Aliases for STK25 Gene
External Ids for STK25 Gene
Previous GeneCards Identifiers for STK25 Gene
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for STK25 Gene
STK25 (Serine/Threonine Kinase 25) is a Protein Coding gene. Diseases associated with STK25 include Cerebral Cavernous Malformations 2 and Myeloproliferative Syndrome, Transient. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is STK24.
UniProtKB/Swiss-Prot for STK25 Gene
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.