Aliases for STIP1 Gene
Aliases for STIP1 Gene
External Ids for STIP1 Gene
- HGNC: 11387
- Entrez Gene: 10963
- Ensembl: ENSG00000168439
- OMIM: 605063
- UniProtKB: P31948
Previous GeneCards Identifiers for STIP1 Gene
- GC11P066389
- GC11M065612
- GC11P063728
- GC11P063729
- GC11P063709
- GC11P063953
- GC11P060283
Summaries for STIP1 Gene
-
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
GeneCards Summary for STIP1 Gene
STIP1 (Stress Induced Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Prion diseases and Neuroscience. An important paralog of this gene is TTC31.
UniProtKB/Swiss-Prot for STIP1 Gene
-
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Additional gene information for STIP1 Gene
- Monarch Initiative
- Search for STIP1 at DataMed
- Search for STIP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIP1 Gene
Genomics for STIP1 Gene
GeneHancer (GH) Regulatory Elements for STIP1 Gene
Promoters and enhancers for STIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STIP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for STIP1 Gene
Genomic Locations for STIP1 Gene
- chr11:64,185,272-64,204,548
- (GRCh38/hg38)
- Size:
- 19,277 bases
- Orientation:
- Plus strand
- chr11:63,952,744-63,972,020
- (GRCh37/hg19)
Genomic View for STIP1 Gene
Genes around STIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
STIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STIP1 Gene
Proteins for STIP1 Gene
-
Protein details for STIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31948-STIP1_HUMAN
- Recommended name:
- Stress-induced-phosphoprotein 1
- Protein Accession:
- P31948
- B4DM70
- F5H0T1
- G3XAD8
- Q3ZCU9
- Q5TZU9
Protein attributes for STIP1 Gene
- Size:
- 543 amino acids
- Molecular mass:
- 62639 Da
- Quaternary structure:
-
- Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG (PubMed:14532270). Interacts with METTL21B (PubMed:23349634). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360). Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).
Three dimensional structures from OCA and Proteopedia for STIP1 Gene
Protein Expression for STIP1 Gene
Post-translational modifications for STIP1 Gene
Other Protein References for STIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STIP1 (STI1)
- Novus Biologicals Antibodies for STIP1
-
Abcam antibodies for STIP1
-
Cloud-Clone Corp. Antibodies for STIP1
- Invitrogen Antibodies for STIP1
- GeneTex STIP1 antibody for STIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for STIP1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STIP1
- Origene Custom Protein Services for STIP1
- ProSpec Recombinant Proteins for STIP1
-
Cloud-Clone Corp. Proteins for STIP1
- antibodies-online: Search results for 6 available STIP1 Proteins ranked by validation data
- Compare Top STIP1 Proteins
-
Quality Products:
- GeneTex Proteins for STIP1
-
Abcam proteins for STIP1
Assay Products
-
Cloud-Clone Corp. Assay Kits for STIP1
- antibodies-online: Search results for 4 available STIP1 Elisa Kits ranked by validation data
- Compare Top STIP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for STIP1 Gene
Domains & Families for STIP1 Gene
Gene Families for STIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for STIP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31948UniProtKB/Swiss-Prot:
STIP1_HUMAN :- The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
- Domain:
-
- The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
Function for STIP1 Gene
Molecular function for STIP1 Gene
- GENATLAS Biochemistry:
- stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts
- UniProtKB/Swiss-Prot Function:
- Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Phenotypes From GWAS Catalog for STIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 20029029 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0030544 | Hsp70 protein binding | IEA | -- |
| GO:0051087 | chaperone binding | IEA | -- |
Phenotypes for STIP1 Gene
- MGI mutant phenotypes for STIP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for STIP1:
Animal Models for STIP1 Gene
- MGI Knock Outs for STIP1:
-
- Stip1 tm1.2Mamp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STIP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for STIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STIP1 gene
- Search ViGene Biosciences for STIP1
CRISPR Products
-
OriGene CRISPR knockouts for STIP1
- genomics-online: gRNA clones - Search results for available STIP1 gene related products
- Applied Biological Materials CRISPR for STIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STIP1
- GenScript: Design CRISPR guide RNA sequences for STIP1
miRNA for STIP1 Gene
- miRTarBase miRNAs that target STIP1
-
- hsa-mir-16-5p (MIRT032016)
- hsa-mir-1180-3p (MIRT035915)
- hsa-mir-484 (MIRT041679)
- hsa-mir-193a-3p (MIRT044894)
- hsa-mir-183-5p (MIRT047040)
- hsa-let-7b-5p (MIRT051957)
- hsa-mir-218-5p (MIRT439523)
- hsa-mir-1207-5p (MIRT736061)
- hsa-mir-1909-3p (MIRT738379)
- hsa-mir-3153 (MIRT740401)
- hsa-mir-4311 (MIRT743953)
- hsa-mir-4688 (MIRT747026)
- hsa-mir-4763-3p (MIRT748569)
- hsa-mir-4802-3p (MIRT749010)
- hsa-mir-486-3p (MIRT749133)
- hsa-mir-6085 (MIRT751814)
- hsa-mir-6721-5p (MIRT753840)
- hsa-mir-6722-3p (MIRT753892)
- hsa-mir-6733-5p (MIRT754125)
- hsa-mir-6739-5p (MIRT754322)
- hsa-mir-6743-5p (MIRT754426)
- hsa-mir-6783-5p (MIRT755765)
- hsa-mir-6789-5p (MIRT756020)
- hsa-mir-6813-5p (MIRT756750)
miRNA Products
- Search ViGene Biosciences for STIP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STIP1
- Browse OriGene Inhibitory RNA Products For STIP1
- genomics-online: shRNA clones - Search results for available STIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for STIP1
- VectorBuilder custom plasmid, inducible vectors for STIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available STIP1 gene related products
- orf clones - Search results for available STIP1 gene related products
- Applied Biological Materials Clones for STIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for STIP1
-
ViGene Biosciences adenoviral particle packaged cDNA for STIP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STIP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIP1 Gene
Localization for STIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STIP1 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | TAS | 1569099 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0043209 | myelin sheath | IEA | -- |
Pathways & Interactions for STIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Prion diseases | ||
| 2 | Neuroscience | ||
Pathways by source for STIP1 Gene
1 KEGG pathway for STIP1 Gene
1 Cell Signaling Technology pathway for STIP1 Gene
Interacting Proteins for STIP1 Gene
Selected Interacting proteins:
ENSP00000305958
P31948-STIP1_HUMAN
for STIP1 Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006950 | response to stress | TAS | 1569099 |
No data available for SIGNOR curated interactions for STIP1 Gene
Drugs & Compounds for STIP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 202 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for STIP1 Gene
mRNA/cDNA for STIP1 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (739) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STIP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for STIP1
- genomics-online: gRNA clones - Search results for available STIP1 gene related products
- Applied Biological Materials CRISPR for STIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STIP1
- GenScript: Design CRISPR guide RNA sequences for STIP1
miRNA Products
- Search ViGene Biosciences for STIP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STIP1
- Browse OriGene Inhibitory RNA Products For STIP1
- genomics-online: shRNA clones - Search results for available STIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for STIP1
- VectorBuilder custom plasmid, inducible vectors for STIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available STIP1 gene related products
- orf clones - Search results for available STIP1 gene related products
- Applied Biological Materials Clones for STIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18c | · | 18d |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: |
Expression for STIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intermediate Mesoderm (Gastrulation Derivatives)
- Brain (Nervous System)
-
Ovary (Reproductive System)
-
Stomach (Gastrointestinal Tract)
-
Esophagus (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
-
Testis (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Uterus (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STIP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STIP1 Gene:
STIP1SOURCE GeneReport for Unigene cluster for STIP1 Gene:
Hs.337295Evidence on tissue expression from TISSUES for STIP1 Gene
- Nervous system(4.9)
- Liver(4.6)
- Lung(4.6)
- Skin(4.6)
- Intestine(3.9)
- Heart(3)
- Blood(2.7)
- Eye(2.6)
- Adrenal gland(2.4)
- Stomach(2.3)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for STIP1
-
OriGene qPCR primer pairs and template standards for STIP1
- genomics-online: primer clones - Search results for available STIP1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIP1 Gene
Orthologs for STIP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STIP1 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | STIP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | STIP1 33 34 |
|
||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Stip1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Stip1 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | STIP1 34 |
|
OneToOne | |
| LOC101748085 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | STIP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stip1 33 |
|
||
| MGC76181 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | stip1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stip1 33 34 |
|
||
| Dr.29081 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010188 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hop 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sti-1 33 34 |
|
||
| R09E12.3 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL224W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STI1 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07062g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G12270 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.8435 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0644100 33 |
|
||
| Os.13461 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.8679 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2588 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00714 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sti1 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.271 33 |
|
- Species where no ortholog for STIP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for STIP1 Gene
(3) SIMAP similar genes for STIP1 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for STIP1 Gene
Variants for STIP1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011255 | -- | 64,191,636(+) | C/ | intron_variant | |
| rs1000025707 | -- | 64,195,353(+) | T/C | intron_variant | |
| rs1000071954 | -- | 64,186,662(+) | G/A | intron_variant | |
| rs1000223597 | -- | 64,184,206(+) | G/A | upstream_transcript_variant | |
| rs1000448855 | -- | 64,187,996(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv15n68 | CNV | loss | 17160897 |
| dgv1963n54 | CNV | loss | 21841781 |
| nsv1159904 | CNV | deletion | 26073780 |
| nsv469961 | CNV | loss | 18288195 |
| nsv555184 | CNV | loss | 21841781 |
| nsv555187 | CNV | loss | 21841781 |
| nsv825943 | CNV | gain | 20364138 |
| nsv951010 | CNV | deletion | 24416366 |
| nsv972037 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STIP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STIP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIP1 Gene
Disorders for STIP1 Gene
Additional Disease Information for STIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for STIP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STIP1 Gene
Publications for STIP1 Gene
- Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1. (PMID: 1569099) Honoré B … Celis JE (The Journal of biological chemistry 1992) 2 3 4 22 58
- The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins GA … Bleecker ER (The Journal of allergy and clinical immunology 2009) 3 22 44 58
- Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PMID: 10786835) Scheufler C … Moarefi I (Cell 2000) 3 4 22 58
- The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4 58
- SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. (PMID: 24880080) Hamamoto R … Nakamura Y (Cancer letters 2014) 3 4 58
Products for STIP1 Gene
- R&D Systems Antibodies for STIP1 (STI1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STIP1
- Origene Custom Protein Services for STIP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STIP1
- Browse OriGene Inhibitory RNA Products For STIP1
- OriGene qPCR primer pairs and template standards for STIP1
- OriGene qPCR primer pairs for STIP1
- OriGene CRISPR knockouts for STIP1
- OriGene ORF clones in human for STIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STIP1
- GenScript: Next-day shipping of latest version cDNA ORF clones for STIP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STIP1
- GenScript Custom Assay Services for STIP1
- GenScript Custom overexpressing Cell Line Services for STIP1
- GenScript: Design CRISPR guide RNA sequences for STIP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STIP1
- Sino Biological Human cDNA Clone for STIP1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for STIP1
- Novus Biologicals lysates and proteins for STIP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STIP1
- Abcam proteins for STIP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for STIP1
- Cloud-Clone Corp. Antibodies for STIP1
- Cloud-Clone Corp. Proteins for STIP1
- Cloud-Clone Corp. Assay Kits for STIP1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for STIP1
- VectorBuilder custom plasmid, inducible vectors for STIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STIP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 63 available STIP1 Antibodies ranked by validation data
- Compare Top STIP1 Antibodies
- antibodies-online: Search results for 4 available STIP1 Elisa Kits ranked by validation data
- Compare Top STIP1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available STIP1 Proteins ranked by validation data
- Compare Top STIP1 Proteins
- Quality Products:
- GeneTex STIP1 antibody for STIP1
- GeneTex Proteins for STIP1
- ViGene Biosciences adenoviral particle packaged cDNA for STIP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for STIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for STIP1 gene
- Search ViGene Biosciences for STIP1
- Santa Cruz Biotechnology (SCBT) Antibodies for STIP1
- Search Santa Cruz Biotechnology (SCBT) for STIP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STIP1
- Horizon Cell Lines for STIP1
- genomics-online: cdna clones - Search results for available STIP1 gene related products
- orf clones - Search results for available STIP1 gene related products
- genomics-online: gRNA clones - Search results for available STIP1 gene related products
- genomics-online: primer clones - Search results for available STIP1 gene related products
- genomics-online: shRNA clones - Search results for available STIP1 gene related products
Sources for STIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems