Aliases for STIP1 Gene
External Ids for STIP1 Gene
Previous GeneCards Identifiers for STIP1 Gene
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
GeneCards Summary for STIP1 Gene
STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Diseases associated with STIP1 include Prion Disease and Retinitis Pigmentosa 61. Among its related pathways are Prion disease and Neuroscience. An important paralog of this gene is RPAP3.
UniProtKB/Swiss-Prot Summary for STIP1 Gene
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).