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Aliases for STIM2 Gene

Aliases for STIM2 Gene

  • Stromal Interaction Molecule 2 2 3 5
  • KIAA1482 4

External Ids for STIM2 Gene

Previous GeneCards Identifiers for STIM2 Gene

  • GC04P027012
  • GC04P026550
  • GC04P026613
  • GC04P026538
  • GC04P026472
  • GC04P026200

Summaries for STIM2 Gene

Entrez Gene Summary for STIM2 Gene

  • This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

GeneCards Summary for STIM2 Gene

STIM2 (Stromal Interaction Molecule 2) is a Protein Coding gene. Diseases associated with STIM2 include Stormorken Syndrome and Myopathy, Tubular Aggregate, 1. Among its related pathways are Calcium signaling pathway and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and store-operated calcium channel activity. An important paralog of this gene is STIM1.

UniProtKB/Swiss-Prot for STIM2 Gene

  • Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Tocris Summary for STIM2 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Gene Wiki entry for STIM2 Gene

Additional gene information for STIM2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIM2 Gene

Genomics for STIM2 Gene

GeneHancer (GH) Regulatory Elements for STIM2 Gene

Promoters and enhancers for STIM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I026856 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 564.8 +2.4 2422 6.7 HDGF PKNOX1 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 POLR2B LOC105374546 STIM2
GH04I026881 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 43.4 +27.1 27139 6.7 MEIS2 PKNOX1 BATF IRF4 RFX5 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 STIM2 LOC105374546 TBC1D19 LOC100421493 GC04P026973
GH04I026991 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.1 +135.7 135735 3.4 HDAC1 BMI1 BATF IRF4 TCF12 EGR1 ATF7 BCLAF1 IKZF2 RUNX3 STIM2 LOC105374546 GC04P026984 GC04M027054
GH04I026821 Enhancer 1.1 Ensembl ENCODE 19.6 -35.3 -35308 1.5 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 RUNX3 RXRA JUNB STIM2 GC04P026778
GH04I026826 Enhancer 1 Ensembl ENCODE 18.2 -30.7 -30688 1.2 EBF1 BMI1 BATF IRF4 RELA NFATC1 ATF7 ETV6 IKZF2 RUNX3 STIM2 GC04P026778
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STIM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STIM2 gene promoter:

Genomic Locations for STIM2 Gene

Genomic Locations for STIM2 Gene
chr4:26,857,678-27,025,381
(GRCh38/hg38)
Size:
167,704 bases
Orientation:
Plus strand
chr4:26,859,300-27,027,003
(GRCh37/hg19)

Genomic View for STIM2 Gene

Genes around STIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIM2 Gene

Proteins for STIM2 Gene

  • Protein details for STIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P246-STIM2_HUMAN
    Recommended name:
    Stromal interaction molecule 2
    Protein Accession:
    Q9P246
    Secondary Accessions:
    • A6H8L7
    • B7ZVY0
    • Q96BF1
    • Q9BQH2
    • Q9H8R1

    Protein attributes for STIM2 Gene

    Size:
    746 amino acids
    Molecular mass:
    83971 Da
    Quaternary structure:
    • Oligomer with STIM1. Interacts with ORAI1.
    SequenceCaution:
    • Sequence=BAA96006.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=BAB14545.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14545.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB66512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STIM2 Gene

    Alternative splice isoforms for STIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STIM2 Gene

Post-translational modifications for STIM2 Gene

No data available for DME Specific Peptides for STIM2 Gene

Domains & Families for STIM2 Gene

Gene Families for STIM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for STIM2 Gene

Suggested Antigen Peptide Sequences for STIM2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STIM2: view

No data available for UniProtKB/Swiss-Prot for STIM2 Gene

Function for STIM2 Gene

Molecular function for STIM2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Phenotypes From GWAS Catalog for STIM2 Gene

Gene Ontology (GO) - Molecular Function for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IMP 18160041
GO:0005509 calcium ion binding IDA 18166150
GO:0005515 protein binding IPI 11463338
GO:0015279 store-operated calcium channel activity IDA 16860747
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STIM2: view
genes like me logo Genes that share phenotypes with STIM2: view

Animal Models for STIM2 Gene

MGI Knock Outs for STIM2:

miRNA for STIM2 Gene

Clone Products

  • Addgene plasmids for STIM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIM2 Gene

Localization for STIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIM2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STIM2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 18160041
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA 18160041
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STIM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STIM2 Gene

Pathways & Interactions for STIM2 Gene

genes like me logo Genes that share pathways with STIM2: view

Pathways by source for STIM2 Gene

1 Cell Signaling Technology pathway for STIM2 Gene
1 KEGG pathway for STIM2 Gene

Gene Ontology (GO) - Biological Process for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006874 cellular calcium ion homeostasis IMP 18160041
genes like me logo Genes that share ontologies with STIM2: view

No data available for SIGNOR curated interactions for STIM2 Gene

Drugs & Compounds for STIM2 Gene

(1) Drugs for STIM2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0

(5) Tocris Compounds for STIM2 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with STIM2: view

Transcripts for STIM2 Gene

Unigene Clusters for STIM2 Gene

Stromal interaction molecule 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for STIM2

Alternative Splicing Database (ASD) splice patterns (SP) for STIM2 Gene

No ASD Table

Relevant External Links for STIM2 Gene

GeneLoc Exon Structure for
STIM2
ECgene alternative splicing isoforms for
STIM2

Expression for STIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STIM2 Gene

Protein differential expression in normal tissues from HIPED for STIM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.4) and Breast (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STIM2 Gene



Protein tissue co-expression partners for STIM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STIM2 Gene:

STIM2

SOURCE GeneReport for Unigene cluster for STIM2 Gene:

Hs.744950

mRNA Expression by UniProt/SwissProt for STIM2 Gene:

Q9P246-STIM2_HUMAN
Tissue specificity: Expressed in all tissues and tumor cell lines examined.

Evidence on tissue expression from TISSUES for STIM2 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with STIM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIM2 Gene

Orthologs for STIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STIM2 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia STIM2 34 33
  • 91.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STIM2 33 34
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STIM2 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Stim2 16 34 33
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Stim2 33
  • 85.28 (n)
chicken
(Gallus gallus)
Aves STIM2 34 33
  • 79.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STIM2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stim2 33
  • 73.09 (n)
zebrafish
(Danio rerio)
Actinopterygii stim2b 34 33
  • 63.42 (n)
OneToMany
STIM2 (2 of 2) 34
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Stim 35 34
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55B1BM.1b 35
  • 29 (a)
Y55B1BM.1a 35
  • 28 (a)
stim-1 34
  • 25 (a)
OneToMany
Species where no ortholog for STIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STIM2 Gene

ENSEMBL:
Gene Tree for STIM2 (if available)
TreeFam:
Gene Tree for STIM2 (if available)

Paralogs for STIM2 Gene

Paralogs for STIM2 Gene

genes like me logo Genes that share paralogs with STIM2: view

Variants for STIM2 Gene

Sequence variations from dbSNP and Humsavar for STIM2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000009444 -- 26,991,225(+) A/G intron_variant
rs1000057179 -- 27,003,553(+) C/T intron_variant
rs1000085504 -- 26,902,739(+) A/C/G intron_variant
rs1000087515 -- 27,016,505(+) G/A intron_variant
rs1000144855 -- 26,861,689(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STIM2 Gene

Variant ID Type Subtype PubMed ID
nsv822513 CNV loss 20364138
nsv593880 CNV loss 21841781
nsv593872 CNV loss 21841781
nsv470021 CNV loss 18288195
nsv461312 CNV loss 19166990
esv3599996 CNV loss 21293372
esv3599995 CNV loss 21293372
esv3563592 CNV deletion 23714750
esv2662300 CNV deletion 23128226
esv2570509 CNV deletion 19546169
esv23369 CNV loss 19812545
esv2334135 CNV deletion 18987734
esv1919348 CNV deletion 18987734
esv1000535 CNV deletion 20482838
dgv8995n54 CNV loss 21841781
dgv8994n54 CNV loss 21841781
dgv8993n54 CNV loss 21841781
dgv139n6 CNV deletion 16902084

Variation tolerance for STIM2 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.92; 79.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIM2 Gene

Disorders for STIM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STIM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stormorken syndrome
  • strmk
myopathy, tubular aggregate, 1
  • tam1
- elite association - COSMIC cancer census association via MalaCards
Search STIM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STIM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STIM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STIM2 Gene

Publications for STIM2 Gene

  1. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. (PMID: 17905723) Parvez S … Penner R (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008) 3 4 22 58
  2. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. (PMID: 11463338) Williams RT … Dziadek MA (The Biochemical journal 2001) 2 3 4 58
  3. STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion. (PMID: 23359669) Thiel M … Penner R (The Journal of physiology 2013) 3 4 58
  4. Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. (PMID: 21217057) Zheng L … Ikura M (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  5. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre RN … Steffen LM (PLoS genetics 2011) 3 44 58

Products for STIM2 Gene

Sources for STIM2 Gene

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