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Aliases for STK31 Gene

Aliases for STK31 Gene

  • Serine/Threonine Kinase 31 2 3 5
  • Serine/Threonine-Protein Kinase NYD-SPK 3 4
  • Sugen Kinase 396 3 4
  • SGK396 3 4
  • Testis Tissue Sperm-Binding Protein Li 78m 3
  • Serine/Threonine-Protein Kinase 31 3
  • Tudor Domain Containing 8 3
  • EC 4
  • TDRD8 3

External Ids for STK31 Gene

Previous GeneCards Identifiers for STK31 Gene

  • GC07P023392
  • GC07P023458
  • GC07P023492
  • GC07P023523
  • GC07P023716
  • GC07P023749
  • GC07P023634

Summaries for STK31 Gene

Entrez Gene Summary for STK31 Gene

  • This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK31 Gene

STK31 (Serine/Threonine Kinase 31) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein kinase activity.

Additional gene information for STK31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK31 Gene

Genomics for STK31 Gene

GeneHancer (GH) Regulatory Elements for STK31 Gene

Promoters and enhancers for STK31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I023708 Promoter/Enhancer 0.9 EPDnew ENCODE 559.2 -0.6 -617 1.8 HNF4A ZBTB33 CHAMP1 STK31 ENSG00000234286
GH07I023722 Enhancer 0.7 ENCODE 42.1 +12.8 12814 0.4 LEF1 ATF1 NFRKB ZBTB40 CTBP1 POLR2A FOXK2 BRD9 L3MBTL2 NR4A1 PCMTD1P3 STK31 CLK2P1 TRA2A CCDC126 TPT1P7
GH07I023759 Enhancer 1.1 Ensembl ENCODE 22.6 +50.1 50054 1.3 HDAC1 PKNOX1 FEZF1 BRCA1 RFX5 YY1 TCF12 ZNF366 SCRT2 RCOR1 STK31 FAM221A PCMTD1P3 TPT1P7
GH07I023679 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 7.9 -29.7 -29678 1.9 NFIB RB1 KLF17 MZF1 SIN3A KLF5 RAD21 YY1 ETS1 ZNF335 FAM221A ENSG00000234286 STK31
GH07I023697 Enhancer 0.8 ENCODE 12.9 -13.0 -12990 0.3 RB1 ARNT RAD21 CHAMP1 TCF12 ARID2 EGR1 ZNF143 CREM EGR2 TRA2A STK31 FAM221A ENSG00000234286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STK31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK31 gene promoter:

Genomic Locations for STK31 Gene

Genomic Locations for STK31 Gene
122,347 bases
Plus strand

Genomic View for STK31 Gene

Genes around STK31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK31 Gene

Proteins for STK31 Gene

  • Protein details for STK31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 31
    Protein Accession:
    Secondary Accessions:
    • B4DZ06
    • B7WPP5
    • C9J4F9
    • Q6PCD3
    • Q9BXH8

    Protein attributes for STK31 Gene

    1019 amino acids
    Molecular mass:
    115694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK31 Gene


neXtProt entry for STK31 Gene

Post-translational modifications for STK31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for STK31 Gene

Domains & Families for STK31 Gene

Gene Families for STK31 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK31: view

Function for STK31 Gene

Molecular function for STK31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK31 Gene

Phenotypes From GWAS Catalog for STK31 Gene

Gene Ontology (GO) - Molecular Function for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IBA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with STK31: view
genes like me logo Genes that share phenotypes with STK31: view

Animal Models for STK31 Gene

MGI Knock Outs for STK31:

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STK31 Gene

Localization for STK31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK31 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with STK31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for STK31 Gene

Pathways & Interactions for STK31 Gene

SuperPathways for STK31 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK31: view

Pathways by source for STK31 Gene

1 Qiagen pathway for STK31 Gene

Interacting Proteins for STK31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BXU1-STK31_HUMAN ENSP00000348132 for STK31 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process IBA --
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with STK31: view

No data available for SIGNOR curated interactions for STK31 Gene

Drugs & Compounds for STK31 Gene

No Compound Related Data Available

Transcripts for STK31 Gene

Unigene Clusters for STK31 Gene

Serine/threonine kinase 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK31 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27

Relevant External Links for STK31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK31 Gene

This gene is overexpressed in Testis (x36.6).

Protein differential expression in normal tissues from HIPED for STK31 Gene

This gene is overexpressed in Testis (37.7) and Ovary (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK31 Gene

Protein tissue co-expression partners for STK31 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK31 Gene:


SOURCE GeneReport for Unigene cluster for STK31 Gene:


mRNA Expression by UniProt/SwissProt for STK31 Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with STK31: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK31 Gene

Orthologs for STK31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STK31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK31 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia STK31 33 34
  • 88.74 (n)
(Bos Taurus)
Mammalia LOC781749 33
  • 88.51 (n)
STK31 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Stk31 33
  • 84.61 (n)
(Mus musculus)
Mammalia Stk31 33 16 34
  • 84.58 (n)
(Monodelphis domestica)
Mammalia STK31 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia STK31 34
  • 60 (a)
(Gallus gallus)
Aves STK31 33 34
  • 63.73 (n)
(Anolis carolinensis)
Reptilia STK31 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk31 33
  • 58.03 (n)
(Danio rerio)
Actinopterygii LOC100330765 33
  • 50.5 (n)
STK31 34
  • 34 (a)
Species where no ortholog for STK31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK31 Gene

Gene Tree for STK31 (if available)
Gene Tree for STK31 (if available)

Paralogs for STK31 Gene

No data available for Paralogs for STK31 Gene

Variants for STK31 Gene

Sequence variations from dbSNP and Humsavar for STK31 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_041158 A lung neuroendocrine carcinoma sample p.His684Tyr
VAR_041160 A lung small cell carcinoma sample p.Val860Leu
rs1000017960 -- 23,817,749(+) C/G intron_variant
rs1000056443 -- 23,808,013(+) A/G intron_variant
rs1000059340 -- 23,731,202(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK31 Gene

Variant ID Type Subtype PubMed ID
nsv970451 CNV duplication 23825009
nsv830924 CNV loss 17160897
nsv7393 OTHER inversion 18451855
nsv510074 OTHER sequence alteration 20534489
nsv366286 CNV deletion 16902084
nsv365951 CNV deletion 16902084
nsv1151728 CNV deletion 26484159
nsv1142665 CNV deletion 24896259
nsv1129435 OTHER inversion 24896259
nsv1109853 CNV deletion 24896259
nsv1068712 OTHER inversion 25765185
esv7170 OTHER inversion 19470904
esv2759519 CNV loss 17122850
esv2734132 CNV deletion 23290073
esv2734131 CNV deletion 23290073
esv2673027 CNV deletion 23128226
esv2602899 CNV deletion 19546169
esv2372085 CNV deletion 18987734
esv1343786 CNV deletion 17803354

Variation tolerance for STK31 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.99; 93.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK31 Gene

Disorders for STK31 Gene

Additional Disease Information for STK31

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STK31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK31 Gene

Publications for STK31 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer. (PMID: 27044426) Yin FF … Wang YK (Virology journal 2016) 3 58

Products for STK31 Gene

Sources for STK31 Gene

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