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Aliases for STEAP4 Gene

Aliases for STEAP4 Gene

  • STEAP4 Metalloreductase 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 9 2 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 4 3 4
  • Seven Chromosome Locus Associated With HCC 2 3
  • SixTransMembrane Protein Of Prostate 2 3 4
  • STEAP Family Member 4 2 3
  • TNFAIP9 3 4
  • STAMP2 3 4
  • Tumor Necrosis-Alpha-Induced Adipose-Related Protein 3
  • Six Transmembrane Prostate Protein 2 3
  • Metalloreductase STEAP4 3
  • EC 1.16.1.- 4
  • EC 1.16.1 56
  • SchLAH 3
  • TIARP 3

External Ids for STEAP4 Gene

Previous HGNC Symbols for STEAP4 Gene


Previous GeneCards Identifiers for STEAP4 Gene

  • GC07M087552
  • GC07M087745
  • GC07M087900
  • GC07M082517
  • GC07M087905

Summaries for STEAP4 Gene

Entrez Gene Summary for STEAP4 Gene

  • The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for STEAP4 Gene

STEAP4 (STEAP4 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP4 include Arthritis and Prostate Cancer. Among its related pathways are Copper homeostasis. Gene Ontology (GO) annotations related to this gene include phosphogluconate dehydrogenase (decarboxylating) activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot for STEAP4 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).

Additional gene information for STEAP4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP4 Gene

Genomics for STEAP4 Gene

GeneHancer (GH) Regulatory Elements for STEAP4 Gene

Promoters and enhancers for STEAP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I088306 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552 -0.3 -253 1.9 SMARCE1 CTCF STAT1 MAX CEBPB ELF1 CEBPG E2F1 ZNF217 CTBP1 STEAP4 PIR57969
GH07I088268 Enhancer 0.6 FANTOM5 ENCODE 12.3 +37.9 37857 0.3 POLR2A STEAP4 GC07M088271 GC07M088224 ENSG00000228113
GH07I088354 Enhancer 0.5 FANTOM5 Ensembl 11.9 -48.3 -48288 0.8 STEAP4 PIR57969
GH07I088395 Enhancer 0.8 Ensembl ENCODE 6.1 -89.3 -89284 1.2 PKNOX1 JUN ELF1 ATF2 BCL11A IKZF1 ETV6 ATF7 RUNX3 STEAP4 GC07M088373 PIR57969
GH07I088314 Enhancer 0.6 FANTOM5 4.9 -7.4 -7448 0.3 PKNOX1 IKZF1 ATF7 ELF1 IKZF2 NR2F2 SPI1 TEX47 STEAP4 PIR57969
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STEAP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STEAP4 gene promoter:

Genomic Locations for STEAP4 Gene

Genomic Locations for STEAP4 Gene
36,022 bases
Minus strand

Genomic View for STEAP4 Gene

Genes around STEAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP4 Gene

Proteins for STEAP4 Gene

  • Protein details for STEAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloreductase STEAP4
    Protein Accession:
    Secondary Accessions:
    • Q658Q9
    • Q687X4
    • Q8WWB0
    • Q9H5R1

    Protein attributes for STEAP4 Gene

    459 amino acids
    Molecular mass:
    51981 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.
    • Sequence=AAQ04064.1; Type=Frameshift; Positions=384; Evidence={ECO:0000305}; Sequence=BAB15559.1; Type=Frameshift; Positions=252, 364; Evidence={ECO:0000305}; Sequence=CAH56271.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STEAP4 Gene


neXtProt entry for STEAP4 Gene

Selected DME Specific Peptides for STEAP4 Gene


Post-translational modifications for STEAP4 Gene

  • Glycosylation at isoforms=323
  • Modification sites at PhosphoSitePlus

Other Protein References for STEAP4 Gene

Domains & Families for STEAP4 Gene

Gene Families for STEAP4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for STEAP4 Gene

Suggested Antigen Peptide Sequences for STEAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STEAP family.
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP4: view

Function for STEAP4 Gene

Molecular function for STEAP4 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).
UniProtKB/Swiss-Prot Induction:
By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).

Enzyme Numbers (IUBMB) for STEAP4 Gene

Gene Ontology (GO) - Molecular Function for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008823 cupric reductase activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IBA --
genes like me logo Genes that share ontologies with STEAP4: view
genes like me logo Genes that share phenotypes with STEAP4: view

Animal Models for STEAP4 Gene

MGI Knock Outs for STEAP4:

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STEAP4 Gene

Localization for STEAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP4 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 4
endosome 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with STEAP4: view

Pathways & Interactions for STEAP4 Gene

SuperPathways for STEAP4 Gene

SuperPathway Contained pathways
1 Copper homeostasis
genes like me logo Genes that share pathways with STEAP4: view

Pathways by source for STEAP4 Gene

1 BioSystems pathway for STEAP4 Gene

Interacting Proteins for STEAP4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q687X5-STEA4_HUMAN ENSP00000369419 for STEAP4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015677 copper ion import IBA --
GO:0045444 fat cell differentiation ISS --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with STEAP4: view

No data available for SIGNOR curated interactions for STEAP4 Gene

Drugs & Compounds for STEAP4 Gene

(3) Drugs for STEAP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP4: view

Transcripts for STEAP4 Gene

Unigene Clusters for STEAP4 Gene

STEAP family member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -

Relevant External Links for STEAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STEAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STEAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.6) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for STEAP4 Gene

This gene is overexpressed in Nasal epithelium (38.7) and Testis (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STEAP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of STEAP4 Gene:


SOURCE GeneReport for Unigene cluster for STEAP4 Gene:


mRNA Expression by UniProt/SwissProt for STEAP4 Gene:

Tissue specificity: Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

Evidence on tissue expression from TISSUES for STEAP4 Gene

  • Liver(4.4)
  • Lung(4.3)
  • Stomach(4.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with STEAP4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP4 Gene

Orthologs for STEAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STEAP4 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia STEAP4 33 34
  • 89.67 (n)
(Bos Taurus)
Mammalia STEAP4 33 34
  • 88.38 (n)
(Rattus norvegicus)
Mammalia Steap4 33
  • 82.57 (n)
(Mus musculus)
Mammalia Steap4 33 16 34
  • 82.06 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 74 (a)
-- 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia STEAP4 34
  • 75 (a)
(Gallus gallus)
Aves STEAP4 33 34
  • 72.48 (n)
(Anolis carolinensis)
Reptilia STEAP4 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia steap4 33
  • 68.59 (n)
(Danio rerio)
Actinopterygii steap4 33 34
  • 60.89 (n)
Dr.12725 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7528 33
Species where no ortholog for STEAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP4 Gene

Gene Tree for STEAP4 (if available)
Gene Tree for STEAP4 (if available)

Paralogs for STEAP4 Gene

Paralogs for STEAP4 Gene

(6) SIMAP similar genes for STEAP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP4: view

Variants for STEAP4 Gene

Sequence variations from dbSNP and Humsavar for STEAP4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000017750 -- 88,295,654(-) G/C intron_variant
rs1000023687 -- 88,290,658(-) T/C intron_variant
rs1000093600 -- 88,286,560(-) C/G intron_variant
rs1000216726 -- 88,283,437(-) G/T intron_variant
rs1000291580 -- 88,276,705(-) G/A 3_prime_UTR_variant

Variation tolerance for STEAP4 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STEAP4 Gene

Disorders for STEAP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STEAP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • inflammatory disorder of joint
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STEAP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STEAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP4 Gene

Publications for STEAP4 Gene

  1. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. (PMID: 19289123) Kralisch S … Fasshauer M (FEBS letters 2009) 3 4 22 58
  2. Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. (PMID: 15897894) Korkmaz CG … Saatcioglu F (Oncogene 2005) 2 3 4 58
  3. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. (PMID: 11443137) Moldes M … Chambaut-Guérin AM (The Journal of biological chemistry 2001) 2 3 22 58
  4. STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes. (PMID: 20127040) Chen X … Guo X (International journal of molecular medicine 2010) 3 22 58
  5. Genetic variability at the six transmembrane protein of prostate 2 locus and the metabolic syndrome: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. (PMID: 20382686) Miot A … DESIR Study Group (The Journal of clinical endocrinology and metabolism 2010) 3 44 58

Products for STEAP4 Gene

Sources for STEAP4 Gene

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