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Aliases for STK11IP Gene

Aliases for STK11IP Gene

  • Serine/Threonine Kinase 11 Interacting Protein 2 3 5
  • LKB1-Interacting Protein 1 3 4
  • STK11IP1 3 4
  • LKB1IP 3 4
  • LIP1 3 4
  • Serine/Threonine-Protein Kinase 11-Interacting Protein 3
  • STK11 Interacting Protein 3
  • LKB1 Interacting Protein 2
  • KIAA1898 4

External Ids for STK11IP Gene

Previous GeneCards Identifiers for STK11IP Gene

  • GC02P218485
  • GC02P219183
  • GC02P220426
  • GC02P220665
  • GC02P220288
  • GC02P220170
  • GC02P220462
  • GC02P212315

Summaries for STK11IP Gene

GeneCards Summary for STK11IP Gene

STK11IP (Serine/Threonine Kinase 11 Interacting Protein) is a Protein Coding gene. Diseases associated with STK11IP include Peutz-Jeghers Syndrome and Bannayan-Riley-Ruvalcaba Syndrome. Among its related pathways are Innate Immune System and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot for STK11IP Gene

  • May regulate STK11/LKB1 function by controlling its subcellular localization.

Additional gene information for STK11IP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11IP Gene

Genomics for STK11IP Gene

GeneHancer (GH) Regulatory Elements for STK11IP Gene

Promoters and enhancers for STK11IP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I219594 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.0 -957 4.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B STK11IP NHEJ1 DNPEP RN7SKP213
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.1 -26.3 -26329 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
GH02I219495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -99.8 -99834 5 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000268603 GC02M219493 GMPPA ZNF142 STK36 RNF25 CNOT9 USP37 NHEJ1 STK11IP
GH02I218658 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 -938.3 -938273 2.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 SLC30A9 E2F8 ZNF142 BCS1L CNOT9 NHEJ1 USP37 AAMP SLC23A3 STK11IP PLCD4 RNF25
GH02I219368 Enhancer 1.1 Ensembl ENCODE 18.8 -228.6 -228554 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 RXRA YY2 REST TSHZ1 LOC105373883 ZNF142 STK36 CNOT9 RNF25 ENSG00000269068 STK11IP ENSG00000268896 ANKZF1 OBSL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STK11IP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK11IP gene promoter:

Genomic Locations for STK11IP Gene

Genomic Locations for STK11IP Gene
18,592 bases
Plus strand

Genomic View for STK11IP Gene

Genes around STK11IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK11IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK11IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11IP Gene

Proteins for STK11IP Gene

  • Protein details for STK11IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 11-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q8NAW9
    • Q8WXE4
    • Q96CN3
    • Q96PY9

    Protein attributes for STK11IP Gene

    1099 amino acids
    Molecular mass:
    121401 Da
    Quaternary structure:
    • Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.
    • This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences.

    Alternative splice isoforms for STK11IP Gene


neXtProt entry for STK11IP Gene

Post-translational modifications for STK11IP Gene

  • Ubiquitination at isoforms=2114 and posLast=294294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STK11IP Gene

Domains & Families for STK11IP Gene

Gene Families for STK11IP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STK11IP Gene

Suggested Antigen Peptide Sequences for STK11IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STK11IP family.
  • Belongs to the STK11IP family.
genes like me logo Genes that share domains with STK11IP: view

Function for STK11IP Gene

Molecular function for STK11IP Gene

UniProtKB/Swiss-Prot Function:
May regulate STK11/LKB1 function by controlling its subcellular localization.

Gene Ontology (GO) - Molecular Function for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 11741830
genes like me logo Genes that share ontologies with STK11IP: view
genes like me logo Genes that share phenotypes with STK11IP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK11IP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK11IP Gene

Localization for STK11IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11IP Gene

Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK11IP gene
Compartment Confidence
lysosome 5
extracellular 4
cytosol 3
plasma membrane 2
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA 11741830
GO:0005765 lysosomal membrane HDA 17897319
GO:0035578 azurophil granule lumen TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with STK11IP: view

Pathways & Interactions for STK11IP Gene

genes like me logo Genes that share pathways with STK11IP: view

Pathways by source for STK11IP Gene

1 BioSystems pathway for STK11IP Gene
3 Reactome pathways for STK11IP Gene

Interacting Proteins for STK11IP Gene

Selected Interacting proteins: Q8N1F8-S11IP_HUMAN for STK11IP Gene via IID

Gene Ontology (GO) - Biological Process for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 11741830
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with STK11IP: view

No data available for SIGNOR curated interactions for STK11IP Gene

Drugs & Compounds for STK11IP Gene

No Compound Related Data Available

Transcripts for STK11IP Gene

Unigene Clusters for STK11IP Gene

Serine/threonine kinase 11 interacting protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP7: - - -
SP10: - -

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP6: -

Relevant External Links for STK11IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK11IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK11IP Gene

Protein differential expression in normal tissues from HIPED for STK11IP Gene

This gene is overexpressed in Breast (31.8), Pancreas (8.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK11IP Gene

Protein tissue co-expression partners for STK11IP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK11IP Gene:


SOURCE GeneReport for Unigene cluster for STK11IP Gene:


Evidence on tissue expression from TISSUES for STK11IP Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with STK11IP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK11IP Gene

Orthologs for STK11IP Gene

This gene was present in the common ancestor of animals.

Orthologs for STK11IP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK11IP 33 34
  • 99.02 (n)
(Canis familiaris)
Mammalia STK11IP 33 34
  • 82.09 (n)
(Rattus norvegicus)
Mammalia Stk11ip 33
  • 79.73 (n)
(Mus musculus)
Mammalia Stk11ip 33 16 34
  • 79.33 (n)
(Bos Taurus)
Mammalia STK11IP 34
  • 78 (a)
(Monodelphis domestica)
Mammalia STK11IP 34
  • 61 (a)
(Gallus gallus)
Aves STK11IP 33 34
  • 58.32 (n)
(Anolis carolinensis)
Reptilia STK11IP 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11ip 33
  • 49.53 (n)
(Danio rerio)
Actinopterygii stk11ip 33 34
  • 48.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9044 34
  • 18 (a)
Species where no ortholog for STK11IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK11IP Gene

Gene Tree for STK11IP (if available)
Gene Tree for STK11IP (if available)

Paralogs for STK11IP Gene

Paralogs for STK11IP Gene

genes like me logo Genes that share paralogs with STK11IP: view

Variants for STK11IP Gene

Sequence variations from dbSNP and Humsavar for STK11IP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000273638 -- 219,610,051(+) A/G 3_prime_UTR_variant, intron_variant
rs1000275226 -- 219,600,254(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000311597 -- 219,613,264(+) T/A/C/G genic_downstream_transcript_variant, intron_variant
rs1000410457 -- 219,608,525(+) A/G intron_variant
rs1000448610 -- 219,612,335(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK11IP Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489

Variation tolerance for STK11IP Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK11IP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11IP Gene

Disorders for STK11IP Gene

MalaCards: The human disease database

(2) MalaCards diseases for STK11IP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
peutz-jeghers syndrome
  • pjs
bannayan-riley-ruvalcaba syndrome
  • brrs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STK11IP

genes like me logo Genes that share disorders with STK11IP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK11IP Gene

Publications for STK11IP Gene

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PMID: 11741830) Smith DP … Ashworth A (Human molecular genetics 2001) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. (PMID: 12438709) Buchet-Poyau K … Antonarakis SE (Cytogenetic and genome research 2002) 4 22 58
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for STK11IP Gene

Sources for STK11IP Gene

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