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STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that... See more...
Aliases for STIP1 Gene
Aliases for STIP1 Gene
External Ids for STIP1 Gene
- HGNC: 11387
- NCBI Entrez Gene: 10963
- Ensembl: ENSG00000168439
- OMIM®: 605063
- UniProtKB/Swiss-Prot: P31948
Previous GeneCards Identifiers for STIP1 Gene
- GC11P066389
- GC11M065612
- GC11P064203
- GC11P063728
- GC11P063729
- GC11P063709
- GC11P063953
- GC11P060283
Summaries for STIP1 Gene
-
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
GeneCards Summary for STIP1 Gene
STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Diseases associated with STIP1 include Prion Disease and Retinitis Pigmentosa 61. Among its related pathways are Prion disease and Neuroscience. An important paralog of this gene is RPAP3.
UniProtKB/Swiss-Prot Summary for STIP1 Gene
-
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Additional gene information for STIP1 Gene
- HGNC (11387)
- NCBI Entrez Gene (10963)
- Ensembl (ENSG00000168439)
- OMIM® (605063)
- UniProtKB/Swiss-Prot (P31948)
- Open Targets Platform(ENSG00000168439)
- Monarch Initiative
- Search for STIP1 at DataMed
- Search for STIP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STIP1 Gene
Genomics for STIP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STIP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STIP1
- Top Transcription factor binding sites by QIAGEN in the STIP1 gene promoter:
-
- AREB6
- Bach2
- CUTL1
- Egr-2
- NF-kappaB
- NF-kappaB1
- POU2F1
- POU2F1a
- Sp1
- USF-1
Genomic Locations for STIP1 Gene
Latest Assembly
- chr11:64,185,272-64,204,543
- (GRCh38/hg38)
- Size:
- 19,272 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:63,952,744-63,972,015
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 19,272 bases
- Orientation:
- Plus strand
- chr11:63,952,744-63,972,015
- (GRCh37/hg19 by Ensembl)
- Size:
- 19,272 bases
- Orientation:
- Plus strand
Genomic View for STIP1 Gene
Genes around STIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
STIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STIP1 Gene
Proteins for STIP1 Gene
-
Protein details for STIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31948-STIP1_HUMAN
- Recommended name:
- Stress-induced-phosphoprotein 1
- Protein Accession:
- P31948
- B4DM70
- F5H0T1
- G3XAD8
- Q3ZCU9
- Q5TZU9
Protein attributes for STIP1 Gene
- Size:
- 543 amino acids
- Molecular mass:
- 62639 Da
- Quaternary structure:
-
- Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG (PubMed:14532270). Interacts with METTL21B (PubMed:23349634). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360). Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).
Three dimensional structures from OCA and Proteopedia for STIP1 Gene
Protein Expression for STIP1 Gene
Post-translational modifications for STIP1 Gene
Other Protein References for STIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences STI1 / STIP1 Monoclonal Antibody (LS-B6208) and STI1 / STIP1 Monoclonal Antibody (LS-B6209)
- G Biosciences Immunotag™ STIP1 Antibody
- Novus Biologicals Antibodies for STIP1
-
Abcam antibodies for STIP1
- Invitrogen Antibodies for STIP1 (AFLGC-STIP1)
-
Custom Antibody ServicesProSci Antibodies for STIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for STIP1
Protein products for research
-
OriGene Purified Proteins for STIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for STIP1
- Origene Custom Protein Services for STIP1
- ProSpec Recombinant Proteins for STIP1
-
Abcam proteins for STIP1
Assay products for research
- antibodies-online: Show 10 available STIP1 Elisa Kits ranked by validation data
- Compare Top STIP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for STIP1 Gene
Domains & Families for STIP1 Gene
Gene Families for STIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for STIP1 Gene
- InterPro:
- Blocks:
-
- Heat shock chaperonin-binding
- TPR-related region
- ProtoNet:
Suggested Antigen Peptide Sequences for STIP1 Gene
- GenScript: Design optimal peptide antigens:
-
- STIP1 protein (Q3ZCU9_HUMAN)
- Transformation-sensitive protein IEF SSP 3521 (STIP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P31948UniProtKB/Swiss-Prot:
STIP1_HUMAN :- The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
- Domain:
-
- The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
Function for STIP1 Gene
Molecular function for STIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
- GENATLAS Biochemistry:
- stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts
Phenotypes From GWAS Catalog for STIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IEA,IPI | 20029029 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0030544 | Hsp70 protein binding | IEA | -- |
| GO:0051087 | chaperone binding | IEA | -- |
Phenotypes for STIP1 Gene
- MGI mutant phenotypes for STIP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for STIP1:
Animal Models for STIP1 Gene
- MGI Knock Outs for STIP1:
-
- Stip1 Stip1<tm1.2Mamp>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STIP1 - Starting at $85 >
- * STIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for STIP1
miRNA for STIP1 Gene
- miRTarBase miRNAs that target STIP1
-
- hsa-miR-16-5p (MIRT032016)
- hsa-miR-1180-3p (MIRT035915)
- hsa-miR-484 (MIRT041679)
- hsa-miR-193a-3p (MIRT044894)
- hsa-miR-183-5p (MIRT047040)
- hsa-let-7b-5p (MIRT051957)
- hsa-miR-218-5p (MIRT439523)
- hsa-miR-1207-5p (MIRT736061)
- hsa-miR-1909-3p (MIRT738379)
- hsa-miR-3153 (MIRT740401)
- hsa-miR-4311 (MIRT743953)
- hsa-miR-4688 (MIRT747026)
- hsa-miR-4763-3p (MIRT748569)
- hsa-miR-4802-3p (MIRT749010)
- hsa-miR-486-3p (MIRT749133)
- hsa-miR-6085 (MIRT751814)
- hsa-miR-6721-5p (MIRT753840)
- hsa-miR-6722-3p (MIRT753892)
- hsa-miR-6733-5p (MIRT754125)
- hsa-miR-6739-5p (MIRT754322)
- hsa-miR-6743-5p (MIRT754426)
- hsa-miR-6783-5p (MIRT755765)
- hsa-miR-6789-5p (MIRT756020)
- hsa-miR-6813-5p (MIRT756750)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STIP1
- Browse OriGene Inhibitory RNA Products For STIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STIP1
Clone products for research
- Applied Biological Materials (abm): Clones for STIP1 - Starting at $45 >
- * STIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STIP1
Cell Lines for research
-
Horizon Cell Lines for STIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIP1 Gene
Localization for STIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STIP1 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | TAS | 1569099 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0032991 | protein-containing complex | IDA | 23349634 |
Pathways & Interactions for STIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Neuroscience | ||
| 2 | Prion disease |
.55
|
|
Pathways by source for STIP1 Gene
1 KEGG pathway for STIP1 Gene
1 Cell Signaling Technology pathway for STIP1 Gene
Interacting Proteins for STIP1 Gene
Selected Interacting proteins:
P31948-STIP1_HUMAN
ENSP00000351646
for STIP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STIP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0098761 | cellular response to interleukin-7 | IEA | -- |
Drugs & Compounds for STIP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 271 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for STIP1 Gene
mRNA/cDNA for STIP1 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000305218 2140 nts (view in UCSC)
- ENST00000355603 528 nts (view in UCSC)
- ENST00000358794 2743 nts (view in UCSC)
- ENST00000536973 738 nts (view in UCSC)
- ENST00000537479 601 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STIP1 - Starting at $85 >
- * STIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for STIP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STIP1
- Browse OriGene Inhibitory RNA Products For STIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STIP1
Clone products for research
- Applied Biological Materials (abm): Clones for STIP1 - Starting at $45 >
- * STIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STIP1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18c | · | 18d |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: |
Relevant External Links for STIP1 Gene
- GeneLoc Exon Structure for
- STIP1
Expression for STIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STIP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STIP1
SOURCE GeneReport for Unigene cluster for STIP1 Gene:
Hs.337295Evidence on tissue expression from TISSUES for STIP1 Gene
- Nervous system(4.9)
- Skin(4.7)
- Lung(4.7)
- Liver(4.7)
- Intestine(4.2)
- Heart(3.4)
- Blood(3.1)
- Eye(3.1)
- Adrenal gland(2.9)
- Pancreas(2.7)
- Stomach(2.7)
- Kidney(2.7)
- Muscle(2.4)
- Lymph node(2.3)
- Spleen(2.2)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for STIP1
-
OriGene qPCR primer pairs and template standards for STIP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIP1 Gene
Orthologs for STIP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STIP1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | STIP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STIP1 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Stip1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Stip1 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STIP1 31 |
|
OneToOne | |
| LOC101748085 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | STIP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stip1 30 |
|
||
| MGC76181 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | stip1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | stip1 30 31 |
|
OneToOne | |
| Dr.29081 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010188 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Hop 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | sti-1 30 31 |
|
OneToOne | |
| R09E12.3 32 |
|
|
|||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL224W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STI1 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07062g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G12270 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.8435 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0644100 30 |
|
||
| Os.13461 30 |
|
||||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.8679 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2588 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00714 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sti1 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.271 30 |
|
- Species where no ortholog for STIP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for STIP1 Gene
- ENSEMBL:
- Gene Tree for STIP1 (if available)
- TreeFam:
- Gene Tree for STIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STIP1: view image
Paralogs for STIP1 Gene
Paralogs for STIP1 Gene
(3) SIMAP similar genes for STIP1 Gene using alignment to 7 proteins:
- STIP1_HUMAN
- F5GXD8_HUMAN
- F5H0T1_HUMAN
- F5H783_HUMAN
- G3XAD8_HUMAN
- H0YGI8_HUMAN
- Q3ZCU9_HUMAN
Pseudogenes.org Pseudogenes for STIP1 Gene
Variants for STIP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STIP1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs142164377 | Benign: not provided | 64,193,128(+) |
C/T NM_006819.3(STIP1):c.60C>T (p.Ile20=) |
SYNONYMOUS | |
| rs151183233 | Benign: not provided | 64,193,149(+) |
C/T NM_006819.3(STIP1):c.81C>T (p.Tyr27=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv15n68 | CNV | loss | 17160897 |
| dgv1963n54 | CNV | loss | 21841781 |
| nsv1159904 | CNV | deletion | 26073780 |
| nsv469961 | CNV | loss | 18288195 |
| nsv555184 | CNV | loss | 21841781 |
| nsv555187 | CNV | loss | 21841781 |
| nsv825943 | CNV | gain | 20364138 |
| nsv951010 | CNV | deletion | 24416366 |
| nsv972037 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STIP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STIP1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIP1 Gene
Disorders for STIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prion disease |
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| retinitis pigmentosa 61 |
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Search STIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
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- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STIP1 Gene
Publications for STIP1 Gene
- Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1. (PMID: 1569099) Honoré B … Celis JE (The Journal of biological chemistry 1992) 2 3 4 23
- The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins GA … Bleecker ER (The Journal of allergy and clinical immunology 2009) 3 23 41
- Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PMID: 10786835) Scheufler C … Moarefi I (Cell 2000) 3 4 23
- Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. (PMID: 29127155) Woodford MR … Mollapour M (The EMBO journal 2017) 3 4
- The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4
ExternalLinks
Products for STIP1 Gene
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- antibodies-online: Show 97 available STIP1 Antibodies ranked by validation data
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- antibodies-online: Show 21 available STIP1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for STIP1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STIP1
Sources for STIP1 Gene
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