The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and me... See more...

Aliases for STEAP4 Gene

Aliases for STEAP4 Gene

  • STEAP4 Metalloreductase 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 9 2 3 4
  • STAMP2 2 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 4 3 4
  • Seven Chromosome Locus Associated With HCC 2 3
  • SixTransMembrane Protein Of Prostate 2 3 4
  • Metalloreductase STEAP4 3 4
  • STEAP Family Member 4 2 3
  • TNFAIP9 3 4
  • SchLAH 2 3
  • TIARP 2 3
  • Tumor Necrosis-Alpha-Induced Adipose-Related Protein 3
  • Six Transmembrane Prostate Protein 2 3
  • EC 1.16.1.9 4
  • EC 1.16.1 51
  • FLJ23153 2
  • STEAP4 5

External Ids for STEAP4 Gene

Previous HGNC Symbols for STEAP4 Gene

  • TNFAIP9

Previous GeneCards Identifiers for STEAP4 Gene

  • GC07M087552
  • GC07M087745
  • GC07M087900
  • GC07M082517
  • GC07M087905
  • GC07M088276
  • GC07M088278

Summaries for STEAP4 Gene

Entrez Gene Summary for STEAP4 Gene

  • The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for STEAP4 Gene

STEAP4 (STEAP4 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP4 include Hepatocellular Carcinoma and Arthritis. Among its related pathways are Copper homeostasis. Gene Ontology (GO) annotations related to this gene include phosphogluconate dehydrogenase (decarboxylating) activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot Summary for STEAP4 Gene

  • Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).

Additional gene information for STEAP4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STEAP4 Gene

Genomics for STEAP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STEAP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J088306 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 601.9 +0.2 230 2.9 CEBPG EZH2 SCRT2 CTBP1 CEBPB ZNF217 MYC NR2F2 CTCF ELF1 STEAP4 lnc-STEAP4-1 SRI ENSG00000228113
GH07J088309 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -10.0 -10009 15 TCF12 IKZF2 SP1 PKNOX1 MNT RELB CEBPB USF1 ARNT ELF1 STEAP4 TEX47 ENSG00000228113 SRI TP53TG1 LOC107986815 ZNF804B
GH07J088268 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.3 +37.8 37793 3.4 YBX1 SPI1 PLRG1 NCOA3 SUPT5H POLR2A SREBF1 MCM2 piR-36393-491 piR-50308-592 piR-43583-512 STEAP4 DBF4 EIF4A1P13 ENSG00000207094 SRI lnc-STEAP4-1 ENSG00000228113
GH07J088331 Enhancer 0.6 Ensembl ENCODE 9.4 -22.4 -22407 5 SP1 RUNX3 NR2F2 SPI1 RXRA ZNF680 STEAP4 ENSG00000228113 LOC107986815 ZNF804B
GH07J088395 Enhancer 0.9 Ensembl ENCODE 6.1 -89.5 -89507 4.4 RELA TCF12 IKZF2 TRIM22 PKNOX1 CEBPB ARID3A DPF2 RUNX3 BCL11A ZNF804B STEAP4 L13713-216 piR-34924
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STEAP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STEAP4

Top Transcription factor binding sites by QIAGEN in the STEAP4 gene promoter:
  • Cart-1
  • Hlf
  • HNF-3beta
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • RelA
  • RORalpha2
  • SRY

Genomic Locations for STEAP4 Gene

Genomic Locations for STEAP4 Gene
chr7:88,270,892-88,306,894
(GRCh38/hg38)
Size:
36,003 bases
Orientation:
Minus strand
chr7:87,905,744-87,936,228
(GRCh37/hg19)
Size:
30,485 bases
Orientation:
Minus strand

Genomic View for STEAP4 Gene

Genes around STEAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP4 Gene

Proteins for STEAP4 Gene

  • Protein details for STEAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q687X5-STEA4_HUMAN
    Recommended name:
    Metalloreductase STEAP4
    Protein Accession:
    Q687X5
    Secondary Accessions:
    • Q658Q9
    • Q687X4
    • Q8WWB0
    • Q9H5R1

    Protein attributes for STEAP4 Gene

    Size:
    459 amino acids
    Molecular mass:
    51981 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Homotrimer (PubMed:30337524). Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.
    SequenceCaution:
    • Sequence=AAQ04064.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15559.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAH56271.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STEAP4 Gene

    Alternative splice isoforms for STEAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP4 Gene

Selected DME Specific Peptides for STEAP4 Gene

Q687X5:
  • RFPDWLDHW
  • GTKYRRFP
  • NQYPESNAEYLA

Post-translational modifications for STEAP4 Gene

  • Glycosylation at Asn323
  • Modification sites at PhosphoSitePlus

Other Protein References for STEAP4 Gene

Domains & Families for STEAP4 Gene

Gene Families for STEAP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for STEAP4 Gene

Suggested Antigen Peptide Sequences for STEAP4 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor, alpha-induced protein 9 (STEA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q687X5

UniProtKB/Swiss-Prot:

STEA4_HUMAN :
  • Belongs to the STEAP family.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP4: view

Function for STEAP4 Gene

Molecular function for STEAP4 Gene

UniProtKB/Swiss-Prot Function:
Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH; Xref=Rhea:RHEA:28795, Rhea:RHEA-COMP:11342, Rhea:RHEA-COMP:11344, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.16.1.9; Evidence={ECO:0000269|PubMed:30337524};.
UniProtKB/Swiss-Prot Induction:
By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.7 uM for Fe(3+)-NTA {ECO:0000269|PubMed:30337524}; KM=4.2 uM for NADPH {ECO:0000269|PubMed:30337524};

Enzyme Numbers (IUBMB) for STEAP4 Gene

Phenotypes From GWAS Catalog for STEAP4 Gene

Gene Ontology (GO) - Molecular Function for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008823 cupric reductase activity IBA 21873635
GO:0009055 electron transfer activity IDA 30337524
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IDA 30337524
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STEAP4: view
genes like me logo Genes that share phenotypes with STEAP4: view

Animal Models for STEAP4 Gene

MGI Knock Outs for STEAP4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STEAP4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STEAP4 Gene

Localization for STEAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP4 Gene

Cell membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Early endosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 4
endosome 4
golgi apparatus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IDA,ISS --
genes like me logo Genes that share ontologies with STEAP4: view

Pathways & Interactions for STEAP4 Gene

PathCards logo

SuperPathways for STEAP4 Gene

SuperPathway Contained pathways
1 Copper homeostasis
genes like me logo Genes that share pathways with STEAP4: view

Pathways by source for STEAP4 Gene

1 BioSystems pathway for STEAP4 Gene

Interacting Proteins for STEAP4 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000369419 Q687X5-STEA4_HUMAN for STEAP4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015677 copper ion import IBA 21873635
GO:0022900 electron transport chain IEA --
GO:0045444 fat cell differentiation ISS --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with STEAP4: view

No data available for SIGNOR curated interactions for STEAP4 Gene

Drugs & Compounds for STEAP4 Gene

(3) Drugs for STEAP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0
heme Pharma Agonist 0
genes like me logo Genes that share compounds with STEAP4: view

Transcripts for STEAP4 Gene

mRNA/cDNA for STEAP4 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STEAP4

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -
SP3:

Relevant External Links for STEAP4 Gene

GeneLoc Exon Structure for
STEAP4

Expression for STEAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STEAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.6) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for STEAP4 Gene

This gene is overexpressed in Nasal epithelium (38.7) and Testis (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STEAP4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STEAP4

SOURCE GeneReport for Unigene cluster for STEAP4 Gene:

Hs.521008

mRNA Expression by UniProt/SwissProt for STEAP4 Gene:

Q687X5-STEA4_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

Evidence on tissue expression from TISSUES for STEAP4 Gene

  • Liver(4.5)
  • Lung(4.3)
  • Stomach(4.2)
  • Heart(2.7)
  • Intestine(2.4)
  • Kidney(2.2)
  • Muscle(2.2)
  • Spleen(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with STEAP4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP4 Gene

Orthologs for STEAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STEAP4 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STEAP4 30 31
  • 89.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STEAP4 30 31
  • 88.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Steap4 30
  • 82.57 (n)
Mouse
(Mus musculus)
Mammalia Steap4 30 17 31
  • 82.06 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia STEAP4 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STEAP4 30 31
  • 72.48 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STEAP4 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia steap4 30
  • 68.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii steap4 30 31
  • 60.89 (n)
OneToOne
Dr.12725 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7528 30
Species where no ortholog for STEAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STEAP4 Gene

ENSEMBL:
Gene Tree for STEAP4 (if available)
TreeFam:
Gene Tree for STEAP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STEAP4: view image

Paralogs for STEAP4 Gene

Paralogs for STEAP4 Gene

(6) SIMAP similar genes for STEAP4 Gene using alignment to 2 proteins:

  • STEA4_HUMAN
  • C9JS50_HUMAN
genes like me logo Genes that share paralogs with STEAP4: view

Variants for STEAP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STEAP4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
722292 Likely Benign: not provided 88,280,924(-) T/A SYNONYMOUS_VARIANT
773216 Benign: not provided 88,282,672(-) C/A MISSENSE_VARIANT,INTRON_VARIANT
790602 Benign: not provided 88,282,795(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
rs1981529 - p.Gly75Asp
rs34741656 - p.Ala122Thr

Additional dbSNP identifiers (rs#s) for STEAP4 Gene

Variation tolerance for STEAP4 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP4 Gene

Human Gene Mutation Database (HGMD)
STEAP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STEAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STEAP4 Gene

Disorders for STEAP4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for STEAP4 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
arthritis
  • inflammatory disorder of joint
rheumatoid arthritis
  • ra
prostate cancer
  • prostate cancer, somatic
diabetes mellitus, noninsulin-dependent
  • niddm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STEAP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STEAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP4 Gene

Publications for STEAP4 Gene

  1. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. (PMID: 19289123) Kralisch S … Fasshauer M (FEBS letters 2009) 3 4 23
  2. Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. (PMID: 15897894) Korkmaz CG … Saatcioglu F (Oncogene 2005) 2 3 4
  3. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. (PMID: 11443137) Moldes M … Chambaut-Guérin AM (The Journal of biological chemistry 2001) 2 3 23
  4. Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction. (PMID: 30337524) Oosterheert W … Gros P (Nature communications 2018) 3 4
  5. STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes. (PMID: 20127040) Chen X … Guo X (International journal of molecular medicine 2010) 3 23

Products for STEAP4 Gene

Sources for STEAP4 Gene