Aliases for STK11IP Gene

Aliases for STK11IP Gene

  • Serine/Threonine Kinase 11 Interacting Protein 2 3 5
  • STK11IP1 2 3 4
  • LKB1IP 2 3 4
  • LIP1 2 3 4
  • Serine/Threonine-Protein Kinase 11-Interacting Protein 3 4
  • LKB1-Interacting Protein 1 3 4
  • KIAA1898 2 4
  • STK11 Interacting Protein 3
  • LKB1 Interacting Protein 2
  • STK11IP 5

External Ids for STK11IP Gene

Previous GeneCards Identifiers for STK11IP Gene

  • GC02P218485
  • GC02P219183
  • GC02P220426
  • GC02P220665
  • GC02P220288
  • GC02P220170
  • GC02P220462
  • GC02P212315

Summaries for STK11IP Gene

GeneCards Summary for STK11IP Gene

STK11IP (Serine/Threonine Kinase 11 Interacting Protein) is a Protein Coding gene. Diseases associated with STK11IP include Peutz-Jeghers Syndrome and Cowden Syndrome. Among its related pathways are Innate Immune System and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot Summary for STK11IP Gene

  • May regulate STK11/LKB1 function by controlling its subcellular localization.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STK11IP Gene

Genomics for STK11IP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STK11IP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK11IP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STK11IP

Top Transcription factor binding sites by QIAGEN in the STK11IP gene promoter:
  • AhR
  • ARP-1
  • ATF-2
  • c-Jun
  • Max
  • NF-E2
  • NF-E2 p45
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for STK11IP Gene

Latest Assembly
chr2:219,597,857-219,616,451
(GRCh38/hg38)
Size:
18,595 bases
Orientation:
Plus strand

Previous Assembly
chr2:220,462,579-220,481,173
(GRCh37/hg19 by Entrez Gene)
Size:
18,595 bases
Orientation:
Plus strand

chr2:220,462,582-220,481,173
(GRCh37/hg19 by Ensembl)
Size:
18,592 bases
Orientation:
Plus strand

Genomic View for STK11IP Gene

Genes around STK11IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK11IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK11IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11IP Gene

Proteins for STK11IP Gene

  • Protein details for STK11IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1F8-S11IP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 11-interacting protein
    Protein Accession:
    Q8N1F8
    Secondary Accessions:
    • C9JQV3
    • Q8NAW9
    • Q8WXE4
    • Q96CN3
    • Q96PY9

    Protein attributes for STK11IP Gene

    Size:
    1088 amino acids
    Molecular mass:
    120259 Da
    Quaternary structure:
    • Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.
    SequenceCaution:
    • Sequence=AAH34051.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAL49726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for STK11IP Gene

Post-translational modifications for STK11IP Gene

  • Ubiquitination at Lys103 and Lys283
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STK11IP Gene

Domains & Families for STK11IP Gene

Gene Families for STK11IP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STK11IP Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature

Suggested Antigen Peptide Sequences for STK11IP Gene

GenScript: Design optimal peptide antigens:
  • LKB1-interacting protein 1 (S11IP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N1F8

UniProtKB/Swiss-Prot:

S11IP_HUMAN :
  • Belongs to the STK11IP family.
Family:
  • Belongs to the STK11IP family.
genes like me logo Genes that share domains with STK11IP: view

Function for STK11IP Gene

Molecular function for STK11IP Gene

UniProtKB/Swiss-Prot Function:
May regulate STK11/LKB1 function by controlling its subcellular localization.

Phenotypes From GWAS Catalog for STK11IP Gene

Gene Ontology (GO) - Molecular Function for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019901 protein kinase binding IPI 11741830
genes like me logo Genes that share ontologies with STK11IP: view
genes like me logo Genes that share phenotypes with STK11IP: view

Animal Models for research

  • Taconic Biosciences Mouse Models for STK11IP

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK11IP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK11IP Gene

Localization for STK11IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11IP Gene

Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK11IP gene
Compartment Confidence
extracellular 4
lysosome 4
cytosol 3
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA,IDA 11741830
GO:0005765 lysosomal membrane HDA 17897319
GO:0035578 azurophil granule lumen TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with STK11IP: view

Pathways & Interactions for STK11IP Gene

PathCards logo

SuperPathways for STK11IP Gene

genes like me logo Genes that share pathways with STK11IP: view

Pathways by source for STK11IP Gene

1 BioSystems pathway for STK11IP Gene
3 Reactome pathways for STK11IP Gene

Interacting Proteins for STK11IP Gene

Gene Ontology (GO) - Biological Process for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IBA,IDA 11741830
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with STK11IP: view

No data available for SIGNOR curated interactions for STK11IP Gene

Drugs & Compounds for STK11IP Gene

No Compound Related Data Available

Transcripts for STK11IP Gene

mRNA/cDNA for STK11IP Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STK11IP

Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10: - -

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for STK11IP Gene

GeneLoc Exon Structure for
STK11IP

Expression for STK11IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK11IP Gene

Protein differential expression in normal tissues from HIPED for STK11IP Gene

This gene is overexpressed in Breast (31.8), Pancreas (8.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK11IP Gene



Protein tissue co-expression partners for STK11IP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STK11IP

SOURCE GeneReport for Unigene cluster for STK11IP Gene:

Hs.22410

Evidence on tissue expression from TISSUES for STK11IP Gene

  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with STK11IP: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK11IP Gene

Orthologs for STK11IP Gene

This gene was present in the common ancestor of animals.

Orthologs for STK11IP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STK11IP 29 30
  • 99.02 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STK11IP 29 30
  • 82.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stk11ip 29
  • 79.73 (n)
Mouse
(Mus musculus)
Mammalia Stk11ip 29 16 30
  • 79.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STK11IP 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STK11IP 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STK11IP 29 30
  • 58.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STK11IP 30
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stk11ip 29
  • 49.53 (n)
Zebrafish
(Danio rerio)
Actinopterygii stk11ip 29 30
  • 48.29 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9044 30
  • 18 (a)
OneToOne
Species where no ortholog for STK11IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STK11IP Gene

ENSEMBL:
Gene Tree for STK11IP (if available)
TreeFam:
Gene Tree for STK11IP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STK11IP: view image
Alliance of Genome Resources:
Additional Orthologs for STK11IP

Paralogs for STK11IP Gene

Paralogs for STK11IP Gene

genes like me logo Genes that share paralogs with STK11IP: view

Variants for STK11IP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STK11IP Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs17853279 -- p.Ile1074Val
rs17855575 -- p.Arg382His
rs17855576 -- p.Arg399Gly
rs627530 -- p.Ser741Phe
rs673951 -- p.Val552Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STK11IP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STK11IP Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489

Variation tolerance for STK11IP Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK11IP Gene

Human Gene Mutation Database (HGMD)
STK11IP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK11IP
Leiden Open Variation Database (LOVD)
STK11IP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11IP Gene

Disorders for STK11IP Gene

MalaCards: The human disease database

(2) MalaCards diseases for STK11IP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
peutz-jeghers syndrome
  • pjs
cowden syndrome
  • cowden disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STK11IP

genes like me logo Genes that share disorders with STK11IP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK11IP Gene

Publications for STK11IP Gene

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PMID: 11741830) Smith DP … Ashworth A (Human molecular genetics 2001) 2 3 4 22
  2. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. (PMID: 12438709) Buchet-Poyau K … Antonarakis SE (Cytogenetic and genome research 2002) 4 22
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4
  4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for STK11IP Gene

Sources for STK11IP Gene