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This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical... See more...
Aliases for STK25 Gene
Aliases for STK25 Gene
External Ids for STK25 Gene
- HGNC: 11404
- NCBI Entrez Gene: 10494
- Ensembl: ENSG00000115694
- OMIM®: 602255
- UniProtKB/Swiss-Prot: O00506
Previous GeneCards Identifiers for STK25 Gene
- GC02P238953
- GC02P239845
- GC02M242453
- GC02M242755
- GC02M242154
- GC02M234189
- GC02M242434
Summaries for STK25 Gene
-
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for STK25 Gene
STK25 (Serine/Threonine Kinase 25) is a Protein Coding gene. Diseases associated with STK25 include Anoxia and Cerebral Cavernous Malformations. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is STK24.
UniProtKB/Swiss-Prot Summary for STK25 Gene
-
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
Additional gene information for STK25 Gene
- HGNC (11404)
- NCBI Entrez Gene (10494)
- Ensembl (ENSG00000115694)
- OMIM® (602255)
- UniProtKB/Swiss-Prot (O00506)
- Open Targets Platform(ENSG00000115694)
- Search for STK25 at DataMed
- Search for STK25 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK25 Gene
Genomics for STK25 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STK25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STK25 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK25
- Top Transcription factor binding sites by QIAGEN in the STK25 gene promoter:
-
- AML1a
- c-Myb
- CUTL1
- Lmo2
- LUN-1
- NF-kappaB1
- p53
- Pax-4a
- SRY
- XBP-1
Genomic Locations for STK25 Gene
Latest Assembly
- chr2:241,492,670-241,509,730
- (GRCh38/hg38)
- Size:
- 17,061 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:242,432,085-242,448,987
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,903 bases
- Orientation:
- Minus strand
- chr2:242,432,089-242,449,145
- (GRCh37/hg19 by Ensembl)
- Size:
- 17,057 bases
- Orientation:
- Minus strand
Genomic View for STK25 Gene
Genes around STK25 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
STK25 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STK25 Gene
Proteins for STK25 Gene
-
Protein details for STK25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00506-STK25_HUMAN
- Recommended name:
- Serine/threonine-protein kinase 25
- Protein Accession:
- O00506
- A8K6Z3
- A8K7D2
- B7Z9K1
- Q15522
- Q5BJF1
Protein attributes for STK25 Gene
- Size:
- 426 amino acids
- Molecular mass:
- 48112 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer. Interacts with CTTNBP2NL.
Protein Expression for STK25 Gene
Selected DME Specific Peptides for STK25 Gene
- O00506:
-
- IGKGSFGEV
- VAIKIID
- GITAIEL
- GTPFWMAP
- WMAPEVI
- KLWIIMEYL
- AEDEIEDIQQEI
- HRDIKAAN
- IHRDIKAAN
- LLKHKFI
- KADIWSLGIT
- LDYLHSE
- ADFGVAGQLTDT
- VKLADFG
Post-translational modifications for STK25 Gene
Other Protein References for STK25 Gene
- ENSEMBL proteins:
-
- ENSP00000325748
- ENSP00000384162
- ENSP00000385687
- ENSP00000384444
- ENSP00000385541
- ENSP00000404469
- ENSP00000399212
- ENSP00000417020
- ENSP00000403607
- ENSP00000395104
- ENSP00000404960
- ENSP00000412617
- ENSP00000403866
- ENSP00000401114
- ENSP00000406208
- ENSP00000414191
- ENSP00000404552
- ENSP00000446008
- ENSP00000444886
- O00506.202
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences STK25 Antibody (LS-B10544) and STK25 Antibody (LS-B13818)
- G Biosciences Immunotag™ STK25 Antibody
- GeneTex Anti-STK25 antibody [N1C1]
-
Custom Antibody ServicesOriGene Antibodies for STK25
- Novus Biologicals Antibodies for STK25
-
Abcam antibodies for STK25
- Invitrogen Antibodies for STK25 (AFLGC-STK25)
-
Boster Bio Antibodies for STK25
-
Custom Antibody ServicesProSci Antibodies for STK25
-
Santa Cruz Biotechnology (SCBT) Antibodies for STK25
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for STK25
- Origene Custom Protein Services for STK25
-
Abcam proteins for STK25
Assay products for research
Domains & Families for STK25 Gene
Gene Families for STK25 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for STK25 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for STK25 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ78718 (A8K6Z3_HUMAN)
- cDNA, FLJ78865, highly similar to Serine/threonine-protein kinase 25 (EC 2.7.11.1) (B7Z9K1_HUMAN)
- Sterile 20/oxidant stress-response kinase 1 (STK25_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00506UniProtKB/Swiss-Prot:
STK25_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for STK25 Gene
Molecular function for STK25 Gene
- UniProtKB/Swiss-Prot Function:
- Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.
- GENATLAS Biochemistry:
- serine/threonine kinase 25,yeast Sp11/Ste20 related ,widely expressed,activated by oxidant stress,not activated by growth factors,alkylating agents,cytokines or environmental stress,not activating the MAPK,ERK or INK pathways
Enzyme Numbers (IUBMB) for STK25 Gene
Phenotypes From GWAS Catalog for STK25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | TAS | 9160885 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15037601 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for STK25 Gene
- MGI mutant phenotypes for STK25:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for STK25:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased viability
- no effect
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased viability (proliferation)
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability
- Decreased cell proliferation
- Increased virus production
- Paclitaxel antagonistic effect
Animal Models for STK25 Gene
- MGI Knock Outs for STK25:
-
- Stk25 Stk25<tm1.2Bwh>
Animal Models for research
-
Taconic Biosciences Mouse Models for STK25
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STK25 - Starting at $85 >
- * STK25 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STK25
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK25
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK25
miRNA for STK25 Gene
- miRTarBase miRNAs that target STK25
-
- hsa-miR-186-5p (MIRT044928)
- hsa-miR-92a-3p (MIRT049469)
- hsa-miR-640 (MIRT629760)
- hsa-miR-5001-3p (MIRT629761)
- hsa-miR-378a-5p (MIRT629762)
- hsa-miR-6821-3p (MIRT629763)
- hsa-miR-6790-3p (MIRT629764)
- hsa-miR-3653-5p (MIRT629765)
- hsa-miR-6513-3p (MIRT629766)
- hsa-miR-7151-5p (MIRT629767)
- hsa-miR-8079 (MIRT629768)
- hsa-miR-1245a (MIRT629769)
- hsa-miR-6868-3p (MIRT723633)
- hsa-miR-3667-3p (MIRT723634)
- hsa-miR-6734-3p (MIRT723635)
- hsa-miR-338-3p (MIRT723636)
- hsa-miR-7157-5p (MIRT723637)
- hsa-miR-4310 (MIRT723638)
- hsa-miR-1179 (MIRT723639)
- hsa-miR-4681 (MIRT723640)
- hsa-miR-1324 (MIRT762551)
- hsa-miR-4330 (MIRT768717)
- hsa-miR-4728-3p (MIRT771679)
- hsa-miR-628-5p (MIRT776130)
- hsa-miR-6759-3p (MIRT778441)
- hsa-miR-6892-3p (MIRT781171)
- hsa-miR-891a-3p (MIRT782625)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK25
- Browse OriGene Inhibitory RNA Products For STK25
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK25
Clone products for research
- Applied Biological Materials (abm): Clones for STK25 - Starting at $45 >
- * STK25 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG206799
- MR206799
- MR206799L3
- MR206799L4
- RC203215
- RC203215L1
- RC203215L2
- RC203215L3
- RC203215L4
- RC233841
- RC233842
- RC234064
- RC234065
- RC237501
- RC237502
- RC237503
- RC237658
- RG203215
- RG233841
- RG233842
- RG234064
- RG234065
- RR211900
- RR211900L3
- RR211900L4
- MR206799L3V
- MR206799L4V
- RC203215L1V
- RC203215L2V
- RC203215L3V
- RC203215L4V
- RR211900L3V
- RR211900L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STK25
- Addgene plasmids for STK25
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK25
Cell Lines for research
-
Horizon Cell Lines for STK25
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK25 Gene
Localization for STK25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STK25 Gene
- Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| nucleus | 3 |
| cytosol | 3 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 22652780 |
| GO:0005794 | colocalizes_with Golgi apparatus | IEA,IDA | 22652780 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for STK25 Gene
Pathways & Interactions for STK25 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
Sperm Motility
.37
|
|
Pathways by source for STK25 Gene
1 Qiagen pathway for STK25 Gene
- Sperm Motility
Interacting Proteins for STK25 Gene
Selected Interacting proteins:
O00506-STK25_HUMAN
ENSP00000325748
for STK25 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STK25
SIGNOR curated interactions for STK25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 17657516 |
| GO:0006979 | response to oxidative stress | TAS | 8887545 |
| GO:0007163 | establishment or maintenance of cell polarity | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8887545 |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for STK25 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 |
Transcripts for STK25 Gene
mRNA/cDNA for STK25 Gene
- 9 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 35 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316586 4515 nts (view in UCSC)
- ENST00000401869 2251 nts (view in UCSC)
- ENST00000403346 2210 nts (view in UCSC)
- ENST00000405585 1643 nts (view in UCSC)
- ENST00000405883 1904 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STK25 - Starting at $85 >
- * STK25 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STK25
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK25
-
Santa Cruz Biotechnology (SCBT) CRISPR for STK25
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK25
- Browse OriGene Inhibitory RNA Products For STK25
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK25
Clone products for research
- Applied Biological Materials (abm): Clones for STK25 - Starting at $45 >
- * STK25 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG206799
- MR206799
- MR206799L3
- MR206799L4
- RC203215
- RC203215L1
- RC203215L2
- RC203215L3
- RC203215L4
- RC233841
- RC233842
- RC234064
- RC234065
- RC237501
- RC237502
- RC237503
- RC237658
- RG203215
- RG233841
- RG233842
- RG234064
- RG234065
- RR211900
- RR211900L3
- RR211900L4
- MR206799L3V
- MR206799L4V
- RC203215L1V
- RC203215L2V
- RC203215L3V
- RC203215L4V
- RR211900L3V
- RR211900L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STK25
- Addgene plasmids for STK25
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK25
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP25: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP28: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP29: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP30: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP31: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP32: |
| ExUns: | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
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| SP19: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP20: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP31: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP32: |
| ExUns: | 14c | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18 |
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Relevant External Links for STK25 Gene
- GeneLoc Exon Structure for
- STK25
Expression for STK25 Gene
mRNA differential expression in normal tissues according to GTEx for STK25 Gene
This gene is overexpressed in Muscle - Skeletal (x4.4).
This gene is overexpressed in Saliva (33.9), Lung (9.8), and Cervix (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK25 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK25
SOURCE GeneReport for Unigene cluster for STK25 Gene:
Hs.516807mRNA Expression by UniProt/SwissProt for STK25 Gene:
O00506-STK25_HUMAN
Tissue specificity:
Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.
Evidence on tissue expression from TISSUES for STK25 Gene
- Nervous system(4.9)
- Eye(3.6)
- Lung(3.4)
- Pancreas(3.4)
- Liver(3.1)
- Muscle(3.1)
- Skin(2.6)
- Kidney(2.5)
- Heart(2.5)
- Lymph node(2.3)
- Intestine(2.2)
- Spleen(2.2)
Primer products for research
-
OriGene qPCR primer pairs for STK25
-
OriGene qPCR primer pairs and template standards for STK25
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK25 Gene
Orthologs for STK25 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STK25 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STK25 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STK25 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stk25 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Stk25 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STK25 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STK25 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STK25 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stk25 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | stk25a 31 |
|
OneToMany | |
| stk25b 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5169 32 |
|
|
|
| GckIII 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | gck-1 30 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPS1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4671 31 |
|
OneToMany |
- Species where no ortholog for STK25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STK25 Gene
- ENSEMBL:
- Gene Tree for STK25 (if available)
- TreeFam:
- Gene Tree for STK25 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STK25: view image
Paralogs for STK25 Gene
Paralogs for STK25 Gene
(147) SIMAP similar genes for STK25 Gene using alignment to 15 proteins:
- STK25_HUMAN
- A8K6Z3_HUMAN
- B7Z9K1_HUMAN
- C9J232_HUMAN
- C9J6L2_HUMAN
- C9J8E8_HUMAN
- C9JCC0_HUMAN
- C9JDH9_HUMAN
- C9JFA1_HUMAN
- C9JIH8_HUMAN
- C9JJV0_HUMAN
- C9JN58_HUMAN
- C9K0M6_HUMAN
- E7EM58_HUMAN
- H7C279_HUMAN
- DKFZp686J1430
- STK24
- MST4
- PAK2
- STK3
- MINK1
- MYO3A
- KSR1
- PAK1
- TNIK
- STK4
- MAP4K3
- MAP4K5
- TAOK3
- PAK3
- MYO3B
- MAP4K1
- STK4/SLC36AL fusion
- SLK
- NEK9
- MAP4K2
- MAP4K4
- MAP2K1
- TBCK
- MAPK4
- MAPK9
- CDK12
- CDK10
- NEK8
- FGFR3
- CDK19
- PAK4
- NEK4
- MAP3K2
- PKMYT1
- PAK7
- MAPK14
- MARK4
- STRADA
- FGFR1
- MAP2K3
- CDK7
- MAP2K5
- CDK1
- MAP3K3
- BRAF
- TAOK1
- STRADB
- MAPK7
- CDK11B
- PRKY
- NEK7
- MARK2
- STK11
- MAP3K6
- MAP3K15
- SGK494
- NLK
- AXL
- OBSCN
- MAPK3
- WNK4
- TAOK2
- PRKCB
- CAMKK2
- PRKAA1
- NEK6
- DKFZp564L2416
- EGFR
- SRGAP3
- RAF1
- WNK1
- CHEK1
- BRSK2
- MST094
- CDK16
- CDK17
- OXSR1
- YSK4
- PLK4
- MOK
- MAPK10
- GRK5
- ERBB2
- FGFR4
- SGK1
- FLT4
- MAP2K7
- PRKCH
- ADRBK1
- STK36
- STK32A
- RPS6KA5
- PASK
- MAP3K19
- DKFZp686A2068
- DAPK3
- NRK
- PHKG2
- AURKB
- GRK6
- MAP3K4
- CDKL3
- TYK2
- CDK4
- CDK3
- STK39
- PRKACA
- PKN1
- DAPK1
- ABL1
- FPGT-TNNI3K
- FLT1
- PRKCG
- RPS6KA1
- RPS6KA4
- NEK11
- CDKL1
- AKT2
- RPS6KA3
- HCK
- RPS6KA2
- TXK
- PTK7
- PRKD2
- CAMKV
- NUAK1
- BLK
- TESK2
- STK38L
- SIK3
- IKBKB
- CDC42BPA
- MAST4
- JAK2
- MAP2K6
- FGR
- EPHA6
- ULK1
- SGK2
- TYRO3
- SQSTM1-ALK
- PPFIBP1-ALK
- LRRK1
- KIF5B-ALK_K17;A20
- EML4-ALK
- ALK
Pseudogenes.org Pseudogenes for STK25 Gene
Variants for STK25 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK25 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs137904208 | Likely Benign: not provided | 241,493,424(-) |
G/A NM_014808.4(FARP2):c.3027G>A (p.Glu1009=) |
SYNONYMOUS_VARIANT,THREE_PRIME_UTR | |
| rs144436834 | Likely Benign: not provided | 241,494,098(-) |
G/A NM_014808.4(FARP2):c.3138G>A (p.Glu1046=) |
SYNONYMOUS_VARIANT,THREE_PRIME_UTR | |
| rs34341643 | - |
p.Gln64His |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759120 | CNV | loss | 17122850 |
| nsv10229 | CNV | gain | 18304495 |
| nsv1109345 | CNV | deletion | 24896259 |
| nsv834588 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STK25 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STK25
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK25 Gene
Disorders for STK25 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anoxia |
|
|
| cerebral cavernous malformations |
|
|
| cerebral cavernous malformations 3 |
|
|
| cavernous malformation |
|
|
| chromosome 2q37 deletion syndrome |
|
|
Search STK25 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STK25
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STK25 Gene
Publications for STK25 Gene
- Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. (PMID: 8887545) Pombo CM … Force T (The EMBO journal 1996) 2 3 4 23
- YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PMID: 15037601) Preisinger C … Barr FA (The Journal of cell biology 2004) 2 3 4
- YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. (PMID: 9160885) Osada S … Ohno S (Oncogene 1997) 2 3 4
- A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4
- CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. (PMID: 17657516) Voss K … Felbor U (Neurogenetics 2007) 3 23
ExternalLinks
Products for STK25 Gene
- Custom Antibody ServicesOriGene Antibodies for STK25
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STK25
- Origene Custom Protein Services for STK25
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STK25
- Browse OriGene Inhibitory RNA Products For STK25
- OriGene qPCR primer pairs for STK25
- OriGene qPCR primer pairs and template standards for STK25
- OriGene CRISPR knockouts for STK25
- MG206799
- MR206799
- MR206799L3
- MR206799L4
- RC203215
- RC203215L1
- RC203215L2
- RC203215L3
- RC203215L4
- RC233841
- RC233842
- RC234064
- RC234065
- RC237501
- RC237502
- RC237503
- RC237658
- RG203215
- RG233841
- RG233842
- RG234064
- RG234065
- RR211900
- RR211900L3
- RR211900L4
- MR206799L3V
- MR206799L4V
- RC203215L1V
- RC203215L2V
- RC203215L3V
- RC203215L4V
- RR211900L3V
- RR211900L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STK25
- Sino Biological Human cDNA Clone for STK25
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STK25
- Novus Biologicals proteins and lysates for STK25
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STK25
- Abcam proteins for STK25
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for STK25
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for STK25 (AFLGC-STK25)
- VectorBuilder Custom and pre-made DNA vectors for STK25 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for STK25 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for STK25 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for STK25 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STK25
- Addgene plasmids for STK25
- antibodies-online: Show 28 available STK25 Antibodies ranked by validation data
- Compare Top STK25 Antibodies
- antibodies-online: Search results for available STK25 related products ranked by validation data
- antibodies-online: Show 11 available STK25 Proteins ranked by validation data
- Compare Top STK25 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for STK25
- Search Santa Cruz Biotechnology (SCBT) for STK25 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STK25
- Horizon Cell Lines for STK25
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STK25
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STK25
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STK25
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK25
- Boster Bio Antibodies for STK25
- Browse Boster Bio ELISA Kits
Sources for STK25 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB