected DME Specific Peptides for STK32A Gene


Post-translational modifications for STK32A Gene

No Post-translational modifications

Domains & Families for STK32A Gene

Gene Families for STK32A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK32A Gene

Suggested Antigen Peptide Sequences for STK32A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32A: view

Function for STK32A Gene

Molecular function for STK32A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32A Gene

Gene Ontology (GO) - Molecular Function for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32A: view
genes like me logo Genes that share phenotypes with STK32A: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK32A Gene

Localization for STK32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK32A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32A gene
Compartment Confidence
plasma membrane 3
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STK32A: view

Pathways & Interactions for STK32A Gene

SuperPathways for STK32A Gene

No Data Available

Interacting Proteins for STK32A Gene

Gene Ontology (GO) - Biological Process for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with STK32A: view

No data available for Pathways by source and SIGNOR curated interactions for STK32A Gene

Drugs & Compounds for STK32A Gene

(2) Drugs for STK32A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for STK32A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32A: view

Transcripts for STK32A Gene

Unigene Clusters for STK32A Gene

Serine/threonine kinase 32A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32A Gene

No ASD Table

Relevant External Links for STK32A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK32A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK32A Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for STK32A Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK32A Gene

Protein tissue co-expression partners for STK32A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK32A Gene:


SOURCE GeneReport for Unigene cluster for STK32A Gene:

genes like me logo Genes that share expression patterns with STK32A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK32A Gene

Orthologs for STK32A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK32A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK32A 33 34
  • 99.33 (n)
(Bos Taurus)
Mammalia STK32A 33 34
  • 90.89 (n)
(Rattus norvegicus)
Mammalia Stk32a 33
  • 88.38 (n)
(Mus musculus)
Mammalia Stk32a 33 16 34
  • 88.22 (n)
(Canis familiaris)
Mammalia STK32A 33 34
  • 87.56 (n)
(Monodelphis domestica)
Mammalia STK32A 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia STK32A 34
  • 78 (a)
(Gallus gallus)
Aves STK32A 33 34
  • 76.46 (n)
(Anolis carolinensis)
Reptilia STK32A 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32a 33
  • 72.32 (n)
(Danio rerio)
Actinopterygii stk32a 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32944 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea M03C11.1 34
  • 42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07062 33
  • 50.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk33 33
  • 48.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for STK32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32A Gene

Gene Tree for STK32A (if available)
Gene Tree for STK32A (if available)

Paralogs for STK32A Gene

Variants for STK32A Gene

Sequence variations from dbSNP and Humsavar for STK32A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_041164 A metastatic melanoma sample p.Ser89Phe
VAR_041165 A lung neuroendocrine carcinoma sample p.Met316Ile
rs1000026849 -- 147,321,337(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000054251 -- 147,240,365(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000065445 -- 147,325,519(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK32A Gene

Variant ID Type Subtype PubMed ID
nsv820475 CNV deletion 20802225
nsv819857 CNV gain 19587683
nsv599938 CNV gain 21841781
nsv519847 CNV gain+loss 19592680
nsv476569 CNV novel sequence insertion 20440878
nsv1114741 CNV deletion 24896259
esv3607092 CNV loss 21293372
esv3607090 CNV loss 21293372
esv3566783 CNV deletion 23714750
esv2763507 CNV loss 21179565
esv2730889 CNV deletion 23290073
esv2730888 CNV deletion 23290073
esv2730887 CNV deletion 23290073
esv2670979 CNV deletion 23128226
esv2670464 CNV deletion 23128226
esv2669201 CNV deletion 23128226
esv1301490 CNV deletion 17803354
dgv975n67 CNV gain 20364138

Variation tolerance for STK32A Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32A Gene

Disorders for STK32A Gene

Additional Disease Information for STK32A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STK32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32A Gene

Publications for STK32A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen LL … Saavalainen P (Tissue antigens 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for STK32A Gene

Sources for STK32A Gene

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