STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that... See more...

Aliases for STIP1 Gene

Aliases for STIP1 Gene

  • Stress Induced Phosphoprotein 1 2 3 5
  • Stress-Induced-Phosphoprotein 1 2 3 4
  • STI1 2 3 4
  • Transformation-Sensitive Protein IEF SSP 3521 3 4
  • Renal Carcinoma Antigen NY-REN-11 3 4
  • Hsp70/Hsp90-Organizing Protein 2 3
  • Hsc70/Hsp90-Organizing Protein 3 4
  • HOP 2 3
  • Epididymis Secretory Sperm Binding Protein Li 94n 3
  • NY-REN-11 Antigen 3
  • IEF-SSP-3521 3
  • HEL-S-94n 3
  • STI1L 3
  • STIP1 5
  • P60 3
  • Hop 4

External Ids for STIP1 Gene

Previous GeneCards Identifiers for STIP1 Gene

  • GC11P066389
  • GC11M065612
  • GC11P064203
  • GC11P063728
  • GC11P063729
  • GC11P063709
  • GC11P063953
  • GC11P060283

Summaries for STIP1 Gene

Entrez Gene Summary for STIP1 Gene

  • STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

GeneCards Summary for STIP1 Gene

STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Diseases associated with STIP1 include Prion Disease and Retinitis Pigmentosa 61. Among its related pathways are Prion disease and Neuroscience. An important paralog of this gene is RPAP3.

UniProtKB/Swiss-Prot Summary for STIP1 Gene

  • Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

Gene Wiki entry for STIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STIP1 Gene

Genomics for STIP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064183 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 +0.4 429 5 CHD2 TBP SP1 MXD4 CEBPA MNT DEK IKZF1 SMAD5 ETS1 STIP1 lnc-MACROD1-1 lnc-STIP1-1 TRPT1 KCNK4 IMMP1LP1 RTN3 FERMT3 NRXN2 ZFTA
GH11J064156 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.6 -28.4 -28371 1.4 SAP130 TFAP4 HNRNPL STIP1 ENSG00000256341 FLRT1 COX8A ENSG00000256100 RNU6-45P ENSG00000256481 FERMT3 MARK2 CCDC88B
GH11J064218 Enhancer 0.7 Ensembl 11.6 +33.4 33429 0.6 FOXA2 SMAD4 SAP130 RARA BCL6 FOXP1 CTCF RAD21 ELF3 ZFP36 FKBP2 PPP1R14B PPP1R14B-AS1 PLCB3 ENSG00000257086 STIP1 GPR137 BAD MACROD1 ENSG00000256116
GH11J064219 Enhancer 0.3 Ensembl 11.6 +34.2 34229 0.2 POLR2A HNRNPL TRMT112 FKBP2 PPP1R14B PPP1R14B-AS1 PLCB3 ENSG00000257086 STIP1 GPR137 BAD MACROD1
GH11J064062 Enhancer 0.6 Ensembl dbSUPER 4.9 -120.7 -120671 2 ZFP91 ZNF24 GLIS2 ENSG00000257086 STIP1 LINC02723 piR-50184 ENSG00000256481 ENSG00000256824 FLRT1 L13712-002 MACROD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STIP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STIP1

Top Transcription factor binding sites by QIAGEN in the STIP1 gene promoter:
  • AREB6
  • Bach2
  • CUTL1
  • Egr-2
  • NF-kappaB
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • Sp1
  • USF-1

Genomic Locations for STIP1 Gene

Latest Assembly
chr11:64,185,272-64,204,543
(GRCh38/hg38)
Size:
19,272 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,952,744-63,972,015
(GRCh37/hg19 by Entrez Gene)
Size:
19,272 bases
Orientation:
Plus strand

chr11:63,952,744-63,972,015
(GRCh37/hg19 by Ensembl)
Size:
19,272 bases
Orientation:
Plus strand

Genomic View for STIP1 Gene

Genes around STIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIP1 Gene

Proteins for STIP1 Gene

  • Protein details for STIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31948-STIP1_HUMAN
    Recommended name:
    Stress-induced-phosphoprotein 1
    Protein Accession:
    P31948
    Secondary Accessions:
    • B4DM70
    • F5H0T1
    • G3XAD8
    • Q3ZCU9
    • Q5TZU9

    Protein attributes for STIP1 Gene

    Size:
    543 amino acids
    Molecular mass:
    62639 Da
    Quaternary structure:
    • Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG (PubMed:14532270). Interacts with METTL21B (PubMed:23349634). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360). Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).

    Three dimensional structures from OCA and Proteopedia for STIP1 Gene

    Alternative splice isoforms for STIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STIP1 Gene

Post-translational modifications for STIP1 Gene

  • Ubiquitination at Lys10, Lys13, Lys32, Lys68, Lys109, Lys123, Lys100, Lys246, Lys284, Lys325, Lys434, Lys442, Lys446, Lys462, and Lys513
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STIP1 Gene

Domains & Families for STIP1 Gene

Gene Families for STIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for STIP1 Gene

InterPro:
Blocks:
  • Heat shock chaperonin-binding
  • TPR-related region
ProtoNet:

Suggested Antigen Peptide Sequences for STIP1 Gene

GenScript: Design optimal peptide antigens:
  • STIP1 protein (Q3ZCU9_HUMAN)
  • Transformation-sensitive protein IEF SSP 3521 (STIP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31948

UniProtKB/Swiss-Prot:

STIP1_HUMAN :
  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
Domain:
  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
genes like me logo Genes that share domains with STIP1: view

Function for STIP1 Gene

Molecular function for STIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
GENATLAS Biochemistry:
stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts

Phenotypes From GWAS Catalog for STIP1 Gene

Gene Ontology (GO) - Molecular Function for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA,IPI 20029029
GO:0008022 protein C-terminus binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with STIP1: view
genes like me logo Genes that share phenotypes with STIP1: view

Animal Models for STIP1 Gene

MGI Knock Outs for STIP1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STIP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIP1 Gene

Localization for STIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus TAS 1569099
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 23349634
genes like me logo Genes that share ontologies with STIP1: view

Pathways & Interactions for STIP1 Gene

PathCards logo

SuperPathways for STIP1 Gene

SuperPathway Contained pathways
1 Neuroscience
2 Prion disease
genes like me logo Genes that share pathways with STIP1: view

Pathways by source for STIP1 Gene

1 KEGG pathway for STIP1 Gene
1 Cell Signaling Technology pathway for STIP1 Gene

SIGNOR curated interactions for STIP1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098761 cellular response to interleukin-7 IEA --
genes like me logo Genes that share ontologies with STIP1: view

Drugs & Compounds for STIP1 Gene

(3) Drugs for STIP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 271

(1) Additional Compounds for STIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STIP1: view

Transcripts for STIP1 Gene

mRNA/cDNA for STIP1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STIP1

Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: -
SP9:

ExUns: 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for STIP1 Gene

GeneLoc Exon Structure for
STIP1

Expression for STIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STIP1 Gene



Protein tissue co-expression partners for STIP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STIP1

SOURCE GeneReport for Unigene cluster for STIP1 Gene:

Hs.337295

Evidence on tissue expression from TISSUES for STIP1 Gene

  • Nervous system(4.9)
  • Skin(4.7)
  • Lung(4.7)
  • Liver(4.7)
  • Intestine(4.2)
  • Heart(3.4)
  • Blood(3.1)
  • Eye(3.1)
  • Adrenal gland(2.9)
  • Pancreas(2.7)
  • Stomach(2.7)
  • Kidney(2.7)
  • Muscle(2.4)
  • Lymph node(2.3)
  • Spleen(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with STIP1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIP1 Gene

Orthologs for STIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STIP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STIP1 30 31
  • 99.83 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia STIP1 30 31
  • 90.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STIP1 30 31
  • 89.81 (n)
OneToMany
-- 31
  • 57 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Stip1 30
  • 88.4 (n)
Mouse
(Mus musculus)
Mammalia Stip1 30 17 31
  • 87.85 (n)
OneToOne
Chicken
(Gallus gallus)
Aves STIP1 31
  • 75 (a)
OneToOne
LOC101748085 30
  • 71.19 (n)
Lizard
(Anolis carolinensis)
Reptilia STIP1 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stip1 30
  • 75.57 (n)
MGC76181 30
African clawed frog
(Xenopus laevis)
Amphibia stip1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii stip1 30 31
  • 73.41 (n)
OneToOne
Dr.29081 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010188 30
  • 61.58 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Hop 30 31 32
  • 60.54 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea sti-1 30 31
  • 59.28 (n)
OneToOne
R09E12.3 32
  • 56 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL224W 30
  • 51.18 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 30 31 33
  • 49.88 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07062g 30
  • 49.57 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G12270 30
  • 52.2 (n)
Soybean
(Glycine max)
eudicotyledons Gma.8435 30
Rice
(Oryza sativa)
Liliopsida Os02g0644100 30
  • 53.02 (n)
Os.13461 30
Wheat
(Triticum aestivum)
Liliopsida Ta.8679 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2588 31
  • 52 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU00714 30
  • 51.61 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sti1 30
  • 50 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.271 30
Species where no ortholog for STIP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STIP1 Gene

ENSEMBL:
Gene Tree for STIP1 (if available)
TreeFam:
Gene Tree for STIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STIP1: view image

Paralogs for STIP1 Gene

(3) SIMAP similar genes for STIP1 Gene using alignment to 7 proteins:

  • STIP1_HUMAN
  • F5GXD8_HUMAN
  • F5H0T1_HUMAN
  • F5H783_HUMAN
  • G3XAD8_HUMAN
  • H0YGI8_HUMAN
  • Q3ZCU9_HUMAN

Pseudogenes.org Pseudogenes for STIP1 Gene

genes like me logo Genes that share paralogs with STIP1: view

Variants for STIP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STIP1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs142164377 Benign: not provided 64,193,128(+) C/T
NM_006819.3(STIP1):c.60C>T (p.Ile20=)
SYNONYMOUS
rs151183233 Benign: not provided 64,193,149(+) C/T
NM_006819.3(STIP1):c.81C>T (p.Tyr27=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STIP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STIP1 Gene

Variant ID Type Subtype PubMed ID
dgv15n68 CNV loss 17160897
dgv1963n54 CNV loss 21841781
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv825943 CNV gain 20364138
nsv951010 CNV deletion 24416366
nsv972037 CNV duplication 23825009

Variation tolerance for STIP1 Gene

Residual Variation Intolerance Score: 7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STIP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIP1 Gene

Disorders for STIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STIP1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
prion disease
  • prion disease pathway
retinitis pigmentosa 61
  • rp61
- elite association - COSMIC cancer census association via MalaCards
Search STIP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STIP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with STIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STIP1 Gene

Publications for STIP1 Gene

  1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1. (PMID: 1569099) Honoré B … Celis JE (The Journal of biological chemistry 1992) 2 3 4 23
  2. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins GA … Bleecker ER (The Journal of allergy and clinical immunology 2009) 3 23 41
  3. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PMID: 10786835) Scheufler C … Moarefi I (Cell 2000) 3 4 23
  4. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. (PMID: 29127155) Woodford MR … Mollapour M (The EMBO journal 2017) 3 4
  5. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4

Products for STIP1 Gene

Sources for STIP1 Gene