This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Ju... See more...

Aliases for STK19 Gene

Aliases for STK19 Gene

  • Serine/Threonine Kinase 19 2 3 5
  • G11 2 3 4
  • RP1 2 3 4
  • Serine/Threonine-Protein Kinase 19 3 4
  • D6S60 2 3
  • Nuclear Serine/Threonine Protein Kinase 3
  • MHC Class III HLA-RP1 3
  • Protein G11 4
  • Protein RP1 4
  • EC 2.7.11.1 4
  • HLA-RP1 3
  • D6S60E 3
  • STK19 5

External Ids for STK19 Gene

Previous GeneCards Identifiers for STK19 Gene

  • GC06P032001
  • GC06P031710
  • GC06P032043
  • GC06P032047
  • GC06P031938
  • GC06P031725

Summaries for STK19 Gene

Entrez Gene Summary for STK19 Gene

  • This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK19 Gene

STK19 (Serine/Threonine Kinase 19) is a Protein Coding gene. Diseases associated with STK19 include Hyperpigmentation Of The Skin and Melanoma. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot Summary for STK19 Gene

  • Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.

Gene Wiki entry for STK19 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK19 Gene

Genomics for STK19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STK19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK19

Top Transcription factor binding sites by QIAGEN in the STK19 gene promoter:
  • AP-1
  • E2F-4
  • E2F-5
  • Max
  • NF-kappaB
  • NF-kappaB1
  • Pax-5

Genomic Locations for STK19 Gene

Genomic Locations for STK19 Gene
chr6:31,971,091-31,982,821
(GRCh38/hg38)
Size:
11,731 bases
Orientation:
Plus strand
chr6:31,938,868-31,950,598
(GRCh37/hg19)
Size:
11,731 bases
Orientation:
Plus strand

Genomic View for STK19 Gene

Genes around STK19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for STK19 Gene

  • Protein details for STK19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49842-STK19_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 19
    Protein Accession:
    P49842
    Secondary Accessions:
    • A6NF95
    • A6NFW8
    • B0QZR5
    • Q13159
    • Q31617
    • Q5JP77
    • Q5ST72
    • Q5ST75

    Protein attributes for STK19 Gene

    Size:
    368 amino acids
    Molecular mass:
    40916 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts (via N-terminus) with BAG1.

    Alternative splice isoforms for STK19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK19 Gene

Post-translational modifications for STK19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK19 Gene

Antibody Products

  • Boster Bio Antibodies for STK19
  • Santa Cruz Biotechnology (SCBT) Antibodies for STK19

No data available for DME Specific Peptides for STK19 Gene

Domains & Families for STK19 Gene

Gene Families for STK19 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STK19 Gene

GenScript: Design optimal peptide antigens:
  • Protein RP1 (STK19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49842

UniProtKB/Swiss-Prot:

STK19_HUMAN :
  • Belongs to the STK19 family.
Family:
  • Belongs to the STK19 family.
genes like me logo Genes that share domains with STK19: view

Function for STK19 Gene

Molecular function for STK19 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:30712867, ECO:0000305|PubMed:9812991};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000305|PubMed:9812991};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by ZT-12-037-01 (1a) (N2-cyclopropyl-N4-(1-isopropylpiperidin-4-yl)- 6,7-dimethoxyquinazoline-2,4-diamine) (PubMed:30712867). Inhibition by ZT-12-037-01 (1a) blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth (PubMed:30712867).
GENATLAS Biochemistry:
serine/threonine 19,widely expressed

Enzyme Numbers (IUBMB) for STK19 Gene

Phenotypes From GWAS Catalog for STK19 Gene

Gene Ontology (GO) - Molecular Function for STK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IDA 30712867
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK19: view
genes like me logo Genes that share phenotypes with STK19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK19

CRISPR Products

miRNA for STK19 Gene

miRTarBase miRNAs that target STK19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK19

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK19 Gene

Localization for STK19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK19 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9812991
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with STK19: view

Pathways & Interactions for STK19 Gene

PathCards logo

SuperPathways for STK19 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.37
genes like me logo Genes that share pathways with STK19: view

Pathways by source for STK19 Gene

1 Qiagen pathway for STK19 Gene
  • Sperm Motility

Gene Ontology (GO) - Biological Process for STK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 30712867
GO:0016310 phosphorylation IEA --
GO:0046579 positive regulation of Ras protein signal transduction IDA 30712867
genes like me logo Genes that share ontologies with STK19: view

No data available for SIGNOR curated interactions for STK19 Gene

Drugs & Compounds for STK19 Gene

(4) Drugs for STK19 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 56
genes like me logo Genes that share compounds with STK19: view

Transcripts for STK19 Gene

mRNA/cDNA for STK19 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK19

Alternative Splicing Database (ASD) splice patterns (SP) for STK19 Gene

No ASD Table

Relevant External Links for STK19 Gene

GeneLoc Exon Structure for
STK19

Expression for STK19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK19 Gene

mRNA differential expression in normal tissues according to GTEx for STK19 Gene

This gene is overexpressed in Adrenal Gland (x5.7).

Protein differential expression in normal tissues from HIPED for STK19 Gene

This gene is overexpressed in Bone (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK19 Gene



Protein tissue co-expression partners for STK19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK19

SOURCE GeneReport for Unigene cluster for STK19 Gene:

Hs.654371

mRNA Expression by UniProt/SwissProt for STK19 Gene:

P49842-STK19_HUMAN
Tissue specificity: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.

Evidence on tissue expression from TISSUES for STK19 Gene

  • Blood(4.3)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with STK19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK19 Gene

Orthologs for STK19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STK19 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STK19 30 31
  • 88.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STK19 30 31
  • 85.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stk19 30
  • 82.94 (n)
Mouse
(Mus musculus)
Mammalia Stk19 30 17 31
  • 82.41 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STK19 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STK19 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stk19 30
  • 52.06 (n)
Str.17311 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22507 30
Zebrafish
(Danio rerio)
Actinopterygii stk19 30 31 31 31
  • 59.59 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11099 30
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G20495 30
  • 45.48 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0458800 30
  • 44.17 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToOne
Species where no ortholog for STK19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STK19 Gene

ENSEMBL:
Gene Tree for STK19 (if available)
TreeFam:
Gene Tree for STK19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK19: view image

Paralogs for STK19 Gene

No data available for Paralogs for STK19 Gene

Variants for STK19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK19 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs267600971 Likely Pathogenic: Squamous cell carcinoma of the skin; Malignant melanoma of skin. - 31,972,346(+) G/Ap.Asp89Asn MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs34843142 - p.Ala39Asp
rs616634 - p.Ser311Gly
rs7743647 - p.Ala331Val

Additional dbSNP identifiers (rs#s) for STK19 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK19 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10466n54 CNV loss 21841781
dgv10468n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv10474n54 CNV gain 21841781
dgv10476n54 CNV loss 21841781
dgv10477n54 CNV loss 21841781
dgv10478n54 CNV loss 21841781
dgv10479n54 CNV loss 21841781
dgv20n31 CNV gain 19718026
dgv3474e59 CNV duplication 20981092
dgv3475e59 CNV duplication 20981092
esv2666636 CNV deletion 23128226
esv2731825 CNV deletion 23290073
esv2759415 CNV gain+loss 17122850
esv28110 CNV gain+loss 19812545
esv3413736 CNV duplication 20981092
esv3608574 CNV loss 21293372
esv3890827 CNV gain+loss 25118596
nsv1073969 CNV deletion 25765185
nsv10824 CNV gain+loss 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv284 CNV deletion 15895083
nsv285 CNV deletion 15895083
nsv428141 CNV gain+loss 18775914
nsv5247 CNV deletion 18451855
nsv601970 CNV loss 21841781
nsv601971 CNV gain 21841781
nsv602045 CNV gain 21841781
nsv602050 CNV loss 21841781
nsv602072 CNV loss 21841781
nsv819957 CNV loss 19587683
nsv823507 CNV loss 20364138
nsv823508 CNV gain 20364138
nsv830628 CNV loss 17160897
nsv950155 CNV deletion 24416366
nsv981129 CNV duplication 23825009

Variation tolerance for STK19 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK19 Gene

Disorders for STK19 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STK19 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hyperpigmentation of the skin
melanoma
  • malignant melanoma
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search STK19 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STK19_HUMAN
  • Note=Gain-of-function variants in STK19 are involved in NRAS-driven melanomagenesis (PubMed:30712867). Melanoma are malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites (PubMed:30712867). Conditional knockin mice overexpressing Asn-89 variant exhibit hyperpigmentation of the skin, ears, and tail, and the melanin content in skin was significantly increased after tamoxifen induction (PubMed:30712867). Moreover, knockin mice overexpressing Asn-89 variant promote NRAS 'Arg-61'-driven melanomagenesis (PubMed:30712867). {ECO:0000269 PubMed:30712867}.

Additional Disease Information for STK19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STK19: view

No data available for Genatlas for STK19 Gene

Publications for STK19 Gene

  1. The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. (PMID: 9812991) Gomez-Escobar N … Campbell RD (The Journal of biological chemistry 1998) 2 3 4 23
  2. Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. (PMID: 8012361) Sargent CA … Campbell RD (Human molecular genetics 1994) 2 3 4 23
  3. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. (PMID: 30712867) Yin C … Cui R (Cell 2019) 3 4
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for STK19 Gene

Sources for STK19 Gene