STK3 Gene (Protein Coding)

Serine/Threonine Kinase 3

GC08M098372
GIFtS:
47
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chro... See more...

Aliases for STK3 Gene

Aliases for STK3 Gene

  • Serine/Threonine Kinase 3 2 3 5
  • KRS1 2 3 4
  • MST2 2 3 4
  • Serine/Threonine Kinase 3 (Ste20, Yeast Homolog) 2 3
  • Mammalian STE20-Like Protein Kinase 2 3 4
  • Serine/Threonine-Protein Kinase Krs-1 3 4
  • Serine/Threonine-Protein Kinase 3 3 4
  • STE20-Like Kinase MST2 3 4
  • EC 2.7.11.1 4 50
  • MST-2 3 4
  • Serine/Threonine Kinase 3 (STE20 Homolog, Yeast) 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Hippo (Drosophila) Homolog 2
  • Hippo Homolog 3
  • KB-1458E12.1 3
  • EC 2.7.11 50
  • STK3 5

External Ids for STK3 Gene

Previous GeneCards Identifiers for STK3 Gene

  • GC08M098475
  • GC08M099540
  • GC08M099135
  • GC08M099423
  • GC08M099536
  • GC08M099466
  • GC08M094670
  • GC08M099413
  • GC08M098401

Summaries for STK3 Gene

Entrez Gene Summary for STK3 Gene

  • This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for STK3 Gene

STK3 (Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with STK3 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot Summary for STK3 Gene

  • Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.

Gene Wiki entry for STK3 Gene

Additional gene information for STK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK3 Gene

Genomics for STK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for STK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK3

Top Transcription factor binding sites by QIAGEN in the STK3 gene promoter:
  • AhR
  • C/EBPbeta
  • CUTL1
  • FOXF2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • Hlf
  • MyoD
  • STAT5B

Genomic Locations for STK3 Gene

Latest Assembly
chr8:98,371,228-98,944,329
(GRCh38/hg38)
Size:
573,102 bases
Orientation:
Minus strand

Previous Assembly
chr8:99,466,861-99,954,838
(GRCh37/hg19 by Entrez Gene)
Size:
487,978 bases
Orientation:
Minus strand

chr8:99,413,631-99,955,055
(GRCh37/hg19 by Ensembl)
Size:
541,425 bases
Orientation:
Minus strand

Genomic View for STK3 Gene

Genes around STK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STK3 Gene

Proteins for STK3 Gene

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  3. Assay products for research

  • Protein details for STK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13188-STK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 3
    Protein Accession:
    Q13188
    Secondary Accessions:
    • A8K722
    • B3KYA7
    • Q15445
    • Q15801
    • Q96FM6

    Protein attributes for STK3 Gene

    Size:
    491 amino acids
    Molecular mass:
    56301 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (By similarity). Interacts with and stabilizes SAV1 (PubMed:15688006, PubMed:16930133, PubMed:28087714). Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAH domain). Interacts with DLG5 (via PDZ domain 3) (PubMed:28087714). Interacts with LATS1; this interaction is inhibited in the presence of DLG5 (PubMed:28087714). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714).

    Three dimensional structures from OCA and Proteopedia for STK3 Gene

    Alternative splice isoforms for STK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK3 Gene

Protein Expression for STK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for STK3 Gene

Q13188:
  • DIKAGNIL
  • HKESGQV
  • EMAEGKPPY
  • STMSEGAQTMIEHNSTMLESDLGTMVINS
  • RPSFMDYFDKQD
  • GTPFWMAP
  • YYGSYFK
  • LEKLGEG
  • IEELRQR
  • ATQLLQHPF
  • VAIKQVPVESD
  • ALDPMME
  • ADFGVAGQLTDT
  • KAGNILL
  • HRDIKAGN
  • KLGEGSYGSV
  • IMQQCDS
  • DFVKKCL
  • WMAPEVI
  • WKVPQDGD
  • GSVFKAI
  • DSHTMVK
  • IKAKRHEE
  • IHPMRAIFMIP

Post-translational modifications for STK3 Gene

  • Phosphorylation at Thr-117 and Thr-384 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF1.
  • Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for STK3 Gene

Gene Families for STK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for STK3 Gene

InterPro:

Suggested Antigen Peptide Sequences for STK3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16404 fis, clone UTERU2008019, highly similar to Serine/threonine-protein kinase 3 (EC 2.7.11.1) (B3KYA7_HUMAN)
  • cDNA FLJ90748 fis, clone PLACE1011824, highly similar to Human Ste20-like kinase (MST2) mRNA (Q8NBU1_HUMAN)
  • Serine/threonine-protein kinase Krs-1 (STK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13188

UniProtKB/Swiss-Prot:

STK3_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK3: view

Function for STK3 Gene

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Molecular function for STK3 Gene

UniProtKB/Swiss-Prot Function:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Activity increases during mitosis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-180, which are inhibited by the proto-oncogene product RAF1. Activated by RASSF1 which acts by preventing its dephosphorylation.
GENATLAS Biochemistry:
serine threonine kinase 3

Enzyme Numbers (IUBMB) for STK3 Gene

Phenotypes From GWAS Catalog for STK3 Gene

Gene Ontology (GO) - Molecular Function for STK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 8566796
GO:0003730 mRNA 3'-UTR binding IEA --
GO:0004672 protein kinase activity IEA,IDA 28087714
GO:0004674 protein serine/threonine kinase activity IEA,IDA 8566796
genes like me logo Genes that share ontologies with STK3: view
genes like me logo Genes that share phenotypes with STK3: view

Animal Models for STK3 Gene

MGI Knock Outs for STK3:

Animal Models for research

  • Taconic Biosciences Mouse Models for STK3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK3 Gene

Localization for STK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK3 Gene

Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:19525978, PubMed:11278283). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978). {ECO:0000269 PubMed:11278283, ECO:0000269 PubMed:19525978}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Rods & Rings (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21145499
GO:0005737 cytoplasm IBA,IDA 19525978
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 19962960
genes like me logo Genes that share ontologies with STK3: view

Pathways & Interactions for STK3 Gene

genes like me logo Genes that share pathways with STK3: view

Pathways by source for STK3 Gene

1 BioSystems pathway for STK3 Gene
2 Reactome pathways for STK3 Gene
1 Qiagen pathway for STK3 Gene
  • Sperm Motility
2 Cell Signaling Technology pathways for STK3 Gene

SIGNOR curated interactions for STK3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001841 neural tube formation IEA --
GO:0003157 endocardium development IEA --
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IEA,IDA 8566796
GO:0006915 apoptotic process TAS 11278283
genes like me logo Genes that share ontologies with STK3: view

Drugs & Compounds for STK3 Gene

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  1. Drug products for research

(4) Drugs for STK3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with STK3: view

Transcripts for STK3 Gene

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mRNA/cDNA for STK3 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK3

Alternative Splicing Database (ASD) splice patterns (SP) for STK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: -
SP3:

Relevant External Links for STK3 Gene

GeneLoc Exon Structure for
STK3

Expression for STK3 Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK3 Gene

mRNA expression in normal human tissues for STK3 Gene
mRNA expression by GTEx for STK3 GenemRNA expression by BioGPS for STK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for STK3 Gene

This gene is overexpressed in Lung (40.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK3 Gene



Protein tissue co-expression partners for STK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK3

SOURCE GeneReport for Unigene cluster for STK3 Gene:

Hs.492333

mRNA Expression by UniProt/SwissProt for STK3 Gene:

Q13188-STK3_HUMAN
Tissue specificity: Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.

Evidence on tissue expression from TISSUES for STK3 Gene

  • Eye(4.2)
  • Kidney(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with STK3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK3 Gene

Orthologs for STK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia STK3 29 30
  • 99.68 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia STK3 30
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia STK3 29 30
  • 94.82 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia STK3 29 30
  • 93.79 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Stk3 29 16 30
  • 90.06 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Stk3 29
  • 89.37 (n)
Oppossum
(Monodelphis domestica)
 Mammalia STK3 30
  • 89 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves STK3 30
  • 96 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia STK3 30
  • 95 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia stk3 29
  • 81.44 (n)
Zebrafish
(Danio rerio)
 Actinopterygii stk3 29 30
  • 77.87 (n)
 OneToOne
wufc19e11 29
Fruit Fly
(Drosophila melanogaster)
 Insecta hpo 29 30
  • 63.43 (n)
 OneToMany
CG11228 31
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006044 29
  • 59.43 (n)
Worm
(Caenorhabditis elegans)
 Secernentea cst-2 29 30
  • 66.9 (n)
 ManyToMany
C24A8.4a 31
  • 59 (a)
C24A8.4b 31
  • 59 (a)
F14H12.4a 31
  • 54 (a)
F14H12.4b 31
  • 54 (a)
cst-1 30
  • 53 (a)
 ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SPS1 30
  • 28 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.8767 30
  • 69 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1634 29
Species where no ortholog for STK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STK3 Gene

ENSEMBL:
Gene Tree for STK3 (if available)
TreeFam:
Gene Tree for STK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK3: view image
Alliance of Genome Resources:
Additional Orthologs for STK3

Paralogs for STK3 Gene

Paralogs for STK3 Gene

(54) SIMAP similar genes for STK3 Gene using alignment to 5 proteins:

  • STK3_HUMAN
  • B3KYA7_HUMAN
  • E5RFQ9_HUMAN
  • E5RIM6_HUMAN
  • Q8NBU1_HUMAN
genes like me logo Genes that share paralogs with STK3: view

Variants for STK3 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
VAR_041122 An ovarian clear cell carcinoma sample p.Val60Leu
rs36047674 -- p.Phe418Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STK3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STK3 Gene

Variant ID Type Subtype PubMed ID
esv24438 CNV loss 19812545
esv2652228 CNV deletion 19546169
esv2737350 CNV deletion 23290073
esv2737352 CNV deletion 23290073
esv3572918 CNV loss 25503493
esv3618155 CNV loss 21293372
esv3618156 CNV loss 21293372
esv3618157 CNV loss 21293372
esv3891446 CNV gain 25118596
nsv1030498 CNV loss 25217958
nsv1150495 CNV duplication 26484159
nsv507477 OTHER sequence alteration 20534489
nsv515049 CNV gain 21397061
nsv611808 CNV loss 21841781
nsv611809 CNV loss 21841781
nsv6327 CNV deletion 18451855
nsv831406 CNV loss 17160897
nsv981968 CNV duplication 23825009

Variation tolerance for STK3 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK3 Gene

Human Gene Mutation Database (HGMD)
STK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK3
Leiden Open Variation Database (LOVD)
STK3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK3 Gene

Disorders for STK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK3 Gene - From: COP

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search STK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STK3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with STK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK3 Gene

Publications for STK3 Gene

  1. Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. (PMID: 20212043) Kilili GK … Kyriakis JM (The Journal of biological chemistry 2010) 3 4 22
  2. Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. (PMID: 20231902) Kim D … Cheng JQ (PloS one 2010) 3 4 22
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M … Avruch J (Current biology : CB 2008) 3 4 22
  4. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PMID: 15688006) Chan EH … Silljé HH (Oncogene 2005) 3 4 22
  5. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. (PMID: 15618521) O'Neill E … Kolch W (Science (New York, N.Y.) 2004) 3 4 22

ExternalLinks

View latest publications for STK3 gene in Mastermind

Products for STK3 Gene

  • Addgene plasmids for STK3

Sources for STK3 Gene