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STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Diseases associated with STIP1 include Prion Disease and Retinitis Pigmentosa 61. Among its related pathways are Prion disease and Neuroscience. An important paralog of this gene is RPAP3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IEA,IPI | 20029029 |
GO:0008022 | protein C-terminus binding | IEA | -- |
GO:0030544 | Hsp70 protein binding | IEA | -- |
GO:0051087 | chaperone binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 16130169 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | TAS | 1569099 |
GO:0005829 | cytosol | TAS | -- |
GO:0032991 | protein-containing complex | IDA | 23349634 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neuroscience | ||
2 | Prion disease |
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0098761 | cellular response to interleukin-7 | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 271 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 18c | · | 18d |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STIP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | STIP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STIP1 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Stip1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Stip1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STIP1 31 |
|
OneToOne | |
LOC101748085 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | STIP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stip1 30 |
|
||
MGC76181 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | stip1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stip1 30 31 |
|
OneToOne | |
Dr.29081 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010188 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Hop 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | sti-1 30 31 |
|
OneToOne | |
R09E12.3 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL224W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STI1 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07062g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G12270 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.8435 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0644100 30 |
|
||
Os.13461 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.8679 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2588 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00714 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sti1 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.271 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs142164377 | Benign: not provided | 64,193,128(+) |
C/T NM_006819.3(STIP1):c.60C>T (p.Ile20=) |
SYNONYMOUS | |
rs151183233 | Benign: not provided | 64,193,149(+) |
C/T NM_006819.3(STIP1):c.81C>T (p.Tyr27=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv15n68 | CNV | loss | 17160897 |
dgv1963n54 | CNV | loss | 21841781 |
nsv1159904 | CNV | deletion | 26073780 |
nsv469961 | CNV | loss | 18288195 |
nsv555184 | CNV | loss | 21841781 |
nsv555187 | CNV | loss | 21841781 |
nsv825943 | CNV | gain | 20364138 |
nsv951010 | CNV | deletion | 24416366 |
nsv972037 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prion disease |
|
|
retinitis pigmentosa 61 |
|
|