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Aliases for STIP1 Gene

Aliases for STIP1 Gene

  • Stress Induced Phosphoprotein 1 2 3 5
  • Transformation-Sensitive Protein IEF SSP 3521 3 4
  • Renal Carcinoma Antigen NY-REN-11 3 4
  • Stress-Induced-Phosphoprotein 1 2 3
  • Hsp70/Hsp90-Organizing Protein 2 3
  • Hsc70/Hsp90-Organizing Protein 3 4
  • STI1 3 4
  • HOP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 94n 3
  • NY-REN-11 Antigen 3
  • IEF-SSP-3521 3
  • HEL-S-94n 3
  • STI1L 3
  • P60 3

External Ids for STIP1 Gene

Previous GeneCards Identifiers for STIP1 Gene

  • GC11P066389
  • GC11M065612
  • GC11P063728
  • GC11P063729
  • GC11P063709
  • GC11P063953
  • GC11P060283

Summaries for STIP1 Gene

Entrez Gene Summary for STIP1 Gene

  • STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

GeneCards Summary for STIP1 Gene

STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Prion diseases and Neuroscience. An important paralog of this gene is TTC31.

UniProtKB/Swiss-Prot for STIP1 Gene

  • Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

Gene Wiki entry for STIP1 Gene

Additional gene information for STIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIP1 Gene

Genomics for STIP1 Gene

GeneHancer (GH) Regulatory Elements for STIP1 Gene

Promoters and enhancers for STIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064183 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.4 401 4.4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC STIP1 GC11M064182 TRPT1 ENSG00000257086 IMMP1LP1 FERMT3 SF1 C11orf95 ZNHIT2 PLCB3
GH11I064152 Enhancer 1 Ensembl ENCODE 11.5 -31.7 -31720 1.7 RB1 ARID4B SIN3A ZSCAN9 RAD21 RARA ZNF143 RUNX3 THAP11 DEK TRMT112 TRPT1 STIP1 ENSG00000256341 FLRT1 COX8A ENSG00000256100 RNU6-45P ENSG00000256481 FERMT3
GH11I064156 Enhancer 0.7 ENCODE dbSUPER 11.6 -28.5 -28488 0.2 SKI TFAP4 SAP130 POLR2A STIP1 ENSG00000256341 FLRT1 COX8A ENSG00000256100 RNU6-45P ENSG00000256481 FERMT3 MARK2 ENSG00000256116
GH11I064180 Enhancer 1.2 Ensembl ENCODE 0.8 -3.7 -3715 2.1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF48 SLC30A9 PIR58555 PIR62169 TRPT1 FERMT3 PLCB3 ENSG00000257086 ENSG00000256341 NAA40 CCDC88B STIP1
GH11I064204 Enhancer 0.9 ENCODE 0.4 +19.4 19412 1.2 HDGF ATF1 SMAD1 ARNT ZNF2 POLR2B ARID2 ZNF143 ATF7 RUNX3 FERMT3 TRPT1 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD GC11M064182
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STIP1 gene promoter:

Genomic Locations for STIP1 Gene

Genomic Locations for STIP1 Gene
19,277 bases
Plus strand

Genomic View for STIP1 Gene

Genes around STIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIP1 Gene

Proteins for STIP1 Gene

  • Protein details for STIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Stress-induced-phosphoprotein 1
    Protein Accession:
    Secondary Accessions:
    • B4DM70
    • F5H0T1
    • G3XAD8
    • Q3ZCU9
    • Q5TZU9

    Protein attributes for STIP1 Gene

    543 amino acids
    Molecular mass:
    62639 Da
    Quaternary structure:
    • Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG (PubMed:14532270). Interacts with METTL21B (PubMed:23349634). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360). Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).

    Three dimensional structures from OCA and Proteopedia for STIP1 Gene

    Alternative splice isoforms for STIP1 Gene


neXtProt entry for STIP1 Gene

Post-translational modifications for STIP1 Gene

  • Ubiquitination at posLast=1010, posLast=1313, isoforms=2, 332, posLast=6868, posLast=109109, posLast=123123, posLast=284284, posLast=325325, posLast=434434, isoforms=2, 3442, isoforms=2, 3446, isoforms=2, 3462, and isoforms=2, 3513
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for STIP1

No data available for DME Specific Peptides for STIP1 Gene

Domains & Families for STIP1 Gene

Gene Families for STIP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for STIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
genes like me logo Genes that share domains with STIP1: view

Function for STIP1 Gene

Molecular function for STIP1 Gene

GENATLAS Biochemistry:
stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts
UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

Phenotypes From GWAS Catalog for STIP1 Gene

Gene Ontology (GO) - Molecular Function for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 20029029
GO:0008022 protein C-terminus binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with STIP1: view
genes like me logo Genes that share phenotypes with STIP1: view

Animal Models for STIP1 Gene

MGI Knock Outs for STIP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIP1 Gene

Localization for STIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
plasma membrane 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus TAS 1569099
GO:0005829 cytosol TAS --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with STIP1: view

Pathways & Interactions for STIP1 Gene

SuperPathways for STIP1 Gene

SuperPathway Contained pathways
1 Prion diseases
2 Neuroscience
genes like me logo Genes that share pathways with STIP1: view

Pathways by source for STIP1 Gene

1 KEGG pathway for STIP1 Gene
1 Cell Signaling Technology pathway for STIP1 Gene

Gene Ontology (GO) - Biological Process for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 1569099
genes like me logo Genes that share ontologies with STIP1: view

No data available for SIGNOR curated interactions for STIP1 Gene

Drugs & Compounds for STIP1 Gene

(3) Drugs for STIP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202

(1) Additional Compounds for STIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STIP1: view

Transcripts for STIP1 Gene

Unigene Clusters for STIP1 Gene

Stress-induced-phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - - - - - - -
SP2: - - - -
SP4: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: -

ExUns: 18c · 18d

Relevant External Links for STIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STIP1 Gene

Protein tissue co-expression partners for STIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STIP1 Gene:


SOURCE GeneReport for Unigene cluster for STIP1 Gene:


Evidence on tissue expression from TISSUES for STIP1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Lung(4.6)
  • Skin(4.6)
  • Intestine(3.9)
  • Heart(3)
  • Blood(2.7)
  • Eye(2.6)
  • Adrenal gland(2.4)
  • Stomach(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with STIP1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIP1 Gene

Orthologs for STIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STIP1 33 34
  • 99.83 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
-- 34
  • 73 (a)
(Canis familiaris)
Mammalia STIP1 33 34
  • 90.48 (n)
(Bos Taurus)
Mammalia STIP1 33 34
  • 89.81 (n)
-- 34
  • 57 (a)
(Rattus norvegicus)
Mammalia Stip1 33
  • 88.4 (n)
(Mus musculus)
Mammalia Stip1 33 16 34
  • 87.85 (n)
(Gallus gallus)
Aves STIP1 34
  • 75 (a)
LOC101748085 33
  • 71.19 (n)
(Anolis carolinensis)
Reptilia STIP1 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stip1 33
  • 75.57 (n)
MGC76181 33
African clawed frog
(Xenopus laevis)
Amphibia stip1-prov 33
(Danio rerio)
Actinopterygii stip1 33 34
  • 73.41 (n)
Dr.29081 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010188 33
  • 61.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hop 35 33 34
  • 60.54 (n)
(Caenorhabditis elegans)
Secernentea sti-1 33 34
  • 59.28 (n)
R09E12.3 35
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL224W 33
  • 51.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 33 34 36
  • 49.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07062g 33
  • 49.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12270 33
  • 52.2 (n)
(Glycine max)
eudicotyledons Gma.8435 33
(Oryza sativa)
Liliopsida Os02g0644100 33
  • 53.02 (n)
Os.13461 33
(Triticum aestivum)
Liliopsida Ta.8679 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2588 34
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00714 33
  • 51.61 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sti1 33
  • 50 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.271 33
Species where no ortholog for STIP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STIP1 Gene

Gene Tree for STIP1 (if available)
Gene Tree for STIP1 (if available)

Paralogs for STIP1 Gene

Paralogs for STIP1 Gene

(3) SIMAP similar genes for STIP1 Gene using alignment to 7 proteins: Pseudogenes for STIP1 Gene

genes like me logo Genes that share paralogs with STIP1: view

Variants for STIP1 Gene

Sequence variations from dbSNP and Humsavar for STIP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000011255 -- 64,191,636(+) C/ intron_variant
rs1000025707 -- 64,195,353(+) T/C intron_variant
rs1000071954 -- 64,186,662(+) G/A intron_variant
rs1000223597 -- 64,184,206(+) G/A upstream_transcript_variant
rs1000448855 -- 64,187,996(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STIP1 Gene

Variant ID Type Subtype PubMed ID
dgv15n68 CNV loss 17160897
dgv1963n54 CNV loss 21841781
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv825943 CNV gain 20364138
nsv951010 CNV deletion 24416366
nsv972037 CNV duplication 23825009

Variation tolerance for STIP1 Gene

Residual Variation Intolerance Score: 7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIP1 Gene

Disorders for STIP1 Gene

Additional Disease Information for STIP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STIP1 Gene

Publications for STIP1 Gene

  1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1. (PMID: 1569099) Honoré B … Celis JE (The Journal of biological chemistry 1992) 2 3 4 22 58
  2. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins GA … Bleecker ER (The Journal of allergy and clinical immunology 2009) 3 22 44 58
  3. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PMID: 10786835) Scheufler C … Moarefi I (Cell 2000) 3 4 22 58
  4. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4 58
  5. SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. (PMID: 24880080) Hamamoto R … Nakamura Y (Cancer letters 2014) 3 4 58

Products for STIP1 Gene

Sources for STIP1 Gene

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