Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
STK3 (Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with STK3 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Sweet Taste Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 8566796 |
GO:0003730 | mRNA 3'-UTR binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,IDA | 28087714 |
GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 8566796 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 19525978 |
GO:0005829 | cytosol | TAS | -- |
GO:0032991 | protein-containing complex | IDA | 19962960 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK signaling pathway | ||
2 | Apoptosis and Autophagy | ||
3 | Cytoskeletal Signaling | ||
4 | Hippo signaling pathway | ||
5 | Hippo signaling pathway - multiple species |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001841 | neural tube formation | IEA | -- |
GO:0003157 | endocardium development | IEA | -- |
GO:0006417 | regulation of translation | IEA | -- |
GO:0006468 | protein phosphorylation | IEA,IDA | 8566796 |
GO:0006915 | apoptotic process | TAS | 11278283 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STK3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | STK3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STK3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STK3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stk3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Stk3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | STK3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STK3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STK3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stk3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stk3 30 31 |
|
OneToOne | |
wufc19e11 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | hpo 30 31 |
|
OneToMany | |
CG11228 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006044 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cst-2 30 31 |
|
ManyToMany | |
C24A8.4a 32 |
|
|
|||
C24A8.4b 32 |
|
|
|||
F14H12.4a 32 |
|
|
|||
F14H12.4b 32 |
|
|
|||
cst-1 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPS1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8767 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1634 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_041122 | An ovarian clear cell carcinoma sample | p.Val60Leu | |||
rs36047674 | - | p.Phe418Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24438 | CNV | loss | 19812545 |
esv2652228 | CNV | deletion | 19546169 |
esv2737350 | CNV | deletion | 23290073 |
esv2737352 | CNV | deletion | 23290073 |
esv3572918 | CNV | loss | 25503493 |
esv3618155 | CNV | loss | 21293372 |
esv3618156 | CNV | loss | 21293372 |
esv3618157 | CNV | loss | 21293372 |
esv3891446 | CNV | gain | 25118596 |
nsv1030498 | CNV | loss | 25217958 |
nsv1150495 | CNV | duplication | 26484159 |
nsv507477 | OTHER | sequence alteration | 20534489 |
nsv515049 | CNV | gain | 21397061 |
nsv611808 | CNV | loss | 21841781 |
nsv611809 | CNV | loss | 21841781 |
nsv6327 | CNV | deletion | 18451855 |
nsv831406 | CNV | loss | 17160897 |
nsv981968 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
non-syndromic x-linked intellectual disability |
|
|