This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multipl... See more...

Aliases for STK24 Gene

Aliases for STK24 Gene

  • Serine/Threonine Kinase 24 2 3 5
  • Mammalian STE20-Like Protein Kinase 3 3 4
  • Serine/Threonine-Protein Kinase 24 3 4
  • Sterile 20-Like Kinase 3 2 3
  • STE20-Like Kinase MST3 3 4
  • STE20-Like Kinase 3 2 3
  • EC 2.7.11.1 4 52
  • MST3 3 4
  • STK3 3 4
  • Serine/Threonine Kinase 24 (STE20 Homolog, Yeast) 3
  • Serine/Threonine Kinase 24 (Ste20, Yeast Homolog) 2
  • Epididymis Secretory Protein Li 95 3
  • EC 2.7.11 52
  • HEL-S-95 3
  • MST3B 3
  • STE20 3
  • MST-3 4

External Ids for STK24 Gene

Previous GeneCards Identifiers for STK24 Gene

  • GC13M097464
  • GC13M093491
  • GC13M097941
  • GC13M096802
  • GC13M097902
  • GC13M099103
  • GC13M079700

Summaries for STK24 Gene

Entrez Gene Summary for STK24 Gene

  • This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for STK24 Gene

STK24 (Serine/Threonine Kinase 24) is a Protein Coding gene. Diseases associated with STK24 include Cerebral Cavernous Malformations and Inflammatory Bowel Disease 14. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK25.

UniProtKB/Swiss-Prot Summary for STK24 Gene

  • Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene Wiki entry for STK24 Gene

Additional gene information for STK24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK24 Gene

Genomics for STK24 Gene

GeneHancer (GH) Regulatory Elements for STK24 Gene

Promoters and enhancers for STK24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J098562 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 512.9 +7.2 7172 16.3 EP300 FOXK2 ZBTB40 ZSCAN5C POLR2G NCOR1 PHF8 ZFX ZIC2 POLR2A STK24 STK24-AS1 ENSG00000271437 lnc-FARP1-4
GH13J098522 Promoter/Enhancer 0.8 EPDnew dbSUPER 512 +55.8 55828 0.1 ZNF263 KLF17 PRDM1 ZNF600 STK24 STK24-AS1 lnc-SLC15A1-1 ENSG00000271437 lnc-FARP1-4
GH13J098519 Promoter/Enhancer 0.6 EPDnew dbSUPER 500.2 +58.7 58656 0.1 ZNF600 STK24 lnc-SLC15A1-1 ENSG00000271437 lnc-FARP1-4
GH13J098578 Enhancer 0.3 ENCODE dbSUPER 505.9 -1.1 -1102 0.2 STK24 STK24-AS1 piR-61945-128
GH13J098482 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 21.8 +92.6 92592 5.9 ZNF217 ZSCAN5C TCF12 FOS ZNF639 CTCF ZIC2 CLOCK ZNF423 KLF4 STK24-AS1 STK24 DOCK9-AS1 DOCK9 lnc-SLC15A1-1 lnc-IPO5-10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK24 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK24

Top Transcription factor binding sites by QIAGEN in the STK24 gene promoter:
  • AhR
  • Arnt
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • HSF1 (long)
  • HSF1short
  • Pbx1a
  • Roaz

Genomic Locations for STK24 Gene

Genomic Locations for STK24 Gene
chr13:98,445,185-98,577,940
(GRCh38/hg38)
Size:
132,756 bases
Orientation:
Minus strand
chr13:99,102,455-99,230,194
(GRCh37/hg19)
Size:
127,740 bases
Orientation:
Minus strand

Genomic View for STK24 Gene

Genes around STK24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK24 Gene

Proteins for STK24 Gene

  • Protein details for STK24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E0-STK24_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 24
    Protein Accession:
    Q9Y6E0
    Secondary Accessions:
    • O14840
    • Q5JV92

    Protein attributes for STK24 Gene

    Size:
    443 amino acids
    Molecular mass:
    49308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer (PubMed:20124694). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1 (PubMed:27807006).

    Three dimensional structures from OCA and Proteopedia for STK24 Gene

    Alternative splice isoforms for STK24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK24 Gene

Selected DME Specific Peptides for STK24 Gene

Q9Y6E0:
  • IGKGSFGEV
  • GTPFWMAP
  • LLKHKFI
  • KADIWSLGIT
  • LDYLHSE
  • ADFGVAGQLTDT
  • VKLADFG
  • VAIKIID
  • GITAIEL
  • WMAPEVI
  • KLWIIMEYL
  • AEDEIEDIQQEI
  • HRDIKAAN
  • IHRDIKAAN

Post-translational modifications for STK24 Gene

  • Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis.
  • Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.
  • Ubiquitination at Lys238
  • Modification sites at PhosphoSitePlus

Domains & Families for STK24 Gene

Gene Families for STK24 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK24 Gene

Suggested Antigen Peptide Sequences for STK24 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61159, highly similar to Serine/threonine-protein kinase 24 (EC 2.7.11.1) (B4DR80_HUMAN)
  • Serine/threonine kinase 24 (STE20 homolog, yeast) (Q5JV93_HUMAN)
  • Serine/threonine kinase 24 (STE20 homolog, yeast) (Q5JV98_HUMAN)
  • Serine/threonine kinase 24 (STE20 homolog, yeast) (Q5JV99_HUMAN)
  • Serine/threonine kinase 24 (STE20 homolog, yeast), isoform CRA_c (Q5U0E6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6E0

UniProtKB/Swiss-Prot:

STK24_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK24: view

Function for STK24 Gene

Molecular function for STK24 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=12.8 uM for manganese ions {ECO:0000269 PubMed:15917084}; KM=34.9 uM for cobalt ions {ECO:0000269 PubMed:15917084}; KM=22.7 uM for magnesium ions {ECO:0000269 PubMed:15917084}; KM=4.1 uM for zinc ions {ECO:0000269 PubMed:15917084}; Vmax=2623.1 pmol/min/mg enzyme for manganese ions {ECO:0000269 PubMed:15917084}; Vmax=1746.1 pmol/min/mg enzyme for cobalt ions {ECO:0000269 PubMed:15917084}; Vmax=129.1 pmol/min/mg enzyme for magnesium ions {ECO:0000269 PubMed:15917084}; Vmax=22.3 pmol/min/mg enzyme for zinc ions {ECO:0000269 PubMed:15917084};
GENATLAS Biochemistry:
serine/threonine kinase 24,Ste20 yeast homolog

Enzyme Numbers (IUBMB) for STK24 Gene

Phenotypes From GWAS Catalog for STK24 Gene

Gene Ontology (GO) - Molecular Function for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 9353338
GO:0004674 protein serine/threonine kinase activity IBA,IDA 16314523
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with STK24: view
genes like me logo Genes that share phenotypes with STK24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK24

Clone Products

  • Addgene plasmids for STK24

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK24 Gene

Localization for STK24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK24 Gene

Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK24 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12107159
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA,TAS 27807006
GO:0005794 Golgi apparatus TAS 27807006
genes like me logo Genes that share ontologies with STK24: view

Pathways & Interactions for STK24 Gene

genes like me logo Genes that share pathways with STK24: view

Pathways by source for STK24 Gene

1 Qiagen pathway for STK24 Gene
  • Sperm Motility
2 Cell Signaling Technology pathways for STK24 Gene

SIGNOR curated interactions for STK24 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 19604147
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 9353338
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP 19604147
GO:0009267 cellular response to starvation IMP 27807006
genes like me logo Genes that share ontologies with STK24: view

Drugs & Compounds for STK24 Gene

(4) Drugs for STK24 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Manganese Approved Nutra 51
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK24: view

Transcripts for STK24 Gene

mRNA/cDNA for STK24 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK24

Clone Products

  • Addgene plasmids for STK24

Alternative Splicing Database (ASD) splice patterns (SP) for STK24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for STK24 Gene

GeneLoc Exon Structure for
STK24

Expression for STK24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK24 Gene

Protein differential expression in normal tissues from HIPED for STK24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK24 Gene



Protein tissue co-expression partners for STK24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK24

SOURCE GeneReport for Unigene cluster for STK24 Gene:

Hs.508514

mRNA Expression by UniProt/SwissProt for STK24 Gene:

Q9Y6E0-STK24_HUMAN
Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

Evidence on tissue expression from TISSUES for STK24 Gene

  • Nervous system(4.3)
  • Skin(4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with STK24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK24 Gene

Orthologs for STK24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK24 31 30
  • 97.45 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK24 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK24 31 30
  • 90.4 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK24 31
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK24 31 30
  • 88.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stk24 17 31 30
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Stk24 30
  • 87.08 (n)
chicken
(Gallus gallus)
Aves STK24 31 30
  • 78.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK24 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk24 30
  • 77.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3008 30
zebrafish
(Danio rerio)
Actinopterygii stk24a 31
  • 75 (a)
OneToMany
stk24b 31 30
  • 73.12 (n)
OneToMany
wufi29b08 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2079 30
fruit fly
(Drosophila melanogaster)
Insecta CG5169 32
  • 73 (a)
GckIII 31
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-1 31 32
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 31
  • 31 (a)
OneToMany
KIC1 33
rice
(Oryza sativa)
Liliopsida Os.18593 30
corn
(Zea mays)
Liliopsida Zm.17164 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 31
  • 65 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04096 30
  • 58.73 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sid1 30
  • 52.46 (n)
Species where no ortholog for STK24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK24 Gene

ENSEMBL:
Gene Tree for STK24 (if available)
TreeFam:
Gene Tree for STK24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK24: view image

Paralogs for STK24 Gene

(51) SIMAP similar genes for STK24 Gene using alignment to 9 proteins:

  • STK24_HUMAN
  • B4DR80_HUMAN
  • H0Y630_HUMAN
  • L8E7H5_HUMAN
  • Q5JV98_HUMAN
  • Q5JV99_HUMAN
  • Q5U0E6_HUMAN
  • Q6FG81_HUMAN
  • Q6P0Y1_HUMAN

Pseudogenes.org Pseudogenes for STK24 Gene

genes like me logo Genes that share paralogs with STK24: view

Variants for STK24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK24 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs55897869 - p.Leu426Ile
rs55953606 - p.Ala414Val

Additional dbSNP identifiers (rs#s) for STK24 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK24 Gene

Variant ID Type Subtype PubMed ID
dgv3346n54 CNV gain 21841781
dgv3347n54 CNV loss 21841781
dgv3348n54 CNV gain 21841781
dgv3349n54 CNV gain+loss 21841781
dgv3350n54 CNV loss 21841781
esv1791098 CNV insertion 17803354
esv26178 CNV loss 19812545
esv2747857 CNV deletion 23290073
esv2747858 CNV deletion 23290073
esv3633311 CNV loss 21293372
nsv1122856 CNV deletion 24896259
nsv1131063 CNV deletion 24896259
nsv1141 CNV insertion 18451855
nsv1142 CNV insertion 18451855
nsv456088 CNV gain 19166990
nsv456089 CNV loss 19166990
nsv471172 CNV gain 18288195
nsv476968 CNV novel sequence insertion 20440878
nsv509511 CNV insertion 20534489
nsv513394 CNV insertion 21212237
nsv517409 CNV gain+loss 19592680
nsv562868 CNV gain 21841781
nsv562873 CNV loss 21841781
nsv562874 CNV loss 21841781
nsv562875 CNV gain 21841781
nsv562876 CNV loss 21841781
nsv562880 CNV gain+loss 21841781
nsv562885 CNV loss 21841781
nsv562890 CNV loss 21841781
nsv7246 OTHER inversion 18451855
nsv832695 CNV loss 17160897

Variation tolerance for STK24 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK24 Gene

Disorders for STK24 Gene

MalaCards: The human disease database

(8) MalaCards diseases for STK24 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search STK24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STK24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STK24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK24 Gene

Publications for STK24 Gene

  1. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. (PMID: 10644707) Zhou TH … Pei G (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PMID: 9353338) Schinkmann K … Blenis J (The Journal of biological chemistry 1997) 2 3 4 23 54
  3. Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway. (PMID: 19782762) Lin CY … Yuan CJ (The international journal of biochemistry & cell biology 2010) 3 4 23 54
  4. Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation. (PMID: 19604147) Chen CB … Porter AG (Bioscience reports 2009) 3 4 23 54
  5. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PMID: 16314523) Stegert MR … Hemmings BA (Molecular and cellular biology 2005) 3 4 23 54

Products for STK24 Gene

Sources for STK24 Gene