Aliases for STK16 Gene

Aliases for STK16 Gene

  • Serine/Threonine Kinase 16 2 3 5
  • PKL12 2 3 4
  • MPSK 2 3 4
  • Myristoylated And Palmitoylated Serine/Threonine-Protein Kinase 3 4
  • Serine/Threonine-Protein Kinase 16 3 4
  • Tyrosine-Protein Kinase STK16 3 4
  • TGF-Beta-Stimulated Factor 1 3 4
  • Protein Kinase PKL12 3 4
  • EC 2.7.11.1 4 51
  • TSF1 3 4
  • HPSK 3 4
  • Protein Kinase Expressed In Day 12 Fetal Liver 3
  • EC 2.7.10.2 4
  • STK16 5
  • MPSK1 4
  • TSF-1 4
  • KRCT 3
  • PSK 3

External Ids for STK16 Gene

Previous GeneCards Identifiers for STK16 Gene

  • GC02P218126
  • GC02P218831
  • GC02P220074
  • GC02P220312
  • GC02P220313
  • GC02P219935
  • GC02P219818
  • GC02P220110
  • GC02P211963

Summaries for STK16 Gene

GeneCards Summary for STK16 Gene

STK16 (Serine/Threonine Kinase 16) is a Protein Coding gene. Diseases associated with STK16 include Diffuse Mesangial Sclerosis. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AAK1.

UniProtKB/Swiss-Prot Summary for STK16 Gene

  • Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Gene Wiki entry for STK16 Gene

Additional gene information for STK16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK16 Gene

Genomics for STK16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STK16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J219244 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +4.7 4656 11.3 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 REST TFE3 RFX1 GLB1L TUBA4A STK16 ZFAND2B DES ENSG00000234638 ANKZF1 ATG9A DNAJB2 MIR153-1
GH02J219245 Enhancer 0.3 ENCODE dbSUPER 600.7 -1.2 -1178 0 GLB1L HSALNG0022359 STK16 lnc-TUBA4A-1 piR-38630 ANKZF1
GH02J219569 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +326.1 326076 4 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 LEF1 SOX13 IKZF1 ZNF692 INHA OBSL1 lnc-OBSL1-2 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L
GH02J219243 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 0.7 -2.2 -2154 1 SP1 USF1 YY1 HNF4A ZBTB33 GLB1L lnc-TUBA4A-1 piR-38630 STK16 ANKZF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK16

Top Transcription factor binding sites by QIAGEN in the STK16 gene promoter:
  • AP-1
  • MyoD
  • NF-kappaB1

Genomic Locations for STK16 Gene

Genomic Locations for STK16 Gene
chr2:219,245,455-219,250,337
(GRCh38/hg38)
Size:
4,883 bases
Orientation:
Plus strand
chr2:220,110,177-220,115,059
(GRCh37/hg19)
Size:
4,883 bases
Orientation:
Plus strand

Genomic View for STK16 Gene

Genes around STK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK16 Gene

Proteins for STK16 Gene

  • Protein details for STK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75716-STK16_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 16
    Protein Accession:
    O75716
    Secondary Accessions:
    • A8K9H9
    • Q5U0F8
    • Q96KI2
    • Q9BUH4
    • Q9UEN3
    • Q9UP78

    Protein attributes for STK16 Gene

    Size:
    305 amino acids
    Molecular mass:
    34656 Da
    Quaternary structure:
    • Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.
    SequenceCaution:
    • Sequence=AAV38392.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA06700.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK16 Gene

neXtProt entry for STK16 Gene

Selected DME Specific Peptides for STK16 Gene

O75716:
  • EGGFSYV
  • YALKRIL

Post-translational modifications for STK16 Gene

  • Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.
  • It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.
  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

Domains & Families for STK16 Gene

Gene Families for STK16 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK16 Gene

Suggested Antigen Peptide Sequences for STK16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60771, highly similar to Serine/threonine-protein kinase 16 (EC 2.7.11.1) (B4DPS1_HUMAN)
  • hPSK (STK16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75716

UniProtKB/Swiss-Prot:

STK16_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK16: view

Function for STK16 Gene

Molecular function for STK16 Gene

UniProtKB/Swiss-Prot Function:
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10027};.

Enzyme Numbers (IUBMB) for STK16 Gene

Phenotypes From GWAS Catalog for STK16 Gene

Gene Ontology (GO) - Molecular Function for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with STK16: view
genes like me logo Genes that share phenotypes with STK16: view

Animal Models for STK16 Gene

MGI Knock Outs for STK16:
  • Stk16 Stk16<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for STK16

CRISPR Products

miRNA for STK16 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK16

Clone Products

  • Addgene plasmids for STK16

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK16 Gene

Localization for STK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK16 Gene

Cytoplasm, perinuclear region. Membrane. Lipid-anchor. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK16 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005798 Golgi-associated vesicle IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK16: view

Pathways & Interactions for STK16 Gene

PathCards logo

SuperPathways for STK16 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.37
genes like me logo Genes that share pathways with STK16: view

Pathways by source for STK16 Gene

1 Qiagen pathway for STK16 Gene
  • Sperm Motility

SIGNOR curated interactions for STK16 Gene

Other effect:

Gene Ontology (GO) - Biological Process for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0046777 protein autophosphorylation IEA,IDA 18184589
genes like me logo Genes that share ontologies with STK16: view

Drugs & Compounds for STK16 Gene

(2) Drugs for STK16 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for STK16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with STK16: view

Transcripts for STK16 Gene

mRNA/cDNA for STK16 Gene

6 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK16

Clone Products

  • Addgene plasmids for STK16

Alternative Splicing Database (ASD) splice patterns (SP) for STK16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for STK16 Gene

GeneLoc Exon Structure for
STK16

Expression for STK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK16 Gene

This gene is overexpressed in Lung (53.6) and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK16 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK16

SOURCE GeneReport for Unigene cluster for STK16 Gene:

Hs.153003

mRNA Expression by UniProt/SwissProt for STK16 Gene:

O75716-STK16_HUMAN
Tissue specificity: Ubiquitously expressed at very low levels.

Evidence on tissue expression from TISSUES for STK16 Gene

  • Nervous system(4.6)
  • Spleen(4.4)
  • Blood(4.4)
  • Intestine(4.3)
  • Lymph node(4.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with STK16: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK16 Gene

Orthologs for STK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STK16 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STK16 30 31
  • 92.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STK16 30 31
  • 90.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STK16 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stk16 30
  • 89.95 (n)
Mouse
(Mus musculus)
Mammalia Stk16 30 17 31
  • 89.18 (n)
OneToOne
Chicken
(Gallus gallus)
Aves STK16 30 31
  • 71.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STK16 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stk16 30
  • 69.95 (n)
Str.4158 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24224 30
Zebrafish
(Danio rerio)
Actinopterygii stk16 30 31
  • 67.35 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG1227 30 31 32
  • 51.09 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea D2045.7 31
  • 24 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFL143C 30
  • 45.57 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV7 30 31
  • 43.14 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PK3 30
  • 49.25 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0372800 30
  • 48.46 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU07399 30
  • 49.61 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk13 30
  • 44.05 (n)
Species where no ortholog for STK16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STK16 Gene

ENSEMBL:
Gene Tree for STK16 (if available)
TreeFam:
Gene Tree for STK16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK16: view image

Paralogs for STK16 Gene

Paralogs for STK16 Gene

(2) SIMAP similar genes for STK16 Gene using alignment to 4 proteins:

  • STK16_HUMAN
  • B4DPS1_HUMAN
  • B8ZZI5_HUMAN
  • B8ZZN3_HUMAN

Pseudogenes.org Pseudogenes for STK16 Gene

genes like me logo Genes that share paralogs with STK16: view

Variants for STK16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK16 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs17849638 - p.Arg266Trp
rs34282267 - p.Ile77Val
rs34799131 - p.His41Arg
rs35454203 - p.Pro277Leu
rs35947471 - p.Glu55Lys

Additional dbSNP identifiers (rs#s) for STK16 Gene

Structural Variations from Database of Genomic Variants (DGV) for STK16 Gene

Variant ID Type Subtype PubMed ID
esv3893555 CNV loss 25118596
nsv508885 CNV insertion 20534489
nsv834543 CNV loss 17160897
nsv954842 CNV deletion 24416366
nsv963775 CNV duplication 23825009

Variation tolerance for STK16 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK16 Gene

Disorders for STK16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK16 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diffuse mesangial sclerosis
  • diffuse isolated mesangial sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search STK16 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with STK16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK16 Gene

Publications for STK16 Gene

  1. A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. (PMID: 10947953) Ohta S … Nagata K (The Biochemical journal 2000) 3 4 23
  2. Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. (PMID: 9712705) Ligos JM … Bernad A (Biochemical and biophysical research communications 1998) 2 3 4
  3. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. (PMID: 18184589) Eswaran J … Knapp S (Structure (London, England : 1993) 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for STK16 Gene

Sources for STK16 Gene